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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭謙仁(Chian-Ren Jeng) | |
| dc.contributor.author | Szu-Yu Wang | en |
| dc.contributor.author | 汪思宇 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:04:39Z | - |
| dc.date.available | 2021-09-17 | |
| dc.date.available | 2022-11-23T09:04:39Z | - |
| dc.date.copyright | 2021-09-17 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-15 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79593 | - |
| dc.description.abstract | "現今塑膠垃圾污染嚴重，當塑膠垃圾流入海洋後，除了造成環境污染外，也會纏繞或因誤食進入海洋生物體內，造成海洋動物的傷害甚至死亡。塑膠性質穩定，且不易被大量分解，其易被降解成小片段塑膠或形成塑膠微粒，此時易被攝食進入海洋生物體內，造成許物理性、免疫性、代謝性和繁殖功能的損害；因此，評估塑膠微粒對海洋動物，特別是高階哺乳類的影響有其必要性。本篇論文利用遠雄海洋公園圈養瓶鼻海豚健康檢查所收集的血液，於實驗室分離周邊血液單核細胞(PBMC)，以兩種微米(Microplastics, MPs)及奈米(Nanoplastics, NPs)等級的塑膠微粒，在濃度10 μg/ml下共同培養。藉由染色、穿透式電顯及流式細胞儀和次世代定序分析評估細胞存活、氧化壓力誘導、細胞凋亡及細胞轉錄的改變。結果可觀察到在暴露不同濃度的塑膠微粒和奈米微粒並未造成PBMC的細胞毒性，即細胞存活率無明顯改變。再評估細胞凋亡方面，處理組隨同控制組因培養時間增加而有上升。此外，MPs可造成ROS 氧化壓力顯著增加。次世代定序mRNA 轉錄組分析結果顯示基因表現數量有發生改變，而且部分基因和免疫功能相關。在此，本研究顯示無修飾塑膠微粒和奈米微粒，在低劑量下仍會對瓶鼻海豚的PBMC免疫功能產生影響，因此，不應忽視其對鯨豚及高等哺乳類的衝擊。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:04:39Z (GMT). No. of bitstreams: 1 U0001-1409202114542900.pdf: 12943760 bytes, checksum: 8ae00714f8b5fb156b0946e4d288bc01 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "摘要 II ABSTRACT III CONTENTS IV LIST OF TABLES VIII CHAPTER I. GENERAL INTRODUCTION 1 1.1 The Characters of Plastics 1 1.1.1 Brief of plastics history 1 1.1.2 Introduction of plastics 2 1.1.3 Polystyrene (PS) 4 1.1.4 World plastics production 5 1.2 Plastics pollution 6 1.2.1 The effect of plastic pollution in terrestrial system 7 1.2.2 The effect of plastic pollution in marine system 9 1.2.3 The impact of plastic pollution in Human 11 1.2.4 The impact of plastic pollution in Marine mammal 13 1.3 Characters of Microplastics and Nanoplastics 14 1.3.1 Microplastics (MPs) and Nanoplastics (NPs) 14 1.3.2 Effect of microplastics and nanoplastics in environment and organism 15 1.3.3 Toxicity of microplastics and nanoplastics in in vitro and in vivo study 16 1.3.4 Toxicity of microplastics - in vitro 16 1.3.5 Toxicity of microplastics - in vivo 18 1.3.6 The impact of MPs in Cetaceans 20 1.3.7 Toxicity of nanoplastics - in vitro 21 1.3.8 Toxicity of nanoplastics - in vivo 22 1.4 Aim of study 24 CHAPTER II. MANUSCRIPT 26 Section 1: Introduction 26 Section 2: Material and method 28 2.1. Animals and blood sample collection 28 2.2. Characterization of Microplastics and Nanoplastics 29 2.3. Isolation of PBMC 30 2.4. Cytotoxicity assay of PBMC 31 2.5. Microscopic detection of engulfed MPs and NPs in PBMC 32 2.6. Detection of NPs in PBMCs using TEM observation 32 2.7. Alamar blue cell viability assay 33 2.8. Cell Apoptosis assay 34 2.9. Intracellular ROS (reactive oxygen species) production 34 2.10. RNA extraction, purification and library amplification 35 2.11. mRNA sequencing (RNA-seq) and transcriptomic analysis 36 2.12. Statistical analysis 36 Section 3: Results 37 3.1 Characterization of Microplastics and Nanoplastics 37 3.2 Cytotoxicity of MPs and NPs in c-PBMC 38 3.3 Morphology of engulfed MPs and NPs in c-PBMC 38 3.4 Detection of NPs in c-PBMC by transmission electron microscopy (TEM) 39 3.5 Cell viability 39 3.6 Cell Apoptosis 40 3.7 Intracellular ROS (reactive oxygen species) production 40 3.8 Differential expression genes (DEGs) 40 3.9 Functional-related transcriptomics 42 Section 4: Discussion 43 Section 5: Conclusion 47 CHAPTER III. DISCUSSION AND FUTURE WORK 50 TABLES 52 FIGURES 61 REFERENCES 75" | |
| dc.language.iso | en | |
| dc.title | 微米及奈米塑膠對瓶鼻海豚周邊血液單核細胞之影響 | zh_TW |
| dc.title | Effect of Microplastics and Nanoplastics on the Peripheral Blood Mononuclear Cells of Bottlenose Dolphins Tursiops truncatus | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 張惠雯(Hui-Wen Chang) | |
| dc.contributor.oralexamcommittee | 張晏禎(Hsin-Tsai Liu),楊瑋誠(Chih-Yang Tseng) | |
| dc.subject.keyword | 瓶鼻海豚,塑膠微粒,奈米微粒,細胞凋亡,氧化壓力,次世代定序, | zh_TW |
| dc.subject.keyword | Cetacean,microplastics,nanoplastics,apoptosis,ROS,NGS, | en |
| dc.relation.page | 107 | |
| dc.identifier.doi | 10.6342/NTU202103170 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-09-16 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 分子暨比較病理生物學研究所 | zh_TW |
| 顯示於系所單位： | 分子暨比較病理生物學研究所 | |
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