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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳示國 | |
| dc.contributor.author | Po-Yu Liao | en |
| dc.contributor.author | 廖柏喻 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:02:21Z | - |
| dc.date.available | 2024-02-13 | |
| dc.date.copyright | 2019-02-13 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-01-30 | |
| dc.identifier.citation | Abbott, S. B. G. and C. B. Saper (2018). 'Role of the median preoptic nucleus in the autonomic response to heat-exposure.' Temperature 5(1): 4-6.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71519 | - |
| dc.description.abstract | 在哺乳動物之視網膜中，自主感光視神經細胞透過視黑質自身感光，並對於藍光最為敏感，其對於動物的生理時鐘，荷爾蒙恆定，瞳孔反射及認知行為當中，扮演相當重要的角色。在群居生活當中，社交行為扮演非常重要的一環，尤其對個體間至族群，社會結構的影響。而在過去人類研究當中，光線能影響我們在認知的行為表現，而究竟日常生活當中，環境的光線是如何影響我們的社交行為，其機制尚未明瞭，因此，我們結合不同基因轉殖鼠及行為學等實驗方式，探索其中的大腦神經迴路。從我們的研究結果發現，在接受一小時光照刺激後，小鼠的短期社交記憶表現受到影響，當部分自主感光視神經細胞亞型被去除時，小鼠的社交記憶形成則不受光線影響。此外，我們也發現神經性荷爾蒙催產激素可能參與其調控，催產素神經活性也可能間接的受到來自光線的刺激而改變其活性。綜合以上結果，自主感光視神經細胞及催產激素在光線調控小鼠社交記憶神經迴路中皆扮演舉足輕重的角色，然而，這些研究成果也為未來光線如何調控社交行為打開一道曙光。 | zh_TW |
| dc.description.abstract | In mammalian’s retinas, intrinsically photosensitive retinal ganglion cells (ipRGCs) can directly sense environmental light through photopigment melanopsin, which is most sensitive to blue light wavelength, independent of rods and cones. It has been shown that ipRGCs are important for circadian photoentrainment, pupil light reflex, sleep and mood regulation. In colony formation, social behavior plays a critical role between individuals, groups and social structure. It has been shown that light could influence the cognition functions in humans such as awareness and perception. However, the detail neural circuits for how external light influences our social behavior remains unclear. To test whether light could modulate social behavior, we combined different transgenic mouse lines and several behavior tests to investigate the neural circuits in the brain. Here we observed that one-hour light pulse could decrease sociosexual memory in mice. Genetically elimination of ipRGCs could block the light-dependent reduction of sociosexual memory. Moreover, application of oxytocin antagonist could also block the sociosexual memory, suggesting that oxytocin may involve in light-dependent modulation of sociosexual memory. In summary, it is likely that ipRGCs could transmit light information to modulate the release of oxytocin which influences sociosexual memory acquisition. These results provide novel direction to study how light influence the formation of sociosexual memory. | en |
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| dc.description.tableofcontents | Contents
謝誌 i 中文摘要 iii Abstract iv Anatomical Abbreviations vi Contents xv Chapter I 1 Introduction 1 1.1 Connection between external light and social behavior 1 1.2 Social interaction, memory and recognition 2 1.3 Intrinsically photosensitive retinal ganglion cells (ipRGCs) 5 1.3.1 General description of ipRGCs 5 1.3.2 Subtypes of ipRGCs and its projection sites 6 1.4 Oxytocin in mammals 8 1.4.1 General description of oxytocin 8 1.4.2 Oxytocin release and neuron innervation in mouse brain 10 1.4.3 Daily concentration of oxytocin changes and light regulation 11 1.4.4 Oxytocin in social memory and social interaction 13 1.4.5 Investigation of oxytocin neuron whole brain innervation in mice 14 Statement of purpose 19 Chapter II 21 Materials and methods 21 2.1 Animals 21 2.2 Genotyping 21 2.2.1 DNA extraction 21 2.2.2 Polymerase chain reaction (PCR) 22 2.3 General two-trial social memory test and experimental design 22 2.5 Three-chamber test 25 2.6 Novel object recognition test 26 2.7 Oxytocin receptors antagonist infusion and behavior test 27 2.7.1 Stereotactic unilateral cannulation 27 2.7.2 Intracerebroventricular (i.c.v) injection and social memory test 28 2.8 Social encounter and immunohistochemistry staining 28 2.9 Brain and both eyes virus injection 30 2.9.1 General stereotactic virus injection procedures 30 2.10 Chemogenetic experiment 31 2.10.1 Pharmacological ipRGCs stimulation experiment 31 2.10.2 CNO administration and behavior test 31 2.11 Oxytocin ELISA 32 2.11.1 WT mice samples collection 32 2.11.2 Oxytocin ELISA 33 2.12 Data analysis 33 2.13 Oxytocin neuron whole brain innervation in mouse brain 34 2.13.1 Animals and care 34 2.13.2 Alkaline phosphatase staining 35 2.13.3 Analysis 36 Chapter III 37 Results 37 3.1 Light history impairs social memory in mice 37 3.2 Light effect at different level of familiarity between paired subjects 38 3.3 Light effect results from the social memory formation in first social encounter 39 3.4 Light history impairs social memory exists sexual dimorphic 41 3.5 M1 Brn3b positive ipRGCs were involved in light impairs social memory formation prominently 41 3.6 Oxytocin signaling involves in social memory formation 43 3.7 Light inhibits oxytocin neuron activation in SON after social encounter 44 3.8 Chemogenetic method for mimicking light pulse in melanopsin knockout mice 45 3.9 Oxytocin neuron manipulation in SON 45 3.10 Oxytocin neuron whole brain innervation in mouse 46 3.10.1 Labeling Oxytocin neurons with cre and reporter mouse 46 3.10.2 Oxytocin neurons in the hypothalamic area 47 3.10.3 Fibers of oxytocin neurons in the hypothalamus region 48 3.10.4 Interbrain pallidum and thalamic area 50 3.10.5 Striatum 50 3.10.6 Midbrain 51 3.10.7 Hindbrain and medulla 52 3.10.8 Cortex and olfactory areas 53 Chapter IV 55 Discussion 55 4.1 Light for motor activity and social behavior in mice 55 4.2 Melanopsin dependent social interaction ability was dramatically elevated 57 4.3 Circadian regulates memory and recognition 58 4.4 Light and oxytocin concentration in mice 59 4.5 Oxytocin neuron activity regulation after light stimulation 60 4.6 Different distributions of the presenting OXTR neuron input process might contribute to sexual dimorphism in short-term social memory and social interaction 62 4.7 Pheromones and light effect on social interaction 64 4.8 Oxytocin modulation in medial amygdala might involve in olfactory cue processing and influence social memory formation source from external light indirectly 66 4.9 Oxytocin neuron innervation in mouse 67 4.9.1 Comparison to previous reports 67 4.9.2 Innervation in hypothalamic area 70 4.9.3 Innervation in pallidum and limbic system 74 4.9.4 Innervation in basal ganglia 76 4.9.5 Innervation in cortical and olfactory areas 77 4.9.6 Innervation in thalamus 79 4.9.10 Innervation in midbrain 79 4.9.11 Innervation in hindbrain and medulla 80 Implications of this study 82 References 83 Figures 97 Figure 1: Transgenic mice were used in this study 97 Figure 2: Sociosexual behavior test paradigm 98 Figure 3: Day-light lamp stimulus influence the social memory in mice 99 Figure 4: Day-light lamp stimulus influence the social memory in mice 100 Figure 5: LED light stimulus influence the social memory in mice 101 Figure 6: LED light stimulus influence the social memory in mice 102 Figure 7: Circadian and light regulate social memory in mice 103 Figure 8: Light history didn’t affect social memory at male to male mice 104 Figure 9: Social memory have no influence in male to male after LED light stimulation 105 Figure 10: Light influences social memory formation after social affiliation but not memory consolidation 106 Figure 11: Light impairment survive under infrared light recording 107 Figure 12: Light didn’t affect mice short-term social memory by performing three-chamber test 109 Figure 13: Light didn’t affect mice non-social novel recognition 110 Figure 14: Melanopsin expressing ipRGCs are important for social memory formation 111 Figure 15: Melanopsin expressing ipRGCs are important for social memory formation 112 Figure 16: Partially M1 ipRGCs attend in light modulates social memory 113 Figure 17: Partially M1 ipRGCs attend in light modulates social memory 114 Figure 18: Partially non-M1 and Brn3b+ ipRGCs attend in light modulates social memory 115 Figure 19: Brn3b+ ipRGCs attend in light modulates social memory 116 Figure 20: Survive ipRGCs present normal social memory formation 117 Figure 21: Transgenic mice under opn4 locus present higher interaction versus female but not social memory ability difference 118 Figure 22: Intracerebroventricular cannulation 119 Figure 23: Oxytocin receptors antagonist administration before encounter impairs social memory formation 120 Figure 24: Light inhibits oxytocin neuron activation after social encounter in the SON 122 Figure 25: ipRGCs activity manipulation by DREADDs 124 Figure 26: Oxytocin neuron manipulation in the SON and behavior test 125 Figure 27: Retinal projection in the pSON 126 Figure 28: Oxytocin plasma concentration in different circadian timing 127 Figure 29: Diagram of neural circuits that light modulates social memory in mice through ipRGCs and OXT neuron 128 Figure 30: Mapping of AP expression under oxytocin promoter 132 Figure 31: Innervation and cell bodies location in the hypothalamus and piriform cortex 134 Figure 32: Sagittal view of oxytocin neuron in hypothalamus 136 Figure 33: Innervation and cell bodies location in the medial/ lateral hypothalamus 137 Figure 34: Innervation and cell bodies location in the preoptic area and pallidum 138 Figure 35: Innervation in amygdala and thalamus 139 Figure 36: Innervation in central and medial amygdala subregions of pallidum and arcuate nucleus in hypothalamus 140 Figure 37: Innervation in the preoptic area and pallidum 141 Figure 38: Innervation in midbrain area and hypothalamic 142 Figure 39: Innervation in periaqueductal nucleus and inferior colliculus 143 Figure 40: Innervation in midbrain and medulla 144 Figure 41: Innervation in diagonal band and septum area 146 Figure 42: Innervation in the nucleus accumbens 147 Figure 43: Innervation in prefrontal cortex and olfactory area 148 Tables 149 Table. 1 Oxytocin neuron cell body location and projection sites in mouse. 149 Table. 2 List of transgenic mouse primers. 151 Appendix 152 Abstracts and posters 152 Matlab code for videos analysis 159 | |
| dc.language.iso | en | |
| dc.title | 光線藉由自主感光視網膜神經細胞調控小鼠社交記憶 | zh_TW |
| dc.title | Light history modulates social memory in mice through intrinsically photosensitive retinal ganglion cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 王致恬,周銘翊,連正章 | |
| dc.subject.keyword | 自主感光視神經細胞,視黑質,社交記憶,社交行為,催產激素, | zh_TW |
| dc.subject.keyword | ipRGCs,melanopsin,social memory,social behavior,oxytocin, | en |
| dc.relation.page | 160 | |
| dc.identifier.doi | 10.6342/NTU201900276 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-01-30 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生命科學系 | zh_TW |
| 顯示於系所單位： | 生命科學系 | |
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