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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | 盧怡文 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:17:37Z | - |
| dc.date.available | 2021-07-01T08:17:37Z | - |
| dc.date.issued | 1994 | |
| dc.identifier.citation | Bielicki, J., Hopwood, JJ., Wilson, PJ., and Ansos, DS. (1993) Recombinant human iduronate-2-sulphatase: correction of mucopolysaccharidosis-type II fibroblasts and characterization of the purified enzyme. Biochem. J. 289 (1): 241-246. Bleekemolen, JE., Stein, M., Kurt, F., Slot. JW., Geuze, HJ. (1988) The two mannose 6-phosphate receptors have almost identical subcellular distributions in U937 monocytes. Eur. J. Cell. Biol. 47 (2): 366-372. Braulke, T., Mach, L., Hoflack, B., and Glossl, J. (1992) Biosynthesis and endocytosis of lysosomal enzyme in human colon carcinoma sw 1116 cells impaired internalization of plasma membrane-associated cation-independent mannose 6-phosphate receptor. Arch. Biochem. Biophys. 298 (1): 17110-17115. Braulke, T., Causin, C., Waheed, A., Junghans, U., Hasilik, A., Maly, P., Humbel, R. E., and von Figura, K. (1988) Mannose 6-phosphate/ insulin-like growth factor II receptor: distinct binding sites for mannose 6-phosphate and insulin-like growth factor II, Biochem. Biophys. Res. Commun. 150: 1287-1292. Corvera, S., Folander, K., Clairmont, K. B., Czezh, M. P. (1988) A highly phosphorylated subpopulation of insulin-like growth factor II /mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction. Proc. Natl. Acad. Sci. USA. 85: 7567-7571. Dahms, N.M., Lobel, P., Breitmeyer, J., Chirgwin, JM., Kornfeld, S. (1987) 46 KDa mannose 6-phosphate receptor: cloning, expression, and homology to the 215 KDa mannose 6-phosphate receptor. Cell. 50 (2): 181-192. Dahms, N.M, Lobel, P., and kornfeld, S. (1989) Mannose 6-phosphate receptors and lysosomal enzyme targeting. J. Biol. Chem. 264: 12115-12118. Dahms, N. M., Rose, P. A., Molkentin, J. D. Zhang, Y., and Brzycki, M. A. (1993) The bovine mannose 6-phosphate / insulin like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. J. Biol. Chem. 268. 5457-5463. Duncan, J. R., Kornfeld, S. (1988) Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus. J. Cell. Biol. 106: 617-628. Gasa, S., Kornfeld, S. (1987) Studies of the biosynthesis of the cation-dependent mannose 6-phosphate receptor in murine cell lines. Arch. Biochem. Biophysics. 257 (1): 170-176. Geuze, H. J., Stoorvogel, W., Strous, G. J., Slot, J. W., Zijderhand-Bleekemolen, J., Mellman, I. (1989) Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicle. J. Cell. Biol. 107: 2491-2501. Glick man, J., Croen, K., Kelly, S., and Al-Awaqatio Q. (1991) Forskolin inhibits and reverses the effects of brefeldin A on Golgi morphology. J. Cell. Biol. 112 (4): 567-577. Goda, Y., Pfeffer, S. R. (1988) Selective recycling of the mannose 6-phosphate, insulin-like growth factor II receptor to the trans Golgi network in vitro. Cell.55: 309-320. Gonzalez, NA., Ferrera, P., Coutino, R., Michalak, C. (1993) Isolation of an inhibitor for the independent mannose 6-phosphate receptor endocytosis of bovine beta-glucuronsidase by human fibroblasts. Arch. Biochem. Biophysics. 306 (2): 391-401. Green, SA., Kelly, RB. (1992) Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal in PC12 cells. J. Cell. Biol. 117(1): 47-55. Griffiths, G., Hoflack, B., Simons, K., Mellman, I., Kornfeld, S. (1988) The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell.5: 329-341. Helenius, A., McCaslin, D. R., Fries, I., and Tanford, C, (1979) Properties of detergents. Method. Enzym. 56: 734-749. Hemer, F., Korner, C., and Braulke, T., (1993) Phosphorylation of the human 46-KDa mannose 6-phosphate receptor in the cytoplasmic domain at serine 56. J. Biol. Chem. 268 (23): 17108-17113. Herzog, V., Neumuller, W., and Holzmann, B. (1987) Thyroglobulin, the major and obligatory exportable protein of thyroid follicle cells, carries the lysosomal recognition marker mannose 6-phosphate. EMBO J. 6: 555-560. Hoflack, B., Kornfeld, S. (1985) Purification and charaterrization of cation dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver. J. Biol. Chem. 260: 12008-12014. Hoflack, B., Kornfeld, S. (1985) Lysosomal enzyme binding to mouse P388D1 macrophage membranes lacking the 215-KDa mannose 6-phosphate receptor: Evidence for the existence of a second mannose 6-phosphate receptor. Proc. Natl. Acad. Sci. USA. 82: 4428-4432. Hoflack, B., Fujimoto, K., and Kornfeld, S. (1987) The interaction of phosphorylated oligosaccharides and lysosomal enzymes with bovine liver cation dependent mannose 6-phosphate receptor. J. Biol. Chem., 262: 123-127. Jin, M., Sahagian, G. G., Snider, M. D. (1989) Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cells. J. Biol. Chem. 264: 7675-7680. Johnson, KF., Kornfeld, S. (1992) A His-Leu- Leu sequence near the carboxyl terminus of the cytoplasmic domin of the cation-dependent mannose 6-phosphate receptor is necessary for lysosomal enzyme sorting function. J. Biol. Chem. 267: 17110-17115. Junghans, V., Waheed, A., and von Figura, K (1988) The cation-dependent mannose 6-phosphate receptor binds ligands in the absence of divalent cations. FEBS Lett. 237: 81-84. Kiess, W., Thomas, CL., Greenstein, LA., Lee, L., Sklar, MM., Rechler, MM., Sahagian, GG., Nissley, SP. (1989) Insulin-like growth factor II inhibit both the cellular uptake of beta-galactosidase and the binding of beta-galactosidase to purified IGF-II/mannose 6-phosphate receptor. J. Biol. Chem. 264: 4710-4714. Kiess, W., Thomas, CL., Sklar, MM., Nissley, SP. (1990) β-galactosidase decreases the binding affinity of the insulin like growth factor II / mannose 6-phosphate receptor for insulin-like-growth-factor II. Eur. J. Biol. 190: 71-77. Kojima, S., Rifkin, DB. (1993) Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells. J. Cell. Phys. 155 (2): 323-332. Kornfeld, S., and Mellman, I. (1989) The Biogenesis of lysosomes. Annu. Rev. Cell. Biol. 5: 483-525. Kornfeld, S. (1992) Structure and function of the mannose 6-phosphate / insulin like growth factor II receptore. Annu. Rev. Biochem. 61: 307-330. Koster, A. and Sattig, P. (1993) Targeted disruption of the M(r) 46,000 mannose 6-phosphate receptor gene in mice results in missrouting of lysosomal proteins. EMBO Journal. 12 (13): 5219-5223. Kostrouch, Z., Munari-Silem, Y., Rajas, F., Bernier-Valentin, F. Rousset, B. (1991) Thyroglobulin internalized by thyrocytes passes through early and late endosomes. Endocrinology. 129 (4): 2202-2211. Kovacina, K. S., Steele-Perkins, G., Purchio, A. F., Lioubiin, M., Miyazono, K., Heldin, C.-H., and Roth, R. A. (1989) Interactions of recombinant and platelet transfoming growth factor-β1 precursor with the insulin-like growth factor II/ mannsoe 6-phosphate receptor. Biochem. Biophys. Res. Commun., 160: 393-398. Kurt, V., Prydz, K., Bomsel, M., Simons, K., Griffith, G., Parton, RG. (1989) Molecular recognition and targeting of lysosomal proteins. J. Cell. Biol., 109 (6): 3259-3265. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 277: 680-685. Lane, L. C. (1978) A simple method for stabilizing protein sulfhydryl groups during SDS-gel electrophoresis. Anal. Biochem. 86: 555-669. Lazzarino, D. A., Gabel, C. A. (1989) Mannose processing is an important determinant in the assembly of phosphorylated high mannose-type oligosaccharides. J. Biol. Chem. 264: 5015-5023. Lee, S.-J. and Nathans, D. (1988) Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors. J. Biol. Chem. 263: 3521-3530. Li, MM., Jourdian, GW. (1991) Isolation and characterization of the two glycosylation isoforms of low molecular weight mannose 6-phosphate receptor from bovine testis. Effect of carbohydrate components on ligand binding. J. Biol. Chem. 266 (26): 17621-17630. Lobel, P., Dahms, NM., Kornfeld, S. (1988) Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. J. Biol. Chem. 263: 2563-2570. Ma, ZM., Grubb, JH., Sly, WS. (1991) Cloning, sequencing, and functional characterization of the murine 46-KDa mannose 6-phosphate receptor. J. Biol. Chem. 266: 10589-10595. Ma, ZM., Grubb, JH., Sly, WS. (1992) Divalent cation-dependent stimulation of ligand binding to the 46-KDa mannose 6-phosphate receptor correlates with divalent cation-dependent tetramerization. J. Biol. Chem. 266: 19017-19022. MacDonald, RG., Pfeffer, SR., Coussens, L., Tepper, MA., Brocklebank, CM., Mole, JE., Anderson, JK., Chen, E., Czech, MP., Ullrich, A. (1988) A single receptor binds both insulin-like growth factor II and mannose 6-phosphate. Science. 239 (4884): 1134-1137. Madiyalakan, R., Jain, F.K., Matta, K. L. (1987) Phosphorylation of the a 1,2-linked mannosylsaccharide by N- acetylglucoseamine-1-phosphotransferase from fibroblasts occurs at the terminal mannose. Biochem. Biophys. Res. Comm. 142: 354-358. Matovcik, LM., Goodhouse, J., Farquhar, MG. (1990) The recycling itinerary of the 46 KDa mannose 6-phosphate receptor--Golgi to late endosomes--coincides with that of the 215 KDa M6PR. Eur. J. Cell. Biol. 53 (2): 203-211. Meite S, A. (1963) Handbook of Analytical Chemistry, P. 1-21. NewYork: McGraw-Hill. Merlin, M.L., and Glyn, R. (1990) Luminescent detection of immunodot and western blots. Method. Enzym. 184: 442-451. Merril, C.R., Goldman, D., Sedman, S.A., and Ebert, N.H. (1981) Ultrasensitive stain for protein in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science. 211: 1437-1438. Morgan, D. O., Edman, J. C., Standing, D. N., Fried, V.A., Smith, M. C. (1987) Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 329: 301-307. Neugebauer, J. (1990) A guide to the properties and uses of detergents in biology and biochemistry. Calbiochem corporation. Nolan, C. M. and Sly, W. S., (1989) I-cell disease and pseud hurler polydystrophy: disorders of lysosomal enzyme phosphorylation and localzation in the Metabolic Basis of In herited DiseaseII, 6th, Scriver, C. R., Beandet, A. L., Sly, W. S., and Valle, D., Eds., Mc Graw-Hill, New York. Oshima, A., Nolan, CM., Kyle, JW., Grubb, JH., Sly, WS. (1988) The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells. J. Biol. Chem. 263: 2553-2562. Oursler, MJ., Riggs, BL., Spelsberg, TC. (1993) Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells. Endocrinology. 133 (5): 2187-2196. Pearse, BM. (1989) Characterization of Coated-vesicle adaptors: their reassembly with clathrin and with recycling receptors. Method Cell. Biol. 3 1: 229-246. Pfeffer, SR., Ploeg, AT., Loonen, MC., Bolhuis, PA., Busch, HM., Reuser, AJ., Galjarrad, H. (1988) Intracellular transport of the mannose 6-phosphate receptor. Prog. Clin. Biol. 270: 365-375. Rizzolo, L. J., Konfeld, R. (1988) Post-translational protein modification in the endoplasmic reticulum. J. Biol. Chem. 263: 9520-9525. Rosorius, O., Mieskes, G., Issinger, OG., and Braulke, T. (1993) Characterization of phosphorylation sites in the cytoplasmic domain of the 300 KDa mannose 6-phosphate receptor. Biochem. J. 292: 833-838. Rumsby, PC., Orskov, C., Haselbacher, G., Ramlau, J., Christiansen, J. (1994) Effect of some peroxisome proliferators on transforming growth factor-beta 1 gene expression and insulin-like growth factor II/mannose-6-phosphate receptor gene expression in rat liver. Carcinogenesis. 15 (2): 419-421. Sahagian, G. G., Distler, J., Jourdian, G. W. (1981) Characterization of a membrane associated receptor from bovine liver that binds phosphomannosyl residues of bovine testicular b-galactosidase. Proc. Natl. Acad Sci. USA. 78: 4289-4293. Smith, P. K., krohn, G. T., Hermanson, A. K. Mallia, F. H. Gartner, M. D., and Klenk. D. C. (1985) Measurement of protein using bicinchonic acid. Anal. Biochem.150: 76-80. Stein, M., Zijderhand-Bleekemolen, J. E., Geuze, H., Hasilik, A., von Figura, K. (1987) Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes. EMBO J. 6: 2677-2681. Tong, P., Korfeld, S. (1989). Ligand interactions of the cation-dependent mannose 6-phsophate receptor. Comparison with the cation independent mannose 6-phosphate receptor. J. Biol. Chem. 264: 7970-7975. Tong, P. Y., Gregory, W., and Kornfeld, S. (1989) Ligand interaction of the cation independent mannose 6-phosphate receptor. The stoichiometry of mannose 6-phosphate binding. J. Biol. Chem. 264: 7962-7969. Vogler, C., Sands, M., Higgins, A., Levy, B., Grubb, J., Birkenmeier, EH., Sly, Ws. (1993) Enzyme replacement with recombinant beta-glucuronidase in the newborn mucopolysaccharidosis type VII mouse. Pediatric Research. 34 (6): 837-840. Waheed, A., Braulke, T., Junghans, U., von Figura, K. (1988) Mannose 6-phosphate/insulin-like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites. Biochem. Biophys. Res. Comm. 152: 1248-1254. Watanabe H., Grubb Jh., and Sly WS. (1990) The overexpressed human 46-KDa Mannose 6-phosphate receptor mediates endocytosis and sorting of beta-gluluronidase. Proc. Natl. Alad Sci. U. S. A. 87 (20): 8036-8040. Wendland, M., Waheed, A., Schmidt, B., Hille, A., Nagel. G., von Figura, K., Pohlmann, R. (1991) Glycosylation of the Mr 46,000 mannose 6-phosphate receptor. Effect on ligand binding, stability, and conformation. J. Biol. Chem. 266: 4598-4604. Westcott, KR., Searles, RP., Rome, LH., (1987) Evidence for ligand- and pH-dependent conformational changes in liposome-associated mannose 6-phosphate receptor. J. Biol. Chem. 262: 6101-6107. Westlund, B., Dahms, N. M., and Kornfeld, S. (1991) The bovine mannose 6-phosphate/IGF-II receptor. Localization of mannose 6-phosphate binding sites to domain 1-3 and 7-11 of extracytoplasmic region. J. Biol. Chem. 266: 23233-23239. Zhang, Y., Dahms, NM. (1993) Site-directed removal of N-glycosylation sites in the bovine cation dependent mannose 6-phosphate receptor: effects on ligand binding, intracellular targetting and association with binding immunoglobulin protein. Biochem. J. 295 (3): 841-848. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76054 | - |
| dc.description.abstract | 利用β-galactosidase sepharose親和管柱，β-glucosidase sepharose親和管柱及膠體過濾管柱（F.P.L.C./SuperoseTM 12），可自人類胎盤中純化出甘露糖六磷酸接受體（mannose 6-phosphate receptor），其分子量為46 KDa。 在pH 6.5的分析緩衝液中，最適合甘露糖六磷酸接受體和β-galactosidase結合，pH值高於7或低於5都不適合甘露糖六磷酸接受體的結合作用。 二價金屬錳離子有助於甘露糖六磷酸接受體和β-galactosidase 的結合，但是二價鋅離子與鎂離子則沒有顯著的影響。 | zh_TW |
| dc.description.abstract | The cation dependent mannose 6-phosphate receptor has been purified from the human placenta by using combination of β-galactosidase sepharose affinity chromatography, β-glucosidase sepharose affinity chromatography and F.P.L.C. SuperoseTM 12 gel filtration chromatography. The molecular weight of the purified mannose 6-phosphate receptor is about 25 KDa. In the ligand binding assay, receptor bound to ligand in the absence or presence of divalent cation with similar efficency. Divalent cations were not required for ligand binding, but the binding of β-galactosidase with the receptor was improved by 10mM Mn2+.The receptor exhibited optimum binding of β-galactosidase at pH 6.5. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:17:37Z (GMT). No. of bitstreams: 0 Previous issue date: 1994 | en |
| dc.description.tableofcontents | 縮寫表……………………………………………………III 材料與試劑……………………………………………………IV 中文摘要……………………………………………………1 英文摘要……………………………………………………2 一．緒言……………………………………………………3 二．實驗方法……………………………………………………10 三．實驗結果……………………………………………………24 四．討論……………………………………………………29 五．結論……………………………………………………33 六．參考文獻……………………………………………………34 七．圖表……………………………………………………44 | |
| dc.language.iso | zh-TW | |
| dc.title | 純化與定性人類胎盤的甘露糖六磷酸接受體 | zh_TW |
| dc.title | Purification and Characterization of Mannose 6-phosphate receptor from the human placenta | en |
| dc.date.schoolyear | 82-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 65 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
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