以鈉離子為模板經夾鎖法合成非共軛醯胺與尿素之車輪烷研究

Abstract

第一部分：以鈉離子為模板經夾鎖法合成非共軛醯胺與尿素之車輪烷研究 我們以鈉離子為模板，引導二胺分子與二醛分子形成具亞胺之大環分子，並且和具有單一尿素基團或醯胺基團之客體分子藉由夾鎖法合成出準車輪烷分子，最後將亞胺鍵還原並純化後可得到穩定且具有胺基的車輪烷分子。 第二部分：尺寸效應對於以鹼金族離子模板導引法合成含寡乙二醇鏈的[2]交環烷效率之影響探討 以鈉離子模板導引法提高合成交環烷產率的策略在此研究中被更進一步地探究，我們變換不同大小的鹼金族離子並與不同長度的含寡乙二醇鏈之二胺分子混合，使其與二醛分子反應，而能成功合成出含不同元件的[2]交環烷，同時比較產率，找出各自最適當大小的鹼金族離子模板。

Part I: Rotaxanes Synthesized Through Sodium-Ion-Templated Clipping of Macrocycles Around Nonconjugated Amide and Urea Functionalities A single urea or amide functionality in a dumbbell-shaped guest can be “clipped” by a macrocycle generated from a diamine and a dialdehyde through the templating effect of a Na+ ion (see scheme). The resulting imine-containing rotaxanes can then be reduced to allow the isolation of stable amine-based rotaxanes. Part II: Size Effects in the Alkali Metal Ion-Templated Formation of Oligo(Ethylene Glycol)-Containing [2]Catenanes. An investigation into the most suitable alkali metal ions for templating the assembly of [2]catenanes from di-, tri-, and tetra(ethylene glycol)-containing guest diamines and isophthalaldehyde has indicated that Na+, K+, and Rb+ ions are optimal for preparing [2]catenanes containing at least one di(ethylene glycol) unit, two tri(ethylene glycol) units, and at least one tetra(ethylene glycol) unit [in the absence of a di (ethylene glycol) unit], respectively.