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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蘇璧伶(Bi-Ling Su) | |
| dc.contributor.author | SZU-CHI HUANG | en |
| dc.contributor.author | 黃思綺 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:02:56Z | - |
| dc.date.available | 2021-11-08 | |
| dc.date.available | 2022-11-23T09:02:56Z | - |
| dc.date.copyright | 2021-11-08 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-02 | |
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Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature. Front Vet Sci, 3, 54. Yang, L. M., Xue, Q. H., Sun, L., Zhu, Y. P., Liu, W. J. (2007). Cloning and characterization of a novel feline IFN-omega. J Interferon Cytokine Res, 27(2), 119-127. Yao, J. C., Guthrie, K. A., Moran, C., Strosberg, J. R., Kulke, M. H., Chan, J. A., LoConte, N., McWilliams, R. R., Wolin, E. M., Mattar, B., McDonough, S., Chen, H. L., Blanke, C. D., Hochster, H. S. (2017). Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518. Journal of Clinical Oncology, 35(15), 1695-+. Zeidner, N. S., Myles, M. H., Mathiasondubard, C. K., Dreitz, M. J., Mullins, J. I., Hoover, E. A. (1990). Alpha-interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome. Antimicrobial Agents and Chemotherapy, 34(9), 1749-1756. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79530 | - |
| dc.description.abstract | "貓慢性齒齦口炎(Feline chronic gingivostomatitis)為一慢性消耗性且疼痛的口腔疾病，其致病病因及機轉尚未完全明瞭，但多數研究顯示貓慢性齒齦口炎為多因素所引起。治療方面，目前可分成內科及外科治療，外科治療需經由全面性口腔評估及齒科檢查後拔除異常牙齒及移除牙菌斑。經齒科拔牙治療後，部分貓隻之口腔黏膜發炎會消退、緩解；然而，經齒科治療後仍未改善之貓隻，稱之為復發型貓慢性齒齦口炎，需以內科藥物控制且大多數的貓隻需要終生服用藥物。內科治療為給予抗生素、止痛藥、干擾素、非固醇類消炎藥、類固醇或免疫抑制劑等，以類固醇最常使用。然而，長期使用類固醇治療可能誘發糖尿病等副作用。 1957 年發現干擾素至今，已有多種人類重組干擾素被應用於多種人類病毒性及腫瘤性疾病，人類重組干擾素也被使用於控制某些犬貓病毒性疾病，然而研究發現貓隻於治療過程中，因產生抗人類重組干擾素的中和抗體而影響藥物活性及降低藥效進而降低治療效果。因此，本研究目的為評估慢性齒齦口炎貓隻加入農業科技研究院動物科技研究所提供之貓重組干擾素⍵ (Feline recombinant interferon omega; ATRIron®)為輔助治療之治療成效評估。慢性齒齦口炎貓隻於治療前、治療後第 2、4 及 6 週回診時，以半定量評分紀錄發炎狀況及飼主觀察，將兩評分作為治療效果的評估。合計發炎狀況及飼主觀察的評分為口炎總分，總分於治療後第四週(p = 0.0006)及第六週(p = 0.0002)，與治療前有顯著差異。治療六週後，17 隻貓的平均改善程度為 40%，13 隻貓的改善程度為 3 隻(3/17, 18%)為顯著改善，5隻(5/17, 29%)為中度改善，5 隻(5/17, 29%)為輕度改善，其餘4 隻(4/17, 24%)則是無明顯改善。在六週治療療程中，肝臟及腎臟指數並無明顯變化。根據本研究結果，ATRIron® 為一個極具潛力、可改善復發型貓慢性齒齦口炎之輔助治療製劑。 " | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:02:56Z (GMT). No. of bitstreams: 1 U0001-2609202113381200.pdf: 12917338 bytes, checksum: 1ad40f115e4ec2a9891be16a806c95ce (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "目錄 口試委員會審定書 # 致謝 ii 中文摘要 ii ABSTRACT iii 附表目錄 vi 附圖目錄 vii 第一章 序言 1 第二章 文獻探討 2 第一節 貓慢性齒齦口炎 2 1.1 定義與臨床特徵 2 1.2 流行病學與病因學 2 1.2.1 貓卡里西病毒 3 1.2.2 第一型貓皰疹病毒 3 1.2.3 反轉錄病毒 3 1.2.4 細菌性病原 4 1.2.5 環境因素 4 1.3 鑑別診斷及診斷 4 1.4 治療 5 1.4.1 醣皮質類固醇 5 1.4.2 環孢素 5 1.4.3 乳鐵蛋白 6 1.4.4 干擾素 7 1.4.5 幹細胞治療 8 1.4.6 抗生素 8 第二節 干擾素 9 2.1 歷史背景 9 2.2 干擾素 10 2.3 第一型干擾素的生理作用 10 2.4 人重組干擾素的臨床應用 11 2.5 貓重組干擾素的臨床應用 12 第三章 材料與方法 13 第一節 動物來源 13 第二節 治療方式 13 第三節 干擾素治療之效果評估 13 3.1 飼主評分 14 3.2 獸醫師評分 15 3.3 總分(Feline chronic gingivostomatitis activity index, FCGSAI) 15 第四節 資料收集 15 第五節 統計分析 16 第四章 結果 17 第一節 貓隻基本資料 17 第二節 干擾素治療之效果評估 17 2.1 飼主評分 17 2.2 獸醫師評分 17 2.3 總分(FCGSAI) 18 第三節 改善程度的比例與分級 18 第四節 治療期間之類固醇使用劑量 18 第五節 口腔病灶位置分佈及組織病理學檢查 18 第六節 副作用的評估 19 第七節 治療前評分分級與同時感染疾病之相關性 20 第八節 長期追蹤 20 第五章 討論 22 參考文獻 22 " | |
| dc.language.iso | zh-TW | |
| dc.title | 貓重組干擾素Omega於貓慢性齒齦口炎輔助治療之臨床效果評估 | zh_TW |
| dc.title | Clinical Application of Feline Recombinant Interferon Omega (ATRIron®) as an Additional Agent in Refractory Feline Chronic Gingivostomatitis | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 周濟眾(Hsin-Tsai Liu),陳文英(Chih-Yang Tseng),高增婷 | |
| dc.subject.keyword | 貓慢性齒齦口炎,貓重組干擾素,皮下給予,輔助治療, | zh_TW |
| dc.subject.keyword | Feline recombinant interferon-omega,Feline chronic gingivostomatitis,Subcutaneous, | en |
| dc.relation.page | 53 | |
| dc.identifier.doi | 10.6342/NTU202103367 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-10-04 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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