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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72195完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林啟萬(Chii-Wann Lin) | |
| dc.contributor.author | Jian-Min Chen | en |
| dc.contributor.author | 陳建民 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:28:15Z | - |
| dc.date.available | 2021-08-21 | |
| dc.date.copyright | 2018-08-21 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-08-16 | |
| dc.identifier.citation | [1] Bhadra, N., Lahowetz, E.A., Foldes, S.T., and Kilgore, K.L.: ‘Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons’, Journal of computational neuroscience, 2007, 22, (3), pp. 313-326
[2] Bhadra, N., and Kilgore, K.: ‘High-frequency nerve conduction block’, in Editor (Ed.)^(Eds.): ‘Book High-frequency nerve conduction block’ (IEEE, 2004, edn.), pp. 4729-4732 [3]王昭閔, and 王顏和: ‘電刺激於脊髓損傷患者排尿功能障礙之應用’, 台灣復健醫學雜誌, 2009, 37, (1), pp. 1-17 [4] Stewart W, Van Rooyen JB, Cundiff G et al: Prevalence and burden of overactive bladder in the united States. World J Urol 2003; 20: 327. [5] Yu HJ, Liu CY, Lee KL, Lee WC, Chen TH: Overactive bladder syndrome among community- dwelling adults in Taiwan: prevalence, correlates, perception, and treatment seeking. Urol Int 2006; 77:327-33. [6] 劉馨慈 (2017). 原發性膀胱過動症:致病機制與生物標誌及肉毒桿菌毒素A療效機轉. 藥理暨毒理學碩士班/博士班. 花蓮縣, 慈濟大學. 博士: 130. [7] Frazier, Elfaridah P., Tim Schneider, and Martin C. Michel. 'Effects of gender, age and hypertension on β-adrenergic receptor function in rat urinary bladder.' Naunyn-Schmiedeberg's archives of pharmacology 373.4 (2006): 300-309. [9] Letcher, Frank S., and Sidney Goldring. 'The effect of radiofrequency current and heat on peripheral nerve action potential in the cat.' Journal of neurosurgery 29.1 (1968): 42-47. [9] Cahana, Alex, et al. 'Pulsed radiofrequency: current clinical and biological literature available.' Pain Medicine 7.5 (2006): 411-423. [10] Kanpolat, Yücel, et al. 'Percutaneous controlled radiofrequency trigeminal rhizotomy for the treatment of idiopathic trigeminal neuralgia: 25-year experience with 1600 patients.' Neurosurgery48.3 (2001): 524-534. [11] Leclaire, Richard, et al. 'Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy.' Spine 26.13 (2001): 1411-1416. [12] Barendse, Gerard AM, et al. 'Randomized controlled trial of percutaneous intradiscal radiofrequency thermocoagulation for chronic discogenic back pain: lack of effect from a 90-second 70 C lesion.' Spine 26.3 (2001): 287-292. [13] McDonald, Greg J., Susan M. Lord, and Nikolai Bogduk. 'Long-term follow-up of patients treated with cervical radiofrequency neurotomy for chronic neck pain.' Neurosurgery 45.1 (1999): 61-68. [14] Rossi, S., et al. 'Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer.' AJR. American journal of roentgenology 167.3 (1996): 759-768. [15] Sluijter, Menno E., and Maarten van Kleef. 'Characteristics and mode of action of radiofrequency lesions.' Current Review of pain 2.3 (1998): 143-150. [16] Sluijter, M., and G. Racz. 'Technical aspects of radiofrequency.' Pain practice 2.3 (2002): 195-200. [17] Munglani, Rajesh. 'The longer term effect of pulsed radiofrequency for neuropathic pain.' Pain 80.1-2 (1999): 437-439. [18] Geurts, J. W. M., et al. 'Radiofrequency treatments in low back pain.' Pain Practice 2.3 (2002): 226-234. [19] Lin, M‐L., et al. 'Pulsed radiofrequency inhibited activation of spinal mitogen‐activated protein kinases and ameliorated early neuropathic pain in rats.' European Journal of Pain 18.5 (2014): 659-670. [20] Sluijter, Menno E., and Farnad Imani. 'Evolution and mode of action of pulsed radiofrequency.' Anesth Pain Med 2.4 (2013): 139-41. [21] Kruse, M. N., A. L. Belton, and W. C. De Groat. 'Changes in bladder and external urethral sphincter function after spinal cord injury in the rat.' American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264.6 (1993): R1157-R1163. [22] Hypolite, Joseph A., et al. 'Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms.' BMC urology 15.1 (2015): 34. [23] 林威佐 (2017). 經皮脈衝射頻電刺激於病理性神經疼痛之止痛效果研究. 生醫電子與資訊學研究所. 台灣大學. 博士論文. [24] 宋柏憲（2017）, 以脈衝射頻電刺激抑制腎動脈狹窄引發高血壓之確效研究.醫學工程研究所.台灣大學. 碩士論文. [25] Kaya, S., et al. (2011). 'Comparison of different treatment protocols in the treatment of idiopathic detrusor overactivity: a randomized controlled trial.' Clinical rehabilitation 25(4): 327-338. [26] William, C. 'The time-frequency analysis of the pudendo-to-pudendal nerve and pelvic-to-pudendal nerve reflexes in anesthetized intact rats.' Journal of Medical and Biological Engineering 24.1 (2004): 17-22. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72195 | - |
| dc.description.abstract | 膀胱過動症患者在台灣盛行率為16.9%，隨著年齡的增加，老年人口有膀胱過動症的比例高達28.2%，膀胱過動症不僅對病患的社交、生活品質造成影響，若長時間處在膀胱排尿功能過動與失調的病症下，容易造成腎臟及輸尿管水腫和腎功能病變，慢性排尿障礙將有可能導致尿道感染、尿失禁，嚴重甚至引發腎衰竭而致死。因此，排尿障礙的病患是不容忽視的問題。因此電刺激調控是一種替代的新治療發展方向。
高頻阻斷技術利用高頻(>1kHz)之震盪電流施予神經束，而快速地造成此神經路徑傳遞阻斷且具低傷害性的電刺激技術，先前文獻進行模擬來驗證其運作機制，於哺乳動物髓鞘神經施以高頻電流，會造成神經膜電位呈現動態穩定的去極化現象而達到高頻阻斷之功能 [1]，此技術目前已於動物神經肌肉標本實驗中，證實其高頻電流可以有效地阻斷神經傳遞而造成肌肉放鬆[2][Bhadra, 2004 #12]。 本研究使用脈衝式射頻電刺激(射頻頻率500KHz、脈衝頻率2Hz、脈衝持續時間80ms、電壓±3V)，在骨盆神經進行電刺激，於神經反射傳導之實驗結果得出參考於臨床之PRF電刺激參數，對於較細小之骨盆神經無造成明顯損傷，尿路動力學實驗結果證實骨盆神經在經過射頻電刺激的達到神經訊號阻斷效果，膀胱過度收縮的狀況得到改善，並且單次五分鐘的脈衝射頻電刺激後，膀胱過動症狀之原發性高血壓SHR鼠排尿效率從30%上升至一週的56%與第二週43%。經過PRF於下泌尿道之電刺激，顯示於兩週後仍然有改善效果，本實驗結果如延續到臨床上，將有助益於治療膀胱過動症以及頻尿的患者。 | zh_TW |
| dc.description.abstract | Overactive bladder affects physical functioning, social functioning and quality of life. And chronic voiding dysfunction will likely lead to urinary tract infections, incontinence, severe and even lead to kidney failure or death. So, patients with voiding dysfunction is the problem can not be ignored.
The aim of this research was to develop a new electrical stimulation method for improving overactive bladder and verify its effect in animal experiments. This study demonstrated the use of low-volt pulsed radio frequency electrical stimulation (frequency 500KHz, pulse frequency 2Hz, pulse duration 80msec, amplitude ±3V) as a method to reduce bladder contractions by electrical stimulation on pelvic nerve. Overactive bladder syndrome will improve with pelvic electrical stimulation therapy. Thus, this results may provide a new approach for treating patients with overactive bladder. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T06:28:15Z (GMT). No. of bitstreams: 1 ntu-107-R05945031-1.pdf: 4084698 bytes, checksum: 939699c9ab8acdeebba8849ceba82b93 (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 目錄i
圖表目錄iii 中文摘要 iv 英文摘要v 第一章 研究背景與目的1 1.1下泌尿系統與其神經控制路徑 1 1.2 共濟失調與膀胱過動症 4 1.3 現行治療方式6 1.4 射頻與脈衝射頻電刺激10 1.4.1射頻電刺激10 1.4.2脈衝射頻電刺激11 1.5 研究動機與目標13 第二章 研究材料與實驗方法14 2.1 實驗系統15 2.1.1 實驗設備15 2.1.2 系統架構20 2.2 動物實驗21 2.2.1 骨盆神經電刺激22 2.2.2 尿路動力學實驗23 2.3 資料分析24 第三章 結果與討論26 3.1 實驗結果26 3.1.1 原發性高血壓鼠之排尿功能26 3.1.2 電刺激後之排尿功能影響31 3.1.3神經反射傳導速度差異36 3.2 討論40 第四章 結論與展望42 參考文獻44 附錄48 | |
| dc.language.iso | zh-TW | |
| dc.subject | 膀胱過動症 | zh_TW |
| dc.subject | 脈衝射頻電刺激 | zh_TW |
| dc.subject | 骨盆神經 | zh_TW |
| dc.subject | 神經反射傳導速度 | zh_TW |
| dc.subject | Pelvic nerve | en |
| dc.subject | Pulsed radio frequency | en |
| dc.subject | Overactive Bladder | en |
| dc.subject | Neuronal response latency | en |
| dc.title | 脈衝射頻電刺激對於自發性高血壓鼠排尿功能之影響 | zh_TW |
| dc.title | Effects of Pulsed Radio Frequency Neuromodulation on Bladder Function in Spontaneously Hypertensive Rat | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 彭志維(Chih-Wei Peng) | |
| dc.contributor.oralexamcommittee | 郭柏齡(Po-Ling Kuo),林木鍊(Mu-Lien Lin) | |
| dc.subject.keyword | 脈衝射頻電刺激,膀胱過動症,骨盆神經,神經反射傳導速度, | zh_TW |
| dc.subject.keyword | Pulsed radio frequency,Overactive Bladder,Pelvic nerve,Neuronal response latency, | en |
| dc.relation.page | 53 | |
| dc.identifier.doi | 10.6342/NTU201803729 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-08-17 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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