請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75782完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | 簡佩玉 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:15:21Z | - |
| dc.date.available | 2021-07-01T08:15:21Z | - |
| dc.date.issued | 1991 | |
| dc.identifier.citation | Adair, J. R., B. L. Hamilton, K. A. Scappaticci, C. J. Helke and R. A. Gillis, 1977, Cardiovascular responses to electrical stimulation of the medullary raphe area of the cat, Brain Res., 128:141-145.
Aghajanian, G. K. and H. J. Haigler, 1974, L-tryptophan as a selective histochemical marker for serotonergic neurons in a single-cell recording studies, Brain Res. 81:364-372. Aghajanian, G. K., R. Y. Wang and J. Baraban, 1978, Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation, Brain Res. 153:169-175. Anderson, S. D., A. I. Basbaum and H. L. Fields, 1977, Response of raphe neurons to peripheral stimulation and to systemic opiates, Brain Res.123:363-368. Aoki, M., S. Mori, K. Kawahara, H. Watanabe and N. Ebata, 1987, Generation of spontaneous respiratory rhythm in high spinal cats, Brain Res. 202:51-63. Basbaum, A. I., C. H. Clanton and H. L. Field, 1978, Three bulbospinal pathways from the rostral medulla of the cat: an auturadiographoc study of pain modulating system, J. Comp. Neurol., 178:209-224. Berger, A. J., 1977, Dorsal respiratory group neurons in the medulla of cat: spinal projections, responses to lung inflation and superior laryngeal nerve stimulation, Brain Res., 135:231-254. Bertrand, F., A. Hugelin, and J. F. Vibert, 1973a, A stereologic model of Pneumotaxic oscillator based on spatial and temporal distributions of neuronal bursts, J. Neurophysiol., 37:91-107. Bertrand, F., A. Hugelin, and J. F. Vibert, 1973b, Quantitative study of anatomical distribution of respiration related neurons in the pons, Exp. Brain Res., 16:383-399. Bianchi, A. L. and W. M. St. John, 1982, Medullary axonal projections of respiratory neurons of pontile pneumotaxic center, Respir. Physiol., 48:357-373. Bianchi, A. L. and J. C. Barillot, 1982, Respiratory neurons in the region of the retrofacial nucleus: pontile, medullary, spinal and vagal projections, Neurosci. Lett., 31:277-282. Blum, P. S., 1981, Contral of sensory transmission by electrical stimulation within the caudal raphe nuclei of the cat, Exp. Neurol., 72:570-581. Bobillier, P., S. Sequin, F. Petitjean, D. Salvert, M. Touret and M. Jouvet, 1976, The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography, Brain Res. 113: 449-486. Bongianni, Fulvia, Giovanni Fontana and Tito Pantaleo, 1988, Effects of electrical and chemical stimulation of the B?tzinger complex on respiratory activity in the cat, Brain Res. 455:254-261. Bowker, R. M., K. N. Westlund, M. C. Sullivan, J. F. Wilber and J. D. Coulter, 1983, Descending serotonergic, peptidergic and cholinergic pathway from the raphe nuclei: a multiple transmitter complex, Brain Res. 288:33-48. Brodal, A., E. Taber and F. Walberg, 1960a, The raphe nuclei of the brain stem in the cat. II. Efferent connections. J. Comp. Neurol., 114:239-260. Brodal, A., F. Walberg and E. Taber, 1960b, The raphe nuclei of the brain stem in the cat. III. Afferent connections. J. Comp. Neurol., 114:261-281. Brodin, E., B. Linderoth, M. Goiny, Y. Yamamoto, B. Gazelius, D. E. Millhorn, T. H?kfelt and U. Ungerstedt, 1990, In vivo release of serotonin in cat dorsal vagal complex and cervical ventral horn induced by electrical stimulation of the medullary raphe nuclei, Brain Res. 535:227-236. Chan-Palay, V., G. Jonsson, and S. L. Palay, 1978, Serotonin and substance P coexist in neurons of the rat’s central nervous system, Proc. Natl. Acad. USA, 75(3):1582-1586. Cohen, M. I. and S. C. Wang, 1959, Respiratory neuronal activity in pons of cat, J. Neurophysiol., 22:33-50. Cohen, M. I., 1967, Discharge patterns of brain-stem respiratory neurons in relation to carbon dioxide tension, J. Neurophysiol., 31:142-165. Cohen, M. I., 1971, Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation, J. Physiol. (London), 217:133-158. Cohen, M. I., 1979, Neurogenesis of respiratory rhythm in the mammal, Physiol. Rev., 59:1105-1173. Connelly, C. A., H. H. Ellenberger and J. L. Feldman 1989, Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat Neurosci. Lett., 105: 34-40. Duh, S.-L. and J.-C. Hwang, 1991, Effect of the medullary raphe nuclei (MRN) on respiratory- modulated activity of the recurrent laryngeal nerve (RLN) in cats, The Sixth Joint Annual Conference of Biological Science held in Taipei,(program and abstracts), p247. Ellenberger, H. H. and J. L. Feldman, 1988, Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats, J. Comp. Neurol. 269: 47-57. Ellenberger, H. H. and J. L. Feldman, 1990, Brainstem connections of the rostral ventral respiratory group of the rat, Brain Res., 513: 35-42. Euler, C. von, I. Marttila, J. E. Remmers and T. Trippenbach, 1976, Effects of lesions in the parabrachial nucleus on the mechanisms for central and reflex termination of inspiration in the cat, Acta Physiol. Scand., 96:324. Ezure, K., M. Manabe and H. Yamada, 1988, Distribution of medullary respiratory neurond in the rat, Brain Res., 455:262-270. Feldman, J. L., 1986, Neurophysiology of breathing in mammals, from: Handbook of Physiology- the Nervous System IV - Intrinsic regulatory systems of the brain, F. E. Bloom, Ed., pp. 463-524. American Physioligical Society. Franck, J., G. Fried, and E. Brodin, 1989, Substance P enhances the release of endogenous serotonin from rat ventral spinal cord, Europ. J. Pharmacol., 174:85-90. Freygang, W. H., Jr. 1958, An analysis of extracellular potentials from single neurons in the lateral geniculate nucleus of the cat, J. Gen. Physiol., 513:35-42. Fung, M.-L., J.-M. Liaw, and J.-C. Hwang, 1989, Effect of electrical stimulation of the superior laryngeal nerve on respiratory-modulated facial nerve activity in cats, Chinese J. Physiol., 32(2): 81-91. Gang, S., A. Mizuguchi, N. Kobayashi and M. Aoki, 1990, Descending axonal projections from the medial parabrachial and K?lliker-Fuse nuclear complex to the nucleus raphe magnus in cats, Neurosci. Lett., 118:273-275. Haji, A., C. Connelly, S. A. Schultz, J. Wallare and J. E. Remmers, 1986, Postsynaptic actions of inhibitory neurotransmitters on bulbar respiratory neurons, in “Neurobiology of the central of breathing” edited by von Euler, C., and H. Lagercrantz, Karolinska Institute Nobel Conference Series, Roven Press, New York, pp. 187-194. Henry, J. L. and F. R. Calareasu, 1974, Pathways from medullary nuclei to spinal cardio-accelleratory neurons in the cat, Exp. Brain Res., 20:505-514. Hilair, G., R. Monteau, and A. L. Bianchi, 1984, A cross-correlation study of interactions among respiratory neurons of dorsal, ventral and retrofacial groups in cat medulla, Brain Res., 302:19-31. H?kfelt, T., A. Ljungdahl, H. Steinbusch, A. Verhofstad, G. Nillson, E. Brodin, B. Pernow, and M. Goldstein, 1978, Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience 3:517-538. Holtman, J. R., Jr., W. P. Norman L. Skirboll, K. L. Dretchen, C. Cuello, T. J. Visser, T. H?kfelt, and R. A. Gillis, 1984a, Evidence for 5-hydroxytryptamine, substance P, and thyrotropin-releasing hormone in neurons innervating the phrenic motor nucleus, J. Neurosci. 4(4):1064-1071. Holtman, J. R., Jr., W. P. Norman and R. A. Gillis, 1984b, Projections from the raphe nucli to the phrenic motor nucleus in the cats, Neurosci. Lett., 44: 105-111. Holtman, J. R., Jr., N. C. Anastasi, W. P. Norman and K. L. Dretchen, 1986a, Effect of electrical and chemical stimulation of the raphe obscurus on phrenic nerve activity in the cat, Brain Res. 362:214-220. Holtman, J. R., Jr., T. E. Dick, and A. J. Berger., 1986b, Involvement of serotonin in the excitation of phrenic motoneurons evoked by stimulation of the raphe obscurus, J. Neurosci., 6(4): 1185-1193. Holtman, J. R., Jr., T. E. Dick, and A. J. Berger, 1987, Serotonin-mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus. Brain Res. 417:12-20. Hunt, S. P. and T. A. Lovick, 1982, The distribution of serotonin, met-enkephalin and β-lipotropnin-like immunoreactivity in neuronal perikarya of the cat brainstem, Neuronsci. Lett. 30:139-145. Hwang, J.-C., W. M. St. John, and D. Bartlett Jr., 1983, Respiratory-related hypoglossal nerve activity: influence of anesthetics, J. Appl. Physiol., 55(3):785-792. Hwang, J.-C., C.-T. Chien and W. M. St. John, 1988, Characterization of respiratory-related activity of the facial nerve. Respir. Physiol. 73:175-188. Hwang, J.-C., L.-C. Hu, and C.-T. Yen, 1990, Inhibitory effect of medullary raphe nuclei (MRN) on respiratory-modulated hypoglossal activity in the cat, The Fifth Joint Annual Conference of Biomedical Science held in Taipei (program and abstracts) p167. Jacobs, B. L., J. Heym and K. Rasmussen, 1983, Raphe neurons: Firing rate correlates with size of drug response, European J. Pharmacol. 90:275-278. Kalia, M., J. L. Feldman and M. I. Cohen, 1979, Afferent projections to inspiratory neuronal region of the ventrolateral nucleus of the tratus solitarius in the cat, Brain Res., 171:135-141 Kuhn, D. M., W. A. Wolf, and W. Lovenberg, 1980, Review of the role of the central serotonergic neuronal system in the blood pressure regulation, Hypertention 2: 243-255. Lalley, P. M., 1986, Responses of phrenic motoneurones of the cat to stimulation of medullary raphe nuclei, J. Physiol. 380: 349-371. Lipski, J., and G. Merrill, 1980, Electrophysiological demonstration of the projection from expiratory neurons in rostral medulla to contralateral dorsal respiratory group, Brain Res., 197:521-524. Loewy, A. D. and S. Mckellar, 1981, serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat, Brain Res. 211:146-152. Martin, R. F., L. M. Jordan and W. D. Willis, 1978, Differential projection of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesion, J. Comp. Neurol. 182: 77-88. McCall, R. B. and S. J. Humphrey, 1982, Involvement of serotonin in the regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity, J. Pharmacol. Exp. Ther., 222:94-102. McCall, R. B., 1983, Serotonergic excitation of sympathetic preganglionic neurons: a microiontophoretic study, Brain Res. 289:121-127. McCall, R. B., 1984, Evidence for serotonergically mediated sympathoexcitatory response to stimulation of medullary raphe nuclei, Brain Res. 311:131-139. McCall, R. B. and M. E. Clement, 1989, Identification of serotonergoc and sympathetic neurons in medullary raphe nuclei, Brain Res. 477:172-182. Merrill, E. G., 1970, The lateral respiratory neurons of the medulla: their associations with nucleus ambiguus, nucleus retroambigualis, the spinal accessory nucleus and the spinal cord, Brain Res. 24:11-28. Merrill, E. G., J. Lipski, I. Kubin and L. Fedorko, 1983, Origin of the expiratory inhibition of nucleus tractus solitarius inspiratory neurons, Brain Res. 263:43-50. Millhorn, D. E., F. L. Eldridge and T. G. Waldrop, 1980, Prolonged stimulation of respiration by endogenous central serotonin, Respir. Physiol. 42: 171-188. Millhorn, D. E., 1986a, Stimulation of raphe (obscurus) nucleus causes long-term potentiation of phrenic nerve activity in cat, J. Physiol., 381: 169-179. Millhorn, D. E., and F. L. Eldridge, 1986b, Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems, J. Appl. Physiol., 61: 1249-1263. Moolenaar, Gwen-Marie, J. A. Holloway and C. O. Trouth, 1976, Responses of caudal raphe neurons to peripheral somatic stimulation, Exp. Neurol.,53: 304-313. Morin, D., S. Hennequin, R. Monteau and G. Hilaire, 1990, Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat, Brain Res., 535:281-287. Morrison, S. F. and G. L. Gebber, 1982, Classification of raphe neurons with cardiac-related activity, Am. J. Physiol. 243: R49-R59. Morrison, S. F. and G. L. Gebber, 1984, Raphe neurons with sympathetic-related activity: baroreceptor responses and spinal connections, Am. J. Physiol. 246: R338-R348. Mueller, R. A., Dag B. A. Lundberg, G. R. Breese J. Hedner, T. Hender and J. Jonason, 1982, The neuropharmacology of respiratory control, Pharmacol. Rev., 34(3):255-285. Nattie, E. E., J. W. Millis, L C. Ou and W. M. St. John, 1988, Kainic acid on the rostral ventrolateral medulla inhibits phrenic output and CO2 sensitivity, J. Appl. Physiol., 65(4):1525-1534. Oliveras, J. L., F. Redjemi, G. Guilbaud and J. M. Besson, 1975, Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat, Pain, 1:139-145. Oliveras, J. L., Y. Hosobuchi, F. Redjemi, G. Guilbaud and J. M. Besson, 1977a, Opiate antagonist, naloxone, strongly reduces analgesia induced by stimulation of a raphe nucleus (centralis inferior), Brain Res., 120:221-229. Oliveras, J. L.,, S. Bourgoin, F. Hery, J. M. Besson, and M. Hamon, 1977b, The topographical distribution of serotonergic terminals in the spinal cord of the cat: biochemical mapping by the combined use of microdissection and microassay procedure, Brain Res., 138:393-406. Oliveras, J. L., Y. Hosobuchi, G. Guilbaud and J. M. Besson, 1978, Analgesic electrical stimulation of the feline nucleus raphe magnus: development of the tolerance and its reversal by 5-HTP, Brain Res. 146:404-409. Palkovits, M ., M. Brownstein, and J. M. Saavedra, 1974, Serotonin content of the brain stem nuclei in the cat, Brain Res., 80:237-249. Pitts, R. F., H. W. Magoun, and S. W. Ranson, 1939, Localization of the medullary respiratory centers in the cat, Am. J. Physiol.,106:673-688. Proudfit H. K. and E. G. Anderson, 1973, Influence of serotonin antagonists on bulbospinal systems, Brain Res. 61:331-341. Proudfit H. K. and E. G. Anderson, 1974, New long latency bulbospinal evoked potentials blocked by serotonin antagonist, Brain Res. 65:542-546. Richter, R. C. and M. M. Behbehani, 1991, Evidence for glutamic acid as a possible neurotransmitter between the mesencephalic nucleus cuneiforms and the medullary nucleus raphe magnus in the lightly anesthetized rat, Brain Res. 544:279-286. Sessle, B. J., G. J. Ball and G. E. Lucier, 1981, Suppressive influences from periaqueductal gray and nucleus raphe magnus on respiration and related reflex activities and on solitary tract neurons, and effect of naloxone, Brain Res. 216:145-161. Shannon, R., 1980, Intercostal and abdominal muscle afferent influence on medullary dorsal respiratory group neurons, Respir. Physiol., 39:73-94. Smith, J. C., D. Morrison, H. H. Ellenberger, M. R. Otto, and J. L. Feldman, 1990, Brainstem projections to the major respiratory neuron populations in the medulla of the cat, J. Comp. Neurol., 281: 69-96. St. John, W. M. and S. C. Wang, 1977, Response of medullary respiratory neurons to hypercapnia and isocapnic hypoxia, J. Appl. Physiol., 43(5):812-821. St. John, W. M., 1981, Respiratory neuron responses to hypercapnia and carotid chemoreceptor stimulation. J. Appl. Physiol., 51(4):816-822. Taber, E., A. Brodal and F. Walberg, 1960, The raphe nuclei of the brain stem in the cat: normal topography and cytoarchitecture and general discussion, J. Comp. Neurol., 114:161-188. Thor, K. B. and C. J. Helke, 1987, Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat, J. Comp. Neurol., 265:275—293. Vandermaelen, C. P. and G. K. Aghajanian, 1983, Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices, Brain Res. 289:109-119. Wang, R. Y. and G. K. Aghajanian, 1977, Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition, Brain Res., 132:186-193. Wang, R. Y. and G. K. Aghajanian, 1982, Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus, J. Neurosci., 2(1):11-16. Wessendorf, M. W., H. K. Proudfit and E. G. Anderson, 1981, The identification of serotonergic neurons in the raphe magnus by conduction velocity, Brain Res., 214:168-173. Wessendorf, M. W. and E. G. Anderson, 1983, Single unit studies of identified bulbospinal serotonergic units, Brain Res., 279:93-103. Wessendorf, M. W. and R. Elde, 1987, The coexistence of serotonin- and substance P-like immunoreactivity in the spinal cord of the rat as shown by immunofluorescent double labeling, J. Neurosci. 7(8):2352-2363. Weyne, J., F. Van Leuven and I. R. Leusen, 1973, Glutamate and Glutamine in the brain: Influence of acute Pco changes in normal rats and in rats under sustained hypercapnia or hypocapnia, Life Sci., 12:211-218. Yen, C.-T, P. S. Blum, and J. A. Spath, Jr., 1983, Contral of cardiovascular function by electrical stimulation within the medullary raphe region of the cat, Exp. Neurol., 79:666-679. Yen, C.-T., and P. S. Blum, 1984, Response properties and functional orginazation of neurons in midline region of medullary reticular formation of cats, J. Neurophysiol. 52(5): 961-979. Yen, C.-T., P. S. Blum and A. R. Light, 1986 Raphe-spinal neuron: convergence of baroreceptor and nociceptor inputs and their morphology from intracellular staining, J. Aut. nerv. sys. Suppl. 275-280. Yen, C.-T. and J.-C. Hwang, 1989, Control of phrenic nerve activity and blood pressure by the medullary raphe nuclei in cats, Proc. Natl. Sci. Counc. B. ROC, 13(2): 89-96. 胡苓芝，1990，延腦縫合核對貓?面神經呼吸活動的影響，國立台灣師範大學，生物學研究所碩士論文。 杜小玲，1991，貓延腦縫合核對喉返神經呼吸活動的影響，國立陽明醫學院，生理學研究所碩士論文。 Proudfit H. K. and E. G. Anderson, 1974, New long latency bulbospinal evoked potentials blocked by serotonin antagonist, Brain Res. 65:542-546. Richter, R. C. and M. M. Behbehani, 1991, Evidence for glutamic acid as a possible neurotransmitter between the mesencephalic nucleus cuneiforms and the medullary nucleus raphe magnus in the lightly anesthetized rat, Brain Res. 544:279-286. Sessle, B. J., G. J. Ball and G. E. Lucier, 1981, Suppressive influences from periaqueductal gray and nucleus raphe magnus on respiration and related reflex activities and on solitary tract neurons, and effect of naloxone, Brain Res. 216:145-161. Shannon, R., 1980, Intercostal and abdominal muscle afferent influence on medullary dorsal respiratory group neurons, Respir. Physiol., 39:73-94. Smith, J. C., D. Morrison, H. H. Ellenberger, M. R. Otto, and J. L. Feldman, 1990, Brainstem projections to the major respiratory neuron populations in the medulla of the cat, J. Comp. Neurol., 281: 69-96. St. John, W. M. and S. C. Wang, 1977, Response of medullary respiratory neurons to hypercapnia and isocapnic hypoxia, J. Appl. Physiol., 43(5):812-821. St. John, W. M., 1981, Respiratory neuron responses to hypercapnia and carotid chemoreceptor stimulation. J. Appl. Physiol., 51(4):816-822. Taber, E., A. Brodal and F. Walberg, 1960, The raphe nuclei of the brain stem in the cat: normal topography and cytoarchitecture and general discussion, J. Comp. Neurol., 114:161-188. Thor, K. B. and C. J. Helke, 1987, Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat, J. Comp. Neurol., 265:275—293. Vandermaelen, C. P. and G. K. Aghajanian, 1983, Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices, Brain Res. 289:109-119. Wang, R. Y. and G. K. Aghajanian, 1977, Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition, Brain Res., 132:186-193. Wang, R. Y. and G. K. Aghajanian, 1982, Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus, J. Neurosci., 2(1):11-16. Wessendorf, M. W., H. K. Proudfit and E. G. Anderson, 1981, The identification of serotonergic neurons in the raphe magnus by conduction velocity, Brain Res., 214:168-173. Wessendorf, M. W. and E. G. Anderson, 1983, Single unit studies of identified bulbospinal serotonergic units, Brain Res., 279:93-103. Wessendorf, M. W. and R. Elde, 1987, The coexistence of serotonin- and substance P-like immunoreactivity in the spinal cord of the rat as shown by immunofluorescent double labeling, J. Neurosci. 7(8):2352-2363. Weyne, J., F. Van Leuven and I. R. Leusen, 1973, Glutamate and Glutamine in the brain: Influence of acute Pco changes in normal rats and in rats under sustained hypercapnia or hypocapnia, Life Sci., 12:211-218. Yen, C.-T, P. S. Blum, and J. A. Spath, Jr., 1983, Contral of cardiovascular function by electrical stimulation within the medullary raphe region of the cat, Exp. Neurol., 79:666-679. Yen, C.-T., and P. S. Blum, 1984, Response properties and functional orginazation of neurons in midline region of medullary reticular formation of cats, J. Neurophysiol. 52(5): 961-979. Yen, C.-T., P. S. Blum and A. R. Light, 1986 Raphe-spinal neuron: convergence of baroreceptor and nociceptor inputs and their morphology from intracellular staining, J. Aut. nerv. sys. Suppl. 275-280. Yen, C.-T. and J.-C. Hwang, 1989, Control of phrenic nerve activity and blood pressure by the medullary raphe nuclei in cats, Proc. Natl. Sci. Counc. B. ROC, 13(2): 89-96. 胡苓芝，1990，延腦縫合核對貓?面神經呼吸活動的影響，國立台灣師範大學，生物學研究所碩士論文。 杜小玲，1991，貓延腦縫合核對喉返神經呼吸活動的影響，國立陽明醫學院，生理學研究所碩士論文。 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75782 | - |
| dc.description.abstract | 本實驗目的是想在延腦吻端縫合核(RMRN)找尋與呼吸有關的單一神經細胞，並探討其對二氧化碳濃度提高的反應及與其他功能細胞間的關聯性。以貓為材料，去大腦、肌肉麻痺、兩側迷走神經切斷後，以人工呼吸機器維持其正常通氣量(ventilation)。分離並記錄膈神經。記錄血壓。然後，將動物維持在高氧和二氧化碳濃度正常(hyperoxic normocapnia)的狀態下，以金屬微電極記錄單一神經細胞。當記錄到確認為細胞本體所發出的動作電位時，將二氧化碳濃度提高(hypercapnia)，以測試該神經細胞的反應。然後，由靜脈注入腎上腺素，使血壓上升。最後再以止血鉗夾住體表皮膚，觀察其放電率的變化。 在所記錄到124個神經細胞中，有41個屬於與呼吸有關的神經細胞，其類型有I，E，IE，EI，T-EI及其他等，但最常見的是EI和T-EI，而41個中有14個的放電率會在二氧化碳濃度增加而降低(p<0.01)。57個神經細胞中，有15個會在血壓上升時增高其放電率，另13個則下降，其餘沒有反應。其中6個屬於與呼吸有關的神經細胞。40個中有11個對傷害性刺激會增加其放電率，另3個則降低，其中有3個屬於與呼吸有關的神經細胞。觀察記錄位置，三群細胞間並無明顯分界。 這些結果顯示，在RMRN確實含有一些與呼吸有關的神經細胞。雖然與呼吸有關的、受血壓影響的、與痛覺傳遞有關的神經細胞大部分屬三種不同細胞群，但卻互相混在一起。 | zh_TW |
| dc.description.abstract | The purpose of the present study was to characterize respiratory-related unit activities in the rostral medullary raphe nuclei (RMRN). Cat was decerebrated, paralyzed, vagotomized and ventilated. Under hyperoxia and normocapnia, the phrenic (C5) was isolated and its activity was monitored. Single unit activity of the RMRN was recorded with metal microelectrode. Phrenic activity triggered average of the spontaneous discharge of the unit was used to characterize respiratory-related neuron. All units were challenged with hypercapnic test. Some of the units were also tested for cardiovascular or nociceptive functions. These were tested by elevation of the blood pressure with intravenous infusion of adrenalin or pinching various parts of the body respectively. In a total of 124 units, 41 neurons showed respiratory-related activities which included inspiratory (I), expiratory (E), inspiratory-expiratory (IE), expiratory-inspiratory (EI), tonic-inspiratory-expiratory (T-IE) and tonic-expiratory-inspiratory (T-EI) patterns. Among these, respiratory-related neurons showed highest probability of EI and T-EI patterns. During hypercapnic test, a large portion of either respiratory or non-respiratory-related neurons showed decrease of discharge rate. Fifty-seven of 124 units were tested for their responses to blood pressure elevation. Among them, 28 were cardiovascular-related. Six of them were also respiratory-related. Fourteen of 40 neurons responded to nociceptive stimulation and 3 of them were demonstrated respiratory-related activity. None of these three functional groups of neurons had topographic organization in RMRN. In other words, neurons in these three groups were intermingled with each other. The results suggest that there are respiratory-related neurons within the RMRN. Portion of the respiratory-related neurons are modulated by other stimulations such as blood pressure change and nociception. These neurons are mixed with cardiovascular-related and nociceptive-related neurons in the RMRN with neither significant overlap nor segregation. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:15:21Z (GMT). No. of bitstreams: 0 Previous issue date: 1991 | en |
| dc.description.tableofcontents | 誌謝 中文摘要. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I 英文摘要. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . II 壹、緒言. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 延腦縫合核的構造. . . . . . . . . . . . . . . . . . . 1 延腦縫合核與呼吸神經管制的關係. . . . . . . . . . . . 3 延腦縫合核的其他功能. . . . . . . . . . . . . . . . . 6 研究目的. . . . . . . . . . . . . . . . . . . . . . . 8 貳、實驗材料與方法. . . . . . . . . . . . . . . . . . 10 一般手術過程. . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 神經之分離與記錄. . . . . . . . . . . . . . . . . . . . . . . . . . 11 單細胞記錄. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 組織切片的確認. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 結果分析. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 統計分析方法. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 參、結果. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 與呼吸有關的神經細胞. . . . . . . . . . . . . . . . . . . . . . . . 16 對升高血壓的反應. . . . . . . . . . . . . . . . . . . . . . . . . . 19 對傷害性刺激的反應. . . . . . . . . . . . . . . . . . . . . . . . . 21 肆、討論. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 與呼吸有關神經細胞的特性. . . . . . . . . . . . . . . . . . . . 22 與心血管有關及痛覺傳遞有關的神經細胞. . . . . . . . . . . . . . 27 結論. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 伍、參考文獻. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 陸、圖表及說明. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 | |
| dc.language.iso | zh-TW | |
| dc.title | 貓延腦吻端縫合核有關呼吸方面單一神經細胞的探討 | zh_TW |
| dc.title | Single Unit Study of Respiratory-related Neuron in Rostral Medullary Raphe Nuclei of Cats | en |
| dc.date.schoolyear | 79-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 78 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
文件中的檔案：
沒有與此文件相關的檔案。
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。