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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71417完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林晃巖 | |
| dc.contributor.author | Ling-Hsuan Tsai | en |
| dc.contributor.author | 蔡陵萱 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:00:22Z | - |
| dc.date.available | 2029-02-12 | |
| dc.date.copyright | 2019-02-19 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-02-12 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71417 | - |
| dc.description.abstract | 光學同調斷層掃描光學系統是近年來其中一種非常具有潛力的造影診斷的光學技術．此項技術在次波長的解析度下可以快速而且有效率的提供生物樣本的縱向結構，這樣的優點在生物醫學領域中可以快速的診斷並且提高治療率。在傳統的光學同調斷層掃描的系統中是以麥克森干涉儀為基本的光學架構，所提供的訊號主要來自系統參考端上反射回來的光訊號和樣品端背向散射返回的背向散射訊號進行干涉所產生之干涉訊號．此光學系統中，光源特定選擇低同調光源以使系統得以達到高解析度的優勢。除此之外，在光學同調斷層掃描系統中，優點在於可以提供活體生物樣本的縱向剖面的二維縱向結構資訊，更進一步結合二維資訊可以清楚的提供整個待測樣本的三維結構而不具有破壞性．因此此光學造影技術成為近年來非常熱門的診斷技術之一。
在研究中，我們將焦點著重在如何從所量測到的光學同調訊號中萃取出我們想要的光學散射資訊，由於精確的分析及量化樣本中所存在的光學資訊仍屬於一個非常具有挑戰的議題，因此近年來在此領域的研究也相當熱門。此研究內容中，我們利用了不同尺寸二氧化鈦奈米粒子薄膜作為待測物替代生物樣本先進行研究．在光學同調系統中所測得之光學散射特性裡，其中包含單重散射及多重散射。接著利用衍伸型惠更斯原理代入光學參數，可以得到在待測樣本中單重散射及多重散射所提供之比例，此項分析功能可以應用於非生物領域中進行快速的量測技術。更進一步，為了更精準的獲得及量化光學散射資訊。我們將光學同調斷層掃描系統結合時域有限差分法的模擬方式，發展出一個新的分析流程。此模擬方式可以提供在樣本中產生複雜光子交互作用的近場和遠場圖。作為第三方的分析輔助工具獲取非均向散射因子，再進一步利用衍生型惠更斯原理計算出待側物的散射係數。以上內容將在此論文中一一討論。 | zh_TW |
| dc.description.abstract | Optical Coherence Tomography (OCT) system is one of a potential image diagnostic technique to explore the diversity in bio-cell for subwavelength structures (microstructure) or quickly diagnosing the diseases for improving the cure rate in biomedical fields. In general OCT, the OCT signals against depth can mainly provide by measuring interference patterns from reference arm and the backscattering light of samples at optical system, and the high axial resolution can be provided with low coherence light source. The features of OCT can approach the cross-section images techniques (2D) or 3D-image by combining A-scans (axial, mode) and B-scans （lateral, mode）to clearly obtain the axial microstructures for biological tissues. In the field for extracting the optical information of measured sample within the OCT signal have been a popular issue recently. In this work, we are going to study this issue and corresponding applications by mainly utilized the mesoporous TiO2 beads films with diameter size for 20, 150, 300, and 500 nm as our non-biological sample and discuss the optical scattering properties of single- and multiple- scattering effects. With the extended Huygens Fresnel theory, the contribution of single- and multiple- scattering composition can be provided. Further, for precisely distinguishing and quantifying the optical properties of scattering coefficient in measured samples, we provide a new analysis flow combining the FDTD simulation method with OCT. The light scattering interactions in near- and far-field patterns between adjacent TiO2 beads can be determined and show in FDTD simulation method to identify the two optical parameters of anisotropy g factor and scattering coefficient in EHF model. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T06:00:22Z (GMT). No. of bitstreams: 1 ntu-108-D99941001-1.pdf: 7629338 bytes, checksum: 15e410a4d86cabbec75953698c81d050 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 ii ABSTRACT iv CONTENTS v LIST OF FIGURES viii LIST OF TABLES xiii Chapter 1 Introduction and Background 1 1.1 Overview 1 1.2 Motivation 8 1.3 Content 11 Chapter 2 The Fundamental Theory 13 2.1 Spectral/Fourier domain OCT 13 2.2 Signal Processing 18 2.2.1 Recalibration (Re-sampling) 18 2.2.2 Axial resolution and imaging depth in OCT system 19 2.2.3 Lateral resolution in OCT system 22 2.3 Spectrometer design 25 2.3.1 Diffraction gratings 25 2.3.2 Light source of OCT system 27 2.4 Noise and Sensitivity (SNR) 28 2.4.1 Shot noise limit 29 2.4.2 Excess Photon Noise 30 2.4.3 Receiver Noise (CCD Noise) 31 Chapter 3 Method and Experimental Setup 34 3.1 Spectral domain OCT system setup (SD-OCT) 34 3.2 Preparation of mesoporous TiO2 beads samples 36 3.3 Scattering properties 37 3.3.1 Mie scattering model (Single scattering effect) 37 3.3.2 Multiple scattering effect 41 3.4 Extended-Huygens Fresnel model 41 3.5 Finite-difference time-domain method (FDTD) 43 Chapter 4 Size-Dependent Multiple-Scattering Effects of Mesoporous TiO2 Beads Distinguished by Optical Coherence Tomography 47 4.1 Overview 47 4.2 Results and Discussions 48 4.2.1 Characterization of mesoporous TiO2 beads 48 4.2.2 Diffused reflectance spectrum of mesoporous TiO2 samples 49 4.2.3 Determination of multiple scattering effects 51 4.3 Summary 57 Chapter 5 Scattering coefficient quantification on Optical Coherence Tomography combined with FDTD simulation method for multiple scattering effect 59 5.1 Overview 59 5.2 Results and discussions 60 5.2.1 Scattering phase function of single TiO2 bead simulated by FDTD 60 5.2.2 Inter-particle spacing effects of near-field scattering patterns 61 5.2.3 Inter-particle distance effects dependent Phase function 62 5.2.4 Anisotropy factors g with different inter-particle spacing 65 5.2.5 Fitting the optical scattering properties in EHF theory 66 5.3 Summary 70 Chapter 6 Conclusions and Future Works 71 6.1 Conclusions 71 6.2 Future Works 72 REFERENCES 74 | |
| dc.language.iso | en | |
| dc.subject | 光學同調斷層掃描技術 | zh_TW |
| dc.subject | 散射性質 | zh_TW |
| dc.subject | 米氏散射 | zh_TW |
| dc.subject | 單重散射 | zh_TW |
| dc.subject | 多重散射 | zh_TW |
| dc.subject | 衍生型惠更斯原理 | zh_TW |
| dc.subject | Optical coherence tomography | en |
| dc.subject | Scattering effect | en |
| dc.subject | Extended Huygens Fresnel model | en |
| dc.subject | Single- and Multiple-scattering effect | en |
| dc.subject | Mie scattering model | en |
| dc.title | 低同調光學干涉系統應用於材料散射量測特性之研究 | zh_TW |
| dc.title | Optical scattering properties analyzed by Low Coherence Tomography system | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.coadvisor | 吳忠幟 | |
| dc.contributor.oralexamcommittee | 黃升龍,黃定洧,李翔傑 | |
| dc.subject.keyword | 光學同調斷層掃描技術,散射性質,衍生型惠更斯原理,多重散射,單重散射,米氏散射, | zh_TW |
| dc.subject.keyword | Optical coherence tomography,Scattering effect,Extended Huygens Fresnel model,Single- and Multiple-scattering effect,Mie scattering model, | en |
| dc.relation.page | 82 | |
| dc.identifier.doi | 10.6342/NTU201900435 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-02-12 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
| 顯示於系所單位： | 光電工程學研究所 | |
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