請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76681
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 何佳安(Ja-an Annie Ho) | |
dc.contributor.author | You-Jin Chen | en |
dc.contributor.author | 陳幼瑾 | zh_TW |
dc.date.accessioned | 2021-07-10T21:34:58Z | - |
dc.date.available | 2021-07-10T21:34:58Z | - |
dc.date.copyright | 2016-11-02 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-17 | |
dc.identifier.citation | 1. Kueppers, R., The biology of Hodgkin's lymphoma. Nat. Rev. Cancer. 2009, 9 (1), 15-27.
2. Campo, E.; Swerdlow, S. H.; Harris, N. L.; Pileri, S.; Stein, H.; Jaffe, E. S., The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011, 117 (19), 5019-5032. 3. Ekstrom-Smedby, K., Epidemiology and etiology of non-Hodgkin lymphoma - a review. Acta Oncol. 2006, 45 (3), 258-271. 4. Torre, L. A.; Bray, F.; Siegel, R. L.; Ferlay, J.; Lortet-Tieulent, J.; Jemal, A., Global Cancer Statistics, 2012. CA Cancer J. Clin. 2015, 65 (2), 87-108. 5. Kuppers, R., Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer. 2005, 5 (4), 251-262. 6. Chiu, B. C.; Hou, N., Epidemiology and etiology of non-hodgkin lymphoma. Cancer Treat. Res. 2015, 165, 1-25. 7. Alexander, D. D.; Mink, P. J.; Adami, H.-O.; Chang, E. T.; Cole, P.; Mandel, J. S.; Trichopoulos, D., The non-Hodgkin lymphomas: A review of the epidemiologic literature. Int. J. Cancer. 2007, 1-39. 8. Merlo, D. F.; Rossi, L.; Pellegrino, C.; Ceppi, M.; Cardellino, U.; Capurro, C.; Ratto, A.; Sambucco, P. L.; Sestito, V.; Tanara, G.; Bocchini, V., Cancer incidence in pet dogs: Findings of the animal tumor registry of Genoa, Italy. J. Vet. Intern. Med. 2008, 22 (4), 976-984. 9. Macewen, E. G., Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment. Cancer Metastasis Rev. 1990, 9 (2), 125-136. 10. Parodi, A.; Wyers, M.; Paris, J., Incidence of canine lymphoid leukosis. Age, sex and breed distribution; results of a necropsic survey. Bibl. Haematol. 1968, (30), 263-267. 11. Priester, W. A.; McKay, F. W., The occurrence of tumors in domestic animals. Natl Cancer Inst Monogr. 1980, (54), 1-210. 12. Edwards, D. S.; Henley, W. E.; Harding, E. F.; Dobson, J. M.; Wood, J. L., Breed incidence of lymphoma in a UK population of insured dogs. Vet. Comp. Oncol. 2003, 1 (4), 200-206. 13. Modiano, J. F.; Breen, M.; O Valli, V. E.; Wojcieszyn, J. W.; Cutter, G. R., Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma. Leukemia. 2007, 21 (1), 184-187. 14. Greenlee, P. G.; Filippa, D. A.; Quimby, F. W.; Patnaik, A. K.; Calvano, S. E.; Matus, R. E.; Kimmel, M.; Hurvitz, A. I.; Lieberman, P. H., Lymphomas in dogs. A morphologic, immunologic, and clinical study. Cancer. 1990, 66 (3), 480-490. 15. Teske, E.; Devos, J. P.; Egberink, H. F.; Vos, J. H., Clustering in canine malignant lymphoma. Vet. Q. 1994, 16 (2), 134-136. 16. FournelFleury, C.; Magnol, J. P.; Bricaire, P.; Marchal, T.; Chabanne, L.; Delverdier, A.; Bryon, P. A.; Felman, P., Cytohistological and immunological classification of canine malignant lymphomas: Comparison with human non-Hodgkin's lymphomas. J. Comp. Pathol. 1997, 117 (1), 35-59. 17. Ruslander, D. A.; Gebhard, D. H.; Tompkins, M. B.; Grindem, C. B.; Page, R. L., Immunophenotypic characterization of canine lymphoproliferative disorders. In Vivo. 1997, 11 (2), 169-172. 18. Fournel-Fleury, C.; Ponce, F.; Felman, P.; Blavier, A.; Bonnefont, C.; Chabanne, L.; Marchal, T.; Cadore, J. L.; Goy-Thollot, I.; Ledieu, D.; Ghernati, I.; Magnol, J. P., Canine T-cell lymphomas: A morphological, immunological, and clinical study of 46 new cases. Vet. Pathol. 2002, 39 (1), 92-109. 19. Caniatti, M.; Roccabianca, P.; Scanziani, E.; Paltrinieri, S.; Moore, P. F., Canine lymphoma: Immunocytochemical analysis of fine-needle aspiration biopsy. Vet. Pathol. 1996, 33 (2), 204-212. 20. Zeppa, P.; Marino, G.; Troncone, G.; Fulciniti, F.; De Renzo, A.; Picardi, M.; Benincasa, G.; Rotoli, B.; Vetrani, A.; Palombini, L., Fine-needle cytology and flow cytometry immunophenotyping and subclassification of non-Hodgkin lymphoma - A critical review of 307 cases with technical suggestions. Cancer Cytopathol. 2004, 102 (1), 55-65. 21. Higgins, R. A.; Blankenship, J. E.; Kinney, M. C., Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch. Pathol. Lab. Med. 2008, 132 (3), 441-461. 22. Arber, D. A., Molecular diagnostic approach to non-Hodgkin's lymphoma. J Mol Diagn. 2000, 2 (4), 178-190. 23. Alizadeh, A. A.; Eisen, M. B.; Davis, R. E.; Ma, C.; Lossos, I. S.; Rosenwald, A.; Boldrick, J. G.; Sabet, H.; Tran, T.; Yu, X.; Powell, J. I.; Yang, L. M.; Marti, G. E.; Moore, T.; Hudson, J.; Lu, L. S.; Lewis, D. B.; Tibshirani, R.; Sherlock, G.; Chan, W. C.; Greiner, T. C.; Weisenburger, D. D.; Armitage, J. O.; Warnke, R.; Levy, R.; Wilson, W.; Grever, M. R.; Byrd, J. C.; Botstein, D.; Brown, P. O.; Staudt, L. M., Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000, 403 (6769), 503-511. 24. Burnett, R. C.; Vernau, W.; Modiano, J. F.; Olver, C. S.; Moore, P. F.; Avery, A. C., Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Vet. Pathol. 2003, 40 (1), 32-41. 25. Lagos-Quintana, M.; Rauhut, R.; Meyer, J.; Borkhardt, A.; Tuschl, T., New microRNAs from mouse and human. RNA. 2003, 9 (2), 175-179. 26. Bartel, D. P., MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 2004, 116 (2), 281-297. 27. Small, E. M.; Frost, R. J. A.; Olson, E. N., MicroRNAs add a new dimension to cardiovascular disease. Circulation. 2010, 121 (8), 1022-1032. 28. Quiat, D.; Olson, E. N., MicroRNAs in cardiovascular disease: From pathogenesis to prevention and treatment. J. Clin. Invest. 2013, 123 (1), 11-18. 29. Pandey, A. K.; Agarwal, P.; Kaur, K.; Datta, M., MicroRNAs in diabetes: Tiny players in big disease. Cell. Physiol. Biochem. 2009, 23 (4-6), 221-232. 30. Lu, J.; Getz, G.; Miska, E. A.; Alvarez-Saavedra, E.; Lamb, J.; Peck, D.; Sweet-Cordero, A.; Ebet, B. L.; Mak, R. H.; Ferrando, A. A.; Downing, J. R.; Jacks, T.; Horvitz, H. R.; Golub, T. R., MicroRNA expression profiles classify human cancers. Nature. 2005, 435 (7043), 834-838. 31. Iorio, M. V.; Croce, C. M., MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol. Med. 2012, 4 (3), 143-159. 32. Garzon, R.; Marcucci, G.; Croce, C. M., Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat. Rev. Drug Discov. 2010, 9 (10), 775-789. 33. He, L.; Hannon, G. J., Micrornas: Small RNAs with a big role in gene regulation. Nat. Rev. Genet. 2004, 5 (7), 522-531. 34. Lee, R. C.; Feinbaum, R. L.; Ambros, V., The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993, 75 (5), 843-854. 35. Krichevsky, A. M.; King, K. S.; Donahue, C. P.; Khrapko, K.; Kosik, K. S., A microRNA array reveals extensive regulation of microRNAs during brain development. RNA. 2003, 9 (10), 1274-1281. 36. Chen, C. Z.; Li, L.; Lodish, H. F.; Bartel, D. P., MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004, 303 (5654), 83-86. 37. Alvarez-Garcia, I.; Miska, E. A., MicroRNA functions in animal development and human disease. Development. 2005, 132 (21), 4653-4662. 38. Miska, E. A., How microRNAs control cell division, differentiation and death. Curr. Opin. Genet. Dev. 2005, 15 (5), 563-568. 39. Jovanovic, M.; Hengartner, M. O., miRNAs and apoptosis: RNAs to die for. Oncogene. 2006, 25 (46), 6176-6187. 40. Jose Bueno, M.; Perez de Castro, I.; Malumbres, M., Control of cell proliferation pathways by microRNAs. Cell cycle. 2008, 7 (20), 3143-3148. 41. Volinia, S.; Calin, G. A.; Liu, C. G.; Ambs, S.; Cimmino, A.; Petrocca, F.; Visone, R.; Iorio, M.; Roldo, C.; Ferracin, M.; Prueitt, R. L.; Yanaihara, N.; Lanza, G.; Scarpa, A.; Vecchione, A.; Negrini, M.; Harris, C. C.; Croce, C. M., A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U. S. A. 2006, 103 (7), 2257-2261. 42. Garzon, R.; Calin, G. A.; Croce, C. M., MicroRNAs in cancer. Annu. Rev. Med. 2009, 60 (1), 167-179. 43. Musilova, K.; Mraz, M., MicroRNAs in B-cell lymphomas: How a complex biology gets more complex. Leukemia. 2015, 29 (5), 1004-1017. 44. Calin, G. A.; Dumitru, C. D.; Shimizu, M.; Bichi, R.; Zupo, S.; Noch, E.; Aldler, H.; Rattan, S.; Keating, M.; Rai, K.; Rassenti, L.; Kipps, T.; Negrini, M.; Bullrich, F.; Croce, C. M., Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. U. S. A. 2002, 99 (24), 15524-15529. 45. Yanaihara, N.; Caplen, N.; Bowman, E.; Seike, M.; Kumamoto, K.; Yi, M.; Stephens, R. M.; Okamoto, A.; Yokota, J.; Tanaka, T.; Colin, G. A.; Liu, C. G.; Croce, C. M.; Harris, C. C., Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 2006, 9 (3), 189-198. 46. Blenkiron, C.; Goldstein, L. D.; Thorne, N. P.; Spiteri, I.; Chin, S.-F.; Dunning, M. J.; Barbosa-Morais, N. L.; Teschendorff, A. E.; Green, A. R.; Ellis, I. O.; Tavare, S.; Caldas, C.; Miska, E. A., MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol. 2007, 8 (10), R214. 47. Lee, E. J.; Gusev, Y.; Jiang, J.; Nuovo, G. J.; Lerner, M. R.; Frankel, W. L.; Morgan, D. L.; Postier, R. G.; Brackett, D. J.; Schmittgen, T. D., Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer. 2007, 120 (5), 1046-1054. 48. Porkka, K. P.; Pfeiffer, M. J.; Waltering, K. K.; Vessella, R. L.; Tammela, T. L. J.; Visakorpi, T., MicroRNA expression profiling in prostate cancer. Cancer Res. 2007, 67 (13), 6130-6135. 49. Paranjape, T.; Slack, F. J.; Weidhaas, J. B., MicroRNAs: Tools for cancer diagnostics. Gut. 2009, 58 (11), 1546-1554. 50. Xi, Y.; Nakajima, G.; Gavin, E.; Morris, C. G.; Kudo, K.; Hayashi, K.; Ju, J., Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA. 2007, 13 (10), 1668-1674. 51. Li, J.; Smyth, P.; Flavin, R.; Cahill, S.; Denning, K.; Aherne, S.; Guenther, S. M.; O'Leary, J. J.; Sheils, O., Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells. BMC Biotechnol. 2007, 7, 36. 52. Mortarino, M.; Gioia, G.; Gelain, M. E.; Albonico, F.; Roccabianca, P.; Ferri, E.; Comazzi, S., Identification of suitable endogenous controls and differentially expressed microRNAs in canine fresh-frozen and FFPE lymphoma samples. Leukemia Res. 2010, 34 (8), 1070-1077. 53. Mitchell, P. S.; Parkin, R. K.; Kroh, E. M.; Fritz, B. R.; Wyman, S. K.; Pogosova-Agadjanyan, E. L.; Peterson, A.; Noteboom, J.; O'Briant, K. C.; Allen, A.; Lin, D. W.; Urban, N.; Drescher, C. W.; Knudsen, B. S.; Stirewalt, D. L.; Gentleman, R.; Vessella, R. L.; Nelson, P. S.; Martin, D. B.; Tewari, M., Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U. S. A. 2008, 105 (30), 10513-10518. 54. Grasedieck, S.; Schoeler, N.; Bommer, M.; Niess, J. H.; Tumani, H.; Rouhi, A.; Bloehdorn, J.; Liebisch, P.; Mertens, D.; Doehner, H.; Buske, C.; Langer, C.; Kuchenbauer, F., Impact of serum storage conditions on microRNA stability. Leukemia. 2012, 26 (11), 2414-2416. 55. Weber, J. A.; Baxter, D. H.; Zhang, S.; Huang, D. Y.; Huang, K. H.; Lee, M. J.; Galas, D. J.; Wang, K., The microRNA spectrum in 12 body fluids. Clin. Chem. 2010, 56 (11), 1733-1741. 56. Metzler, M.; Wilda, M.; Busch, K.; Viehmann, S.; Borkhardt, A., High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer. 2004, 39 (2), 167-169. 57. Lawrie, C. H.; Chi, J.; Taylor, S.; Tramonti, D.; Ballabio, E.; Palazzo, S.; Saunders, N. J.; Pezzella, F.; Boultwood, J.; Wainscoat, J. S.; Hatton, C. S. R., Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma. J. Cell. Mol. Med. 2009, 13 (7), 1248-1260. 58. Eis, P. S.; Tam, W.; Sun, L. P.; Chadburn, A.; Li, Z. D.; Gomez, M. F.; Lund, E.; Dahlberg, J. E., Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. U. S. A. 2005, 102 (10), 3627-3632. 59. Fischer, L.; Hummel, M.; Korfel, A.; Lenze, D.; Joehrens, K.; Thiel, E., Differential micro-RNA expression in primary CNS and nodal diffuse large B-cell lymphomas. Neuro Oncol. 2011, 13 (10), 1090-1098. 60. Zhong, H.; Xu, L.; Zhong, J.-H.; Xiao, F.; Liu, Q.; Huang, H.-H.; Chen, F.-Y., Clinical and prognostic significance of miR-155 and miR-146a expression levels in formalin-fixed/paraffin-embedded tissue of patients with diffuse large B-cell lymphoma. Exp. Ther. Med. 2012, 3 (5), 763-770. 61. Iqbal, J.; Shen, Y.; Huang, X.; Liu, Y.; Wake, L.; Liu, C.; Deffenbacher, K.; Lachel, C. M.; Wang, C.; Rohr, J.; Guo, S.; Smith, L. M.; Wright, G.; Bhagavathi, S.; Dybkaer, K.; Fu, K.; Greiner, T. C.; Vose, J. M.; Jaffe, E.; Rimsza, L.; Rosenwald, A.; Ott, G.; Delabie, J.; Campo, E.; Braziel, R. M.; Cook, J. R.; Tubbs, R. R.; Armitage, J. O.; Weisenburger, D. D.; Staudt, L. M.; Gascoyne, R. D.; McKeithan, T. W.; Chan, W. C., Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma. Blood. 2015, 125 (7), 1137-1145. 62. Lawrie, C. H.; Gal, S.; Dunlop, H. M.; Pushkaran, B.; Liggins, A. P.; Pulford, K.; Banham, A. H.; Pezzella, F.; Boultwood, J.; Wainscoat, J. S.; Hatton, C. S. R.; Harris, A. L., Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2008, 141 (5), 672-675. 63. Fang, C.; Zhu, D.-X.; Dong, H.-J.; Zhou, Z.-J.; Wang, Y.-H.; Liu, L.; Fan, L.; Miao, K.-R.; Liu, P.; Xu, W.; Li, J.-Y., Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma. Ann. Hematol. 2012, 91 (4), 553-559. 64. Tili, E.; Michaille, J. J.; Cimino, A.; Costinean, S.; Dumitru, C. D.; Adair, B.; Fabbri, M.; Alder, H.; Liu, C. G.; Calin, G. A.; Croce, C. M., Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J. Immunol. 2007, 179 (8), 5082-5089. 65. Costinean, S.; Sandhu, S. K.; Pedersen, I. M.; Tili, E.; Trotta, R.; Perrotti, D.; Ciarlariello, D.; Neviani, P.; Harb, J.; Kauffman, L. R.; Shidham, A.; Croce, C. M., Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009, 114 (7), 1374-1382. 66. O'Connell, R. M.; Chaudhuri, A. A.; Rao, D. S.; Baltimore, D., Inositol phosphatase SHIP1 is a primary target of miR-155. Proc. Natl. Acad. Sci. U. S. A. 2009, 106 (17), 7113-7118. 67. Lu, L.-F.; Thai, T.-H.; Calado, D. P.; Chaudhry, A.; Kubo, M.; Tanaka, K.; Loeb, G. B.; Lee, H.; Yoshimura, A.; Rajewsky, K.; Rudensky, A. Y., Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009, 30 (1), 80-91. 68. Rai, D.; Kim, S.-W.; McKeller, M. R.; Dahia, P. L. M.; Aguiar, R. C. T., Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (7), 3111-3116. 69. Dagan, L. N.; Jiang, X.; Bhatt, S.; Cubedo, E.; Rajewsky, K.; Lossos, I. S., miR-155 regulates HGAL expression and increases lymphoma cell motility. Blood. 2012, 119 (2), 513-520. 70. Ovcharenko, D.; Kelnar, K.; Johnson, C.; Leng, N.; Brown, D., Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Res. 2007, 67 (22), 10782-10788. 71. Albonico, F.; Mortarino, M.; Avallone, G.; Gioia, G.; Comazzi, S.; Roccabianca, P., The expression ratio of miR-17-5p and miR-155 correlates with grading in canine splenic lymphoma. Vet. Immunol. Immunopathol. 2013, 155 (1-2), 117-123. 72. Marconato, L.; Gelain, M. E.; Comazzi, S., The dog as a possible animal model for human non-Hodgkin lymphoma: a review. Hematol. Oncol. 2013, 31 (1), 1-9. 73. Ito, D.; Frantz, A. M.; Modiano, J. F., Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications. Vet. Immunol. Immunopathol. 2014, 159 (3-4), 192-201. 74. Pritchard, C. C.; Cheng, H. H.; Tewari, M., MicroRNA profiling: approaches and considerations. Nat. Rev. Genet. 2012, 13 (5), 358-369. 75. Kim, S. W.; Li, Z.; Moore, P. S.; Monaghan, A. P.; Chang, Y.; Nichols, M.; John, B., A sensitive non-radioactive northern blot method to detect small RNAs. Nucleic Acids Res. 2010, 38 (7), e98. 76. Varallyay, E.; Burgyan, J.; Havelda, Z., MicroRNA detection by northern blotting using locked nucleic acid probes. Nat. Protoc. 2008, 3 (2), 190-196. 77. Valoczi, A.; Hornyik, C.; Varga, N.; Burgyan, J.; Kauppinen, S.; Havelda, Z., Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res. 2004, 32 (22), e175. 78. Liu, C. G.; Calin, G. A.; Meloon, B.; Gamliel, N.; Sevignani, C.; Ferracin, M.; Dumitru, C. D.; Shimizu, M.; Zupo, S.; Dono, M.; Alder, H.; Bullrich, F.; Negrini, M.; Croce, C. M., An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc. Natl. Acad. Sci. U. S. A. 2004, 101 (26), 9740-9744. 79. Lee, J. M.; Jung, Y., Two-Temperature Hybridization for Microarray Detection of Label-Free MicroRNAs with Attomole Detection and Superior Specificity. Angew. Chem. Int. Ed. Engl. 2011, 50 (52), 12487-12490. 80. Lehrbach, N. J.; Armisen, J.; Lightfoot, H. L.; Murfitt, K. J.; Bugaut, A.; Balasubramanian, S.; Miska, E. A., LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat. Struct. Mol. Biol. 2009, 16 (10), 1016-1020. 81. Chen, C. F.; Ridzon, D. A.; Broomer, A. J.; Zhou, Z. H.; Lee, D. H.; Nguyen, J. T.; Barbisin, M.; Xu, N. L.; Mahuvakar, V. R.; Andersen, M. R.; Lao, K. Q.; Livak, K. J.; Guegler, K. J., Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005, 33 (20), e179. 82. Peltier, H. J.; Latham, G. J., Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 2008, 14 (5), 844-852. 83. Mestdagh, P.; Feys, T.; Bernard, N.; Guenther, S.; Chen, C.; Speleman, F.; Vandesompele, J., High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA. Nucleic Acids Res. 2008, 36 (21), e143. 84. Gerasimova, Y. V.; Kolpashchikov, D. M., Enzyme-assisted target recycling (EATR) for nucleic acid detection. Chem. Soc. Rev. 2014, 43 (17), 6405-6438. 85. Wang, Q.; Yang, L.; Yang, X.; Wang, K.; He, L.; Zhu, J.; Su, T., An electrochemical DNA biosensor based on the 'Y' junction structure and restriction endonuclease-aided target recycling strategy. Chem. Commun. 2012, 48 (24), 2982-2984. 86. Bi, S.; Zhang, J.; Zhang, S., Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection. Chem. Commun. 2010, 46 (30), 5509-5511. 87. Hsieh, K.; Xiao, Y.; Soh, H. T., Electrochemical DNA Detection via Exonuclease and Target-Catalyzed Transformation of Surface-Bound Probes. Langmuir. 2010, 26 (12), 10392-10396. 88. Liu, L.; Lei, J.; Gao, F.; Ju, H., A DNA machine for sensitive and homogeneous DNA detection via lambda exonuclease assisted amplification. Talanta. 2013, 115, 819-822. 89. Yin, B.-C.; Liu, Y.-Q.; Ye, B.-C., One-Step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification. J. Am. Chem. Soc. 2012, 134 (11), 5064-5067. 90. Ren, Y.; Deng, H.; Shen, W.; Gao, Z., A Highly Sensitive and Selective Electrochemical Biosensor for Direct Detection of MicroRNAs in Serum. Anal. Chem. 2013, 85 (9), 4784-4789. 91. Xi, Q.; Zhou, D.-M.; Kan, Y.-Y.; Ge, J.; Wu, Z.-K.; Yu, R.-Q.; Jiang, J.-H., Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification. Anal. Chem. 2014, 86 (3), 1361-1365. 92. Yang, C.; Dou, B.; Shi, K.; Chai, Y.; Xiang, Y.; Yuan, R., Multiplexed and Amplified Electronic Sensor for the Detection of MicroRNAs from Cancer Cells. Anal. Chem. 2014, 86 (23), 11913-11918. 93. Jou, A. F.-J.; Lu, C.-H.; Ou, Y.-C.; Wang, S.-S.; Hsu, S.-L.; Willner, I.; Ho, J.-A. A., Diagnosing the miR-141 prostate cancer biomarker using nucleic acid-functionalized CdSe/ZnS QDs and telomerase. Chem. Sci. 2015, 6 (1), 659-665. 94. Degliangeli, F.; Kshirsagar, P.; Brunetti, V.; Pompa, P. P.; Fiammengo, R., Absolute and Direct MicroRNA Quantification Using DNA-Gold Nanoparticle Probes. J. Am. Chem. Soc. 2014, 136 (6), 2264-2267. 95. Anisimova, V. E.; Rebrikov, D. V.; Shagin, D. A.; Kozhemyako, V. B.; Menzorova, N. I.; Staroverov, D. B.; Ziganshin, R.; Vagner, L. L.; Rasskazov, V. A.; Lukyanov, S. A.; Shcheglov, A. S., Isolation, characterization and molecular cloning of Duplex-Specific Nuclease from the hepatopancreas of the Kamchatka crab. BMC Biochem. 2008, 9, 14. 96. Shagin, D. A.; Rebrikov, D. V.; Kozhemyako, V. B.; Altshuler, I. M.; Shcheglov, A. S.; Zhulidov, P. A.; Bogdanova, E. A.; Staroverov, D. B.; Rasskazov, V. A.; Lukyanov, S., A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas. Genome Res. 2002, 12 (12), 1935-1942. 97. Zhulidov, P. A.; Bogdanova, E. A.; Shcheglov, A. S.; Vagner, L. L.; Khaspekov, G. L.; Kozhemyako, V. B.; Matz, M. V.; Meleshkevitch, E.; Moroz, L. L.; Lukyanov, S. A.; Shagin, D. A., Simple cDNA normalization using kamchatka crab duplex-specific nuclease. Nucleic Acids Res. 2004, 32 (3), e37. 98. Bogdanova, E. A.; Shagin, D. A.; Lukyanov, S. A., Normalization of full-length enriched cDNA. Mol. Biosyst. 2008, 4 (3), 205-212. 99. Liu, M.; Yuan, M.; Lou, X.; Mao, H.; Zheng, D.; Zou, R.; Zou, N.; Tang, X.; Zhao, J., Label-free optical detection of single-base mismatches by the combination of nuclease and gold nanoparticles. Biosens. Bioelectron. 2011, 26 (11), 4294-4300. 100. Mullis, K.; Faloona, F.; Scharf, S.; Saiki, R.; Horn, G.; Erlich, H., Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harbor Symp. Quant. Biol. 1986, 51, 263-273. 101. Deiman, B.; van Aarle, P.; Sillekens, P., Characteristics and applications of nucleic acid sequence-based amplification (NASBA). Mol. Biotechnol. 2002, 20 (2), 163-179. 102. Johne, R.; Mueller, H.; Rector, A.; van Ranst, M.; Stevens, H., Rolling-circle amplification of viral DNA genomes using phi29 polymerase. Trends Microbiol. 2009, 17 (5), 205-211. 103. Hellyer, T. J.; Nadeau, J. G., Strand displacement amplification: A versatile tool for molecular diagnostics. Expert Rev. Mol. Diagn. 2004, 4 (2), 251-261. 104. Jeong, Y.-J.; Park, K.; Kim, D.-E., Isothermal DNA amplification in vitro: The helicase-dependent amplification system. Cell. Mol. Life Sci. 2009, 66 (20), 3325-3336. 105. Notomi, T.; Okayama, H.; Masubuchi, H.; Yonekawa, T.; Watanabe, K.; Amino, N.; Hase, T., Loop-mediated isothermal amplification of DNA. Nucleic Acids Res. 2000, 28 (12), e63. 106. Walker, G. T.; Fraiser, M. S.; Schram, J. L.; Little, M. C.; Nadeau, J. G.; Malinowski, D. P., Strand displacement amplification--an isothermal, in vitro DNA amplification technique. Nucleic Acids Res. 1992, 20 (7), 1691-1696. 107. Niemz, A.; Ferguson, T. M.; Boyle, D. S., Point-of-care nucleic acid testing for infectious diseases. Trends Biotechnol. 2011, 29 (5), 240-250. 108. Drummond, T. G.; Hill, M. G.; Barton, J. K., Electrochemical DNA sensors. Nat. Biotechnol. 2003, 21 (10), 1192-1199. 109. Palecek, E.; Bartosik, M., Electrochemistry of nucleic acids. Chem. Rev. 2012, 112 (6), 3427-3481. 110. Fan, C. H.; Plaxco, K. W.; Heeger, A. J., Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA. Proc. Natl. Acad. Sci. U. S. A. 2003, 100 (16), 9134-9137. 111. Tyagi, S.; Kramer, F. R., Molecular beacons: Probes that fluoresce upon hybridization. Nat. Biotechnol. 1996, 14 (3), 303-308. 112. Immoos, C. E.; Lee, S. J.; Grinstaff, M. W., DNA-PEG-DNA triblock macromolecules for reagentless DNA detection. J. Am. Chem. Soc. 2004, 126 (35), 10814-10815. 113. Xiao, Y.; Lubin, A. A.; Baker, B. R.; Plaxco, K. W.; Heeger, A. J., Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proc. Natl. Acad. Sci. U. S. A. 2006, 103 (45), 16677-16680. 114. Labib, M.; Khan, N.; Berezovski, M. V., Protein electrocatalysis for direct sensing of circulating microRNAs. Anal. Chem. 2015, 87 (2), 1395-1403. 115. Wang, T.; Viennois, E.; Merlin, D.; Wang, G., Microelectrode miRNA sensors enabled by enzymeless electrochemical signal amplification. Anal. Chem. 2015, 87 (16), 8173-8180. 116. Xiao, Y.; Lubin, A. A.; Heeger, A. J.; Plaxco, K. W., Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. Angew. Chem. Int. Ed. Engl. 2005, 44 (34), 5456-5459. 117. Radi, A. E.; Sanchez, J. L. A.; Baldrich, E.; O'Sullivan, C. K., Reagentless, reusable, ultrasensitive electrochemical molecular beacon aptasensor. J. Am. Chem. Soc. 2006, 128 (1), 117-124. 118. Radi, A.-E.; O'Sullivan, C. K., Aptamer conformational switch as sensitive electrochemical biosensor for potassium ion recognition. Chem. Commun. 2006, (32), 3432-3434. 119. Bard, A. J.; Faulkner, L. R.; Leddy, J.; Zoski, C. G., Electrochemical methods: fundamentals and applications. Wiley New York: 1980; Vol. 2. 120. Kloosterman, W. P.; Wienholds, E.; de Bruijn, E.; Kauppinen, S.; Plasterk, R. H. A., In situ detection of miRNAs in animal embryos using LNA-modified oligonucteotide probes. Nat. Methods. 2006, 3 (1), 27-29. 121. Owczarzy, R.; Tataurov, A. V.; Wu, Y.; Manthey, J. A.; McQuisten, K. A.; Almabrazi, H. G.; Pedersen, K. F.; Lin, Y.; Garretson, J.; McEntaggart, N. O.; Sailor, C. A.; Dawson, R. B.; Peek, A. S., IDT SciTools: A suite for analysis and design of nucleic acid oligomers. Nucleic Acids Res. 2008, 36, W163-W169. 122. Daniel, R. M.; Dines, M.; Petach, H. H., The denaturation and degradation of stable enzymes at high temperatures. Biochem. J. 1996, 317, 1-11. 123. Rittie, L.; Perbal, B., Enzymes used in molecular biology: A useful guide. J. Cell Commun. Signal. 2008, 2 (1-2), 25-45. 124. Ho, J.-A. A.; Chiu, J.-K.; Hong, J.-C.; Lin, C.-C.; Hwang, K.-C.; Hwu, J.-R. R., Gold-nanostructured immunosensor for the electrochemical sensing of biotin based on liposomal competitive assay. J. Nanosci. Nanotechnol. 2009, 9 (4), 2324-2329. 125. Loaiza, O. A.; Campuzano, S.; Lopez-Berlanga, M.; Pedrero, M. A.; Pingarron, J. M., Development of a DNA sensor based on alkanethiol self-assembled monolayer-modified electrodes. Sensors. 2005, 5 (6-10), 344-363. 126. Boon, E. M.; Ceres, D. M.; Drummond, T. G.; Hill, M. G.; Barton, J. K., Mutation detection by electrocatalysis at DNA-modified electrodes. Nat. Biotechnol. 2000, 18 (10), 1096-1100. 127. Ju, H. X.; Zhou, J.; Cai, C. X.; Chen, H. Y., The electrochemical behavior of methylene blue at a microcylinder carbon fiber electrode. Electroanalysis. 1995, 7 (12), 1165-1170. 128. Ricci, F.; Lai, R. Y.; Heeger, A. J.; Plaxco, K. W.; Sumner, J. J., Effect of molecular crowding on the response of an electrochemical DNA sensor. Langmuir. 2007, 23 (12), 6827-6834. 129. Steel, A. B.; Herne, T. M.; Tarlov, M. J., Electrochemical quantitation of DNA immobilized on gold. Anal. Chem. 1998, 70 (22), 4670-4677. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76681 | - |
dc.description.abstract | 微型核糖核酸(MicorRNA, miRNA)為長約22個核苷酸片段,高度保留,非編碼的RNA分子;可藉由配對信使RNA (Messenger RNA)的三端不轉譯區域調控基因表現。MicroRNAs在生物體內扮演重要角色,影響細胞的增生、分化、凋亡及代謝。許多證據顯示,不正常表現的microRNA可藉由調節腫瘤抑癌或致癌基因影響癌症進程。近來研究發現,哺乳類惡性淋巴瘤中,有一種常見的侵襲性非何杰金氏B細胞淋巴瘤(Non-Hodgkin’s B-cell lymphoma)之亞型─瀰漫性大型B細胞淋巴瘤(Diffuse large B-cell lymphoma),有miR-155高度表現的證據。因此,miR-155被認為是有潛力做為淋巴瘤的生物標記核酸分子。本研究中,我們提出一個新的檢測策略,結合Duplex-specific nuclease (DSN)輔助目標分子循環再生(Target recycling)與鏈置換擴增(Strand displacement amplification, SDA)技術,並以電化學分析法偵測樣品中miR-155含量。我們首先以聚丙烯醯胺膠體電泳法證明經由DSN作用後所獲得的核酸片段,足可啟動SDA,並產生訊號誘導序列。接著確定此誘導序列可與電極表面上亞甲藍標定的髮夾型探針進行雜合,進而產生電化學訊號之差異性。以“訊號關閉”的電化學生物感測器,提供檢測miR-155的可行性與潛力,可做為惡性淋巴瘤之液態樣品切片(Liquid biopsy)的臨床診斷工具。 | zh_TW |
dc.description.abstract | MicroRNAs (miRNAs) are a class of small (~22nt), highly conserved, non-coding RNA that negatively regulate gene expression through pairing the 3’ untranslated region of mRNA transcripts. MicroRNAs play a critical role in several cellular regulation such as proliferation, differentiation, apoptosis, and metabolism. Growing evidences have shown that aberrant expression of miRNAs links to various cancers by modulating the expression of tumor suppressors or oncogenes. Recent studies showed that microRNA-155 (miR-155) was up-regulated in mammalian B-cell malignancies, such as diffuse large B cell lymphoma (DLBCL), which is an aggressive type of non-Hodgkin’s lymphoma. MiR-155 is hence suggested as a potential biomarker for lymphoma. Herein, we proposed a new strategy for electrochemical detection of miR-155 based on duplex-specific nuclease (DSN)-assisted target recycling and strand displacement amplification (SDA). Our preliminary results collected by polyacrylamide gel electrophoresis (PAGE) confirmed the production of trigger sequences through DSN reaction, followed by the onset of the SDA, leading to the production of the signal inducer sequences. Finally, signal inducer sequences hybridized with the hairpin probes on electrode surface sensitized with methylene blue, resulting in the establishment of a ‘signal-off’ electrochemical biosensor. This biosensing platform provides a promising applicability and feasible potential toward the detection of miR-155 that can be further extended to clinical diagnosis of liquid biopsy samples for patients with mammalian lymphoma. | en |
dc.description.provenance | Made available in DSpace on 2021-07-10T21:34:58Z (GMT). No. of bitstreams: 1 ntu-105-R03B22031-1.pdf: 3394352 bytes, checksum: 2977d9578a7e532616e7a35ad8f8f5e1 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 第一章 緒論 1
1.1. 淋巴瘤 (Lymphoma) 1 1.1.1 人類淋巴瘤簡介 1 1.1.2 犬淋巴瘤簡介 1 1.1.3 淋巴瘤診斷 5 1.2. 微型核糖核酸 (MicroRNA) 6 1.2.1 microRNA生合成與作用機制 6 1.2.2 microRNA與癌症 8 1.2.3 miR-155作為淋巴癌的生物指標 10 1.2.4 microRNA的檢測方法 10 1.3. 酵素輔助核酸目標循環作用 12 1.3.1 Duplex-specific nuclease輔助目標物循環法 13 1.4. 等溫核酸放大技術 14 1.4.1 單鏈置換擴增法 (Strand displacement amplification, SDA) 14 1.5. 電化學DNA感測器 16 1.6. 電化學偵測法 18 1.7. 研究動機 21 第二章 實驗材料與方法 22 2.1. 核酸序列 22 2.2. 實驗試劑與材料 23 2.3. 實驗儀器 26 2.4. 緩衝溶液 27 2.5. 聚丙醯胺膠體電泳法 (Polyacrylamide gel electrophoresis, PAGE) 28 2.6. DSN輔助目標物循環與單鏈置換擴增法之反應 28 2.6.1. DSN酶切產物探討 28 2.6.2. DSN輔助目標物循環法之測試 28 2.6.3. DSN輔助目標物循環法之最佳化 29 2.6.4. DSN高溫去活反應 29 2.6.5. DSN之目標分子專一性酶切測試 29 2.6.6. 單鏈置換擴增法之測試 30 2.6.7. 單鏈置換擴增法之最佳化 30 2.7. 鍍金時間對MB-hairpin DNA電流訊號之影響 31 2.8. 電解質緩衝液選擇 33 2.9. MB-hairpin DNA修飾於AuNP-SPCE之鑑定 34 2.10. SPCE、AuNP-SPCE與DNA@AuNP-SPCE之電極表面鑑定 36 2.11. 全流程反應 37 第三章 實驗結果與討論 38 3.1 實驗設計 38 3.2 DSN輔助目標分子之循環反應(DSN-assisted target recycling) 41 3.2.1. DSN酶切產物之探討 41 3.2.2. DSN可輔助目標分子進行循環反應 44 3.2.3. DSN反應溫度最佳化 45 3.2.4. DSN使用濃度最佳化 47 3.2.5. DSN加熱處理去活化時間之最佳化 49 3.2.6. DSN之專一性酶切目標分子測試 51 3.3 單鏈置換擴增法(Strand displacement amplification, SDA) 53 3.3.1. 單鏈置換擴增法測試 53 3.3.2. 反應使用酵素比例最佳化 55 3.4 工作電極製備及其最佳化 57 3.4.1. 鍍金時間對MB-hairpin DNA電流訊號之影響 57 3.4.2. 電解質緩衝液選擇 59 3.4.3. MB-hairpin DNA修飾於AuNP-SPCE之鑑定 61 3.4.4. SPCE、AuNP-SPCE、DNA@AuNP-SPCE之電極表面鑑定 63 3.5 全流程反應 66 第四章 結論 70 第五章 參考文獻 72 | |
dc.language.iso | zh-TW | |
dc.title | 發展觸發式雙重訊號放大策略以偵測與癌症有關之微小核酸核醣片段 | zh_TW |
dc.title | A Sensitive Electrochemical Detection of a Tumor-associated MicroRNA by Target-triggered Dual Amplification Strategy | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 邢怡銘(I-Ming Hsing),吳立真(Li-Chen Wu),陳平,鄭建中 | |
dc.subject.keyword | 淋巴瘤,液態切片樣品,微型核糖核酸,電化學感測器,Duplex-specific nuclease,恆溫放大法, | zh_TW |
dc.subject.keyword | lymphoma,liquid biopsy,microRNA,electrochemical biosensor,duplex-specific nuclease,strand displacement amplification, | en |
dc.relation.page | 87 | |
dc.identifier.doi | 10.6342/NTU201602769 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2016-08-18 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生化科技學系 | zh_TW |
顯示於系所單位: | 生化科技學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-105-R03B22031-1.pdf 目前未授權公開取用 | 3.31 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。