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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Chung-Ying Lee | en |
dc.contributor.author | 李忠穎 | zh_TW |
dc.date.accessioned | 2021-07-01T08:12:20Z | - |
dc.date.available | 2021-07-01T08:12:20Z | - |
dc.date.issued | 2000 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75239 | - |
dc.description.abstract | 高等動物的CNS受傷後,會誘發一連串的膠細胞增殖反應(gliotic reaction)。其最明顯的特徵是星形膠細胞增大,與胞內中間絲蛋白glial fibrillary acidic protein(GFAP)的大量增加。先前之研究發現一個280kD的中間絲附屬蛋白(intermediate filament associate protein, IFAP)- IFAP-70/280kD,它在體內的表現只侷限於輻射膠細胞與星形膠細胞之先趨細胞內,並不見於成熟的星形膠細胞。因此,此IFAP可用以標示分化初期之星形膠細胞。我們最近的實驗也發現,在CNS受傷以後,傷口周圍的部分反應型星形膠細胞,會有IFAP-70/280kD之再表現。此IFAP之再表現,顯示這類反應型膠細胞可能發生de-differentiation。依據IFAP-70/280kD之再表現與否,可將反應型星形膠細胞,區分為兩個次族群(subtype):一類帶有IFAP,出現在傷口附近,可能與gliotic scar的形成有關;而另一類則不會再表現IFAP,出現在離傷口較遠處,可能參與受傷CNS的保護機制,與gliotic scar的形成無關。但關於上述兩型之星形膠細胞的性狀與實際功能仍不清楚。一般而言,成熟星形膠細胞已退出細胞週期,並不會進行有絲分裂。然而CNS受傷後,卻可以明顯地發現星形膠細胞數目增加。但是相關研究中,卻一直存在著兩派歧異的說法。一者認為,成熟的星形膠細胞並不會再行有絲分裂,這些增生的反應型星形膠細胞是源自subventricular zone的神經幹細胞,然後再向上遷徙到大腦皮質的傷口周圍。另一者則認為,CNS受傷後,傷口周圍的星形膠細胞會重新進入細胞週期,並行有絲分裂,這些增生的細胞便是來自原地的星形膠細胞。本實驗採用大腦針刺受傷模式,利用BrdU標示傷後增生之細胞,輔以GFAP及IFAP之免疫螢光染色。觀察發現,在帶有IFAP之次族群中,可見BrdU之標示;而不再表現IFAP之次族群則無BrdU之染色。換言之,BrdU+之反應型星形膠細胞必為IFAP+染色,但反之則不然。在傷後5天,傷口周圍區(距傷口邊緣50-800μm)之IFAP+反應型星形膠細胞數量達最高;然而此類細胞在傷口區(距傷口邊緣0-50μm)則到受傷8天才達最高值。BrdU在傷口區之染色則是持續增加至受傷後14天。可見藉由IFAP所標示之反應型星形膠細胞,在大腦受傷時,可能會隨著時間,而逐漸移向傷口。同時其發生de-differentiation之目的,可能便在重新獲得增生的能力,與其參與膠細胞疤形成之需求有關。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:12:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2000 | en |
dc.description.tableofcontents | 摘要………………………………………………………………………………………i 目次………………………………………………………………………………………iv 緒論………………………………………………………………………………………1 前言………………………………………………………………………………………1 中樞神經系統的發育……………………………………………………………………2 星形膠細胞的發育………………………………………………………………………3 輻射膠細胞與星形膠細胞之功能………………………………………………………4 膠細胞增殖反應…………………………………………………………………………5 星形膠細胞在膠細胞增殖反應中的作用………………………………………………6 反應型星形膠細胞之增生………………………………………………………………9 中間絲蛋白(IF)與中間絲附屬蛋白(IFAP)………………………………………10 GFAP與Vimentin…………………………………………………………………………11 Nestin……………………………………………………………………………………12 IFAP-70/280kD…………………………………………………………………………13 實驗目的…………………………………………………………………………………14 實驗材料…………………………………………………………………………………15 實驗動物…………………………………………………………………………………15 抗體………………………………………………………………………………………15 特殊藥品…………………………………………………………………………………15 實驗方法…………………………………………………………………………………15 腦部手術…………………………………………………………………………………15 偽腦部手術(Sham-Operation)………………………………………………………16 標本處理:冷凍組織切片………………………………………………………………16 IFAP-70/280kD與GFAP之單一或雙重免疫螢光染色…………………………………17 BrdU、IFAP-70/280kD與GFAP之多重免疫螢光染色…………………………………17 兩階段免疫螢光染色……………………………………………………………………17 細胞計數…………………………………………………………………………………18 實驗結果…………………………………………………………………………………19 正常及偽手術大白鼠之大腦中GFAP、IFAP-70/280kD與BrdU之免疫螢光染色……20 受傷大腦皮質反應型星形膠細胞之變化………………………………………………21 1 Day Post-Lesion……………………………………………………………………22 1.5 Days Post-Lesion…………………………………………………………………22 2 Days Post-Lesion……………………………………………………………………23 3 Days Post-Lesion……………………………………………………………………24 5 Days Post-Lesion……………………………………………………………………24 8 Days Post-Lesion……………………………………………………………………25 14 Days Post-Lesion…………………………………………………………………26 20 and 30 Days Post-Lesion…………………………………………………………26 腦室下區在大腦受傷後之反應…………………………………………………………27 討論………………………………………………………………………………………28 IFAP-70/280kD在反應型星形膠細胞之再表現………………………………………28 反應型星形膠細胞之增生情形與可能來源……………………………………………30 IFAP-70/280kD與膠細胞疤之形成……………………………………………………33 影響星形膠細胞增生及IFAP-70/280kD再表現之可能因數…………………………34 結語………………………………………………………………………………………35 參考資料…………………………………………………………………………………37 圖表及說明………………………………………………………………………………45 | |
dc.language.iso | zh-TW | |
dc.title | 大白鼠大腦反應型星形膠細胞增生之研究 | zh_TW |
dc.title | Proliferation of A Subpopulation of Reactive Astrocytes Following Needle-Insertion Lesion in Rat | en |
dc.date.schoolyear | 89-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 75 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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