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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70372完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李宗徽(Tzong-Huei Lee) | |
| dc.contributor.author | Yan-Jie Fu | en |
| dc.contributor.author | 傅彥傑 | zh_TW |
| dc.date.accessioned | 2021-06-17T04:26:47Z | - |
| dc.date.available | 2021-01-22 | |
| dc.date.copyright | 2021-01-22 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2021-01-05 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70372 | - |
| dc.description.abstract | 本研究利用病原菌篩選平台 (Escherichia coli, Staphylococcus aureus, Cryptococcus neoformans和Candida albicans) 來篩選具有抗菌潛力的海藻源真菌株。實驗結果顯示，由石蓴 (Ulva lactuca) 單離出之衍生真菌株Aspergillus terreus NTU243之粗萃物具有抗S. aureus和C. albicans的效果，後續選擇土麴黴A. terreus NTU243進行天然物研究，以液態和糙米固態培養之後，分離並純化此株真菌的次級代謝物。共計獲得16個化合物，藉由各種光譜資料解析其結構。其中4個為新化合物，分別為aspulvinones S - V (10 - 13)，另外12個為已知化合物，分別為butyrolactone I (1)、terretonin D (2)、lovastatin acid (3)、monacolin K methyl ester (4)、(+)-terretonin (5)、(+)-terretonin-A (6)、butyrolactone V (7)、butyrolactone IV (8)、butyrolactone II (9)、aspulvinone G (14)、(+)-terrein (15) 和4,4'-dihydroxybiphenyl (16)。所有純物質在各種活性平台的評估上，得知化合物1、13和15具有抑制小鼠神經膠細胞BV-2產生一氧化氮的效果，於10 µM下抑制NO產生的比例分別為34.5%、45.0%和49.2%；所有化合物對人類急性骨髓性白血病單核球細胞THP-1皆不具顯著的細胞毒性；化合物12和13可以抑制MMP-9蛋白的表現與活性，於10 µM下抑制基質金屬蛋白酶MMP-9產生的比例分別為56.0%和67.8%。 | zh_TW |
| dc.description.abstract | Marine fungi have been regarded as an under-explored source of structurally interesting and bioactive natural products with the potential to provide attractive lead compounds for drug discovery. In this study, a number of alga-derived fungal strains were isolated from marine algae collected from northeastern coast of Taiwan. In the preliminary antimicrobial screening against bacteria and fungi, including Escherichia coli, Staphylococcus aureus, Candida albicans and Cryptococcus neoformans, the ethyl acetate extract of solid (brown rice) fermented products of Aspergillus terreus NTU243, a fungus derived from a marine green alga Ulva lactuca, was found to exhibit significant antimicrobial activities against S. aureus and C. albicans. Therefore, bioassay-guided separations of the active principle from liquid and solid fermented products of Aspergillus terreus NTU243 was undertaken, which has resulted in the isolation and purification of 16 compounds. Their structures were elucidated by spectroscopic analysis to be four new aspulvinones S - V (10 - 13) as well as butyrolactone I (1), terretonin D (2), lovastatin acid (3), monacolin K methyl ester (4), (+)-terretonin (5), (+)-terretonin-A (6), butyrolactone V (7), butyrolactone IV (8), butyrolactone II (9), aspulvinone G (14), (+)-terrein (15), and 4,4'-dihydroxybiphenyl (16). All the isolates were assessed for anti-inflammatory activity by measuring the amount of NO production in LPS-induced BV-2 cells, and compounds 1, 13, 15 inhibited 34.5, 45.0 and 49.2%, respectively, of NO production under the concentration of 10 µM. All the compounds showed no cytotoxicity toward human monocytic cell THP-1 derived from an acute monocytic leukemia, and compounds 12 and 13 inhibited 56.0 and 67.8 % of MMP-9 production in THP-1 cells under the concentration of 10 µM, respectively. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T04:26:47Z (GMT). No. of bitstreams: 1 U0001-2407202009145000.pdf: 21253213 bytes, checksum: 9447b90c7ef8aadf4709cc5fb88bfda3 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 致謝.................................................................................................................................i 中文摘要........................................................................................................................ii 英文摘要.......................................................................................................................iii 目錄...............................................................................................................................vi 表目錄...........................................................................................................................ix 圖目錄...........................................................................................................................xi 縮寫表.........................................................................................................................xvi 第一章 緒論與研究目的..............................................................................................1 第二章 文獻回顧..........................................................................................................6 2.1 菌株分類學和介紹.............................................................................................6 2.2土麴黴 (Aspergillus terreus) 真菌成分之文獻回顧.........................................6 第三章 實驗結果........................................................................................................47 3.1 真菌液態發酵及固態發酵萃取液分離流程...................................................47 3.1.1 真菌株Aspergillus terreus NTU243液態發酵培養液分離流程............47 3.1.2 真菌株Aspergillus terreus NTU243固態發酵萃取液分離流程............49 3.2 天然物結構解析...............................................................................................51 3.2.1 Butyrolactone I (1) 之結構解析................................................................51 3.2.2 Terretonin D (2) 之結構解析.....................................................................62 3.2.3 Lovastatin acid (3) 與Monacolin K methyl ester (4) 之結構解析..........73 3.2.4 (+)-terretonin (5) 與 (+)-terretonin-A (6) 之結構解析............................93 3.2.5 Butyrolactone V (7) 之結構解析.............................................................110 3.2.6 Aspernolde D (8) 之結構解析.................................................................120 3.2.7 Butyrolactone II (9) 之結構解析.............................................................130 3.2.8 Aspulvinone S (10) 之結構解析..............................................................138 3.2.9 Aspulvinone T (11) 之結構解析..............................................................148 3.2.10 Aspulvinone U (12) 之結構解析...........................................................157 3.2.11 Aspulvinone V (13) 之結構解析...........................................................165 3.2.12 Aspulvinone G (14) 之結構解析...........................................................173 3.2.13 (+)-Terrein (15) 之結構解析..................................................................180 3.2.14 4,4'-Dihydroxybiphenyl (16) 之結構解析.............................................187 3.3 各成分之物理數據.........................................................................................191 3.4 化合物活性平台測試.....................................................................................195 3.4.1 一氧化氮抑制與細胞存活率之實驗結果..............................................195 3.4.2 細胞毒性試驗..........................................................................................196 3.4.3 電泳酵素分析..........................................................................................196 第四章 實驗部分......................................................................................................195 4.1 儀器設備與試劑.............................................................................................197 4.1.1 化合物之物理性質測定儀器..................................................................197 4.1.2 管柱層析膠體..........................................................................................197 4.1.3 試劑耗材與溶劑......................................................................................197 4.1.4 真菌培養基..............................................................................................198 4.1.5 細菌培養基..............................................................................................198 4.2 實驗材料.........................................................................................................198 4.2.1 真菌材料..................................................................................................198 4.2.2 細菌材料..................................................................................................199 4.2.3 菌種分子鑑定..........................................................................................199 4.2.4 真菌菌株分離與篩選..............................................................................200 4.3 抗菌活性篩選.................................................................................................201 4.3.1 檢測原理..................................................................................................201 4.3.2 測試菌種..................................................................................................201 4.3.3 實驗步驟..................................................................................................202 4.4 真菌培養及成分分離.....................................................................................202 4.4.1 培養基配置..............................................................................................202 4.4.2 真菌菌種保存..........................................................................................203 4.4.3 真菌液態發酵液萃取..............................................................................203 4.4.4 真菌液態發酵液之成分分離與純化......................................................203 4.4.5 真菌固態發酵液萃取..............................................................................204 4.4.6 真菌固態發酵液之成分分離與純化......................................................205 4.5 抗發炎活性評估.............................................................................................207 4.5.1 細胞培養..................................................................................................207 4.5.2 Griess reagent assay...................................................................................208 4.6 細胞毒性試驗.................................................................................................208 4.6.1 目的及原理..............................................................................................208 4.6.2 細胞培養..................................................................................................209 4.6.3 MTT assay.................................................................................................209 4.7 電泳酵素分析.................................................................................................210 4.7.1 目的及原理..............................................................................................210 4.7.2 細胞培養..................................................................................................210 4.7.3 zymography...............................................................................................210 第五章 討論..............................................................................................................212 第六章 參考文獻......................................................................................................214 | |
| dc.language.iso | zh-TW | |
| dc.subject | aspulvinone | zh_TW |
| dc.subject | Aspergillus terreus | zh_TW |
| dc.subject | 基質金屬蛋白酶 | zh_TW |
| dc.subject | 細胞毒性 | zh_TW |
| dc.subject | 抗發炎 | zh_TW |
| dc.subject | 藻源真菌 | zh_TW |
| dc.subject | Aspergillus terreus | en |
| dc.subject | matrix metalloproteinase | en |
| dc.subject | aspulvinone | en |
| dc.subject | alga-derived fungi | en |
| dc.subject | cytotoxicity | en |
| dc.subject | anti-inflammation | en |
| dc.title | 石蓴衍生真菌株Aspergillus terreus NTU243之成分研究 | zh_TW |
| dc.title | Chemical Constituents from a Fungal Strain Aspergillus terreus NTU243 Derived from Ulva lactuca | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 109-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳日榮(Jih-Jung Chen),蕭哲志(Che-Chih Hsiao),宋秉鈞(Ping-Jun Sung) | |
| dc.subject.keyword | 藻源真菌,抗發炎,細胞毒性,基質金屬蛋白酶,Aspergillus terreus,aspulvinone, | zh_TW |
| dc.subject.keyword | alga-derived fungi,Aspergillus terreus,aspulvinone,anti-inflammation,cytotoxicity,matrix metalloproteinase, | en |
| dc.relation.page | 232 | |
| dc.identifier.doi | 10.6342/NTU202001813 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2021-01-06 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
| 顯示於系所單位： | 漁業科學研究所 | |
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