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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 繆希椿 | |
| dc.contributor.author | Che-Wei Hu | en |
| dc.contributor.author | 胡哲瑋 | zh_TW |
| dc.date.accessioned | 2021-07-11T15:05:39Z | - |
| dc.date.available | 2024-08-28 | |
| dc.date.copyright | 2019-08-28 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-08-15 | |
| dc.identifier.citation | Zhu J, Yamane H, Paul WE. Differentiation of Effector CD4 T Cell Populations. 2010;28(1):445-89.
2. Smith-Garvin JE, Koretzky GA, Jordan MS. T Cell Activation. 2009;27(1):591-619. 3. van der Werf N, Redpath SA, Phythian-Adams AT, Azuma M, Allen JE, Maizels RM, et al. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR–GITR ligand costimulation in vivo. The Journal of Immunology. 2011;187(3):1411-20. 4. O'Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nature Reviews Immunology. 2016;16:553. 5. Poznanski SM, Barra NG, Ashkar AA, Schertzer JDJIR. Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function. 2018;67(10):813-28. 6. Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nature Medicine. 2014;20:1327. 7. Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4<sup>+</sup> T Cell Subsets. The Journal of Immunology. 2011;186(6):3299-303. 8. Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nature Communications. 2015;6:6692. 9. Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of T<sub>H</sub>17 and T<sub>reg</sub> cells. The Journal of Experimental Medicine. 2011;208(7):1367-76. 10. Chen HW, Heiniger H-J, Kandutsch AA. Relationship between Sterol Synthesis and DNA Synthesis in Phytohemagglutinin-Stimulated Mouse Lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 1975;72(5):1950-4. 11. Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, et al. Glucose-dependent de novo lipogenesis in B lymphocytes a requirement for ATP-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014;289(10):7011-24. 12. Delmas V, Sassone-Corsi P. The key role of CREM in the cAMP signaling pathway in the testis. Molecular and Cellular Endocrinology. 1994;100(1):121-4. 13. Raker VK, Becker C, Steinbrink K. The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Frontiers in Immunology. 2016;7(123). 14. Jutila MA, Kroese GM, Jutila KL, Stall AM, Fiering S, Herzenberg LA, et al. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. European Journal of Immunology. 1988;18(11):1819-26. 15. Maxwell MA, Muscat GEO. The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles. Nuclear Receptor Signaling. 2006;4(1):nrs.04002. 16. Zhao W, Huang Y, Liu Z, Cao B-B, Peng Y-P, Qiu Y-H. Dopamine receptors modulate cytotoxicity of natural killer cells via cAMP-PKA-CREB signaling pathway. PLoS One. 2013;8(6):e65860. 17. Baumer W, Hoppmann J, Rundfeldt C, Kietzmann M. Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy). 2007;6(1):17-26. 18. Oger S, Méhats C, Dallot E, Cabrol D, Leroy M-J. Evidence for a Role of Phosphodiesterase 4 in Lipopolysaccharide-Stimulated Prostaglandin E<sub>2</sub> Production and Matrix Metalloproteinase-9 Activity in Human Amniochorionic Membranes. The Journal of Immunology. 2005;174(12):8082-9. 19. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, et al. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proceedings of the National Academy of Sciences. 2015;112(5):1529-34. 20. Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, et al. Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor. The Journal of Experimental Medicine. 2001;193(4):497-508. 21. Taskén K, Stokka AJ. The molecular machinery for cAMP-dependent immunomodulation in T-cells. Biochemical Society Transactions. 2006;34(4):476-9. 22. Cekic C, Sag D, Day Y-J, Linden J. Extracellular adenosine regulates naive T cell development and peripheral maintenance. The Journal of Experimental Medicine. 2013;210(12):2693-706. 23. Jenabian M-A, Seddiki N, Yatim A, Carriere M, Hulin A, Younas M, et al. 1. Zhu J, Yamane H, Paul WE. Differentiation of Effector CD4 T Cell Populations. 2010;28(1):445-89. 2. Smith-Garvin JE, Koretzky GA, Jordan MS. T Cell Activation. 2009;27(1):591-619. 3. van der Werf N, Redpath SA, Phythian-Adams AT, Azuma M, Allen JE, Maizels RM, et al. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR–GITR ligand costimulation in vivo. The Journal of Immunology. 2011;187(3):1411-20. 4. O'Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nature Reviews Immunology. 2016;16:553. 5. Poznanski SM, Barra NG, Ashkar AA, Schertzer JDJIR. Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function. 2018;67(10):813-28. 6. Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nature Medicine. 2014;20:1327. 7. Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4<sup>+</sup> T Cell Subsets. The Journal of Immunology. 2011;186(6):3299-303. 8. Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nature Communications. 2015;6:6692. 9. Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of T<sub>H</sub>17 and T<sub>reg</sub> cells. The Journal of Experimental Medicine. 2011;208(7):1367-76. 10. Chen HW, Heiniger H-J, Kandutsch AA. Relationship between Sterol Synthesis and DNA Synthesis in Phytohemagglutinin-Stimulated Mouse Lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 1975;72(5):1950-4. 11. Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, et al. Glucose-dependent de novo lipogenesis in B lymphocytes a requirement for ATP-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem. 2014;289(10):7011-24. 12. Delmas V, Sassone-Corsi P. The key role of CREM in the cAMP signaling pathway in the testis. Molecular and Cellular Endocrinology. 1994;100(1):121-4. 13. Raker VK, Becker C, Steinbrink K. The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases. Frontiers in Immunology. 2016;7(123). 14. Jutila MA, Kroese GM, Jutila KL, Stall AM, Fiering S, Herzenberg LA, et al. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. European Journal of Immunology. 1988;18(11):1819-26. 15. Maxwell MA, Muscat GEO. The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles. Nuclear Receptor Signaling. 2006;4(1):nrs.04002. 16. Zhao W, Huang Y, Liu Z, Cao B-B, Peng Y-P, Qiu Y-H. Dopamine receptors modulate cytotoxicity of natural killer cells via cAMP-PKA-CREB signaling pathway. PLoS One. 2013;8(6):e65860. 17. Baumer W, Hoppmann J, Rundfeldt C, Kietzmann M. Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets-Inflammation & Allergy). 2007;6(1):17-26. 18. Oger S, Méhats C, Dallot E, Cabrol D, Leroy M-J. Evidence for a Role of Phosphodiesterase 4 in Lipopolysaccharide-Stimulated Prostaglandin E<sub>2</sub> Production and Matrix Metalloproteinase-9 Activity in Human Amniochorionic Membranes. The Journal of Immunology. 2005;174(12):8082-9. 19. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, et al. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proceedings of the National Academy of Sciences. 2015;112(5):1529-34. 20. Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, et al. Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor. The Journal of Experimental Medicine. 2001;193(4):497-508. 21. Taskén K, Stokka AJ. The molecular machinery for cAMP-dependent immunomodulation in T-cells. Biochemical Society Transactions. 2006;34(4):476-9. 22. Cekic C, Sag D, Day Y-J, Linden J. Extracellular adenosine regulates naive T cell development and peripheral maintenance. The Journal of Experimental Medicine. 2013;210(12):2693-706. 23. Jenabian M-A, Seddiki N, Yatim A, Carriere M, Hulin A, Younas M, et al. Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection. PLoS pathogens. 2013;9(4):e1003319. 24. Yao C, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S. Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase. Nature Communications. 2013;4:1685. 25. Sunahara RK, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Molecular interventions. 2002;2(3):168. 26. Duan B, Davis R, Sadat EL, Collins J, Sternweis PC, Yuan D, et al. Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice. The Journal of Immunology. 2010;185(1):335-44. 27. Hellevuo K, Yoshimura M, Mons N, Hoffman PL, Cooper D, Tabakoff B. The characterization of a novel human adenylyl cyclase which is present in brain and other tissues. J Biol Chem. 1995;270(19):11581-9. 28. Li C, Xie J, Lu Z, Chen C, Yin Y, Zhan R, et al. ADCY7 supports development of acute myeloid leukemia. Biochemical and biophysical research communications. 2015;465(1):47-52. 29. Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J, Kennedy NA, et al. Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Nature genetics. 2017;49(2):186. 30. Sun X, Huang S, Wang X, Zhang X, Wang X. CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia. Oncotarget. 2018;9(44):27574. 31. Kim JI, Ho IC, Grusby MJ, Glimcher LH. The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines. Immunity. 1999;10(6):745-51. 32. Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S-i, Suzuki K, et al. Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. 2014;211(9):1857-74. 33. Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nature Immunology. 2008;10:167. 34. Xu J, Yang Y, Qiu G, Lal G, Wu Z, Levy DE, et al. c-Maf Regulates IL-10 Expression during Th17 Polarization. The Journal of Immunology. 2009;182(10):6226. 35. Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, et al. A Validated Regulatory Network for Th17 Cell Specification. Cell. 2012;151(2):289-303. 36. 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Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15. Blood. 1999;93(3):886-96. 41. Pasquinelli V, Townsend JC, Jurado JO, Alvarez IB, Quiroga MF, Barnes PF, et al. IFN-γ Production during Active Tuberculosis Is Regulated by Mechanisms That Involve IL-17, SLAM, and CREB. The Journal of Infectious Diseases. 2009;199(5):661-5. 42. Wen AY, Sakamoto KM, Miller LS. The Role of the Transcription Factor CREB in Immune Function. The Journal of Immunology. 2010;185(11):6413-9. 43. Yano S, Ghosh P, Kusaba H, Buchholz M, Longo DL. Effect of Promoter Methylation on the Regulation of <em>IFN-</em>γ Gene During In Vitro Differentiation of Human Peripheral Blood T Cells into a Th2 Population. The Journal of Immunology. 2003;171(5):2510-6. 44. Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, et al. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors CEBP, DBP, and HNF1LFB-1>(CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. 1992;13(2):293-300. 45. Ohlsson E, Schuster M, Hasemann M, Porse B. The multifaceted functions of C/EBPα in normal and malignant haematopoiesis. Leukemia. 2016;30(4):767. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78586 | - |
| dc.description.abstract | Abstract
Metabolism is the basic function for cells to support its physiological needs. Altering cell metabolism programs can affect the functions and fates of cells, including adaptive and innate immune cells. Transcription factor c-Maf contributes to various of cytokine productions and immune responses. However, the role of c-Maf in metabolism remains unknown. We used an online database which provides the expression profile of c-Maf-regulating genes and classified them by KEGG catalog. We found two c-Maf-regulated candidate genes, Adcy7 and Pde7a, which regulate cyclic AMP formation and decomposition, respectively. We employed lentiviral Adcy7-shRNA knockdown (KD) approach to study the role of Adcy7 in TH1 cells. Cyclic AMP (cAMP) level was decreased in Adcy7 KD TH1 cells. IFNγ gene expression and production were reduced in Adcy7 KD TH1 cells. Otherwise, the phosphorylation level of Lck, which plays important role in T cell activation, was decreased in Adcy7 KD TH1 cells. Moreover, two activation markers CD69 and CD25 expression were reduced at 90 mins and 120 mins after re-stimulation in Adcy7 KD TH1 cells. These results indicate that Adcy7 plays positive roles for cAMP production, phosphorylation of Lck, CD69/CD25 expression and IFNγ production in TH1 cells. Key words: Immunometabolism, Adenylyl cyclase 7, Helper T cells 1. CD69/CD25 expression and IFNγ production in TH1 cells. Key words: Immunometabolism, Adenylyl cyclase 7, Helper T cells 1. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T15:05:39Z (GMT). No. of bitstreams: 1 ntu-108-R06449013-1.pdf: 2483027 bytes, checksum: 3a87d343cfcc8fc89262e6205435909e (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | Contents
致謝………………………………………………………………...……………....ii 中文摘要……………………………………………………………………….….iv Abstract…………………………………………………………………………...vi Contents…………………………………………………………………….........viiii Figures of contents……………………………………………………………...x Introduction……………………………………………………………....1 Helper T cell differentiation…………………………………………...1 Immunometabolism …..…………………….………………………….2 Cyclic AMP (cAMP) ……………………………………………..........4 The functions of c-Maf in immune system..………………….….....8 Significance……………………………………………………….…….10 Specific aim …...………………………………………………………..10 Materials and Methods…………………………………………….....11 Materials………………………………………………………………...11 Methods…………………………………………………........................21 Results…….……………………………….………………………......….26 Five c-Maf-regulated nucleotide metabolic candidate genes were found from online database ……….……………………………………...26 cAMP levels in TH1 and TH2 cells were comparable…………………....27 The expression of Adcy7 was elevated in TH1 cells compared to TH2 cells whereas the expression of Pde7a was comparable between TH1 and TH 2 cells.......................................................................27 Reduced Adcy7 expression and cAMP production in Adcy7 KD TH1 cells.……….…………………………………………………….….........28 IFNγ production was declined in Adcy7 KD TH1 cells...……………….29 Phosphorylation of Lck at Y505 residue was reduced in Adcy7 KD TH1 cells………………………………………………………...…...29 Kinetics of CD69 and CD25 expression were measured in TH1 cells.……………………………………………………………………...30 Reduced expression of CD69 and CD25 in Adcy7 KD TH1 cells……….30 Discussion and Conclusion…………………………………………32 References…………………………………..……………………….…35 Table and Figures…………………………………………………….44 Supplementary Figures……………………………………………..65 | |
| dc.language.iso | en | |
| dc.subject | 代謝免疫 | zh_TW |
| dc.subject | 第七型腺?酸環化? | zh_TW |
| dc.subject | 第一型輔助型T細胞 | zh_TW |
| dc.subject | Helper T cells 1 | en |
| dc.subject | Immunometabolism | en |
| dc.subject | Adenylyl cyclase 7 | en |
| dc.title | 第七型腺苷酸環化酶於第一型輔助型T細胞之探討 | zh_TW |
| dc.title | The role of Adenylyl Cyclase VII in TH1 cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李建國,張智芬 | |
| dc.subject.keyword | 代謝免疫,第七型腺?酸環化?,第一型輔助型T細胞, | zh_TW |
| dc.subject.keyword | Immunometabolism,Adenylyl cyclase 7,Helper T cells 1, | en |
| dc.relation.page | 67 | |
| dc.identifier.doi | 10.6342/NTU201902661 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-08-15 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 免疫學研究所 | zh_TW |
| dc.date.embargo-lift | 2024-08-28 | - |
| 顯示於系所單位： | 免疫學研究所 | |
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