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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳嘉文(Kevin Chia-Wen Wu) | |
| dc.contributor.author | Wai-Kei Kuok | en |
| dc.contributor.author | 郭偉琪 | zh_TW |
| dc.date.accessioned | 2021-06-17T04:31:01Z | - |
| dc.date.available | 2023-08-16 | |
| dc.date.copyright | 2018-08-16 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-08-13 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70557 | - |
| dc.description.abstract | 本研究的目的是利用有機金屬框架(MOF525)作為主要材料，輔以導電高分子(PEDOT)改善其導電性，合成出一複合材料並修飾在Pt/Ir 微電極上。先藉由電化學氧化聚合法於微電極上直接聚合導電高分子PEDOT，並分別調控高分子氫鍵數量、電聚合時的溫度、電解質濃度及官能基的種類來最佳化，找出具有效能最好的微結構，然後再將PEDOT修飾過的微電極簡單的浸入MOF525溶液，讓MOF525自行吸附到PEDOT上，最後成為修飾在微電極上的PEDOT/MOF525複合材料。我們藉由氮氣等溫吸脫附曲線、X-射線繞射分析、場發射式掃瞄電子顯微鏡及能量色散X-射線光譜等結果證實我們成功製備出PEDOT/MOF525並修飾在微電極上，具有極高的比表面積及良好的導電性，而位於MOF525結構中心的配體具有很好的電催化特性，因此PEODT/MOF525可以作為一種有效的電催化材料。在生物感測上，我們利用循環伏安法及微分脈衝伏安法偵測多巴胺濃度，發現使用poly(EDOT-ph-COOH)(PEpM)作為高分子修飾電極時有最高達11 nA/μM的靈敏度及4~100 μM線性範圍。同時亦表現出在干擾物AA及UA下對多巴胺有良好的選擇性。 | zh_TW |
| dc.description.abstract | We synthesize a composite material consisting of metal-organic frameworks (i.e. MOF525) and conducting polymer (i.e. PEDOT) on microelectrodes for efficient detection of dopamine. First, we successfully synthesized the PEDOT on the microelectrode directly by electrochemical oxidation polymerization with the optimization of several synthetic conditions such as different amount of hydrogen bonds, temperature of electro-polymerization, concentration of supporting electrolyte, and the type of functional group. Then, MOF525 was attached on the PEODT-modified microelectrode by a simple immersed method. The synthesized MOF525/PEDOT composite-modified microelectrodes exhibit good conductivity and high specific surface area, confirmed by nitrogen adsorption-desorption isotherm, X-ray diffraction (XRD), field-emission scanning electron microscope (FT-SEM), and energy dispersive X-ray spectroscopy (EDX). For bio-sensing application, we proceed cyclic voltammetry and differential pulse voltammetry to measure the concentration of dopamine by using the synthesized MOF525/PEDOT modified microelectrodes. It was found that the MOF525/PEDOT modified microelectrodes with poly(EDOT-ph-COOH) exhibit the highest sensitivity of 11 nA/μM with linear range of 4 to 100 μM. The composite microelectrode also exhibited excellent selectivity for dopamine against common interference ascorbic acid (AA) and uric acid (DA). | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T04:31:01Z (GMT). No. of bitstreams: 1 ntu-107-R05524093-1.pdf: 2699843 bytes, checksum: d986133665d5a51d9e9c0075d0a55e4b (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 第一章 緒論 1
第二章 文獻回顧 3 2-1 金屬有機框架材料(MOF) 3 2-1-1 金屬有機框架材料簡介 3 2-2-2 金屬有機框架材料在電化學感測器的應用 3 2-2 聚二氧乙基噻吩(PEDOT) 6 2-2-1 聚二氧乙基噻吩之性質 6 2-2-2 二氧乙基噻吩官能化 7 2-2-3 不同官能基之PEDOT的結構及應用 9 2-3 多巴胺 10 2-4 微電極 11 2-4-1 微電極的定義及性質 11 2-4-2 微電極的修飾 12 2-5 電化學原理 15 2-6 電化學分析法 17 2-6-1 循環伏安法 17 2-6-2 微分脈衝伏安法 17 第三章 研究動機與目的 19 第四章 實驗方法 20 4-1 實驗藥品 20 4-2 實驗儀器 21 4-3 材料製備 22 4-3-1 合成EDOT-ph-COOH 單體 22 4-3-2 MOF525製備 23 4-3-3 以電聚合法於微電極上合成PEDOT 23 4-3-4 製備MOF525/PEDOT 複合材料修飾之微電極 24 4-4 材料性質分析 25 4-4-1 氮氣等溫吸脫附分析(N2-BET) 25 4-4-2 X-射線繞射分析儀 (XRD) 25 4-4-3 場發射式掃瞄式電子顯微鏡 (FE-SEM) 25 4-4-4 核磁共振光譜 (NMR) 26 4-4-5 電化學實驗 26 第五章 結果與討論 27 5-1 合成EDOT-ph-COOH單體的NMR分析 27 5-2 MOF525 製備 29 5-3 以MOF525/PEM複合材料修飾微電極 30 5-3-1 控制PEM氫鍵數量的影響 33 5-3-2 改變電解質濃度對合成PEM的影響 35 5-3-3 在低溫下以不同電解質濃度合成PEM的影響 38 5-4 以MOF525/PEpC複合材料修飾微電極 40 5-5 以微分脈衝伏安法檢測多巴胺的濃度及干擾物測試 42 第六章 結論 44 第七章 未來展望 45 第八章 參考文獻 46 | |
| dc.language.iso | zh-TW | |
| dc.subject | 電化學感測器 | zh_TW |
| dc.subject | 多巴胺 | zh_TW |
| dc.subject | 有機金屬骨架 | zh_TW |
| dc.subject | 4-乙烯基二氧?吩) | zh_TW |
| dc.subject | 聚(3 | zh_TW |
| dc.subject | 差分脈衝伏安法 | zh_TW |
| dc.subject | 微電極 | zh_TW |
| dc.subject | Differential pulse voltammetry | en |
| dc.subject | electrochemical sensor | en |
| dc.subject | Microelectrode | en |
| dc.subject | dopamine | en |
| dc.subject | Metal–organic frameworks | en |
| dc.subject | 4-ethylenedioxythiophene) | en |
| dc.subject | Poly(3 | en |
| dc.title | 合成 MOF525/PEDOT 複合物作為多巴胺感測之微電極 | zh_TW |
| dc.title | Synthesis of MOF525/PEDOT Composites as Microelectrodes for Electrochemical Sensing of Dopamine | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 黃博浩(PO-HAO HUANG),羅世強(Shyh-Chyang Luo),尤嘯華(Hsiao-hua Yu),陳林祈(Lin-Chi Chen) | |
| dc.subject.keyword | 微電極,差分脈衝伏安法,聚(3,4-乙烯基二氧?吩),有機金屬骨架,多巴胺,電化學感測器, | zh_TW |
| dc.subject.keyword | Microelectrode,Differential pulse voltammetry,Poly(3,4-ethylenedioxythiophene),Metal–organic frameworks,dopamine,electrochemical sensor, | en |
| dc.relation.page | 51 | |
| dc.identifier.doi | 10.6342/NTU201803138 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-08-13 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| 顯示於系所單位： | 化學工程學系 | |
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