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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李秀香(Hsui-Hsiang Lee) | |
| dc.contributor.author | Yu-Ching Liao | en |
| dc.contributor.author | 廖昱晴 | zh_TW |
| dc.date.accessioned | 2021-07-11T14:49:39Z | - |
| dc.date.available | 2025-08-01 | |
| dc.date.copyright | 2020-09-10 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2020-08-11 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78290 | - |
| dc.description.abstract | 樹突修剪為演化保留中一項神經重塑過程，神經元會藉此消除原先的突觸以完善新的神經迴路，此現象亦發生在果蠅變態過程的感覺神經元。先前的 RNA 干擾篩選中，我們發現當果蠅感覺神經元表現 dishevelled (dsh)雙股 RNA 時，會產生 樹突修剪的缺陷。而 dsh 是多個 Wnt 傳導路徑上中心分子，對於發育、再生、抑 或是神經發生而言皆不可或缺;然而 Wnt 傳導路徑是否參與在樹突修剪的調控仍屬未知。 dTCF 為特定存在 Wnt 經典傳導路徑下游的轉錄因子，藉由顯性抑制突變的 dTCF 的表現，我們證實了果蠅感覺神經元的樹突發育及修剪皆需要 dTCF 的作用。 在其他突變檢測中，我們認為 Frizzled 及 Arrow 是作為果蠅感覺神經元上 Wnt 傳導路徑的受體，以調控其樹突修剪。此外，當 Wnt 經典傳導路徑的負調控者 Axin 過度表現時，神經元的樹突修剪亦受到干擾。以持續表現活性之 β-catenin 救援神經細胞後，持續激活 Wnt 經典傳導路徑，受到 dsh 雙股 RNA 或 Axin 過度表現擾動的果蠅感覺神經元因而成功完成樹突修剪。以上，證實了Wnt 經典傳導路徑在 神經樹突修剪中扮演不可或缺的腳色。 | zh_TW |
| dc.description.abstract | Dendrite pruning is a conserved neuronal remodeling process, during which neurons would eliminate their dendrites to rectify neural connectivity. From our previous RNAi screening for the regulators of dendrite pruning in Drosophila sensory neurons, we observed pruning defects in the expression of dishevelled (dsh) double-stranded RNA. Dsh is the center molecule in multiple Wnt signaling essential for development and tissue regeneration, as well as neurogenesis; however, whether Wnt signaling modulates dendrite pruning remains unknown. By overexpressing the truncated transcription factor specific in Wnt canonical pathway, dTCF-∆N, we demonstrate that dTCF is essential to dendrite pruning and morphogenesis. In our mutational analysis, we propose that Frizzled and Arrow are the receptors for Wnt signaling in Drosophila sensory neurons regulating dendritic severing. Additionally, Axin, Wnt repressor, perturbs dendrite pruning in examined cells. After rescuing these neurons with constitutively-active β-catenin, which continuously activates Wnt canonical pathway, we ameliorate pruning phenotypes in neurons resulted from dsh RNAi or Axin overexpression. In conclusion, Wnt canonical pathway is required for dendrite pruning in Drosophila da neurons. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T14:49:39Z (GMT). No. of bitstreams: 1 U0001-0908202018540800.pdf: 22707058 bytes, checksum: d405c8de45d6c930af774122bbbc0c00 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 誌謝......................................................................................................................................................ii 摘要....................................................................................................................................................iii Abstract...........................................................................................................................iv Contents............................................................................................................................v List of Figures.................................................................................................................vii List of Tables.................................................................................................................viii Introduction.....................................................................................................................1 Neural Development..................................................................................................1 Neurite Pruning..........................................................................................................2 Wnt Signaling Pathways............................................................................................3 Wnt Signaling in Neuronal Development..................................................................5 Dendrite Pruning in Drosophila Sensory Neurons.....................................................6 Methods............................................................................................................................8 Results.............................................................................................................................12 dsh is required for dendrite pruning in C4da neurons...............................................12 dTCF is essential to dendrite pruning and morphogenesis.......................................12 Knot cannot rescue dendrite morphogenesis in dTCF-∆N expression.....................15 The roles of Frizzled and Arrow in dendrite severing...............................................16 Mutational analysis of Dsh ......................................................................................18 The knockdown efficiency of dsh-RNAi lines.........................................................19 The off-target effects of dsh dsRNA(R2) on dendrite pruning..................................20 Axin functions as a negative regulator in neuronal pruning of C4da neurons...........21 The role of β-Catenin/Arm in dendrite pruning .......................................................22 Constitutively-active Armadillo could rescue pruning defects in C4da neurons with impaired Wnt signaling............................................................................................23 The roles of Wg, Wnt2, and Wnt4 in dendrite pruning.............................................24 Discussion.......................................................................................................................26 Reference........................................................................................................................35 Figures............................................................................................................................49 Tables..............................................................................................................................82 | |
| dc.language.iso | en | |
| dc.subject | Wnt 經典傳導路徑 | zh_TW |
| dc.subject | 神經重塑 | zh_TW |
| dc.subject | 樹突修剪 | zh_TW |
| dc.subject | Wnt canonical signaling | en |
| dc.subject | neuronal remodeling | en |
| dc.subject | dendrite pruning | en |
| dc.title | Wnt 傳導路徑在果蠅神經元樹突修剪之調控 | zh_TW |
| dc.title | The Role of Wnt Signaling in Dendrite Pruning of Drosophila Sensory Neurons | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 徐立中(Li-Chung Hsu),鄭旭辰(Hsu-Chen Cheng) | |
| dc.subject.keyword | 神經重塑,樹突修剪,Wnt 經典傳導路徑, | zh_TW |
| dc.subject.keyword | neuronal remodeling,dendrite pruning,Wnt canonical signaling, | en |
| dc.relation.page | 81 | |
| dc.identifier.doi | 10.6342/NTU202002727 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2020-08-11 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 分子醫學研究所 | zh_TW |
| dc.date.embargo-lift | 2025-08-01 | - |
| 顯示於系所單位： | 分子醫學研究所 | |
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