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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 董成淵(Chen-Yuan Dong) | |
| dc.contributor.author | Jing-Tang Lin | en |
| dc.contributor.author | 林靖棠 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:04:52Z | - |
| dc.date.available | 2021-10-04 | |
| dc.date.available | 2022-11-23T09:04:52Z | - |
| dc.date.copyright | 2021-10-04 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-16 | |
| dc.identifier.citation | [1] D. E. Johnson, B. Burtness, C. R. Leemans, V. W. Y. Lui, J. E. Bauman and J. R. Grandis, Nature Reviews Disease Primers 6 (1), 92 (2020). [2] https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=1127 pid=1817, (2015). [3] N. C. J. Lee, J. R. Kelly, H. S. Park, Y. An, B. L. Judson, B. A. Burtness and Z. A. Husain, Oral Oncol 85, 35-39 (2018). [4] G. S. Weinstein, H. Quon, H. J. Newman, J. A. Chalian, K. Malloy, A. Lin, A. Desai, V. A. Livolsi, K. T. Montone, K. R. Cohen and B. W. O'Malley, Arch Otolaryngol Head Neck Surg 138 (7), 628-634 (2012). [5] A. K. D'Cruz, R. Vaish, N. Kapre, M. Dandekar, S. Gupta, R. Hawaldar, J. P. Agarwal, G. Pantvaidya, D. Chaukar, A. Deshmukh, S. Kane, S. Arya, S. Ghosh-Laskar, P. Chaturvedi, P. Pai, S. Nair, D. Nair and R. Badwe, N Engl J Med 373 (6), 521-529 (2015). [6] P. Fratzl, Collagen: Structure and Mechanics. (Springer US, 2008). [7] D. O. Velez, B. Tsui, T. Goshia, C. L. Chute, A. Han, H. Carter and S. I. Fraley, Nature Communications 8 (1), 1651 (2017). [8] Y.-Q. Chen, J.-C. Kuo, M.-T. Wei, Y.-C. Chen, M.-H. Yang and A. Chiou, Acta Biomaterialia 84, 280-292 (2019). [9] E. Cohen, T. Tendler, H. Lu, C. K. Hansen, J. Kurtsman, J. Barrios and R. Wieder, Anticancer Research 33 (2), 379 (2013). [10] Z. Raglow and S. M. Thomas, Cancer Letters 357 (2), 448-453 (2015). [11] J. C. Sok, J. A. Lee, S. Dasari, S. Joyce, S. C. Contrucci, A. M. Egloff, B. K. Trevelline, R. Joshi, N. Kumari, J. R. Grandis and S. M. Thomas, Br J Cancer 109 (12), 3049-3056 (2013). [12] R. A. Weale, Pflugers Arch 329 (3), 244-257 (1971). [13] D. H. Goldstein, Polarized Light. (CRC Press, 2017). [14] D. N. America, (2018). [15] R. Mehra, T. Y. Seiwert, S. Gupta, J. Weiss, I. Gluck, J. P. Eder, B. Burtness, M. Tahara, B. Keam, H. Kang, K. Muro, R. Geva, H. C. Chung, C.-C. Lin, D. Aurora-Garg, A. Ray, K. Pathiraja, J. Cheng, L. Q. M. Chow and R. Haddad, British Journal of Cancer 119 (2), 153-159 (2018). [16] R. L. Ferris, G. Blumenschein, Jr., J. Fayette, J. Guigay, A. D. Colevas, L. Licitra, K. Harrington, S. Kasper, E. E. Vokes, C. Even, F. Worden, N. F. Saba, L. C. Iglesias Docampo, R. Haddad, T. Rordorf, N. Kiyota, M. Tahara, M. Monga, M. Lynch, W. J. Geese, J. Kopit, J. W. Shaw and M. L. Gillison, N Engl J Med 375 (19), 1856-1867 (2016). [17] J. Eichberger, D. Schulz, K. Pscheidl, M. Fiedler, T. E. Reichert, R. J. Bauer and T. Ettl, International Journal of Molecular Sciences 21 (21), 8089 (2020). [18] J. H. Rasmussen, G. Lelkaitis, K. Håkansson, I. R. Vogelius, H. H. Johannesen, B. M. Fischer, S. M. Bentzen, L. Specht, C. A. Kristensen, C. von Buchwald, I. Wessel and J. Friborg, British Journal of Cancer 120 (10), 1003-1006 (2019). [19] S. I. Pai and W. H. Westra, Annual Review of Pathology: Mechanisms of Disease 4 (1), 49-70 (2009). [20] R. Moll, M. Divo and L. Langbein, Histochem Cell Biol 129 (6), 705-733 (2008). [21] R. D. B. Fraser, Nature 172 (4380), 675-676 (1953). | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79600 | - |
| dc.description.abstract | 頭頸部鱗狀細胞癌簡稱頭頸癌，為台灣常見癌症之一，肇因酒精以及菸草之大量使用，且已成為台灣嚴峻的健康議題之一。病患經常需要做腫瘤之活體組織切片以此觀察癌症之惡化程度。由於大量證據顯示膠原蛋白纖維之生成可能與腫瘤之轉移及其複製能力有高度相關，本研究以膠原蛋白獨特之雙折射特性研究頭頸癌裡膠原蛋白之走向。我們以瓊斯矩陣(Jones Calculus)運算為基礎構建了一個雙折射理論模型並編寫程式以發展數值計算。實驗裡包含觀察牛筋以及頭頸癌病患之切片，並對19名病患做偏光顯微鏡的全切片影像分析。我們的程式亦表現良好的擬合。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:04:52Z (GMT). No. of bitstreams: 1 U0001-1209202121220200.pdf: 3241434 bytes, checksum: 9471f1d360537bde21b60c6efec38fdd (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 謝辭 i 摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vi Chapter 1 Introduction 1 1.1 Treatment of HNSCC 1 1.2 Importance of collagen in HNSCC 2 1.3 Immunotherapy 5 1.4 Pdl1 and Collagen 8 1.5 Problems of Heterogeneity 8 1.6 Keratins in HNSCC 9 Chapter 2 Principles 11 2.1 Overview 11 2.2 Jones Matrix 11 2.3 Mueller Matrix 15 Chapter 3 Methods 17 3.1 Birefringence of Beef Tendon 17 3.2 Collagen Birefringence 17 Chapter 4 Experiments and Results 19 4.1 Whole Slide Imaging 19 4.2 Data Fitting Results 21 Chapter 5 Conclusions 33 Reference 34 | |
| dc.language.iso | en | |
| dc.title | 以偏光方法觀測頭頸癌之膠原蛋白走向特性 | zh_TW |
| dc.title | Measurement of Collagens in HNSCC by Polarized Light Microscopy | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 婁培人(Hsin-Tsai Liu),陳永芳(Chih-Yang Tseng),黃彥霖 | |
| dc.subject.keyword | 頭頸癌,膠原蛋白,瓊斯矩陣,雙折射,偏光顯微術, | zh_TW |
| dc.subject.keyword | HNSCC,Collagen,Jones Calculus,Birefringence,Polarization Microscopy, | en |
| dc.relation.page | 36 | |
| dc.identifier.doi | 10.6342/NTU202103134 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-09-16 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 應用物理研究所 | zh_TW |
| 顯示於系所單位： | 應用物理研究所 | |
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| 檔案 | 大小 | 格式 | |
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| U0001-1209202121220200.pdf | 3.17 MB | Adobe PDF | 檢視/開啟 |
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