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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 廖秀娟 | |
| dc.contributor.author | Jun-Yi Liu | en |
| dc.contributor.author | 劉俊毅 | zh_TW |
| dc.date.accessioned | 2021-05-19T17:58:20Z | - |
| dc.date.available | 2026-08-05 | |
| dc.date.available | 2021-05-19T17:58:20Z | - |
| dc.date.copyright | 2016-08-26 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-05 | |
| dc.identifier.citation | Abbas, S., and Wink, M. (2009). Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med 75, 216-221.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/7911 | - |
| dc.description.abstract | 苦茶油乃源自於油茶樹的種籽經榨取而得，為亞洲國家傳統常用之食用油品，即使具有傳統的療效，然而對於苦茶油的研究仍缺乏充足的科學證據予以佐證。因此本研究利用模式生物秀麗隱桿線蟲(Caenorhabditis elegans)探討小果種苦茶油對生物體的延緩老化作用，並進一步研究其參與的調控機制。研究結果顯示，C. elegans經小果種苦茶油餵食後，能顯著提升體內抗氧化力且延長在氧化壓力下的壽命；同時在一般培養條件下，亦能顯著延長C. elegans平均壽命達12.3 % (p < 0.001)。此外，小果種苦茶油也能延緩C. elegans老化相關行為如pharyngeal pumping rate及defecation cycle的退化，並且顯著降低C. elegans體內老化指標脂褐素的累積量，若是利用小果種苦茶油中等量的油酸進行實驗，則發現其結果類似。研究結果進一步顯示，小果種苦茶油對C. elegans的延緩老化功效可能透過提升轉錄因子DAF-16/FOXO在氧化壓力下進入細胞核的反應，同時提高1.3倍daf-16 基因表現量(p = 0.079)及其下游抗氧化蛋白例如SOD-3基因表達增加；此外，亦可能透過提升轉錄因子SKN-1/Nrf進入細胞核的反應，同時提高1.31倍skn-1及1.45倍其下游抗氧化基因gcs-1 基因表現量(p = 0.002; p < 0.001)，以提升C. elegans體內抗氧化力。總結來說，本研究顯示小果種苦茶油對生物體具有提升生物體內抗氧化力、延緩老化相關行為，以及延長平均壽命之保健功效，而此保健功效可藉由其脂肪酸組成中含量最高的成分油酸達成。本研究結果提供小果種苦茶油保健功效的科學數據，因此小果種苦茶油對人類健康具有進一步研究及推廣的優勢，並進一步促進台灣農業發展。 | zh_TW |
| dc.description.abstract | Tea seed oil from the seeds of Camellia trees is commonly used as edible oil in Asia. Despite its traditional medical effects, there is insufficient scientific data to support the beneficial effects of tea seed oil to human beings. In this study, the model organism Caenorhabditis elegans was applied to investigate the in vivo delayed aging effects by Camellia tenuifolia seed oil and its underlying mechanisms. The results showed that C. tenuifolia seed oil significantly enhanced the antioxidant activity and extended the longevity in C. elegans under juglone-induced oxidative stress. In addition, C. tenuifolia seed oil significantly increased the lifespan of C. elegans by 12.3 % under normal condition (p < 0.001). Furthermore, the degeneration of age-related behaviors, such as pharyngeal pumping rate and defecation cycle, were significantly attenuated and the accumulation of lipofuscin was significantly decreased during aging process in C. elegans treated with C. tenuifolia seed oil. When C. elegans was pretreated with oleic acid using the concentration corresponding to the content in C. tenuifolia seed oil, the results were similar to aforementioned results in C. tenuifolia seed oil. We further showed that C. tenuifolia seed oil enhanced the translocation of the transcription factor DAF-16/FOXO and increased 1.3-fold mRNA level of daf-16 (p = 0.079), thereby triggering the downstream gene SOD-3 expression. Moreover, the other transcription factor SKN-1/Nrf was shown to translocate to nuclear upon C. tenuifolia seed oil pretreatment, further increasing 1.31-fold mRNA level of skn-1 and 1.45-fold mRNA level of downstream gene gcs-1 to enhance the antioxidant activity (p = 0.002; p < 0.001). In conclusion, our study demonstrated that C. tenuifolia seed oil increased the in vivo antioxidant activity, increased longevity, delayed aging effects, and extended lifespan in C. elegans and oleic acid plays a critical role in the beneficial effects of C. tenuifolia seed oil. Results from this study provide scientific evidence for the health effects of C. tenuifolia seed oil. Therefore, it is suggested that C. tenuifolia seed oil worth further investigation for human health and promoting the agriculture in Taiwan. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-19T17:58:20Z (GMT). No. of bitstreams: 1 ntu-105-R03622003-1.pdf: 1563640 bytes, checksum: c44f952ee9ff9666e9fc3c3cf3fa67f3 (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 誌謝 I
摘要 II ABSTRACT III Graphic Abstract V Highlights VI 目錄 VII 圖次 X 表次 XI 縮寫表 XII 一、研究動機 1 二、文獻回顧 2 2.1 苦茶油 (Tea seed oil) 2 2.1.1 油酸 (Oleic acid) 2 2.1.2 苦茶油的研究現況 3 2.2 老化 (Aging) 4 2.2.1 老化機制 4 2.2.2 植物天然代謝物應用於老化之研究 5 2.2.3 地中海飲食 (Mediterranean diet) 5 2.3 秀麗隱桿線蟲 (Caenorhabditis elegans) 6 2.3.1 基本背景 6 2.3.2 C. elegans於老化研究之探討 7 三、研究目的 10 四、材料與方法 11 4.1 實驗架構流程圖 11 4.2 實驗藥品及小果種苦茶油樣品 12 4.3 C. elegans及培養 12 4.4 氧化壓力下的壽命延長試驗 12 4.5 C. elegans壽命延長試驗 13 4.6 C. elegans老化相關行為試驗 13 4.6.1 Pharyngeal pumping rate 14 4.6.2 Defecation cycle 14 4.7 C. elegans體內脂褐素(lipofuscin)自體螢光分析 14 4.8基因轉殖C. elegans綠色螢光蛋白分析 14 4.9 DAF-16 localization試驗 15 4.10 SKN-1 localization試驗 15 4.11 即時定量反轉錄聚合酶連鎖反應(Real-time Quantitative RT-PCR)分析 16 4.12 統計分析 17 五、結果 19 5.1 氧化壓力(oxidative stress)下的壽命延長(longevity)測試 19 5.2 一般培養條件下小果種苦茶油及油酸對C. elegans壽命延長(lifespan extension)之影響 22 5.3 小果種苦茶油及油酸對C. elegans老化相關行為之影響 25 5.4 小果種苦茶油及油酸對C. elegans體內脂褐素累積之影響 28 5.5 小果種苦茶油及油酸對C. elegans體內超氧化物歧化酶(SOD-3)之影響 30 5.6 小果種苦茶油及油酸對C. elegans體內DAF-16 localization之影響 32 5.7 小果種苦茶油及油酸對C. elegans體內DAF-16及其下游基因表達之影響 34 5.8 小果種苦茶油及油酸對C. elegans體內SKN-1 localization之影響 36 5.9 小果種苦茶油及油酸對C. elegans體內SKN-1及其下游基因表達之影響 39 六、討論 42 6.1 小果種苦茶油對C. elegans延長壽命之效應 42 6.2 小果種苦茶油對C. elegans延緩老化之效應 43 6.3 小果種苦茶油對C. elegans體內之調控機制 45 七、結論 47 八、建議 48 九、參考文獻 49 十、附錄 58 | |
| dc.language.iso | zh-TW | |
| dc.title | 以秀麗隱桿線蟲為模式生物探討小果種苦茶油在生物體內的延緩老化功效 | zh_TW |
| dc.title | Effects of delayed aging by seed oil from Camellia tenuifolia in Caenorhabditis elegans | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 何元順,潘敏雄,羅翊禎 | |
| dc.subject.keyword | 秀麗隱桿線蟲,小果種苦茶油,生物體內抗氧化,老化,油酸,DAF-16,SKN-1, | zh_TW |
| dc.subject.keyword | Caenorhabditis elegans,C. tenuifolia seed oil,in vivo antioxidant activity,aging,oleic acid,DAF-16,SKN-1, | en |
| dc.relation.page | 60 | |
| dc.identifier.doi | 10.6342/NTU201602026 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2016-08-08 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物環境系統工程學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-08-05 | - |
| 顯示於系所單位： | 生物環境系統工程學系 | |
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