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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | 徐肇謙 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:14:51Z | - |
| dc.date.available | 2021-07-01T08:14:51Z | - |
| dc.date.issued | 1989 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75713 | - |
| dc.description.abstract | 本實驗是以LF,TO2和BGK?材料，來探討熱和硫酸鎘對細胞的交互影響，進而探討應用魚類細胞來評估水質的可行性。 硫酸鎘對LF，TO2及BGK的96h LC50分別?50，40，80μM，經37℃前處理1小時後，LF 96h LC50上升?80μM，而TO2和BGK則大於100μM：經41℃前處理30分鍾後96h LC50分別上升?90，70，及100μM。 由SDS-PAGE知經硫酸鎘與熱處理後，LF會?生hsp87,hsp80,hsp70,hsp32,hsp27,hsp23及hsp21;TO2則?生hsp87,hsp70,hsp27及hsp25；BGK則產生hsp87,hsp70,hsp25及hsp23四種蛋白質。 由雙向電泳實驗結果知，經100μM硫酸鎘和熱處理後，LF有四種熱休克蛋白質?生，TO2則有10種，BGK計有20種熱休克蛋白質?生。 由cytoplasmic dot hybridization實驗結果指出：LF，TO2及BGK三種細胞都有Metallothionein基因存在，但100μM硫酸鎘在24小時內卻不會誘發 Metallothionein mRNA 的合成。由PAGE解析卻發現，LF在72小時有 Metallothionein-like合成，TO2和BGK則在43小時就?生。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:14:51Z (GMT). No. of bitstreams: 0 Previous issue date: 1989 | en |
| dc.description.tableofcontents | 目錄 壹．前言………………………01-08 貳．材料與方法………………09-22 一．材料……………………09 1.細胞株與細胞培養……………………09 2.質體……………………09 3.硫酸鎘的制備…………………………10 4.放射性物質的制備………………………10 5.EDTA-磷酸監緩衝液的制備…………10 6.胰蛋白?溶液…………………11 7.電泳貯藏液的制備…………………11 二.方法…………………………14 1.鎘和熱對細胞的影響…………14 2.蛋白質電泳分析……………………15 （1）雙向電泳……………………15 （2）SDS-PAGE…………………16 （3）PAGE………………………19 3.放射性自動顯影術…………………19 4.DNA Dot Hybridization………………19 5.RNA Dot Hybridiazaton………………20 參．結果………………………23-29 一.硫酸鎘的毒性……………………………23 二.溫度處理對細胞存活的影響……………23 三.不同溫度處理後硫酸鎘對細胞株的毒性效應…………24 四.細胞株蛋白質的SDS-PAGE與雙向電泳解析……25 五.Cytoplasmic Dot Hybridization…………………29 六.細胞株Metallothionein 的PAGE解析…………29 肆．討論…………………………………………30-35 伍.參考文獻 陸.圖表 | |
| dc.language.iso | zh-TW | |
| dc.title | 溫度與鎘對魚類細胞株影響之研究 | zh_TW |
| dc.title | Effects of Temperature and Cadmium on Fish cell Lines | en |
| dc.date.schoolyear | 77-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 82 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
| 顯示於系所單位： | 漁業科學研究所 | |
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