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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79598完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中(Pau-Chung Chen) | |
| dc.contributor.author | Wen-Wei Hsu | en |
| dc.contributor.author | 許文瑋 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:04:48Z | - |
| dc.date.available | 2021-11-08 | |
| dc.date.available | 2022-11-23T09:04:48Z | - |
| dc.date.copyright | 2021-11-08 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-14 | |
| dc.identifier.citation | Su FL, Lu MC, Yu SC, Yang CP, Yang CC, Tseng ST, et al. Increasing trend in the prevalence of gestational diabetes mellitus in Taiwan. J Diabetes Investig. 2021. Wu ET, Nien FJ, Kuo CH, Chen SC, Chen KY, Chuang LM, et al. Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria. J Diabetes Investig. 2016;7(1):121-6. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nature Reviews Disease Primers. 2019;5(1):47. Lin Y-W, Lin M-H, Pai L-W, Fang J-W, Mou C-H, Sung F-C, et al. Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus. Scientific Reports. 2021;11(1):17391. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (London, England). 2009;373(9677):1773-9. Damm P. Future risk of diabetes in mother and child after gestational diabetes mellitus. Int J Gynaecol Obstet. 2009;104 Suppl 1:S25-6. Lauenborg J, Mathiesen E, Hansen T, Glümer C, Jørgensen T, Borch-Johnsen K, et al. The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population. J Clin Endocrinol Metab. 2005;90(7):4004-10. Grunnet LG, Hansen S, Hjort L, Madsen CM, Kampmann FB, Thuesen ACB, et al. Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort. Diabetes Care. 2017;40(12):1746-55. Davis JN, Gunderson EP, Gyllenhammer LE, Goran MI. Impact of gestational diabetes mellitus on pubertal changes in adiposity and metabolic profiles in Latino offspring. J Pediatr. 2013;162(4):741-5. Crume TL, Ogden L, West NA, Vehik KS, Scherzinger A, Daniels S, et al. Association of exposure to diabetes in utero with adiposity and fat distribution in a multiethnic population of youth: the Exploring Perinatal Outcomes among Children (EPOCH) Study. Diabetologia. 2011;54(1):87-92. Kubo A, Ferrara A, Windham GC, Greenspan LC, Deardorff J, Hiatt RA, et al. Maternal hyperglycemia during pregnancy predicts adiposity of the offspring. Diabetes Care. 2014;37(11):2996-3002. Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and statural growth. Hum Reprod Update. 2004;10(2):135-47. Li W, Liu Q, Deng X, Chen Y, Yang B, Huang X, et al. Association of prepubertal obesity with pubertal development in Chinese girls and boys: A longitudinal study. Am J Hum Biol. 2018;30(6):e23195. 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Health Promotion Administration, Ministry of Health and Welfare, Taiwan Pediatric Association. Evidences-based Guideline on Children Obesity Prevention and Management. 1 ed. Taipei, Taiwan: Health Promotion Administration, Ministry of Health and Welfare; 2018. 202 p. Frank M Biro Y-MC. UpToDate. Waltham, MA: UpToDate 2021. Wang YN, Zeng Q, Xiong F, Zeng Y. Male external genitalia growth curves and charts for children and adolescents aged 0 to 17 years in Chongqing, China. Asian J Androl. 2018;20(6):567-71. Tomova A, Deepinder F, Robeva R, Lalabonova H, Kumanov P, Agarwal A. Growth and development of male external genitalia: a cross-sectional study of 6200 males aged 0 to 19 years. Arch Pediatr Adolesc Med. 2010;164(12):1152-7. Subramanian A, Idkowiak J, Toulis KA, Thangaratinam S, Arlt W, Nirantharakumar K. Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review. Eur J Endocrinol. 2021;184(1):51-64. Klein KO, Newfield RS, Hassink SG. Bone maturation along the spectrum from normal weight to obesity: a complex interplay of sex, growth factors and weight gain. J Pediatr Endocrinol Metab. 2016;29(3):311-8. Pinhas-Hamiel O, Benary D, Mazor-Aronovich K, Ben-Ami M, Levy-Shraga Y, Boyko V, et al. Advanced bone age and hyperinsulinemia in overweight and obese children. Endocr Pract. 2014;20(1):62-7. Sopher AB, Jean AM, Zwany SK, Winston DM, Pomeranz CB, Bell JJ, et al. Bone age advancement in prepubertal children with obesity and premature adrenarche: possible potentiating factors. Obesity (Silver Spring). 2011;19(6):1259-64. Brix N, Ernst A, Lauridsen LLB, Parner ET, Arah OA, Olsen J, et al. Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses. International Journal of Epidemiology. 2020;49(3):834-44. Kampmann FB, Thuesen ACB, Hjort L, Bjerregaard AA, Chavarro JE, Frystyk J, et al. Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes. Eur J Endocrinol. 2019;181(6):691-700. Malee MP, Verma A, Messerlian G, Tucker R, Vohr BR. Association between maternal and child leptin levels 9 years after pregnancy complicated by gestational diabetes. Horm Metab Res. 2002;34(4):212-6. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79598 | - |
| dc.description.abstract | "研究目標 本研究欲探討罹患妊娠糖尿病(Gestational diabetes mellitus, GDM)的母親，其子代是否會較早進入青春期。 研究方法 本研究為一世代追蹤研究，於2010年至2012年收案，對象為此期間曾在台大醫院產檢之孕婦，藉由病歷回溯方式記錄其口服葡萄糖耐量試驗值以及是否有妊娠糖尿病之診斷。接著於2018年追蹤其子代之健康情形，排除多胞胎妊娠，共有484名孩童接受回訪，內容包括問卷、身體檢查及骨齡X光拍攝。主要觀察結果為骨齡與實際年齡之相差值，其他觀測值包括女童胸部發育、男童睪丸發育以及陰莖長度。統計方法為t檢定及卡方檢定，另多元迴歸分析對於母親初經年齡、家庭年收入、出生週數及孩童受訪年齡進行校正。 結果 484名受訪孩童中，有43名母親在懷孕時確診妊娠糖尿病，另441名為對照組。女童中，GDM組(n=19)及對照組(n=205)的骨齡與實際年齡平均差距無顯著差異(0.6 vs. 0.1年, p=0.141)，然而若以不同診斷標準做分組，在一階段診斷方法(75g口服葡萄糖耐量試驗)中，GDM組女童的骨齡有較超前(0.65 vs. 0.14年，p=0.033)，經過迴歸分析之後，GDM組女童的骨齡依然顯示較超前的發育(0.47年，95%信賴區間0.01-0.94年)。而胸部發育大於坦納氏第一期的比例，GDM組與對照組無顯著差異(10.5 vs. 7.8%, p=0.655)，在分層分析及多元羅吉斯迴歸之後亦無達到顯著差異。 GDM組男童(n=24) 與對照組(n=236)的骨齡與實際年齡平均差距無顯著差異(0 vs. 0.1年，p=0.751)，其睪丸大小(2.2 vs. 2.1 ml, p=0.520)及陰莖長度(35.9 vs.39.6 mm p=0.073)在兩組皆無顯著差異。根據不同的GDM診斷條件進行分組，或是多元迴歸分析的結果，男童在各種青春期發育指標上，兩組皆無顯著差異。 結論 相較於沒有妊娠糖尿病的婦女，曾患妊娠糖尿病的媽媽，其當次產下的女性子代在七至九歲時(青春期前期)骨齡會較超前約半年，但乳房的發育以及男性子代的青春期發展，在兩組間沒有顯著統計差異。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:04:48Z (GMT). No. of bitstreams: 1 U0001-1309202121154700.pdf: 1232681 bytes, checksum: 86de6cccd0c78052ba05a9226bbec8b4 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 謝辭 1 中文摘要 2 Abstract 4 目錄 6 圖表目錄 7 Introduction 8 Methods 9 Study Population 9 Assessment of Maternal Diabetes 10 Pubertal Growth 11 Statistical Analysis 12 Results 12 Participant characteristics 12 Primary analyses 13 Subgroup and adjusted analyses 16 Discussion 20 參考文獻 23 附錄 29 | |
| dc.language.iso | en | |
| dc.title | 母親妊娠糖尿病與孩童青春期發育之相關性研究 | zh_TW |
| dc.title | Associations Between Maternal Gestational Diabetes and Pubertal Growth in Offspring | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李建南(Hsin-Tsai Liu),陳美惠(Chih-Yang Tseng) | |
| dc.subject.keyword | 妊娠糖尿病,口服葡萄糖耐量試驗,性早熟,骨齡,坦納氏期, | zh_TW |
| dc.subject.keyword | Gestational diabetes mellitus,oral glucose tolerance test,precocious puberty,bone age,Tanner stage, | en |
| dc.relation.page | 29 | |
| dc.identifier.doi | 10.6342/NTU202103156 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-09-15 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 公共衛生碩士學位學程 | zh_TW |
| 顯示於系所單位： | 公共衛生碩士學位學程 | |
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| U0001-1309202121154700.pdf | 1.2 MB | Adobe PDF | 檢視/開啟 |
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