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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Li-Fen Lee | en |
dc.contributor.author | 李莉芬 | zh_TW |
dc.date.accessioned | 2021-07-01T08:12:27Z | - |
dc.date.available | 2021-07-01T08:12:27Z | - |
dc.date.issued | 2000 | |
dc.identifier.citation | Akiyoshi, S., Inoue, H., Hana, J. I., Kusasagi, K., Nemoto, N., Miyazono, K. and Kawabata, M. (1999). c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads. J. Biol Chem. 274, 35269-35277. Amararavadi, L. S., Neff, A. W., Sleeman, I. P. and Smith R. C. (1997). Autonomous neural axis formation by ectopic expression of the protooncogene c-ski: Dev. Biol. 192, 392-404. Ambrose, M. R., Bottazzi, M. E. and Goodenow, M. M. (1995). Expression of the c-ski proton-oncogene during cell cycle arrest and myogenic differentiation. DNA Cell Biol. 14, 701-707. Barkas, A. E., Brodeur, E. and Stvnezer, E. (1986). Polyproteins containing a domain encoded by the v-ski oncogene are located in the nuclei of S KV-transformed cells. Virology 151, 131-138. Bayer, S. A., Yackel, J. and Pun, P. (1982). Neurons in the dentate gyms granular layer substantially increase during juvenile and adult life. Science 216, 890-892. Berk, M., Desai, S. Y., Heyman, H. C. and Colemenares, C. (1997). Mice lacing the ski proton-oncogene have defects in neurulation, craniofacial pattering, and skeletal muscle development. Genes Dev. 11, 2029-2039. Beug, H., Dahl. R., Steinlein, P., Meyer, S., Deiner, E-M. and Hayman M. J. (1995). In vitro growth of factor- dependent multipotential hematopoietic cells is induced by the nuclear oncoprotein v-Ski. Oncogene 11, 59-72. Caubit, X., Thangarajah, R., Theil, T., Wirth, J., Nothwang, H. G., Ruther, U. and Krauss, S. (1999). Mouse Dac, a novel nuclear factor with homology to Drosophila Dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud. Dev. Dynam. 214, 66-80. Cohen, B. S., Zheng, G., Heyman, H. C. and Stavnezer, E. (1999).Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents. Nucleic Acids Res. 27, 1006-1014. Colmenares, C. and Stavnezer, E. (1989). The ski oncogene induces muscle differentiation in quail embryo cells. Cell 59, 293-303. Colmenares, C., Sutrave, P., Hughes, S. H. and Stavnezer, E. (1991). Activation of the c-ski oncogene by overexpression. J. Virol. 65, 4929-4935. Engert, J. C., Servaes, S., Sutrave, P., Hughes, S. H. and Rosenthal, N. (1995). Activation of a muscle-specific enhancer by the ski protononcogene. Nucleic Acids Res. 23, 2988-2994. Galman, O. R and Avtalion, R. R. (1989). Further study of the embryonic development of Oreochromis niloticus (Cichlidae, Teleostei) using scanning electron microscopy. .J. Fish Biol. 34, 653-664. Givol, I., Boyer, P. L. and Hughes, S. H. (1995). Isolation and characterization of the chicken c-sno gene. Gene 156, 271-276. Grimes, H. L., Ambrose M. R. and Goodenow M. M. (1993). c-ski transcripts with and w/o exon2 are expressed in skeletal muscle and throughout embryogensis. Oncogene 8, 2863-2868. Grimes, H. L., Szente, B. E. and Goodenow, M. M. (1992). c-ski cDNAs are encoded by eight exons, six of which are closed linked within the chicken genome. Nucleic Acids Res. 20, 1511-1516. Heyman, H. C. and Stavnezer, E. (1994). A Carboxyl-terminal region of the ski oncoprotein mediates homodimerization as well as heterdimerization with the related protein SnoN. J. Biol. Chem. 269, 26996-27003. Huang, C. J., Lin, J. Y. and Tsai, H. J. (1999). Two distinct c-ski protooncogene cDNAs of fish, tilapia (Oreocrhomis aurea). Mol. Reprod. Dev. 54, 223-231. Ichikawa, K., Nagase, T., Ishii, S., Asano, A. and Mimura, N. (1997). Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation: the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes. Biochem. J. 328, 607-613. Kano, K., Tojo, D., Yamanouchi, K., Soeta, C., Tanaka, S., Ishii, S. and Tachi, S. (1998). Skeletal muscles of transgenic mice expressing human snoN, a homologue of c-ski J. Reprod. Dev. 44, 253-260. Koumans, J. T. M. and Akster, H. A. (1995). Myogenic cells in development and growth of fish. Comp. Biochem. Physiol. 110, 3-20. Larsen, J., Meyer, S., Steinlein, P., Beug, H. and Hayman, M. J. (1993). Transformation of chicken bone marrow cells by the v-ski Oncogene 8, 3221-3228. Leferovich, J. M., Lana, D. P., Sutrave, P., Hughes, S. H. and Kelly, A. M. (1995). Regulation of c-ski transgene expression in developing and mature mice. J. Neurosci. 15, 596-603. Li, Y., Turck, C. M., Teumer, J. K. and Stavnezer, E. (1986). Unique sequence, ski, in Solan-kettering Avian Retroviruses with properties of a new cell-derived oncogene. J. Virol. 57, 1065-1072. Ludoiph, D. C., Neff, A. W., Parker, M. A., Mescher, A. L., Smith, R.C., Larsen, J., Beug, H. and Hayman, M. J. (1992). The ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation. Oncogene 7, 1903-1911. Ludolph, D. C., Neff, A. W., Parker, M. A., Mescher, A. L., Smith, R. C. and Malacinski, G. M. (1995). Cloning and expression of the axolotl protooncogene ski Biochim. Biophys. Acta 1260, 102-104. Lyons, G. E., Micales, D. K., Herr, M. J., Horrigan S. K., Namciu, S., Shardy, D. and Stavnezer, E. (1994). Protoncogene c-ski is expressed in both proliferating and postmitotic neural population. Dev. Dynam. 201, 354-365. Nagase, T., Mizuguchi, G., Nomura, N., Ishizaki, R., Ueno, Y. and Ishii, S. (1990). Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product. Nucleic Acids Res. 18, 337-34. Nagase, T., Nomura, N. and Ishii, S. (1993). Complex formation between encoded by the ski gene family. J. Biol. Chem. 268, 13710-13716. Namciu, S., Lieberman, M. A. and Stavnezer, E. (1994). Induction of the c-ski proton-oncogne by phorbol ester correlates with induction of megakaryocyte differentiation. Oncogene 9, 1407-1416. Namciu, S., Lyons, G. E., Mickels, B. K., Heyman, H. C., Colmenares, C. and Stavenzer, E. (1995). Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitro. Dev. Dynam. 204, 291-300. Nicol, R. and Stavnezer, E. (1998). Transcriptional repression by v-Ski and c-Ski mediated by a specific DNA binding site. J. Biol. Chem. 273, 3588-3597. Nomura, T., Khan, M. M., Kaul, S. C., Dong, H. D., Wadhwa, R., Colmenares, C., Kohno, I. and Ishii, S. (1999). Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13, 412-423. Nomura, N., Sasamoto, S., Ishii, S., Date, T., Matsui, M., and Ishizaki, R. (1989). Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res. 17, 5489-5500. Ramirez-Solis, R., Zheng, H., Whiting, J. and Bradley, A. (1993). Hoxb-4(Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell 73, 279-294. Sleeman, J. P., and Laskey, R. (1993). Xenopus c-ski contains a novel coiled-coil protein domain and is maternally expressed during development. Oncogene 8, 67-77. Stavnezer, E., Brodeur, D. and Brennan, L. A. (1989). The v-ski oncogene encodes a truncated set of c-ski coding exons with limited sequence and structural relatedness to v-myc. Mol. Cell Biol. 9, 4038-4045. Stavnezer, E., Gerhard, D. S., Binari, R. C. and Batzas, I. (1981). Generation of transformation Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and iii vivo recombinations. J. Virol. 57, 1073-1083. Sutrave, P., Copeland, T. D., Showalter, S. D. and Hughes, S. H. (1990a). Characterization of chicken c-ski oncogene products expressed by retrovirus vectors. Mel. Cell. Biol. 10, 3137-3144. Sutrave, P., and Hughes, S. H. (1989). Isolation and characterization of three distinct cDNAs for the chicken c-ski gene. Mol. Cell Biol. 9, 4046-4051. Sutrave, P. and Hughes, S. H. (1991a). The ski oncogene. Oncogene 6, 353-356. Sutrave, P., Kelly, A. M. and Hughes, S. H. (l990b). ski can cause selective growth of skeletal muscle in transgenic mice. Genes Dev. 4, 1462-1472. Tarapore, P., Richmond, C., Zheng, G., Cohen, S. B., Kelder, B., Kopchick J., Kruse, U., Sippel, A. E., Colmenares, C. and Stavnezer, E. (1997). DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFl. Nucleic Acids Res. 25, 3895-3903. Zheng, G., Blumenthal, K. M., Ji, Y., Shardy, D. L., Cohen, S. B. and Stavnezer E. (l997a). High affinity dimerization by Ski involves parallel pairing of a novel bipartite α-helical domain. J. Biol. Chem. 272, 3 1855-31864. Zheng. G., Teumer. J., Colmenares, C., Richmond, C. and Stavnezer, E. (l997b). Identification of a core functional and structural domain of the v-Ski oncoprotein responsible for transformation and myogenesis. Oncogene 15, 459-471. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75268 | - |
dc.description.abstract | v-ski感染鳥類胚胎纖維母細胞(quail embryo fibroblast)時,會使細胞轉型,但感染鳥類胚胎體壁細胞(quail embryo body wall cell),反而分化為骨骼肌。c-ski為v-ski的原型致癌基因(proto-oncogene),其蛋白質為一轉錄因數,具體的生化及生理功能仍在探索的階段。 吳郭魚Oreochromis aurea的c-ski有兩種types:tski1及tski2。在成魚器官組織有不同程度及形態的tski表現:其中腦部表現量最高,而骨骼肌最少;在胚胎發生階段亦有不同的表現。 In situ hybridization分析吳郭魚成魚的平滑肌、心肌、骨骼肌,發現tski1及tski2在平滑肌中(腸、胃)不表現,在心肌、骨骼肌表現量亦偏低,且非均勻表現,而tski2的表現量略高於tski1;另外tski1及tski2在腸、胃平滑肌中雖不表現,但在黏膜(mucosa)卻有高度的表現。在腦部皮質處(cortex)的顆粒層(granular layer)有tski1及tski2的高度表現。胚胎發生第17階段(嘴巴可張開、鰓形成),tski1及tski2在腦部皮質層有明顯的表現;肌管(myotube)、肌纖維、鰓軟骨、發生階段軟骨內骨(endochondral bone)的軟骨、神經視網膜亦有表現,且tski1在肌纖維表現較tski2高。在fry階段(卵黃囊完全被吸收、可自由遊動、消化系統完成發育、並開始進食),除了腦、神經視網膜,有tski1及tski2的明顯表現,腹部的白肌(white muscle)、腸、胃亦出現大量表現。 | zh_TW |
dc.description.abstract | Overexpression of v-ski, or its proto-oncogene, c-ski, has an effect on proliferation, morphological transformation and myogemc differentiation in fibroblast culture and transgenic animal. As a transcription factor, the biological role of c-Ski depends on the cellular environment and is under deciphering. Two types of c-ski, tski1 and tski2, have been identified in tilapia, Oreochromis aurea. tski transcripts are widely expressed in different adult tissues and developmental stage embryos. The most and the least abundant tski transcripts are located in the brain and skeleton muscle, respectively. In situ hybridization analyzes the different type of adult tilapia muscles, revealing little expression of tski transcripts in the smooth muscle of intestine and stomach, heart muscle and skeleton muscle. However, tski2 transcripts are more abundant than tskil transcripts in heart and skeleton muscle fiber. Meanwhile, tski transcripts are expressed in the mucosa of intestine and stomach. The gill filament and cortex of cerebrum express abundant tski. The cortex of brain expresses abundant tski transcripts in the stage 17 embryo (mouth opening and gill formation). The myotube, embryo muscle fiber (superficial red muscle and inner white muscle), cartilage in the gill arch and in the developing endochondral bone, and neuroretina also have the expression of tski transcripts. Meanwhile tski1 transcripts are more abundant in muscle fibers than tski2 transcripts. The fry (active swimming and feeding) tissues express high degree of tski transcripts in the cortex of brain, neuroretina. The intestine and stomach also express high tski transcripts, when the digestive system of fry is well developed. | en |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:12:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2000 | en |
dc.description.tableofcontents | 中文摘要. . . . . . . . . . . . . .I 英文摘要. . . . . . . . . . . . . .II 一、文獻回顧. . . . . . . . . . . . . .1 I. ski的發現過程及性質 . . . . . . . . . . . . l II. Ski的結構 . . . . . . . . . . . . 2 III. Ski蛋白質的功能 . . . . . . . . . . . . 4 IV Ski在胚胎發生階段的角色. . . . . . . . . . . . 6 二、前言. . . . . . . . . . . . 7 三、材料與方法. . . . . . . . . . . . 9 四、結果. . . . . . . . . . . . 16 五、討論. . . . . . . . . . . . 19 圖片. . . . . . . . . . . . 24 Fig.1.tski在吳郭魚成魚腸的表現. . . . . . . . . . . . 24 Fig.2.tski在吳郭魚成魚胃的表現. . . . . . . . . . . . 29 Fig.3.tski在吳郭魚成魚骨骼肌的表現. . . . . . . . . . . . 32 Fig.4.tski在吳郭魚成魚心肌的表現. . . . . . . . . . . . 35 Fig.5.tski在吳郭魚成魚鰓的表現. . . . . . . . . . . . 37 Fig.6.tski在吳郭魚成魚腦的表現. . . . . . . . . . . . 40 Fig.7.tski在胚胎發生第17階段的表現. . . . . . . . . . . . 44 Fig.8.tski在fry的表現. . . . . . . . . . . . 50 六、參考文獻. . . . . . . . . . . . 53 附錄、藥品與配方. . . . . . . . . . . .59 | |
dc.language.iso | zh-TW | |
dc.title | tski基因在?郭魚(Oreochromis aura)各發生階段mRNA的分佈表現 | zh_TW |
dc.title | The Expression Distribution of tski mRNA of tilapia (Oreochromis aurea) During the Developmental Stages | en |
dc.date.schoolyear | 89-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 68 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
顯示於系所單位: | 漁業科學研究所 |
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