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標題: | 應用靜電紡絲於覆膜支架之性質分析 Application of Electrospinning in Covered Stents |
作者: | Yen-Ting Wang 王彥婷 |
指導教授: | 蕭浩明 |
關鍵字: | 靜電紡絲,覆膜支架,聚乙烯醇,維生素C,交聯處理, Electrospinning,Covered Stents,Polyvinyl Alcohol,L-Ascorbic Acid,Crosslinking, |
出版年 : | 2017 |
學位: | 碩士 |
摘要: | 隨著現代生活習慣變遷,心血管疾病目前已成為主要的死亡因素,其中之一為主動脈瘤;主動脈瘤修補手術為利用覆膜支架,隔開血流和有病變的主動脈,降低血管破裂風險,提供較佳的治療效果;而覆膜支架除了應用於大血管疾病,在小管腔部位的使用上也有增加的趨勢。
靜電紡絲是近年來非常熱門的奈米纖維製程技術,過程簡單,可以快速將高分子轉變為具有大量孔隙與高比表面積的奈米纖維,能夠運用於很多領域。本研究以具有生物可相容性的高分子聚乙烯醇(PVA)為材料,利用靜電紡絲進行一次性包膜製作小管徑覆膜支架,共分成三個階段。 第一階段檢測不同濃度與參數所製成奈米纖維之型態,探討電紡奈米纖維變因。選定10%聚乙烯醇高分子溶液添加維生素C,在電壓15kV、收集距離16cm的最適化條件下,藉由戊二醛蒸氣做交聯處理,接著進行第二階段電紡奈米纖維膜之性質測試,包含拉伸試驗、熱性質分析與簡易藥物釋放。實驗發現可以藉由添加維生素C與交聯處理,改變或提升電紡奈米纖維膜物理性質;第三階段將鎳鈦合金支架安裝於不鏽鋼圓棒收集器上直接電紡,評估電紡覆膜支架的可行性。結果顯示收集棒轉速與支架型態皆會影響覆膜的成形外觀,而交聯處理則能讓浸泡過PBS後的纖維較不易變形。最後利用支架壓縮機,將電紡覆膜支架順利收入小尺寸導管,釋放後不會有嚴重的破壞產生。 本研究所進行之各項實驗可初步了解應用靜電紡絲於覆膜支架的表現,期望其結果能夠作為一參考基準,未來再經改良後可實際應用於臨床醫療上。 Cardiovascular diseases are now the leading causes of death worldwide, and one of them is aortic aneurysm. Endovascular aneurysm repair surgery separates blood flows and the fragile part of the aortic by a stent graft, therefore reducing the rupture rate, which provides a better treatment. Besides large-vessel diseases, stent grafts, also known as covered stents, have been applied in smaller lumens increasingly. Electrospinning process is an emerging nanofiber technology that can efficiently turn polymers into nanofibers with high porosity and specific surface area. It can be extended into various fields. In this study, electrospinning is applied in small diameter covered stents with biocompatible material polyvinyl alcohol (PVA). The study is organized as follows: In the first part, different conditions and the corresponding electrospun nanofibers are examined. L-ascorbic acid is then added into 10%PVA. Under the condition of a 15kV voltage and placed at 16cm from the needle tip, the electrospun nanofibers are then crosslinked by glutaraldehyde vapor. In the second part, tests are performed on electrospun membranes, including tensile test, thermal property analysis and simple drug release experiment. The results show that either by adding L-ascorbic acid or crosslinking, physical properties of electrospun membranes can be altered or enhanced. In the third part, the Ni-Ti stents are placed on a bar collector, and the feasibility of electrospun covered stents is then evaluated. The results show that both the rotating speed of the collector and the shapes of stents have impact on the graft appearances. Also by crosslinking, the nanofibers are more likely to remain the original morpohlogies after soaked in PBS. In the end, the electrospun covered stent can be crimped into a small tube by using a crimper, and no serious damages are observed after being released from the tube. Experiments performed in this study could give insights into electrospinning in covered stents. It is hoped that the results can be provided as a guideline and the electrospun covered stents can be utilized in medical treatments in the future. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79171 |
DOI: | 10.6342/NTU201702042 |
全文授權: | 有償授權 |
電子全文公開日期: | 2023-08-24 |
顯示於系所單位: | 機械工程學系 |
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