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Design and Implementation of Automated Drug Coating System with Machine Vision
Drug delivery vehicles,Drug Eluting Stent,Machine Vision Technology,Image Modeling and Positioning,Automatic Optical Inspection,
|Publication Year :||2017|
Thanks to the rapid development of medical devices, the drug-eluting stent plays more and more important role in the treatment of cardiovascular disease. Tradition bare metal stent have not met current requirements, and drug-eluting stent is able to provide more effective treatment by drug delivery. The novel drug-eluting stent design with micro-sized drug reservoirs (drug-eluting depot stent) will become the new trend of implantable medical equipment. Down the line, different types of medicine can be coated on a vascular stent, and physicians will be able to control release time of the medicine, empowering drug-eluting stents with more possibility and potential.
Currently, the coating of drug-eluding stent is processed manually with spray nozzle. However, manual handled coating does not make drug-eluting stent more stable, and spray nozzle causes waste of medicine due to the wide coating range. What is more serious that over-coating on the vascular stent surface could have bad impact on many treatments. In addition, the current coating method must not apply to depot drug-eluting stent, and does not achieve the novel treatment of releasing drugs with different stages.
To combat the above disadvantages, this research designed and developed a new automatic coating system of drug delivery vehicles. This automatic system not only improved manual handling coating, but also changed spray nozzle to micro-glass nozzle to achieve target coating. With these significant improvements, the coating of depot drug-eluting stent became feasible. In this automatic system, the self-designed hardware was integrated with three mechanisms including the Precision Motion Control Mechanism, the Image Modeling and Position Mechanism and the Drug Coating Control Mechanism. The software was built with C-Sharp (C#) programming language and multiple libraries, including OpenCV, OpenGL, and the self-developed toolkit ACSTK. Then the integration of the entire the automation system was completed.
Before the coating process, drug-eluting stent had to undergo a lot of manufacturing process such as heat treatment and electrical polishing. The drug-eluting stent actual surface and design surface could have much difference. Therefore, this research used vascular stent images to achieve image modeling and positioning with machine vision technology. Moreover, the system was able to automatically identify vascular stent and micro-sized drug reservoirs characteristics utilizing image processing. Finally, the system controlled the Drug Coating Control mechanism to complete target coating. The result had shown this research successfully developed the automatic coating system of drug delivery vehicles, and it can not only coat the current drug-eluting stents, but also able to apply to depot drug-eluting stents. It can even coat other different types of vascular stents.
|Appears in Collections:||機械工程學系|
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