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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李百祺 | |
dc.contributor.author | Yung-Shao Yang | en |
dc.contributor.author | 楊詠韶 | zh_TW |
dc.date.accessioned | 2021-06-17T03:30:31Z | - |
dc.date.available | 2021-03-22 | |
dc.date.copyright | 2018-03-22 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-02-22 | |
dc.identifier.citation | [1] Sarvazyan, A.P., et al., Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. Ultrasound in Medicine & Biology, 1998. 24(9): p. 1419-1435.
[2] Tanter, M., et al., High-resolution quantitative imaging of cornea elasticity using supersonic shear imaging. IEEE Trans Med Imaging, 2009. 28(12): p. 1881-93. [3] Baker, B.M. and C.S. Chen, Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues. Journal of Cell Science, 2012. 125(13): p. 3015. [4] Yamada, K.M. and E. Cukierman, Modeling Tissue Morphogenesis and Cancer in 3D. Cell, 2007. 130(4): p. 601-610. [5] Herman, G.T., Image Reconstruction From Projections. Real-Time Imaging, 1995. 1(1): p. 3-18. [6] Hao, X., S. Gao, and X. Gao, A novel multiscale nonlinear thresholding method for ultrasonic speckle suppressing. IEEE Transactions on Medical Imaging, 1999. 18(9): p. 787-794. [7] Yang, G.-Z. and D. Firmin, The birth of the first CT scanner. Vol. 19. 2000. 120-125. [8] Zhou, Y., et al., Measurement of high intensity focused ultrasound fields by a fiber optic probe hydrophone. The Journal of the Acoustical Society of America, 2006. 120(2): p. 676-685. [9] Bercoff, J., et al., The role of viscosity in the impulse diffraction field of elastic waves induced by the acoustic radiation force. IEEE Trans Ultrason Ferroelectr Freq Control, 2004. 51(11): p. 1523-36. 10] Heimdal, A., Doppler Based Ultrasound Imaging Methods for Noninvasive Assessment of Tissue Viability. 1999. 11] Zhao, H., et al., Bias Observed in Time-of-Flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam. Ultrasound in Medicine & Biology, 2011. 37(11): p. 1884-1892. [12] Willi, A.K., X-ray computed tomography. Physics in Medicine & Biology, 2006. 51(13): p. R29. [13] Fleischmann, D. and F.E. Boas, Computed tomography—old ideas and new technology. European Radiology, 2011. 21(3): p. 510-517. [14] Kaczmarz, S., Angenäherte Auflösung von Systemen linearer Gleichungen. Bulletin International de l'Académie Polonaise des Sciences et des Lettres, 1937. 35: p. 355-357. [15] Herman, G.T., Fundamentals of Computerized Tomography: Image Reconstruction from Projections. 2009: Springer Publishing Company, Incorporated. 300. [16] Gordon, R., R. Bender, and G.T. Herman, Algebraic Reconstruction Techniques (ART) for three-dimensional electron microscopy and X-ray photography. Journal of Theoretical Biology, 1970. 29(3): p. 471-481. [17] Ng, R., Fourier slice photography. Vol. 24. 2005. 735-744. [18] Mersereau, R.M., Direct fourier transform techniques in 3-D image reconstruction. Computers in Biology and Medicine, 1976. 6(4): p. 247-IN4. [19] Bracewell, R.N., The Fourier Transform and Its Applications. 2000: McGraw Hill. [20] Xu, M. and L.V. Wang, Universal back-projection algorithm for photoacoustic computed tomography. Phys Rev E Stat Nonlin Soft Matter Phys, 2005. 71(1 Pt 2): p. 016706. [21] Deans, S., The Radon Transform and Some of Its Applications. Krieger Publishing Company. [22] Goldman, L.W., Principles of CT and CT Technology. Journal of Nuclear Medicine Technology, 2007. 35(3): p. 115-128. [23] Crawford, C.R., CT filtration aliasing artifacts. IEEE Trans Med Imaging, 1991. 10(1): p. 99-102. [24] Hall, T., et al., Phantom materials for elastography. Vol. 44. 1997. 1355-1365. [25] Madsen, E.L., et al., Tissue-mimicking agar/gelatin materials for use in heterogeneous elastography phantoms. Physics in medicine and biology, 2005. 50(23): p. 5597-5618. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/69844 | - |
dc.description.abstract | 剪切波彈性影像已在人體臨床診斷上開始被廣泛使用,其影像格式與B-mode超音波影像相同,因此這種掃描方式亦有助於彈性影像與B-mode影像的融合。而在本研究中我們提出一種新的掃描方式,希望能導入電腦斷層掃描之影像形式,以便能更適用於如三維細胞培養系統之應用。換言之,為求出剪切波速度分佈,我們提出以量測剪切波產生與偵測間之時間差來求得其飛行時間(time-of-flight),再搭配電腦斷層攝影之掃描與重建方法,便可計算出掃描範圍內的剪切波速度分布。此一方式所重建出之影像為平行於超音波探頭固定深度之切面,故相似於傳統光學顯微鏡之觀察方式,預期將更適於觀察三維細胞培養系統之彈性分佈。相較於一般傳統超音波成像,剪切波電腦斷層能接收不同角度的剪切波傳遞資訊,藉由不同角度、位置的掃描,可以降低在單一角度掃描所受到反射、折射等等之影響,有助於提升影像的正確性。在系統方面,在本研究中我們設計一個移動與旋轉平台,以探頭固定位置,移動放置於移動與旋轉平台上的樣本,以達成與電腦斷層攝影中探頭與樣本之間的相對運動,取得不同角度、位置的發射及接收資訊。在本研究中我們製作出三種結構的彈性影像仿體(軟硬各半、1.5mm寬度長條狀、直徑1.5mm橢圓狀),重建出剪切波速度分布影像,並分析影像重建的結果。實驗結果顯示剪切波彈性影像的可行性,未來工作將針對旋轉與平移機構之誤差,提出有效之降低方法,以近一步提升本方法之準確性。 | zh_TW |
dc.description.abstract | Shear wave elasticity imaging has gained wide clinical acceptance. Its scan format is the same as that of regular ultrasound B-mode imaging, which also makes it convenient for image fusion with the corresponding B-mode image. In this research, we propose a new scan format by adopting the computed tomography approach so that it can be more suitable when imaging the elasticity distribution of a 3D cell culture system. In other words, by using the time-of-flight information between generation and detection of shear waves, the shear wave speed distribution can be calculated by using conventional computed tomographic reconstruction approaches. Such a scan plane is in parallel with the scanning plane of the ultrasound transducers during data acquisition; thus it is similar to that of conventional optical microscopes and suitable for observations of 3D cell culture systems. Compared to the conventional shear wave imaging approach, the proposed approach is expected to be more robust in the presence of unwanted reflection and refraction, as time-of-flight information from multiple angles is measured and used for reconstruction. We have constructed a shear wave computed tomography system in this research, and three different phantoms (half circle, 1.5 mm strip, and 1.5 mm cylinder) were used to test the performance of the proposed approach. Results demonstrate the feasibility of the proposed method, and the future work will focus on reducing errors due to the misalignment between the rotational and linearly translational stages. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T03:30:31Z (GMT). No. of bitstreams: 1 ntu-107-R04945001-1.pdf: 3594238 bytes, checksum: 62bdfbfee7ebfdf006579d5b480dc154 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 誌謝 i
中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF TABLES x 第一章 緒論 1 1.1超音波彈性影像 1 1.2 電腦斷層掃描 2 1.3 研究目標 4 1.4 論文架構 5 第二章 高頻超音波彈性影像 6 2.1彈性影像重建 6 2.1.1 外加作用力 6 2.1.2 位移量測 6 2.1.3 Time-of-flight 8 2.2高頻超音波系統 9 2.2.1 高頻超音波 9 2.2.2 系統同步時序設計 11 第三章電腦斷層攝影系統設計 14 3.1電腦斷層掃描 14 3.2電腦斷層系統實現 16 3.2.1 硬體架構設計 16 3.2.2 軟體架構設計 17 第四章電腦斷層攝影重建 19 4.1 反矩陣法 19 4.2 疊代法 20 4.3 傅立葉切片定理 20 4.4 濾波反投影 22 4.5 Matlab模擬 24 第五章 實驗結果與討論 27 5.1 仿體製作 27 5.2 線性移動與旋轉平台穩定性 28 5.3 投影結果 29 5.3.1 仿體A投影結果 29 5.3.2 仿體B重建結果 30 5.3.3 仿體C投影結果 31 5.3.4 投影結果優化與討論 32 5.4 重建結果 37 5.4.1 仿體A重建結果 37 5.4.2 仿體B重建結果 40 5.4.3 仿體C重建結果 42 5.5 討論 43 5.5.1 濾波器設計 43 5.5.2 對位問題 44 5.5.3 發出聲輻射力到產生剪切波時間差問題 46 5.5.4 三維影像重建 50 第六章 結論與未來工作 55 6.1 結論 55 6.2 未來工作 55 參考文獻 56 | |
dc.language.iso | zh-TW | |
dc.title | 剪切波彈性影像電腦斷層攝影 | zh_TW |
dc.title | Shear Wave Computed Tomography | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 沈哲州,郭柏齡,周呈霙 | |
dc.subject.keyword | 高頻超音波,剪切波,彈性影像, | zh_TW |
dc.subject.keyword | high frequency ultrasound,shear wave,elasticity imaging, | en |
dc.relation.page | 57 | |
dc.identifier.doi | 10.6342/NTU201800453 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-02-22 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
顯示於系所單位: | 生醫電子與資訊學研究所 |
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