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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Miau-Hwa Ko | en |
dc.contributor.author | 柯妙華 | zh_TW |
dc.date.accessioned | 2021-07-01T08:13:49Z | - |
dc.date.available | 2021-07-01T08:13:49Z | - |
dc.date.issued | 1985 | |
dc.identifier.citation | 1. Adair, J.R., B.L. Hamilton, K.A. Scappaticci, C.J. Helke and R.A. Gillis. 1977. Cardiovascular responses to electrical stimulation of the medullary raphe area of the cat. Brain Res. 128: 141-145. 2. Alexander, R.S. 1946. Tonic and reflexs functions of medullary sympathetic cardiovascular centers. J. Neurophysiol. 9: 205-217. 3. Bach, L.M.N. 1952. Relationships between bulbar respiratory, vasomotor and somatic facilitory and inhibitory area. Am. J. Physiol. 171: 417-434. 4. Bagshaw, E.V, and M.H. Evans. 1976. Measurement of current spread from microelectrode when stimulating within the nervous system. Exp. Brain Res. 25: 391-400. 5. Basbaum, A.I. and H.L. Fields. 1979. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J. Comp. Neurol. 187: 513-532. 6. Bobillier, P., S. Seguin, F. Petitjean, D. Salvert, M. Touret and M. Jouvet. 1976. The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography. Brain Res. 113: 449-486. 7. Bolme, P., J. Novotny, B. Uvn?s and P.G. Wright. 1970. Species distribution of sympathetic cholinergic vasodilator nerves in skeletal muscle. Acta Physiol. Scand. 78: 60-64. 8. Cabot, J.B., J.M. Wild and D.H. Cohen. 1979. Raphe inhibition of symoathetic preganglionic neurons. Science 203: 184-186. 9. Chai, C.Y., N.N. Share and S.C.Wang. 1963. Central control of sympathetic cardiac augmentation in lower brain stem of the cat. Am. J. Physiol. 205(4): 55-64. 10. Chai, C.Y. and S.C. Wang. 1962. Localization of central cardiovascular control mechanism in lower brain stem. Am. J. Physiol. 202: 25-30. 11. Coote, J.H., S.M. Hilton and A.W. Zbrozyna. 1973. The ponto-medullary area integrating the defence reaction in the cat and its influences on muscle blood flow. J. Physiol. 229: 257-274. 12. Dahlstrom, A. and K. Fuxe. 1964. Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamine in the cell bodies of brainstem neurons. Acta Physiol. Scand. 62 (suppl. 232): 1-55. 13. Doba, N. and D.J. Reis. 1972. Changes in regional blood flow and cardiodynamics evoked by electrical stimulation of the fastigial nucleus in the cat and their similarity to orthostatic reflexes. J. Physiol. 227: 729-747. 14. Folkow, B., B. Lisander, R.S. Tuttle and S.C. Wang.1968. Changes in cardiac output upon stimulation of the hypothalamic defense area and the medullary depressor area in cat. Acta Physiol. Scand. 72: 220-233. 15. Folkow, B. and E.H. Rubinstein. 1966. Cardiovascular effects of acute and chronic stimulations of the hypothalamic defense area in the rat. Acta Physiol. Scand. 68: 48-57. 16. Goodchild, A.K., R.A.L. Dampney and R. Bandier. 1982. A method for evoking physiological responses by stimulation of cell bodies, but not axons of passage, within localized regions of the central nervous system. J. Neurosci. Meth. 6: 351-363. 17. Green, H.D. and J.H. Kepchar. 1959. Control of peripheral resistance in major systemic vascular beds. Physiol. Rev. 29: 617-686. 18. Gunn, C.G., G. Sevelius, M.J. Puiggari and F.K. Myers. 1968. Vagal cardiomotor mechanisms in the hindbrain of the dog and cat. Am. J. Physiol. 214(2): 258-262. 19. Helke, C.J., J.D. Souza, B.L.Hamilton, VH. Morgenroth, III., R.A. Gillis. 1976. Evidence for a role of central serotonergic neurons in digitalis-induced cardiac arrhythmias. Nature 263: 246-248. 20. Henry, J.L. and F.R. Calaresu. 1974. Pathways from medullary nuclei to spinal cardioacceleratory neurons in the cat. Exp. Brain Res. 20: 505-514. 21. Hilton, S.M. and K.M. Spyer. 1980. Central nervous regulation of vascular resistance. Ann. Rev. Physiol. 42: 399-411. 22. Horeyseck, G., W. Janig, F. Kirchner and V. Thamer. 1976. Activation and inhibition of muscle and cutaneous postganglionic neurones to hindlimb during hypothalamically induced vasoconstriction and atropine-sensitive vasodilation. Pfl?gers Arch. 361: 231-240. 23. Ito, A. and S.M. Schanberg. 1972. Central nervous system mechanisms resonsih1e for blood pressure elevation induced by p-chlorophenylalanine. J. Pharmac. Exp. Ther. 181: 65-74. 24. Koe, B.K. and A. Weissman. 1966. p-chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmac. Exp. Ther. 154: 499-516. 25. Kuhn, D.M., W.A. Wolf, and W. Lovenberg. 1980. Review of the role of the central serotonerrgic neuronal system in blood pressure regulation. Hypertension 2: 243-255. 26. Kullmann, R., W. Sch?nung and E. Simon. 1970. Antagonistic changes of blood flow and sympathetic activity in different vascular beds following central thermal stimulation. I. blood flow in skin, muscle and intestine during spinal cord heating and cooling in anesthetized dogs. Pflugers Arch.319: 146-161. 27. Kuo, J.S., C.Y. Chai, T.M. Lee, C.N. Liu and R.K.S. Lim. 1970. Localization of central cardiovascular control mechanism in the brain stem of the monkey. Exp. Neurol. 29: 131-141. 28. Kuo, J.S., S.C. Wang, C.C. Wang and R.H. Liu. 1981. Vagal bradycardia induced by stimulation of the raphe nuclei in the lower brain stem of cat. Chin. Med. J. 28: 465-470. 29. Lane, J.D., J.E. Smith, P.A. Shea and W.J. McBride.1978. Neurochemical changes following the administration of depletors of biogenic monoamines. Life Sci. 23: 111-120. 30. Lee, T.M., J.S, Kuo and C.Y. Chai. 1972. Central integration mechanism of the Bezold-Jarisch and baroceptor reflexes. Am. J. Physiol. 222(3): 713-720. 31. Lindgren, P. and B.Uvn?s. 1954. postulated vasodilator center in the medulla oblongata. Am. J. Physici. 176: 68-76. 32. Loewy, A.D. and S. McKellar. 1980. The neuroanatomical basis of central cardiovascular control. Fed. Proc. 39: 2495-2503. 33. Loewy, A.D. and S. McKellar. 1981. Serotonergic projections from the ventral medulla to the interme-diolateral cell column in the rat. Brain Res. 211: 146-152. 34. Neil, J.J. and A.D. Loewy. 1982. Decreases in blood pressure in response to L-glutamate microinjections into the A5 catecholamine cell group. Brain Res. 241: 271-278. 35. Neumayr, R.J., B.D. Hare and D.N. Franz. 1974. Evidence for bulbospinal control of sympathetic pre-ganglionic neurons by monoaminergic pathways. Life Sci. 14: 793-806. 36. Peat, M.A. and J.W. Gibb. 1983. High-performance liauid chromatographic determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection. Analytical Biochem. 128: 275-280. 37. Pletscher, A., G. Bartholini, H. Bruderer, W.P. Burkard and K. F. Gey. 1964. Chlorinated arylalkyl-amines affecting the cerebral metabolism of 5-hydroxy- tryptamine. J. Pharmac. Exp. Ther. 145: 344-350. 38. Ranson, S.W. and P.R. Billingsley. 1916. Vasomotor reactions from stimulation of the floor of the fourth ventricle. Am. J. Physiol. 41: 85-90. 39. Riedal, W., M. Iriki and E. Simon. 1972. Regional differentiation of sympathetic activity during peri-pheral heating and cooling in anesthetized rabbits. Pfl?gers Arch. 332: 239-247. 40. Smits, J.F.M., H.V. Essen and H.A.J. Struyker-Boudier. 1978. Serotonin-mediated cardiovascular responses to electrical stimulation of the raphe nuclei in the rat. Life Sci. 23: 173-178. 41. Taher, E. 1961. The cytoarchitecture of the brain stem of the cat. I.brain stem nuclei of cat. J. Comp. Neurol. 116: 27-70. 42. Tuttle, R.S. and R.S. Connor. 1965. An intense hypo-tensive response evoked by medullary stimulation in the pyramidal cat. Am. J. Physiol. 208 (4): 693-697. 43. Uvn?s, B. 1960. Sympathetic vasodilator system and blood flow. Physiol. Rev. 40 (suppl.4): 69-76. 44. Wang, S.C. and S.W. Ranson. 1939. Autonomic responses to electrical stimulation of the lower brain stem. J. Comp. Neurol. 71: 437-455. 45. Ward, D.G.. and C.G. Gunn. 1976. Locus coeruleus complex: differential modulation of depressor mechanisms. Brain Res. 107: 407-411. 46. Watanabe, A.M., T.N. Chase and P.V. Cardon. 1970. Effect of L-dopa alone and combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes. Clin. Pharmac. Ther. 11: 740-746. 47. Whitsett, T.L., P.V. Halushka and L.I. Goldberg. 1970. Attenuation of postganglionic sympathetic nerve activity by L-dopa. Cir. Res. 27: 516-570. 48. Wiklund, L., L. Leger and M. Persson. 1981. Monoamine cell distribution in the cat brain stem: a fluorescence histochemical study with guantification of indolaminergic and locus coeruleus cell groups. J. Comp. Neurol. 203: 613-647. 49. Yen C-T. , P.S. Slum and J.A. Spath, JR. 1983. Control of cardiovascular function by electrical stimulation within the medullary raphe region of the cat. Exp. Neurol. 79: 666-679. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75550 | - |
dc.description.abstract | 以氯醛醣及?酯混合劑麻醉的貓,用來研究延腦縫合核區心臟血管調節機構的分佈位置。電刺激延腦縫合核,除了引起心跳、血壓的改變,也造成局部區域血流量的改變,特定部位的縫合核對特定的血管舒縮功能有特別強的控制力。這些心臟血管反應主要是經由交感神經傳出衝動至周邊的心臟血管系統而引發。腦內血壓胺在利用對氯苯丙胺酸處理減少了90﹪以後,延腦縫合核內能產生刺激反應的區域擴大,而且刺激時所產生之血壓的升降程度亦增強,因此延腦中血壓胺神經元可能扮演著調節血壓的角色,使血壓維持恆定。 | zh_TW |
dc.description.abstract | The topographic organization of the medullary raphe nuclei (MRN) in controlling cardiovascular functions was studied in chloralose-urethane anesthetized cats. Electrical stimulation within the MRN elicited cardiovascular responses which included increases and decreases of heart rate and blood pressure, and changes of resistances in various regional circulatory beds. The MRN could be devided into seven regions according to the types of circulatory responses they produced. The stimulus-produced cardiovascular responses were only slightly affected by bilateral vagotomy, indicating the MRN controls cardiovascular functions primarily through sympathetic outputs. After depleting 90% serotonin in the central nervous system by pretreating the animals with p-chlorophenylalanine for three days, electrical stimulation of the MRN was more effective in changing the blood pressure. The magnitude of pressor and depressor effects increased, and the cardiovascular active zones in the MRN expanded. Therefore, serotonin may play a role in maintaining blood pressure at its normal level. | en |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:13:49Z (GMT). No. of bitstreams: 0 Previous issue date: 1985 | en |
dc.description.tableofcontents | 誌謝……………………………………………………………………………………………………i 縮寫表…………………………………………………………………………………………………ii 目錄……………………………………………………………………………………………………iii 中文摘要………………………………………………………………………………………………1 緒言……………………………………………………………………………………………………2 方法 一、一般手術過程…………………………………………………………………………………5 二、電刺激…………………………………………………………………………………………6 三、切斷兩側迷走神經試驗………………………………………………………………………7 四、膚胺酸化學法刺激……………………………………………………………………………7 五、對氯苯丙胺酸(PCPA)處理之試驗……………………………………………………………8 六、血壓胺(serotonin)之 HPLC分析……………………………………………………………8 七、腦幹切片之製備及刺激點之確定……………………………………………………………9 結果 一、電刺激反應……………………………………………………………………………………10 二、特定分區………………………………………………………………………………………13 三、膚胺酸刺激試驗………………………………………………………………………………13 四、切斷兩側迷走神經之測試……………………………………………………………………13 五、PCPA處理組之測試……………………………………………………………………………14 討論 一、電刺激方法……………………………………………………………………………………44 二、延腦縫合核的分區……………………………………………………………………………45 三、血壓胺(serotonin)神經元如何調節心臟血管之功能 ……………………………………49 英文摘要………………………………………………………………………………………………51 參考文獻………………………………………………………………………………………………52 | |
dc.language.iso | zh-TW | |
dc.title | 貓延腦縫合核心臟血管調節機構之定位 | zh_TW |
dc.title | Topographic organization of the medullary raphe nuclei of the cat in controlling its cardiovascular function: A study with stimulation method | en |
dc.date.schoolyear | 73-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 64 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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