請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75242
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yu-Ping Yang | en |
dc.contributor.author | 楊宇平 | zh_TW |
dc.date.accessioned | 2021-07-01T08:12:21Z | - |
dc.date.available | 2021-07-01T08:12:21Z | - |
dc.date.issued | 2001 | |
dc.identifier.citation | Affolter, M., Nellen, D., Nussebaumer, U. and Basler, K. (1994). Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF β homologs during Drosophila embryogenesis. Development 120, 3105-3117.
Ahmad, K.F., Emgel, C.K. and Prive, G.G. (1993). Crystal structure of the BTB domain from PLZF. Proc. Natl Acad. Sci. USA 95, 12123-12128. Alexandre, C., Lecourtois, M. and Vincent, J. (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 24, 5689-5698. Arora, K. and Nusslein-Volhard, C. (1992). Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes. Development 114, 1003-1024 Arora, K., Dai, H., Kazuko, S. G., Jamal, J., O’Connor, M. B., Letsou, A. and Warrior, R. (1995). The Drosophila schnurri gene acts in the Dpp/TGFβ signaling pathway and encodes a transcription factor homologous to the human MBP family. Cell 81, 781-790. Bardwell, V.J. and Treisman, R. (1994). The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8, 1664-1677. Boutros, M., Paricio, N., Strutt, D.I. and Mlodzik, M. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94, 109-118. Brummel, T. J., Twombly, V., Marques, G, Wrana, J.L., Newfeld, S.J., Attisano, L., Massague, J., O’Connor, M. B. and Gilbart. W.M. (1994). Characterization and relationship of Dpp receptors encoded by the saxaphone and thick veins genes in Drosophila. Cell 78, 251-261. Byars, C.L., Bates, K.L. and Letsou, A. (1999). The dorsal-open group gene raw is required for restricted DJNK signaling during closure. Development 126, 4913-23. Campos-Ortega, J.A. and Hartenstein, V. (1997). “The Embryosnic Development of Drosophila melanogaster.” Springer-Verlag, Berlin. Chou, T.-B. and Perrimon, N. (1996). The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144, 1673-1679. Davies, J.M., Hawe, N., Kabarowski, J., Huang, Q.H., Zhu, J., Brand, N.J., Leprince, D., Dhordain, P., Cook, M., Morriss-Kay, G. and Zelent, A. (1999). Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene 18, 365-375. Dhordain, P., Albagli, O., Ansieau, S., Koken, M.H., Deweindt, C., Quief, S., Lantoine, D., Leutz, A., Kerckaert, J.P. and Leprince, D. (1995). The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomerisation in vivo. Oncogene 11, 2689-2697. Espinas, M.L., Jimenez-Garcia, E., Vaquero, A., Canudas, S., Bernues, J. and Azorin, F. (1999). The N-terminal POZ domain of GAGA mediates the formation of oligomers that bind DNA with high affinity and specificity. J. Biol. Chem. 274, 16461-16469. Goberdhan, D. and Wilson, C. (1998). JNK, cytoskeletal regulator and stress response kinase A Drosophila perspective. BioEssays 20, 1009-1019. Gabay, L., Seger, R. and Shilo, B.-Z. (1997). In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277, 1103-1106. Glise, B., Bourbon, H. and Noselli, S. (1995). hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83, 451-61. Glise, B. and Noselli, S. (1997). Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev 11, 1738-1747. Grieder, N.C., Nellen, R., Burke, R., Basler, K. and Affolter, M. (1995). schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDⅡ-BF1. Cell 81, 791-800. Harland, R.M. (2001). A twist on embryonic signalling. Nature 410, 423-424. Hartenstein, V. (1993). Atlas of Drosophila development. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. Hartenstein, V. and Jan, Y.N. (1992). Studying Drosophila embryogenesis with P-lacZ enhancer trap lines. Roux’s Arch. Dev. Biol. 201, 194-220. Hou, X. S, Goldstein, E. S. and Perrimon, N. (1997). Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev. 11, 1728-1737. Katsani, K.R., Hajibagheri, M.A. and Verrijzer, C.P. (1999). Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology. EMBO J. 18, 698-708. Kim, S.H. and Crews, S.T. (1993). Influence of Drosophila ventral epidermal development by the CNS midline cell and spitz class genes. Development 118, 893-901. Knust, E. (1997). Drosophila morphogenesis: Movements behind the edge. Curr. Biol. 7, 558-561. Kobayashi, A., Yamagiwa, H., Hoshino, H., Muto, A., Sato, K., Morita, M., Hayashi, N., Yamamoto, M. and Igarashi, K. (2000). A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol Cell Biol 20, 1733-1746. Kockel, L., Zeitlinger, J., Staszewski, L.M., Mlodzik, M. and Bohmann, D. (1997). Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev 11, 1748-1758. Letsou, A., Arora, K., Wrana, J.L., Simin, K., Twombley, V., Jamal, J., Staehling-Hampton, K, Hoffman, M.F., Gelbart, W.M., Massague, J. and O’Connor, M.B. (1995). Drosophila dpp signaling is mediated by the punt gene product: a dual ligand binding type Ⅱ receptor of the TGF β receptor family. Cell 80, 899-908. Li, Y.S., Shyy, J.Y., Li, S., Lee, J., Su, B., Karin, M. and Chien, S. (1996). The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol 16, 5947-5954. Li, X., Peng, H., Schultz, D.C., Lopez-Guisa, J.M., Rauscher, F.J. and Marmorstein, R. (1999). Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. Cancer Res 59, 5275-5282. Martin-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A.M. and Martinez-Arias, A. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNKK activity during dorsal closure in Drosophila. Gene Dev 12, 557-570. McEwen, E.G, Cox, R.T. and Peifer, M. (1999). The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning. Development 127, 3607-3617. Melnick, A. and Licht, J.D. (1999). Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93, 3167-3215. Morrison, D.J., Pendergrast, P.S., Stavropoulos, P., Colmenares, S.U., Kobayashi, R. and Hernandez, N. (1999). FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein. Nucleic Acids Res. 27, 1251-1262. Nellen, D., Affolter, M. and Basler, K. (1994). Receptors serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78, 225-237. Noselli, S. (1998). JNK signaling and morphogenesis in Drosophila. Trends Genet 14, 33-38. Noselli, S. and Agnes, F. (1999). Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9, 466-472. N?sslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux’s Arch. Dev. Biol. 183, 267-282. Paricio, N., Feiguin, F., Boutros. M., Eaton, S. and Mlodzik, M. (1999). The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 18, 4669-4678. Poulson, D.F. (1950). Histogenesis, organogenesis, and differentiation in the embryo of Drosophila melanogaster. In Biology of Drosophila (ed. Demerec, M.), pp. 168-274. New York: John Wiley and Sons. Ray, R.P., Arora, K., Nusslein-Volhard, C. and Gelbart, W.M. (1991). The control of cell fate along the dorsal-ventral axis of the drosophila embryo. Development 113, 35-54. Raz, E. and Shilo, B.-Z. (1993). Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGFR receptor homologue. Gene Dev 7, 1937-1948. Read, D., Butte, M.J., Dernburg, A.F., Frasch, M and Kornberg T.B. (2000). Functional studies of the BTB domain in the Drosophila GAGA and Mod (mdg4) proteins. Nucleic Acids Research 28, 3684-3870. Riesgo-Escovar, J.R., Jenni, M., Fritz, A. and Hafen, E. (1996). The Drosophila Jun-N-terminal knoase is required for cell morphogenesis but not for Djun-dependent cell fate specification in the eye. Genes Dev 10, 2759-2768. Riesgo-Escovar, J.R. and Hafen E. (1997a). Drosophila Jun kinase regulates expression of Decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor Djun during dorsal closure. Gene Dev 11, 1717-1727. Riesgo-Escovar, J. R. and Hafen, E. (1997b). Common and distinct roles of DFos and DJun during Drosophila development. Science 278, 669-671. Ring, J.M. and Martinez-Arias, A. (1993). Puckered, a gene involved in position-specific cell differentiation in the dorsal epidermis of the Drosophila larva. Dev Suppl, 251-259. Robinson, U.N. and Cooley, L. (1997). Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell. Biol. 138, 799-810. Ruberte, E., Marty, T., Nellen, D., Affolter, M. and Basler, K. (1995). An absolute requirement for both the type Ⅱ and type Ⅰ receptors, Punt and Thick Veins, for Dpp signaling in vivo. Cell 80, 890-898. Rushlow, C. and Roth, S. (1995). The role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. Adv. Devel. Biol Schweitzer, R. and Shilo, B.-Z. (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13, 191-196. Sluss, H.K., Han, Z., Barrett, T., Goberdhan, D.C.I., Wilson, C., Davis, R.J. and Ip, Y.T. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev 10, 2734-2758. Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signaling in the larval cuticle of Drosophila. Development 124, 3209-3219. Wales, M.M., Biel, M.A., el Deiry, W., Nelkin, B.D., Issa, J.P., Cavenee, W.K., Kuerbitz, S.J. and Baylin, S.B. (1995). p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17pl3.3. Nat Med. 6, 570-577. Wharton, K.A., Ray, R.P. and Gelbart, W.M. (1993). An activity graduent of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117, 807-822. Wodarz, A. and Nusse, R. (1998). Mechanisms of Wnt signaling in development. Annu Rev. Cell Dev. Biol. 14, 59-88. Xue, F. and Cooley, L. (1993). kelch encodes a component of intercellular bridges in Drosophila egg chambers. Cell 72, 681-693. Ye, B.H., Lista, F., Lo Coco, F., Knowles, D.M., Offit, K., Changanti, R.S. and Dalla-Favera, R. (1993). Alteration of a zinc finger-encoding gene, BCL-6, in diffuse large cell lymphoma. Science 262, 747-750. Zeitlinger, J., Kockel, L., Peverali, F.A., Jackson, D.B., Mlodzik, M. and Bohmann, D. (1997). Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants. EMBO 16, 7393-7401. Zecchini, V., Brennan, K. and Martinez-Arias, A. (1999). An activity of Notch regulates JNK signaling and affects dorsal closure in Drosophila. Curr Biol. 9, 460-469. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75242 | - |
dc.description.abstract | 在果蠅胚胎發育中,背部密合(dorsal closure)過程是胚胎體側的表皮細胞移動覆蓋裸露的內胚膜(amnioserosa),將內胚膜包起的過程。至少有三類的基因產物是胚胎背部密合所需要的,並且都表現在表皮細胞。第一類為結構性蛋白,影響細胞形狀。第二類與第三類為表現調節背部密合過程的蛋白質;第二類為Drosophila Jun-amino(N)-terminal kinase (DJNK)訊息分子,第三類為與Decapentaplegic(Dpp,果蠅TGFβ之同源基因),相關的訊息分子。 新發現的基因,shrimp ball(shpb),具有胚胎背部開洞的突變性狀。shpb表現為轉錄因數,具有包含BTB/POZ的高度保守的區域。在胚胎背部密合時期,shpb大量表現在內胚膜內;而shpb突變則造成DJNK訊息的標的基因,如dpp與puc,表現型態與程度的改變。由此觀察,shpb應位於目前已知DJNK訊息的最上游,並且正向調節目前未知的胚胎背部密合起始訊息。shpb所活化的起始訊息經過raw的抑制調節,使得下游的DJNK與Dpp訊息被侷限在前緣細胞(leading edge cell)內表現。並且根據基因本身的表現型態,shpb極有可能連結內胚膜發育與胚胎背部密合的過程。 由於shpb的突變也造成EGFR(Epidermal Growth Factor Receptor)訊息傳遞路徑的標的基因,fasciclin Ⅲ(fas Ⅲ),表現的改變,因此shpb也參與於EGFR訊息路徑,可能是造成突變胚胎腹部型態改變的原因。 | zh_TW |
dc.description.abstract | During dorsal closure in Drosophila, cells of the lateral epidermis migrate over the amnioserosa to encase the embryo. At least three classes of characterized dorsal-opened group gene products, which function in the epidermis, are involved in the process. Class Ⅰ genes code for structural proteins. Class Ⅱ genes encode Drosophila Jun amino (N)-terminal kinase (DJNK) signaling molecule and Class Ⅲ genes encode Decapentaplegic (Dpp)-mediated signaling molecules. A newly discovered embryonic lethal gene, shrimp ball (shpb), encodes a transcription factor with highly conserved BTB/POZ domain. Severe dorsal closure defect was found in shpb mutants. shpb expresses mainly in amnioserosa, indicating its function in amnioserosa. shpb mutation caused lose of two DJNK target gene expression. Dorsal-opened phenotype caused by shpb can be rescued by ubiquitous expression of dpp and mutation of raw. raw mutation also converts the ventral denticles to naked cuticle in shpb mutants. From the observation, we postulate that shpb is acting at the upstream position of the DJNK signaling and positively regulates an unknown initial signal, which is responsible for activation of the dorsal process. shpb may also link the gap between function of dorsal closure and amnioserosa, where is suggested to be the site emitting dorsal closure signal. shpb is also postulated to act in the EGFR (Epidermal Growth Factor Receptor) signaling pathway. shpb mutation causes disappearance of EGFR-dependent Fasciclin Ⅲ (Fas Ⅲ) expression, indicating its positive role in EGFR signaling. | en |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:12:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2001 | en |
dc.description.tableofcontents | List of Tables Ⅳ List of Figures Ⅴ Introduction 1 Early embryogenesis of Drosophila 1 Dorsal closure process in Drosophila embryos 2 The DJNK signaling is essential for dorsal closure 2 puc, a target gene for DJNK signaling 4 Regulation of cell shape changes outside the leading edge 5 The initiating signal for dorsal closure remains elusive 6 raw functions negatively to DJNK signaling 7 The Wingless signaling cascade also promotes dorsal closure 7 The EGFR signaling pathway 8 The EGFR signaling and Dpp may antagonize each other 9 A novel Drosophila gene, shpb 10 Materials & Methods 12 Drosophila strains 12 Mutation screening 13 Imprecise Excision of P transposon 13 Epistasis analysis 13 Molecular cloning 13 Cuticle preparation 16 in situ hybridization 16 Immunostaining studies of embryos 18 β-galactosidase activity assays 19 Results 21 112 lethal mutations were recovered by screening on cFRT chromosome 21 shpb mutants show defect in dorsal closure and denticle pattern 21 P transposon in shpb50b is inserted right at the 5'upstream of CG6792 gene 22 shpb50b mutation phenotype is caused by P transposon insertion 23 CG6792 is affected in shpb50b mutant 23 Shpb is a transcription factor 24 The BTB/POZ domain in Shpb are highly conserved 25 Expression pattern of shpb 25 shpb is transcriptionally misexpressed in mutants of shpb50b alleles 26 Initial formation of cytoskeleton is not altered in shpb mutants 27 dpp and puc expression are decreased in shpb mutant 27 Dorsal-opened phenotype caused by shpb mutation can be rescued by overexpressed dpp 29 shpb is acting upstream of raw 30 shpb is upstream of Jra by cuticular phenotype 31 shpb does not affect wg/en expression 31 shpb does not affect EGFR-dependent dp-ERK pattern 32 Expression of Fas Ⅲ is altered in shpb mutant embryos 32 Discussion 34 shpb codes for a transcription factor with BTB/POZ domain 34 shpb involves in signaling events of dorsal closure 36 shpb regulates DINK signaling positively 37 shpb might involve in a negative feed back loop 38 shpb may act on initiation signal of dorsal closure 40 shpb might be also an amnioserosa gene 41 shpb links the amnioserosa formation and dorsal closure process 42 shpb is involved in the EGFR signaling 42 Ventral patterning in shpb mutants 43 Acknowledgments 45 References 46 | |
dc.language.iso | zh-TW | |
dc.title | 果蠅新基因shrimp ball在胚胎發育背部密合過程所扮演的角色 | zh_TW |
dc.title | Roles of a novel gene, shrimp ball, in the dorsal closure process during Drosophila embryogenesis | en |
dc.date.schoolyear | 89-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 82 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
文件中的檔案:
沒有與此文件相關的檔案。
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。