請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74673完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳克強 | |
| dc.contributor.author | You-Cheng Lai | en |
| dc.contributor.author | 賴佑承 | zh_TW |
| dc.date.accessioned | 2021-06-17T09:05:51Z | - |
| dc.date.available | 2025-01-16 | |
| dc.date.copyright | 2020-01-16 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-01-14 | |
| dc.identifier.citation | Bannister, A.J., and Kouzarides, T. (2011). Regulation of chromatin by histone modifications. Cell Res 21, 381-395.
Boss, P.K., Bastow, R.M., Mylne, J.S., and Dean, C. (2004). Multiple pathways in the decision to flower: enabling, promoting, and resetting. Plant Cell 16 Suppl, S18-31. Cao, Y., Dai, Y., Cui, S., and Ma, L. (2008). Histone H2B monoubiquitination in the chromatin of FLOWERING LOCUS C regulates flowering time in Arabidopsis. Plant Cell 20, 2586-2602. Challa, K.R., Aggarwal, P., and Nath, U. (2016). Activation of YUCCA5 by the transcription factor TCP4 integrates developmental and environmental signals to promote hypocotyl elongation in Arabidopsis. Plant Cell 28, 2117-2130 Chen, J. (2019) Arabidopsis histone demethylase JMJ29 is involved in trichome development. National Taiwan University Master Thesis Chuang, L. (2015) TCP4 interacts with HDA6 and regulates flowering and leaf development in Arabidopsis. National Taiwan University Master Thesis Clough, S.J., and Bent, A.F. (1998) Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J 6, 735-743. Corbesier, L., Vincent, C., Jang, S., Fornara, F., Fan, Q., Searle, I., Giakountis, A., Farrona, S., Gissot, L., and Turnbull, C. (2007). FT protein movement contributes to long-distance signaling in floral induction of Arabidopsis. Science 316, 1030-1033. Deng, S., Jang, I.C., Su, L., Xu, J., and Chua, N.H. (2016). JMJ24 targets CHROMOMETHYLASE3 for proteasomal degradation in Arabidopsis. Genes Dev 30, 251-256. Dutta, A., Choudhary, P., Caruana, J., and Raina, R. (2017). JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time. Plant J 91, 1015-1028. Greenberg, M.V., Deleris, A., Hale, C.J., Liu, A., Feng, S., and Jacobsen, S.E. (2013). Interplay between active chromatin marks and RNA-directed DNA methylation in Arabidopsis thaliana. PLoS Genet 9, e1003946. Gu, X., Le, C., Wang, Y., Li, Z., Jiang, D., Wang, Y., and He, Y. (2013). Arabidopsis FLC clade members form flowering-repressor complexes coordinating responses to endogenous and environmental cues. Nat Commun 4, 1947. He, Y., and Amasino, R.M. (2005). Role of chromatin modification in flowering-time control. Trends Plant Sci 10, 30-35. Helliwell, C.A., Wood, C.C., Robertson, M., James Peacock, W., and Dennis, E.S. (2006). The Arabidopsis FLC protein interacts directly in vivo with SOC1 and FT chromatin and is part of a high-molecular-weight protein complex. Plant J 46, 183-192. Henderson, I.R., and Dean, C. (2004). Control of Arabidopsis flowering: the chill before the bloom. Development 131, 3829-3838. Hsieh, H. (2016) Function of the histone demethylase JMJ28 in controlling flowering time in Arabidopsis. National Taiwan University Master Thesis Huang, S., Zhang, A., Jin, J.B., Zhao, B., Wang, T.J., Wu, Y., Wang, S., Liu, Y., Wang, J., Guo, P., Ahmad, R., Liu, B., and Xu, Z.Y. (2019). Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response. New Phytol 223, 1372-1387. Hung, F.Y., Chen, F.F., Li, C., Chen, C., Chen, J.H., Cui, Y., and Wu, K. (2019). The LDL1/2-HDA6 histone modification complex interacts with TOC1 and regulates the core circadian clock components in Arabidopsis. Front Plant Sci 10, 233. Hung, F.Y., Chen, F.F., Li, C., Chen, C., Lai, Y.C., Chen, J.H., Cui, Y., and Wu, K. (2018). The Arabidopsis LDL1/2-HDA6 histone modification complex is functionally associated with CCA1/LHY in regulation of circadian clock genes. Nucleic Acids Res 46, 10669-10681. Ito, S., Song, Y.H., Josephson-Day, A.R., Miller, R.J., Breton, G., Olmstead, R.G., and Imaizumi, T. (2012). FLOWERING BHLH transcriptional activators control expression of the photoperiodic flowering regulator CONSTANS in Arabidopsis. Proc Natl Acad Sci U S A 109, 3582-3587. Jeong, J.H., Song, H.R., Ko, J.H., Jeong, Y.M., Kwon, Y.E., Seol, J.H., Amasino, R.M., Noh, B., and Noh, Y.S. (2009). Repression of FLOWERING LOCUS T chromatin by functionally redundant histone H3 lysine 4 demethylases in Arabidopsis. PLoS One 4, e8033. Jiang, D., Yang, W., He, Y., and Amasino, R.M. (2007). Arabidopsis relatives of the human lysine-specific demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition. Plant Cell 19, 2975-2987. Jones, M.A., Covington, M.F., DiTacchio, L., Vollmers, C., Panda, S., and Harmer, S.L. (2010). Jumonji domain protein JMJD5 functions in both the plant and human circadian systems. Proc Natl Acad Sci USA 107, 21623-21628 Kabelitz, T., Brzezinka, K., Friedrich, T., Gorka, M., Graf, A., Kappel, C., and Baurle, I. (2016). A JUMONJI protein with E3 ligase and histone H3 Binding activities affects transposon silencing in Arabidopsis. Plant Physiol 171, 344-358. Kim, H.J., Hyun, Y., Park, J.Y., Park, M.J., Park, M.K., Kim, M.D., Kim, H.J., Lee, M.H., Moon, J., Lee, I., and Kim, J. (2004). A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana. Nat Genet 36, 167-171. Kim, S.Y., He, Y., Jacob, Y., Noh, N.Y., Michaels, S., and Amasino, R. (2005). Establishment of the vernalization-responsive, winter-annual habit in Arabidopsis requires a putative histone H3 methyl transferase. Plant Cell 17, 3301-3310. Klose, R.J., and Zhang, Y. (2007). Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol 8, 307-318. Klose, R.J., Kallin, E.M., and Zhang, Y. (2006). JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7, 715-727. Ko, J.H., Mitina, I., Tamada, Y., Hyun, Y., Choi, Y., Amasino, R. M., Noh, B., and Noh, Y.S. (2010). Growth habit determination by the balance of histone methylation activities in Arabidopsis. EMBO J 29, 3208-3215. Koyama, T., Mitsuda, N., Seki, M., Shinozaki, K., and Ohme-Takagi, M. (2010). TCP transcription factors regulate the activities of ASYMMETRIC LEAVES1 and miR164, as well as the auxin response, during differentiation of leaves in Arabidopsis. Plant Cell 22, 3574-3588. Kubota A, Ito S, Shim JS, Johnson RS, Song YH, Breton G, Goralogia GS, Kwon MS, Laboy Cintrón D, Koyama T. (2017). TCP4‐dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis. PLoS Genet 13, e1006856. Kuchen, E.E., Fox, S., de Reuille, P.B., Kennaway, R., Bensmihen, S., Avondo, J., Calder, G.M., Southam, P., Robinson, S., Bangham, A., and Coen, E. (2012). Generation of leaf shape through early patterns of growth and tissue polarity. Science 335, 1092-1096. Lee, H., Suh, S.S., Park, E., Cho, E., Ahn, J.H., Kim, S.G., Lee, J.S., Kwon, Y.M. and Lee, I. (2000). The AGAMOUS‐LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis. Genes Dev 14, 2366-2376. Lee, K., Park, O. S., and Seo, P. J. (2018). JMJ30-mediated demethylation of H3K9me3 drives tissue identity changes to promote callus formation in Arabidopsis. Plant J. 95, 961-975. Li, D., Liu, R., Singh, D., Yuan, X., Kachroo, P., and Raina, R. (2019). JMJ14 encoded H3K4 demethylase modulates immune responses by regulating defence gene expression and pipecolic acid levels. New Phytol DOI: 10.1111/nph.16270. Li, Z., Ou, Y., Zhang, Z., Li, J., and He, Y. (2018). Brassinosteroid signaling recruits histone 3 lysine-27 demethylation activity to FLOWERING LOCUS C chromatin to inhibit the floral transition in Arabidopsis. Mol Plant 11, 1135-1146 Liu, J., Cheng, X., Liu, P., Li, D., Chen, T., and Gu, X. (2017). MicroRNA319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis. PLoS Genet 13, e1006833. Liu, P., Zhang, S., Zhou, B., Luo, X., Zhou, X.F., Cai, B., Jin, Y.H., Niu, Lin, J., Cao, X., and Jin, J.B. (2019). The histone H3K4 demethylase JMJ16 represses leaf senescence in Arabidopsis. Plant Cell 31, 430-443. Lu, F., Li, G., Cui, X., Liu, C., Wang, X.J., and Cao, X. (2008). Comparative analysis of JmjC domain-containing proteins reveals the potential histone demethylases in Arabidopsis and rice. J Integr Plant Biol 50, 886-896. Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., and Richmond, T.J. (1997). Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260. Luo, M., Hung, F.Y., Yang, S., Liu, X., and Wu, K. (2013). Histone lysine demethylases and their functions in plants. Plant Mol Biol Rep 32, 558-565. Macknight, R., Bancroft, I., Page, T., Lister, C., Schmidt, R., Love, K., Westphal, L., Murphy, G., Sherson, S., Cobbett, C., and Dean, C. (1997). FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains. Cell 89, 737-745. Martin, C., and Zhang, Y. (2005). The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 6, 838-849. Michaels, S.D., and Amasino, R.M. (1999). FLOWERING LOCUS C encodes a novel MADS domain protein that acts as a repressor of flowering. Plant Cell 13, 949-956. Michaels, S.D., and Amasino, R.M. (2001). Loss of FLOWERING LOCUS C activity eliminates the late-flowering phenotype of FRIGIDA and autonomous pathway mutations but not responsiveness to vernalization. Plant Cell 13, 935-941. Mouhu, K., Hytonen, T., Folta, K., Rantanen, M., Paulin, L., Auvinen, P., and Elomaa, P. (2009). Identification of flowering genes in strawberry, a perennial SD plant. BMC Plant Biol 9, 122. Nath, U., Crawford, B.C., Carpenter, R., and Coen, E. (2003). Genetic control of surface curvature. Science 299, 1404-1407. Palatnik, J.F., Allen, E., Wu, X., Schommer, C., Schwab, R., Carrington, J.C., and Weigel, D. (2003). Control of leaf morphogenesis by microRNAS. Nature 425, 257-263. Qiu, Q., Mei, H., Deng, X., He, K., Wu, B., Yao, Q., Zhang, J., Lu, F., Ma, J., and Cao, X. (2019). DNA methylation repels targeting of Arabidopsis REF6. Nat Commun 10, 2063. Quesada, V., Macknight, R., Dean, C., and Simpson, G.G. (2003). Autoregulation of FCA pre‐mRNA processing controls Arabidopsis flowering time. EMBO J 22: 3142-3152. Sawa, M., Nusinow, D. A., Kay, S. A. and Imaizumi, T. (2007). FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science 318, 261-265. Saze, H., Shiraishi, A., Miura, A., and Kakutani, T. (2008). Control of genic DNA methylation by a JmjC domain-containing protein in Arabidopsis thaliana. Science 319, 462-465. Simpson, G.G., Dijkwel, P.P., Quesada, V., Henderson, I., and Dean, C. (2003). FY is an RNA 3’ end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Cell 113, 777-787. Song, L., Huang, S.C., Wise, A., Castanon, R., Nery, J.R., Chen, H., Watanabe, M., Thomas, J., Bar‐Joseph, Z., and Ecker, J.R. (2016) A transcription factor hierarchy defines an environmental stress response network. Science 354, aag1550. Song, S.F., Lu, Z.Z., and Zhang, W.W. (2013). The CDF and its sensitivity analysis of stochastic structure with stochastic excitation by advanced stratified line sampling. Sci China-Phys Mech Astron 56, 1559-1567. Spedaletti, V., Polticelli, F., Capodaglio, V., Schinina, M.E., Stano, P., Federico, R., and Tavladoraki, P. (2008). Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry 47, 4936-4947. Suarez-Lopez, P., Wheatley, K., Robson, F., Onouchi, H., Valverde, F., and Coupland, G. (2001). CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis. Nature 410, 1116-1120. Sun, H. (2017) The histone demethylase JMJ28 controls flowering time and transposon silencing in Arabidopsis. National Taiwan University Master Thesis Tessarz, P., and Kouzarides, T. (2014). Histone core modifications regulating nucleosome structure and dynamics. Nat Rev Mol Cell Biol 15, 703-708. Xu, L., Menard, R., Berr, A., Fuchs, J., Cognat, V., Meyer, D., and Shen, W.H. (2009). The E2 ubiquitin-conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana. Plant J 57, 279-288. Yamane, K., Toumazou, C., Tsukada, Y., Erdjument-Bromage, H., Tempst, P., Wong, J., and Zhang, Y. (2006). JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 125, 483-495. Yang, H., Han, Z., Cao, Y., Fan, D., Li, H., Mo, H., Feng, Y., Liu, L., Wang, Z., Yue, Y., Cui, S., Chen, S., Chai, J., and Ma, L. (2012b). A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. PLoS Genet 8, e1002664. Yang, H., Howard, M., and Dean, C. (2016). Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC. Proc Natl Acad Sci U S A 113, 9369-9374. Yang, H., Mo, H., Fan, D., Cao, Y., Cui, S., and Ma, L. (2012a). Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis. Plant Cell Rep 31, 1297-1308. Yang, W., Jiang, D., Jiang, J., and He, Y. (2010). A plant-specific histone H3 lysine 4 demethylase represses the floral transition in Arabidopsis. Plant J 62, 663-673. Yu, C.W., Chang, K.Y., and Wu, K. (2016). Genome-wide analysis of gene regulatory networks of the FVE-HDA6-FLD complex in Arabidopsis. Front Plant Sci 7, 555. Yu, X., Li, L., Guo, M., Chory, J., and Yin, Y. (2008). Modulation of brassinosteroid-regulated gene expression by Jumonji domain containing proteins ELF6 and REF6 in Arabidopsis. Proc Natl Acad Sci U S A 105, 7618-7623. Zheng, S., Hu, H., Ren, H., Yang, Z., Qiu, Q., Qi, W., Liu, X., Chen, X., Cui, X., Li, S., Zhou, B., Sun, D., Cao, X., and Du, J. (2019). The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun 10, 1303. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74673 | - |
| dc.description.abstract | 組蛋白去甲基化酶藉由表觀遺傳修飾影響植物生長發育。組蛋白去甲基酶JMJ28屬於KDM3/JHDM2類並具有組蛋白H3賴胺酸9 (H3K9) 去甲基酶的功能。在本研究中發現，jmj28-1及jmj28-2突變體在長日照及短日照的條件下都有延遲開花的表現型。相較於野生型，參與光週期調控開花的基因CO及FT的基因表現在jmj28突變體中有顯著性下調。過量表達JMJ28的轉殖株則表現出提早開花的表現型，並且CO及FT的基因表現有顯著上升。另外，CO上的H3K9甲基化程度在jmj28突變體中有顯著性上升，而在JMJ28的過表達轉殖株則有顯著下降。此外JMJ28會與轉錄因子FBH及TCP有交互作用。JMJ28會直接結合在CO啟動子上，而JMJ28的這種結合作用至少部分依賴於FBH。這些結果說明JMJ28可能透過調控H3K9去甲基化的方式來影響CO基因表現，並參與阿拉伯芥開花調控。 | zh_TW |
| dc.description.abstract | Histone demethylases (HDMs) play important roles in plant growth and development by modulating epigenetic processes. The histone demethylase JMJ28 belongs to the KDM3/JDHM2 group and has H3K9 demethylation activity. In this study, it was found that the JMJ28 knockout mutants, jmj28-1 and jmj28-2, displayed late flowering phenotypes under both long day and short day conditions. The expression of CO and FT was down regulated in jmj28 mutants. Overexpression of JMJ28 resulted in an early flowering phenotype and increased expression of CO and FT. In addition, the H3K9me2 level of CO near the transcription start site was increased in the jmj28 mutants but decreased in the JMJ28 overexpressing transgenic plants. Furthermore, JMJ28 can interact with the transcription factors, FBHs and TCPs. Moreover, JMJ28 can target on the CO promoter, and the binding of JMJ28 to CO is at least partially dependent on FBHs. Together, these results suggest that JMJ28 is involved in the flowering time by regulating the expression of CO through H3K9 demethylation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T09:05:51Z (GMT). No. of bitstreams: 1 ntu-109-R06b42015-1.pdf: 2896414 bytes, checksum: 905ae05ff71db3295cf9d3ad1c780bf5 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF SUPPLEMENTARY FIGURES ix LIST OF TABLES x LIST OF ABBREVIATIONS xi Chapter 1 Introduction 1 1.1 Histone methylation 1 1.2 Histone lysine demethylases in Arabidopsis 2 1.3 Regulation of flowering time in Arabidopsis 6 1.4 Regulation of flowering time by histone lysine demethylases 8 Chapter 2 Materials and Methods 12 2.1 Plant materials 12 2.2 Plasmid construction 12 2.3 Generating transgenic lines 13 2.4 Quick DNA extraction 14 2.5 RNA Extraction, DNase treatment and reverse transcription 14 2.6 Real-time PCR analysis 17 2.7 Chromatin immunoprecipitation assays 18 2.8 Transfection of tobacco leaves by Agrobacterium 25 2.9 Protoplast transformation 26 2.10 Co-Immunoprecipitation assays 29 Chapter 3 Results 32 3.1 jmj28 mutants are late flowering 32 3.2 JMJ28 is involved in the photoperiodic flowering pathway by regulating CO 32 3.3 JMJ28 overexpressing plants are early flowering 33 3.4 JMJ28 activates CO by regulating H3K9me2 34 3.5 JMJ28 interacts with FBHs 35 3.6 JMJ28 can be recruited by FBH proteins and target to CO promoter 37 3.7 JMJ28 and FBHs act together to regulate gene expression 38 Chapter 4 Discussion 40 4.1 JMJ28 activates CO expression by H3K9me2 demethylation 40 4.2 The binding of JMJ28 on the CO locus may be dependent on FBH proteins 41 4.3 JMJ28 may participate in both the photoperiod and autonomous pathways 42 4.4 Different histone lysine demethylases play distinguished roles in flowering time control 44 FIGURES 46 SUPPLEMENTARY FIGURES 67 TABLES 72 REFERENCES 76 | |
| dc.language.iso | en | |
| dc.subject | 組蛋白修飾 | zh_TW |
| dc.subject | 組蛋白去甲基?JMJ28 | zh_TW |
| dc.subject | CO | zh_TW |
| dc.subject | FBH | zh_TW |
| dc.subject | 開花時間 | zh_TW |
| dc.subject | Histone modifications | en |
| dc.subject | JMJ28 | en |
| dc.subject | CO | en |
| dc.subject | FBH | en |
| dc.subject | flowering time | en |
| dc.title | 阿拉伯芥組蛋白去甲基化酶JMJ28藉由促進CONSTANS表達參與開花調控 | zh_TW |
| dc.title | Arabidopsis histone demethylase JMJ28 regulates flowering time by activating CONSTANS expression | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 鄭貽生,洪傳揚,張孟基,陳柏仰 | |
| dc.subject.keyword | 組蛋白修飾,組蛋白去甲基?JMJ28,CO,FBH,開花時間, | zh_TW |
| dc.subject.keyword | Histone modifications,JMJ28,CO,FBH,flowering time, | en |
| dc.relation.page | 84 | |
| dc.identifier.doi | 10.6342/NTU202000106 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2020-01-14 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 植物科學研究所 | zh_TW |
| 顯示於系所單位： | 植物科學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-109-1.pdf 未授權公開取用 | 2.83 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。