請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70685
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江俊斌 | |
dc.contributor.author | Yang-Che Wu | en |
dc.contributor.author | 巫仰哲 | zh_TW |
dc.date.accessioned | 2021-06-17T04:34:52Z | - |
dc.date.available | 2018-09-04 | |
dc.date.copyright | 2018-09-04 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-09 | |
dc.identifier.citation | X. References
Aynali G, Ozkan M, Aynali A, et al. The evaluation of serum vitamin B12, folic acid and hemoglobin levels in patients with recurrent minor aphthous stomatitis. Kulak Burun Bogaz Ihtis Derg 2013; 23: 148-52. Barnadas MA, Remacha A, Condomines J, de Moragas JM. Hematologic deficiencies in patients with recurrent oral aphthae. Med Clin (Barc) 1997; 109: 85-7. Burgan SZ, Sawair FA, Amarin ZO. Hematologic status in patients with recurrent aphthous stomatitis in Jordan. Saudi Med J 2006; 27: 381-4. Chang JYF, Chiang CP, Hsiao CK, Sun A. Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med 2009;38:48-54. Chang JYF, Chiang CP, Wang YP, Wu YC, Chen HM, Sun A. Anti-gastric parietal cell and anti-thyroid autoantibodies in patients with desquamative gingivitis. J Oral Pathol Med 2017;46:307-12. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A. Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. J Formos Med Assoc 2015;114:532-8. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A. Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis. J Formos Med Assoc 2015;114:736-41. Chang JYF, Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A. Hematinic deficiencies and anemia statuses in oral mucosal disease patients with folic acid deficiency. J Formos Med Assoc 2015;114:806-12. Chang JYF, Wang YP, Wu YC, Wu YH, Tseng CH, Sun A. Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive erosive oral lichen planus patients with desqamative gingivitis. J Formos Med Assoc 2016;115:860-6. Chen HM, Wang YP, Chang JYF, Wu YC, Cheng SJ. Sun A. Significant association of deficiency of hemoglobin, iron and vitamin B12 and high homocysteine level with oral lichen planus. J Formos Med Assoc 2015;114:124-9. Chiang CP, Chueh LH, Lin SK, Chen MY. Oral manifestations in human immunodeficiency virus-infected patients in Taiwan. J Formos Med Assoc 1998;97:600-5. Compilato D, Carroccio A, Calvino F, Di Fede G, Campisi G. Haematological deficiencies in patients with recurrent aphthosis. J Eur Acad Dermatol Venereol 2010;24:667-73. Dayan CM, Daniels GH. Chronic autoimmune thyroiditis. N Engl J Med 1996;335:99-107. de Benoist B. Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008;29(suppl):S238–44. Gulcan E, Toker S, Hatipoğlu H, Gulcan A, Toker A. Cyanocobalamin may be beneficial in the treatment of recurrent aphthous ulcers even when vitamin B12 levels are normal. Am J Med Sci 2008; 336: 379-82. Haisraeli-Shalish M, Livneh A, Katz J, Doolman R, Sela BA. Recurrent aphthous stomatitis and thiamine deficiency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 634-6. Harker LA, Harlan JM, Ross R. Effect of sulfinpyrazone on homocysteine induced endothelial injury and arteriosclerosis in baboons. Circ Res 1983;53:731-9. Harker LA, Slichter SJ, Scott CR, Ross R. Homocysteinemia: vascular injury and arterial thrombosis. N Engl J Med 1974;291:537-43. Hawkins BR, Ip MS, Lam KS, Ma JT, Wy CL, Yeung RT, et al. HLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hong Kong Chinese. J Neurol Neurosurg Psychiatry 1986;49:316-9. Hawkins BR, Lam KS, Ma JT, Wang C, Yeung RT. Strong association between HLA DRw9 and Hashimoto's thyroiditis in southern Chinese. Acta Endocrinol (Copenh) 1987;114:543-6. Hawkins BR, Ma JT, Lam KS, Wang CC, Yeung RT. Association of HLA antigens with thyrotoxic Graves' disease and periodic paralysis in Hong Kong Chinese. Clin Endocrinol (Oxf) 1985;23:245-52. Hayrinen-Immonen R. Immune-activation in recurrent oral ulcers (ROU). Scan J Dent Res 1992: 100: 222-7. Hayrinen-Immonen R, Nordstrom D, Malmstrom M, Hietanen J, Konttinen YT. Immune-inflammatory cells in recurrent oral ulcers (ROU). Scan J Dent Res 1991; 99: 510-8. Healy CM, Carvalho D, Pearson JD, Thornhill MH. Raised anti-endothelial cell autoantibodies (AECA), but not anti-neutrophil cytoplasmic autoantibodies (ANCA), in recurrent oral ulceration: modulation of AECA binding by tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Clin Exp Immunol 1996;106:523-8. Jontell M, Ståhlblad PA, Rosdahl I, Lindblom B. HLA-DR3 antigens in erosive oral lichen planus, cutaneous lichen planus, and lichenoid reactions. Acta Odontol Scand 1987;45:309-12. Khan NF, Saeed M, Chaudhary S, Khan NF. Haematological parameters and recurrent aphthous stomatitis. J Coll Physicians Surg Pak 2013; 23: 124-7. Kleinman DV, Swango PA, Pindborg JJ. Epidemiology of oral mucosal lesions in United States schoolchildren: 1986-87. Community Dent Oral Epidemiol 1994: 22: 243-53 Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D. Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol 2006; 27: 229-32. Kozlak ST, Walsh SJ, Lalla RV. Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis. J Oral Pathol Med 2010;39:420-3. Lahner E, Annibale B. Pernicious anemia: new insights from a gastroenterological point of view. World J Gastroenterol 2009;15:5121–8. Landesberg R, Fallon M, Insel R. Alterations of T helper/inducer and T suppressor/inducer cells in patients with recurrent aphthous ulcers. Oral Surg Oral Med Oral Pathol 1990; 69: 205-8. Lee HW, Hahm KB, Lee JS, Ju YS, Lee KM, Lee KW. Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. J Dig Dis 2009;10:265-71. Lin HP, Wang YP, Chen HM, Kuo YS, Lang MJ, Sun A. Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. J Formos Med Assoc 2013;112:319-25. Lo CC, Hsu PI, Lo GH, et al. Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome. World J Gastroenterol 2005;11:4715-20. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-77. Lopez-Jornet P, Camacho-Alonso F, Martos N. Hematological study of patients with aphthous stomatitis. Int J Dermatol 2014;53:159-63. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed, Philadelphia: Sauders Elsevier. 2009; 411. Nolan A, McIntosh WB, Allam BF, Lamey PJ. Recurrent aphthous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy. J Oral Pathol Med 1991; 20: 389-91. Olszewska M, Sulej J, Kotowski B. Frequency and prognostic value of IgA and IgG endomysial antibodies in recurrent aphthous stomatitis. Acta Derm Venereol 2006;86:332-4. Pedersen A, Klausen B, Hougen HP, Stenvang JP. T-lymphocyte subsets in recurrent aphthous ulceration. J Oral Pathol Med 1989; 18: 59-60. Piskin S, Sayan C, Durukan N, Senol M. Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol 2002; 16: 66-7. Porter SR, Scully C, Flint S. Hematologic status in recurrent aphthous stomatitis compared with other oral disease. Oral Surg Oral Med Oral Pathol 1988; 66: 41-4. Rogers RS, Sans WM, Shorter RG. Lymphocytotoxicity in aphthous stomatitis: lymphocytotoxicity for oral epithelial cells in recurrent aphthous stomatitis and Behcet syndrome. Arch Dermatol 1974; 109: 361-3. Robinson NA, Porter SR. Low frequency of anti-endomysial antibodies in recurrent aphthous stomatitis. Ann Acad Med Singapore 2004;33(4 Suppl):43-7. Safadi RA. Prevalence of recurrent aphthous ulceration in Jordanian dental patients. BMC Oral Health 2009; 9: 31. Savage NW, Mahanonda R, Seymour GJ, Bryson GJ, Collins RJ. The proportion of suppressor-inducer T-lymphocytes is reduced in recurrent aphthous stomatitis. J Oral Pathol 1988; 17: 293-7. Savage NW, Seymour GJ, Kruger BJ. T-lymphocyte subset changes in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1985; 60: 175-81. Scully C. Aphthous ulceration. N Engl J Med 2006;355:165-72. Scully C, Gorsky M, Lozada-Nur F. The diagnosis and management of recurrent aphthous stomatitis: a consensus approach. J Am Dent Assoc 2003;134:200-7. Shine JW. Microcytic anemia. Am Fam Physician 1997;55:2455-62. Ship JA. Recurrent aphthous stomatitis: An update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;81:141-7. Spence JD. Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol 2007:6:830-8. Sun A, Chang JYF, Chiang CP. Blood examination is necessary for oral mucosal disease patients. J Formos Med Assoc 2016;115:1-2. Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM, Chiang CP. Do all the patients with vitamin B12 deficiency have pernicious anemia? J Oral Pathol Med 2016;45:23-7. Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM, Chiang CP. Effective vitamin B12 treatment can reduce serum anti-gastric parietal cell antibody titer in oral mucosal disease patients. J Formos Med Assoc 2016;115:837-44. Sun A, Chen HM, Cheng SJ, Wang YP, Chang JYF, Wu YC, et al. Significant association of deficiency of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis. J Oral Pathol Med 2015;44:300-5. Sun A, Chiang CP, Chiou PS, Wang JT, Liu BY, Wu YC. Immunomodulation by levamisole in patients with recurrent aphthous ulcers or oral lichen planus. J Oral Pathol Med 1994;23:172-7. Sun A, Hsieh RP, Chu CT, Wu YC. Strong association of HLA-DRw9 in Chinese with recurrent oral ulcers. J Am Acad Dermatol 1991;24:195-8. Sun A, Hsieh RP, Liu BY, Wang JT, Leu JS, Wu YC, et al. Strong association of antiepithelial cell antibodies with HLA-DR3 or DR7 phenotype in patients with recurrent oral ulcers. J Formos Med Assoc. 2000;99:290-4. Sun A, Lin HP, Wang YP, Chiang CP. Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. J Oral Pathol Med 2012;41:500-4. Sun A, Wang YP, Lin HP, Chen HM, Cheng SJ, Chiang CP. Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. Oral Dis 2013;19:519-24. Sun A, Wang YP, Lin HP, Jia JS, Chiang CP. Do all the patients with gastric parietal cell antibodies have pernicious anemia? Oral Dis 2013;19:381-6. Sun A, Wu YC. Anti-mucosal antibodies in recurrent aphthous ulcers. J Formos Med Assoc 1989;88:122-7. Sun A, Wu YC, Hsieh RP, Kwan HW, Lu YC. Changes of T-lymphocyte subset in recurrent aphthous ulcers. J Formos Med Assoc 1987; 86: 718-22. Thongprasom K, Youngnak P, Aneksuk V. Hematologic abnormalities in recurrent oral ulceration. Southeast Asian J Trop Med Public Health 2002; 33: 872-7. Wang YP, Chang JYF, Wu YC, Cheng SJ, Chen HM, Sun A. Oral manifestations and blood profile in patients with thalassemia trait. J Formos Med Assoc 2013;112:761-5. Wang YP, Lin HP, Chen HM, Kuo YS, Lang MJ, Sun A. Hemoglobin, iron, and vitamin B12 deficiencies and high blood homocysteine levels in patients with anti-thyroid autoantibodies. J Formos Med Assoc 2014;113:155-60. Wang YP, Wu YC, Cheng SJ, Chen HM, Sun A, Chang JYF. High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients. J Formos Med Assoc 2015;114:813-9. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-50. Weusten BL, van de Wiel A. Aphthous ulcers and vitamin B12 deficiency. Neth J Med 1998; 53: 172-5. WHO/UNICEF/UNU. Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers. Geneva, Switzerland: World Health Organization; 2001. Wray D, Ferguson MM, Hutcheon WA, Dagg JH. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1978; 7: 418-23. Wu YC, Wang YP, Chang JYF, Cheng SJ, Chen HM, Sun A. Oral manifestations and blood profile in patients with iron deficiency anemia. J Formos Med Assoc 2014;113:83-7. Wu YC, Wu YH, Wang YP, Chang JYF, Chen HM, Sun A. Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. J Formos Med Assoc 2016;115:1061-8. Wu YC, Wu YH, Wang YP, Chang JYF, Chen HM, Sun A. Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. J Formos Med Assoc 2017;116:4-9. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70685 | - |
dc.description.abstract | 背景/目的:復發性口腔潰瘍(recurrent aphthous stomatitis, RAS)是一種常見發生於非角化黏膜且疼痛之口腔潰瘍疾病,部分復發性口腔潰瘍患者會合併萎縮性舌炎(atrophic glossitis, AG)。本研究之主要目的為檢驗不同型態RAS患者血清中之胃壁細胞抗體(gastric parietal cell antibody, GPCA)、甲狀腺球蛋白抗體(thyroglobulin antibody, TGA)、甲狀腺微小體抗體(thyroid microsomal antibody, TMA)出現頻率,評估AG陽性RAS (AG+/RAS) 患者及AG陰性RAS (AG-/RAS) 患者是否有貧血及補血素缺乏之情形,評估RAS合併AG或RAS疾病本身是否為造成AG+/RAS及AG-/RAS患者貧血及補血素缺乏之重要因子。
方法:本研究之主要方法為量測355位RAS患者及355位年齡、性別相符之控制組個體之平均血色素、血清鐵、維生素B12、葉酸、GPCA、TGA及 TMA濃度。 結果:我們發現13.0%、19.4% 及 19.7%之355位RAS患者,16.7%、23.3% 及 21.7%之60位大型(major-typed) RAS患者,12.2%、18.6% 及19.3%之295位小型(minor-typed) RAS患者,18.1%、20.0% 及 21.9%之160位AG+/RAS患者,及8.7%、19.0% 及 17.9%之195位AG-/RAS患者,其血清中分別有GPCA、TGA及 TMA自體抗體出現。RAS、大型RAS、小型RAS 、AG+/RAS、AG-/RAS患者之GPCA、TGA及 TMA自體抗體出現頻率,皆比健康控制組個體為高(所有P值皆< 0.001)。65位TGA/TMA陽性RAS患者有量測血清中甲狀腺刺激素(thyroid-stimulating hormone, TSH)濃度,我們發現76.9%、12.3% 及10.8%之TGA/TMA陽性RAS患者,分別有正常、較低及較高之血清TSH濃度。另外AG+/RAS及AG-/RAS患者,皆有較低之平均血色素、血清鐵及維生素B12濃度,且其血色素、血清鐵、維生素B12及葉酸缺乏頻率,皆比健康控制組個體為高。另外AG+/RAS患者有較低之平均血色素及血清鐵(只有女性患者)濃度,且其血色素及血清鐵缺乏頻率,皆比AG-/RAS患者為高。69位貧血AG+/RAS患者中,30位 (43.5%)為正常血球性貧血、23 位(33.3%)為缺鐵性貧血、16位 (23.2%)為其他型態貧血。38位貧血AG-/RAS患者中,26位 (68.4%)為正常血球性貧血、5位 (13.2%)為缺鐵性貧血、7位 (18.4%)為其他型態貧血。 結論:約三分之一RAS患者其血清中有GPCA、TGA或 TMA自體抗體存在,因為部分GPCA陽性患者,會發展成惡性貧血、自體免疫萎縮性胃炎或胃癌。部分TGA/TMA陽性患者,會引起自體免疫甲狀腺疾病,最後造成甲狀腺功能異常,因此這些GPCA、TGA或 TMA自體抗體陽性患者,必須轉診至內科檢查及治療。另外部分AG+/RAS及AG-/RAS患者有貧血及補血素缺乏情形,且AG+/RAS患者比AG-/RAS患者,有較嚴重之貧血及補血素缺乏情形。RAS合併AG或RAS疾病本身是造成AG+/RAS及AG-/RAS患者貧血及補血素缺乏之重要因子。 關鍵字:復發性口腔潰瘍、萎縮性舌炎、胃壁細胞抗體、甲狀腺球蛋白抗體、甲狀腺微小體抗體、貧血、補血素缺乏、鐵、維生素B12、葉酸 | zh_TW |
dc.description.abstract | II. Abstract
Background/Purpose: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease characterized by recurrent and painful ulcerations on the nonkeratinized oral mucosa. Some of RAS patients have concomitant atrophic glossitis (AG). The purposes of this study were to examine the frequencies of presence of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) in different types of RAS patients, to evaluate whether AG-positive RAS (AG+/RAS) patients or AG-negative RAS (AG-/RAS) patients had anemia and hematinic deficiencies, and to assess whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively. Methods: The mean blood hemoglobin (Hb) and serm iron, vitamin B12, folic acid, GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control subjects. Results: We found that 13.0%, 19.4%, and 19.7% of 355 RAS patients, 16.7%, 23.3%, and 21.7% of 60 major-typed RAS patients, 12.2%, 18.6%, and 19.3% of 295 minor-typed RAS patients, 18.1%, 20.0%, and 21.9% of 160 AG+/RAS patients, and 8.7%, 19.0%, and 17.9% of 195 AG-/RAS patients had the presence of GPCA, TGA, and TMA in their sera, respectively. RAS, major-typed RAS, minor-typed RAS, AG+/RAS, and AG-/RAS patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Of 65 TGA/TMA-positive RAS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 76.9%, 12.3%, and 10.8% of these TGA/TMA-positive RAS patients had normal, lower, and higher serum TSH levels, respectively. Moreover, both AG+/RAS and AG-/RAS patients had significantly lower mean Hb, iron, and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, vitamin B12, and folic acid deficiencies than healthy control subjects. Furthermore, AG+/RAS patients had significantly lower mean Hb and serum iron level (for women only) and significantly greater frequencies of Hb and iron deficiencies than AG-/RAS patients. Of 69 anemic AG+/RAS patients, 30 (43.5%) had normocytic anemia, 23 (33.3%) had iron deficiency anemia, and 16 (23.2%) had other types of anemia. Of 38 anemic AG-/RAS patients, 26 (68.4%) had normocytic anemia, 5 (13.2%) had iron deficiency anemia, and 7 (18.4%) had other types of anemia. Conclusions: We conclude that approximately one-third RAS patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction such as hyperthyroidism and hypothyroidism, these patients should be referred to medical doctors for further management. Moreover, some of AG+/RAS or AG-/RAS patients do have anemia and hematinic deficiencies and AG+/RAS patients do have severer anemia statuses and iron deficiency than AG-/RAS patients. RAS combined with AG or RAS itself does play a significant role in causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively. Keywords: recurrent aphthous stomatitis; atrophic glossitis, gastric parietal cell antibody, thyroglobulin antibody, thyroid microsomal antibody, anemia, hematinic deficiency, iron, vitamin B12, folic acid | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T04:34:52Z (GMT). No. of bitstreams: 1 ntu-107-D02422003-1.pdf: 684429 bytes, checksum: 3a789264ad63f81c76faa619f1e3efb4 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 口試委員會審定書 1
致謝 2 I.中文摘要 3 II. Abstract 5 III. Introduction 9 IV. Literrature review 12 A. General description for recurrent aphthous stomatitis 12 B. Immunopathogenesis of recurrent aphthous stomatitis 13 C. Autoantibodies in patients with recurrent aphthous stomatitis 17 D. Nutritional deficiencies in patients with recurrent aphthous stomatitis 19 V. Spcific goals 24 VI. Materials and methods 25 A. Subjects 25 B. Determination of serum gastric parietal cell antibody level 26 C. Determination of serum thyroglobulin or thyroid microsomal antibody level 27 D. Determination of complete blood count and serum iron, vitamin B12, folic acid, and homocysteine concentrations 28 E. Statistical analyses 28 VII. Results 30 A. Gastric parietal cell and thyroid autoantibodies in patients with recurrent aphthous stomatitis 30 B. Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis 32 VIII. Discussion 35 A. Gastric parietal cell and thyroid autoantibodies in patients with recurrent aphthous stomatitis 35 B. Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis 40 IX. Conclusions 45 X. References 47 XI. Tables 56 XII. Appendix 64 A. Curriculum Vita 64 B. Publications 65 | |
dc.language.iso | en | |
dc.title | 復發性口腔潰瘍患者之自體抗體、貧血及補血素缺乏研究 | zh_TW |
dc.title | Autoantibodies, anemia, and hematinic deficiencies in patients with recurrent aphthous stomatitis | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 陳信銘,孫安迪 | |
dc.contributor.oralexamcommittee | 靳應台,張龍昌,余權航 | |
dc.subject.keyword | 復發性口腔潰瘍,萎縮性舌炎,胃壁細胞抗體,甲狀腺球蛋白抗體,甲狀腺微小體抗體,貧血,補血素缺乏,鐵,維生素B12,葉酸, | zh_TW |
dc.subject.keyword | recurrent aphthous stomatitis,atrophic glossitis,gastric parietal cell antibody,thyroglobulin antibody,thyroid microsomal antibody,anemia,hematinic deficiency,iron,vitamin B12,folic acid, | en |
dc.relation.page | 68 | |
dc.identifier.doi | 10.6342/NTU201802472 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-08-09 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-107-1.pdf 目前未授權公開取用 | 668.39 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。