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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | 黃鈺琪 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:18:03Z | - |
| dc.date.available | 2021-07-01T08:18:03Z | - |
| dc.date.issued | 1995 | |
| dc.identifier.citation | Algate. P.A., Steelman, L.S.,Mayo, M.W., Miyajima, A., and McCubrey, J.A. Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line. Blood 1994 May 183(9):2459-68 Arai, K.. Watanabe, S.. Koyano, N., Lee, H.J.. Miyajima. A., Yssel, H, Arai. N., and Yokota, T. Cytokine network: control of allergic response and hemopoiesis by hemopoietic growth factors. Journal of Dermatology 1992 Oct, 19(10):575-83 Areces, L.B., Jucker. M., San Miguel, J.A., Mui, A., Miyajima, A., and Feldman,R.A. Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit. Proceedings of the National Academy of Sciences of the United States of America 1993 May 190(9):3963-7 Baxter, G.T., Miller, DL., Kuo, R.C., Wada, H.G., and Owicki, J.C. PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments. Biochemistry 1992 Nov 1731(45):10950-4 Chen, J.X., Watanabe, S., Muto, A., Miyajima, A., Yokota, T., and Arai, K. Activation of early response genes and cell proliferation by human “interleukin-3, granulocyte-macrophage colony-stimulating factor, and” interleukin-5 receptors: comparison with human interleukin-4 receptor signaling. Journal of Allergy & Clinical Immunology 1994 Sep94 (3 Pt 2):605-11 Chiba, T.,Nagata, Y., Kishi, A., Sakamaki, K., Miyajima, A., Yamamoto, M., Engel, JD., and Todokoro, K. Induction of erythroid-specific gene expression in lymphoid cells. Proceedings of the National Academy of Sciences of the United States of America 1993 Dec 15, 90(24):11593-7 Cohen, J.J. Apoptosis. [Review] Immunology Today 1993 Mar, 14(3):126-30 Collins, M.K.L.and Rivas, AL. The control of apoptosis in mammalian cells. TIBS 1993 Aug, 18:307-9 de Vate, James., Kiley, S., Garris, T., Bryant, W., Hooker, J., Posekany, K., Parker, P., Cook, P., Fletcher, D., and Ways, D.K. Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation. Cell Growth and Differentiation 1995 Apr, 6:371-82 Eder, M.,Griffin, J.D., and Ernst, T.J. The human granulocyte-macrophage colony- stimulating factor receptor is capable of initiating signal transduction in NIH3T3 cells. EMBO Journal 1993 Apr; 12(4):1647-56 Eki, T., Enomoto, T.. Masutani, C., Miyajima, A., Takada, R.. Murakami, Y., Ohno, T., Hanaoka, F., and Ui, M. Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. Journal of Virology 1991 Sep; 65(9):4874-81 Gorman, D.M., Itoh, N.. Jenkins, NA., Gilbert, D.J., Copeland, N.G.. and Miyajima, A. Chromosomal localization and organization of the murine genes “encoding the beta subunits (AIC2A and A-IC2B) of the interleukin 3.” “granulocyte macrophage colony- stimulating factor, and interleukin 5” receptors. Journal of Biological Chemistry 1992 Aug 5; 267(22): 15842-8 Guo, X., Ohno, Y., Miyajima, A., Sunouchi, M., and Takanaka, A. Oxvsterols inhibit gap junctional communication between rat hepatocytes in primary culture. Pharmacology & Toxicology 1993 Jul; 73(1):10-3 Hanazono, Y., Chiba, S., Sasaki, K., Mano. H., Miyajima, A.. Arai, K., Yazaki, Y., and Hirai, H. c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3. EMBO Journal 1993 Apr; 12(4): 1641-6 Hannun, Y.A. and Obeid L.M. Ceramide: an intracellular signal for apoptosis. TIBS 1995 Feb; 20:73-77 Hara, T. and Miyajima, A. Regulation of IL-3 receptor expression: evidence for a post- transcriptional mechanism that dominantly suppresses the expression of beta subunits. International Immunology 1994 Oct; 6(10): 1525-33 Hara,T. and Miyajima, A.Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO Journal 1992 May; 11(5):1875-84 Hara, T.,Harada, N., Mitsui, H., Miura, T., Ishizaka. T., and Miyajima, A. Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood 1994 Jul 1; 84(1):189-99 Harada, N. Yang G., Miyajima, A.,and Howard, M. Identification of an essential region for growth signal transduction in the cytoplasmic domain of the human interleukin-4 receptor. Journal of Biological Chemistry 1992 Nov 15; 267(32):22752-8 Hass-Kogan, DA., Kogan, S.C., Levi, D., Dazin, P., T’Ang, Anne., T. Fung, YK., and Israel, MA.Inhibition of apoptosis by the retinoblastoma gene product. EMBO Journal 1995 14(3):461-472 Heaney, ML. Vera. J.C. Raines, MA. and Golde, D.W. Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cells. PNAS 1995 Mar; 92:2365-9 Hoffman. V. and Liebermann D.A. Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes. and tumor srppressor genes as positive and negative modulators. Oncogene 1994 Apr 18; 9; 1807-12 Houge, G., Doskeland, S.O., Boe. R., and Lanotte M. Selective cleavage of 28SrRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. FEBS Letters 1993 Jan 2; 315(1): 16-20 Houge, G., Robaye, B., Eikhom, T.S., Golstein. J., Mellgren. G., Gjertsen, B.T., Lanotte. M.,and Doskeland S.O., Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis. Molecular and Cellular Biology 1995 Apr 15(4):2051-62 Ihle, J.N. and Kerr, TM. Jaks and stats in signaling by the cytokine receptor superfamily TIG 1995 Feb, 11(2):69-73 Imler, J.L., Miyajima, A., and Zurawski, G. Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2. EMBO Journal 1992 Jun;11(6):2047-53 Ishida, H., Yang, G., Harada. N., Hastings. R.L., Castle, B.E.. Kastelein, R.,Miyajima, A., and Howard, M. Evaluation of murine interleukin 4 (IL-4) receptor expression using anti-receptor monoclonal antibodies and SI nuclease protection analyses. Cellular Immunology 1991 Aug,136(1):142-54 Izuhara, K., Miyajima,A., and Harada, N. The chimeric receptor between interleukin-2 receptor beta chain and interleukin-4 receptor transduces interleukin-2 signal. Biochemical & Biophysical Research Communications 1993 Feb 15; 190(3):992-1000 Izuhara, K., Yang, G., Miyajima, A., Howard. M., and Harada, N. Structure of the IL4 receptor and signal transduction mechanism of IL4 [Review] Research in Immunology 1993 Oct, 144(8):584-90 Kinoshita, T.,Yokota, T., Arai, K., and Miyajima, A. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO Journal 1995 Jan 16; 14(2):266-75 Kitamura,T., and Miyajima, A. Functional reconstitution of the human interleukin-3 receptor. Blood 1992 Jul 1; 80(1):84-90 Kitamura, T., Hayashida, K., Sakamaki, K., Yokota, T., Arai, K., and Miyajima, A. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proceedings of the National Academy of Sciences of the United States of America 1991 Jun 15; 88 (12):5082-6 Kitamura, T.,Sato. N., Arai, K., and Miyajima, A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-C SF receptors. Cell 1991 Sep 2066(6):1165-74 Kitamura, T., Takaku, F., and Miyajima, A. IL-1 up-regulates the expression of cytokine receptors on a “factor-dependent human hemopoietic cell line, TF-1.” International Immunology 1991 Jun, 3(6):571-7 Lappi, D.A., Martineau, D., Sarmientos, P., Garofano, L., Aranda, A.P., Miyajima. A., Kitamura,, T., and Baird, A. Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor. Growth Factors 1993, 9(1):31-9 Liao, Y.D. A pyrimidine-guanine sequence-specific ribonuclease from Rana catesbeiana (bullfrog) oocytes. Nucleic Acids Research 1992 Mar 25; 20(6):1371-7 Liao, Y.D. and Wang, J.J. Yolk granules are the major compartment for bullfrog (Rana catesbeiana) oocyte-specific ribonuclease. European Journal of Biochemistry 1994 May 15,222(1):215-20 Linette, G.P., and Korsmeyer S.J. Differentiation and cell death: lessons from the immune system. Current Opinion in Cell Biology 19946809-15 Martin, S.J., Green, D.R., and Cotter, T.G. Dicing with death: dissecting the components of the apoptosis machinery. TIBS 1994 Jan, 19:26-30 McConkey, D.J.and Orrenius, S.Signal transduction pathways to apoptosis. TIBS 1994 Oct, 4:370-375 Milatovich, A., Kitamura, T., Miyajima, A., and Francke, U. Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region. American Journal of Human Genetics 1993 Nov; 53(5): 1146-53 Miyajima, A.”Molecular structure of the IL-3,GM-CSF and IL-5 receptors. [Review]” International Journal of Cell Cloning 1992 May, 10(3): 126-34 Miyajima, A., Hara,T., and Kitamura, I. Common subunits of cytokine receptors and the functional redundancy of cytokines. [Review] Trends in Biochemical Sciences 1992 Oct, 17(10):378-82 Miyajima, A., Kitamura,T., Tarada, N., Yokota, T., and Arai, K. Cytokine receptors and signal transduction. [Review] Annual Review of Immunology 1992; 10:295-331 Miyajima, A., Mui, A.L.,Ogorochi, T., and Sakamaki, K. “Receptors for granulocyte-macrophage colony stimulating factor,”“interleukin-3, and interleukin-5. [Review]” Blood 1993 Oct 1; 82(7):1960-74 Mott, H.R. and Campbell, I.D. Four-helix bundle growth factors and their receptors: protein-protein interactions. Current Opinion in Structural Biology 1995; 5: 114-21 Mui,AL.and Miyajima, A.Cytokine receptors and signal transduction.[Review] Progress in Growth Factor Research 1994,5(1):15-35 Mui, AL. and Miyajima, A. Interleukin-3 and granulocyte-macrophage colony stimulating factor receptor signal transduction. [Review] Proceedings of the Society for Experimental Biology & Medicine 1994 Jul; 206(3):284-8 Nagata. S.and Golstein, P. The Fas death factor. Science 1995 Mar 10267: 1149-56 Nakagawa, Y.. Kosugi. H., Miyajima, A., Arai, K., and Yokota, T. Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. Journal of Biological Chemistry 1994 Apr 8; 269(14): 10905-12 Nishida, J., Yokota, T. and Miyajima, A. [IL-3: production mechanism and the receptor]. [Japanese] ‘Tanpakushitsu Kakusan Koso-Protein, Nucleic Acid, Enzyme 1991” May; 36(7): 1159-67 Nishikomori, R., Kawai, M., Jung, E.Y., Tai, G., Miyajima, A., Aral, N., Mayumi, M., and Heike, T. Cis-acting DNA elements of mouse granulocyte-macrophage colony-stimulating factor gene responsive to Fc epsilon receptor cross-linking stimulation in the mouse mast cell line MC/9. Journal of Immunology 1995 Jan 15; 154(2):694-702 Ogorochi, T., Hara, T., Wang, H.M., Maruyama, K., and Miyajima, A. Monoclonal antibodies specific for low-affinity interleukin-3 (IL-3) binding protein AIC2A: evidence that AIC2A is a component of a high-affinity IL-3 receptor. Blood 1992 Feb 15; 79(4):895-903 Quelle, F.W., Sato, N., Witthuhn, B.A., Inhorn, R.C., Eder, M., Miyajima, A., Griffin, J.D., and Ihle, J.N. JAK2 associates with the beta c chain of the receptor for “granulocyte-macrophage colony-stimulating factor, and its activation” requires the membrane-proximal region. Molecular & Cellular Biology 1994 Jul; 14(7):4335-41 Rajotte, D., Haddad, P., Haman, A., Cragoe, E.J. Jr., and Hoang, T. Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. Journal of Biological Chemistry 1992 May 15; 267(14):9980-7 Rao, P., Kitamura, T., Miyajima, A., and Mufson, R.A. Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. Journal of Immunology 1995 Feb 15; 154(4): 1664-74 Russell. SM., Keegan, A.D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, MC., Miyajima, A., Pun, R.K., and Paul, W.E. et al., Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor [see comments]. Science 1993 Dec 17; 262(5141): 1880-3 Sakamaki, K.,Miyajima, I., Kitamura, T., and Miyajima. A. Critical cvtopiasmic domains of the common beta subunit of the human “GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and’ tyrosine phosphorylation. EMBO Journal 1992 Oct; 11(10):3541-9 Sakamaki, K., Wang, H.M., Miyajima, I., Kitamura, T Todokoro. K., Harada. N.and Miyajima, A. Ligand-dependent activation of chimeric receptors with the cytoplasmic domain of the interleukin-3 receptor beta subunit (beta IL3). Journal of Biological Chemistry 1993 Jul 25268(2 1): 15833-9 Sato. N.and Miyajima. A. Multimeric cytokine receptors: common versus specific functions. [Review] Current Opinion in Cell Biology 1994 Apr; 6(2):174-9 Sato, N., Caux, C.,Kitamura, T., Watanabe, Y., Arai, K., Banchereau, J., and Miyajima. A. Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Blood 1993 Aug 182(3):752-61 Sato, N., Sakamaki, K., Terada, N., Arai, K., and Miyajima, A. Signal transduction by the high-affinity GM-C SF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO Journal 1993 Nov; 12(11):4181-9 Satoh,T. Nakafuku, M., Miyajima, A., and Kaziro, Y Involvement of ras p21 protein in signal-transduction pathways from “interleukin 2, interleukin 3, and granulocyte/macrophage” “colony-stimulating factor, but not from interleukin 4.” Proceedings of the National Academy of Sciences of the United States of America 1991 Apr 15; 88(8):3314-8 Schreurs, J., Gorman, D.M., and Miyajima, A. Cytokine receptors: a new superfamily of receptors. [Review] International Review of Cytology 1992; 137B: 121-55 Schreurs, J., Hung, P., May, W.S., Arai, K., and Miyajima, A. AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A structure. International Immunology 1991 Dec, 3(12):1231-42 Shanafelt, A.B., Miyajima, A., Kitamura, T., and Kastelein, R.A. The amino-terminal helix of GM-CSF and IL-S governs high affinity binding to their receptors. EMBO Journal 199 Dec; 10(13):4105-12 Singer, G.G., Carrera, AC., Marshak-Rothstein, A., Martinez-A, C., and Abbas, A.K. Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Current Opinion in Immunology 19946:913-20 Steller, H.Mechanisms and genes of cellular suicide. Science 1995 Mar l0; 267: 1145-9 Stocking, C., Bergholz, U., Friel, J., Klingler, K., Wagener, T., Starke, C., Kitamura, T., Miyajima, A., and Ostertag, W. Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line. Growth Factors 1993, 8(3): 197-209 Svoboda, M.,Przybylski, M., Schreurs, J., Miyajima, A., Hogeland. K., and Deinzer. M. Mass spectrometric determination of glycosylation sites and oligosaccharide composition of insect-expressed mouse interleukin-3. Journal of Chromatography 1991 Jan 2: 562(1-2):403-19 Takagi, M., Nakahata, T., Kubo, T., Shiohara. M., Koike, K., Miyajima, A., Arai. K., Nishikawa, S.. Zsebo. KM., and Komiyama, A. Stimulation of mouse connective tissue- type mast cells by ‘hemopoietic stem cell factor, a ligand for the c-kit receptor. Journal of Immunology 1992 Jun 1; 148(11):3446-53 Takai, S., Yamada, K., Hirayama, N., Miyajima, A., and Taniyama. T. Mapping of the human gene encoding the mutual signal-transducing subunit (beta-chain) of granulocyte-macrophage colony-stimulating “factor (GM-C SF), interleukin-3 (IL-3), and interleukin-5 (IL-5)” receptor complexes to chromosome 22q13.1. Human Genetics 1994 Feb; 93(2): 198-200 Takaki, S., Mita, S.. Kitamura, T., Yonehara, S., Yamaguchi. N., Tominaga, A., Miyajima, A., and Takatsu, K. Identification of the second subunit of the murine interleukin-5 “receptor: interieukin-3 receptor-like protein, AIC2B is a component” of the high affinity interleukin-5 receptor. EMBO Journal 1991 Oct:, 10(10):2833-8 Takaki, S., Murata, Y.,Kitamura, T., Miyajima, A., Tominaga, A., and Takatsu, K. Reconstitution of the functional receptors for murine and human interleukin 5. Journal of Experimental Medicine 1993 Jun 1177(6):1523-9 Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, Shinji, Millan, J.A., and Reed, J.C. Cloning and functional analysis if BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 1995 Jan 27, 80:279-84 Taniguchi, T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 1995 Apr 14268:251-5 Tavernier, J., Devos, R.. Cornelis, S., Tuypens, T., Van der Heyden, J.. Fiers, W.,and Plaetinck, G. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 1991 Sep 20, 66(6): 1175-84 Thompson,E.B.Apoptosis and steroid hormones. [Review] Molecular Endocrinology 1994 Jun, 8(6):665-73 Thulasi, R., Harbour, D.V., and Thompson, E.B. Suppression of c-myc is a critical step in glucocorticoid-induced human leukemic cell lysis. Journal of Biological Chemistry 1993 Aug 25,268(24): 18306-12 Vaux, D.L. Toward an understanding of the molecular mechanisms of physiological cell death. [Review] Proceedings of the National Academy of Sciences of the United States of America 1993 Feb 1:90(3)786-9 Vaux. DL., Cory, S., and Adams, J.M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988 Sep 29,335(6189):440-2 Wada, H.G., Indelicato, S.R., Meyer, L., Kitamura. T.,Miyajima. A.. Kirk, G.. Muir. V.C.. and Parce, J.W. “GM-CSF triggers a rapid, glucose dependent extracellular” acidification by TF-1 cells: evidence for sodium/proton antiporter and PKC mediated activation of acid production. Journal of Cellular Physiology 1993 Jan 154(1): 129-38 Wagner, A.J., Kokontis, J.M., and Hay, N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p2lwafl/cipl. Genes & Development 1994 Dec 1, 8(23):2817-30 Wang,H.M., Ogorochi, T., Arai, K., and Miyajima, A. Structure of mouse interleukin 3 (IL-3) binding protein (AJC2A).Amino acid residues critical for IL-3 binding. Journal of Biological Chemistry 1992 Jan 1 5267(2):979-83 Watanabe, S., Mui, AL., Muto, A., Chen, J.X.. Hayashida, K., Yokota, T., Miyajima, A., and Arai, K. Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells. Molecular & Cellular Biology 1993 Mar, 13(3):1440-8 Watanabe, S., Muto, A., Yokota, T., Miyajima, A., and Arai, K. Differential regulation of early response genes and cell proliferation through the human granulocyte macrophage colony-stimulating factor receptor: selective activation of the c-fos promoter by genistein. Molecular Biology of the Cell 1993 Oct; 4(10):983-92 Watanabe, S.,Nakayama, N., Yokota, T., Arai, K., and Miyajima, A. [Hemopoietic growth factors and signal transduction]. [Japanese] “Tanpakushitsu Kakusan Koso-Protein, Nucleic Acid, Enzyme 1991” May36(7): 1114-23 Watanabe, Y.,Kitamura, T., Hayashida, K., and Miyajima, A. Monoclonal antibody against the common beta subunit (beta c) of the “human interleukin-3 (IL-3), IL-5, and granulocyte-macrophage” colony-stimulating factor receptors shows upregulation of beta c by IL-I and tumor necrosis factor-alpha. Blood 1992 Nov 1; 80(9):2215-20 Wrighton, N., Campbell, L.A., Harada, N., Miyajima, A.,., and Lee, F. “The murine interleukin-4 receptor gene: genomic structure,” expression and potential for alternative splicing. Growth Factors 1992; 6(2): 103-18 Wu, Y., Mikulski, S.M., Ardelt, W., Rybak, S.M., and Youle, R.J. A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. Journal of Biological Chemistry 1993 May 15; 268(14): 10686-93 Xie, G.X., Miyajima, A., and Goldstein, A. Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands [published erratum appears in Proc Natl Acad Sci U.S.A 1992 Aug L89(15):7287]. Proceedings of the National Academy of Sciences of the United States of America 1992 May 1; 89(9):4124-8 Yokota, T.,Watanabe, S., Mui, A.L., Muto, A, Miyajima, A., and Arai, K. Reconstitution of functional human GM-CSF receptor in mouse NIH3T3 fibroblasts and BA/F3 proB cells. Leukemia 1993 Aug, 7 Suppl 2:S102-7 Youle. R.J, Wu, Y.N. Mikulski, SM., Shogen, K., Hamilton, R.S.. Newton, D., D’Alessio, G.. and Gravell, M. RNase inhibition of human immunodeficiency virus infection of H9 cells. Proceedings of the National Academy of Sciences of the United States of America 1994 Jun 21; 91(13):6012-6 Yousefi, S., Green, D.R., Blaser, K., and Simon, H.U. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proceedings of the National Academy of Sciences of the United States of America 1994 Nov 8; 91(23); 10868-72 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76100 | - |
| dc.description.abstract | 在細胞死亡的研究中，apoptosis（細胞自戕）逐漸成?眾多研究者感興趣的焦點。僅管真正與apoptosis進行的過程有關的現象和機制到目前?止還沒有徹底發現，但由於很多研究者的參與，使我們能對apoptosis有愈來愈深的瞭解。 進行apoptosis的細胞在型態上的變化有核濃縮及形成碎片，細胞萎縮，細胞內的胞器重組，及表面形成氣泡而使細胞逐漸碎裂成片。在大部分的例子中，進行apoptosis這種死亡的細胞內同時也有因活化DNase I (去氧核醣核酸水解酵素 I)而導至chromosomal DNA（染色體去氧核醣核酸）碎裂成片的現象。近來更發現當細胞進行apoptosis時，其內的28S rRNA（核醣體核醣核酸）會被RNase（核醣核酸水解酵素）在特定位置切斷的現象。 本論文中主要目的乃在探討TF-1細胞進行apoptosis時是否有特定之RNase被活化。實驗採用兩種方法讓TF-1細胞進行apoptosis，一?去除其生長因數，GM-CSF (granulocye-macrophage colony stimulating-factor，顆粒球細胞-巨噬細胞株落刺激因數），一?加入TPA。結果發現 TF-1細胞因去除GM-CSF而引起的apoptosis時有一些特殊的RNase可被活化，然而這些RNase在其他原因所造成的死亡現象（例如，由熱處理或DMSO引起的細胞壞死，或是由TPA引起的apoptosis）中並無發現可被活化。另外，在D2細胞（不依賴GM-CSF即可生長的TF-1突變細胞株）中發現在TF-1細胞因去除GM-CSF導致的apoptosis中所引起的、可活化的RNase也存在，某些則無。這些RNase在TPA處理過的D2細胞中亦均消失。但在TPA所引起的apoptosis卻有另外其他群的RNase被活化。 因此，由上述所發現之實驗證據可推測，在細胞產生apoptosis時有些RNase會被活化，但這些RNase的種類會因細胞種類不同或引起apoptosis的因素不同而有異。 | zh_TW |
| dc.description.abstract | Apoptosis, a suicide- like process, is a major focus for a wide variety of biological investigators, recently.The detail mechanism of apoptosis has not been identified thoroughly, but its morphological phenomena and the basic machinery is more and more clearly. The morphological changes of cellular apoptosis include nuclear condensation and fragmentation followed by a loss of cell viability, cell shrinkage accompanied by organelle rearrangements, and surface blebbing leading to cell fragmentation. In most cases, apoptotic cell death is also accompanying by fragmentation of chromosomal DNA resulting from the activation of DNase I. Most recently, it is even identified that 28S rRNA sites specifically cleaved in cells undergoing apoptosis. One major aim of the present study was to find those specific RNase activated in apoptotic systems. For these purpose, the RNase activity was studied in the GM-CSF depression of TF-1 cells induced apoptosis. We found that some RNase was present in activated form when GM-CSF depression no matter in TF-1 cell or D2 cell, TF-1 mutant and GM-CSF independent, but absent in other cellular death, e.g. necrosis induced by heat-shock or DMSO treatment, or apoptosis induced by TPA. But, some RNase indeed present only the GM-CSF induced apoptotic TF-1 cells. Furthermore, we also found there has RNase activity of some other groups increased by TPA induction. Therefore, we suggest that there has some specific RNase activity could be induced in cellular apoptotic death, and which kinds of RNase would be activated depends on cell types of the inducer of apoptotic system. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:18:03Z (GMT). No. of bitstreams: 0 Previous issue date: 1995 | en |
| dc.description.tableofcontents | 中文摘要. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 英文摘要. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 一、前言. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 二、材料與方法. . . . . . . . . . . . . . . . . . . . . . . . 15 三、結果. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 四、討論. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 五、圖次. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 六、參考文獻. . . . . . . . . . . . . . . . . . . . . . . . . . 65 | |
| dc.language.iso | zh-TW | |
| dc.title | 利用TF-1細胞探討細胞自戕和核醣核酸水解酵素的關係 | zh_TW |
| dc.title | Relationship between Apoptosis and RNase in TF-1 cell | en |
| dc.date.schoolyear | 83-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 73 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科學研究所 | zh_TW |
| 顯示於系所單位： | 生化科學研究所 | |
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