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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張正憲 | |
dc.contributor.author | Chien-Hao Tseng | en |
dc.contributor.author | 曾千豪 | zh_TW |
dc.date.accessioned | 2021-06-17T02:17:32Z | - |
dc.date.available | 2020-01-04 | |
dc.date.copyright | 2018-01-04 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-27 | |
dc.identifier.citation | [1] Sauerbrey, G. (1959). “Verwendung von Schwingquarzen zur Wägung dünner Schichten und zur Mikrowägung,” Zeitschrift für Physik A Hadrons and Nuclei, 155(2), 206-222.
[2] Konash, P. L., and Bastiaans, G. J. (1980). “Piezoelectric crystals as detectors in liquid chromatography,” Analytical chemistry, 52(12), 1929-1931. [3] Kanazawa, K. K., and Gordon, J. G. (1985). “Frequency of a quartz microbalance in contact with liquid,” Analytical Chemistry, 57(8), 1770-1771. [4] Martin, S. J., Granstaff, V. E., and Frye, G. C. (1991). “Characterization of a quartz crystal microbalance with simultaneous mass and liquid loading,” Analytical Chemistry, 63(20), 2272-2281. [5] Thompson, M., Arthur, C. L., and Dhaliwal, G. K. (1986). “Liquid-phase piezoelectric and acoustic transmission studies of interfacial immunochemistry,” Analytical chemistry, 58(6), 1206-1209. [6] Wang, H., Iovenitti, P., Harvey, E., and Masood, S. (2003). “Numerical investigation of mixing in microchannels with patterned grooves,” Journal of Micromechanics and Microengineering, 13(6), 801. [7] Stroock, A. D., Dertinger, S. K., Ajdari, A., Mezić, I., Stone, H. A., and Whitesides, G. M. (2002). “Chaotic mixer for microchannels,” Science, 295(5555), 647-651. [8] Fu, L. M., Yang, R. J., Lin, C. H., and Chien, Y. S. (2005). “A novel microfluidic mixer utilizing electrokinetic driving forces under low switching frequency,” Electrophoresis, 26(9), 1814-1824. [9] Feng, J. J., Krishnamoorthy, S., and Sundaram, S. (2007). “Numerical analysis of mixing by electrothermal induced flow in microfluidic systems,” Biomicrofluidics, 1(2), 024102. [10] Cao, J., Cheng, P., and Hong, F. J. (2008). “A numerical study of an electrothermal vortex enhanced micromixer,” Microfluidics and Nanofluidics, 5(1), 13-21. [11] Zahn, M. L. (1979). Electromagnetic field theory. [12] Sin, M. L., Gau, V., Liao, J. C., and Wong, P. K. (2010). “Electrothermal fluid manipulation of high-conductivity samples for laboratory automation applications,” JALA: Journal of the Association for Laboratory Automation, 15(6), 426-432. [13] Sigurdson, M., Wang, D., and Meinhart, C. D. (2005). “Electrothermal stirring for heterogeneous immunoassays,” Lab on a Chip, 5(12), 1366-1373. [14] Huang, Y. H. (2015). 電熱效應於石英晶體微天平及微混合器之研究. 臺灣大學應用力學研究所學位論文, 1-121. [15] 林柏彣. (2015). 以交流電動力提升微混合器效能之實驗與數值模擬研究. 臺灣大學應用力學研究所學位論文, 1-85. [16] Ramos, A., Morgan, H., Green, N. G., and Castellanos, A. (1998). “Ac electrokinetics: a review of forces in microelectrode structures,” Journal of Physics D: Applied Physics, 31(18), 2338. [17] Green, N. G., Ramos, A., González, A., Morgan, H., and Castellanos, A. (2000). “Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. I. Experimental measurements,” Physical review E, 61(4), 4011. [18] González, A., Ramos, A., Green, N. G., Castellanos, A., and Morgan, H. (2000). “Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. II. A linear double-layer analysis,” Physical review E, 61(4), 4019. [19] Green, N. G., Ramos, A., Gonzalez, A., Morgan, H., and Castellanos, A. (2002). “Fluid flow induced by nonuniform ac electric fields in electrolytes on microelectrodes. III. Observation of streamlines and numerical simulation,” Physical review E, 66(2), 026305. [20] Castellanos, A., Ramos, A., Gonzalez, A., Green, N. G., and Morgan, H. (2003). “Electrohydrodynamics and dielectrophoresis in microsystems: scaling laws,” Journal of Physics D: Applied Physics, 36(20), 2584. [21] 廖柏任. (2008). 石英晶體微天平應用於人體免疫球蛋白檢測之實驗及模擬. 臺灣大學應用力學研究所學位論文, 1-117. [22] Dutta, P., and Beskok, A. (2001). “Analytical solution of combined electroosmotic/pressure driven flows in two-dimensional straight channels: finite Debye layer effects,” Analytical chemistry, 73(9), 1979-1986. [23] Engler, M., Kockmann, N., Kiefer, T., and Woias, P. (2004). “Numerical and experimental investigations on liquid mixing in static micromixers,” Chemical Engineering Journal, 101(1), 315-322. [24] Zoltowski, P. (1998). “On the electrical capacitance of interfaces exhibiting constant phase element behaviour,” Journal of Electroanalytical Chemistry, 443(1), 149-154. [25] 洪梓豪. (2010). 應用旅波電滲於微混合器之模擬與分析. 臺灣大學應用力學研究所學位論文, 1-154. [26] Huang, K. R., Chang, J. S., Chao, S. D., Wu, K. C., Yang, C. K., Lai, C. Y., and Chen, S. H. (2008). “Simulation on binding efficiency of immunoassay for a biosensor with applying electrothermal effect,” Journal of Applied Physics, 104(6), 064702. [27] Technical Terminology. TXC Corporation. Retrieved from http://www.txccorp.com/index_en.php?action=c_technology_1&cid=1 [28] Chen, M. H. (2004). 以毛細管電泳法與電灑游離質譜法探討內包錯合物之研究. 中央大學化學研究所學位論文, 1-150. [29] Fischer, H. B., List, J. E., Koh, C. R., Imberger, J., & Brooks, N. H. (2013). Mixing in inland and coastal waters, Elsevier, pp.30-54. [30] Karlsson, R., Michaelsson, A., & Mattsson, L. (1991). “Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system,” Journal of immunological methods, 145(1-2), 229-240. [31] Qi, J., & Savinell, R. F. (1990). “Mass transfer in a laminar-flow parallel plate electrolytic cell with simultaneous development of velocity and concentration boundary layers,” Journal of applied electrochemistry, 20(6), 885-892. [32] Davies, J. (1996). Surface analytical techniques for probing biomaterial processes. CRC press. [33] Morton, T. A., Myszka, D. G., & Chaiken, I. M. (1995). “Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration,” Analytical biochemistry, 227(1), 176-185. [34] Camillone, N. (2004). “Diffusion-limited thiol adsorption on the gold (111) surface,” Langmuir, 20(4), 1199-1206. [35] Oh, J., Hart, R., Capurro, J., & Noh, H. M. (2009). “Comprehensive analysis of particle motion under non-uniform AC electric fields in a microchannel,” Lab on a Chip, 9(1), 62-78. [36] Ng, W. Y., Goh, S., Lam, Y. C., Yang, C., & Rodríguez, I. (2009). “DC-biased AC-electroosmotic and AC-electrothermal flow mixing in microchannels,” Lab on a Chip, 9(6), 802-809. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68319 | - |
dc.description.abstract | 微混合器與石英晶體微天平為生化、生醫領域常見的微流體系統,主要用來進行不同種類的藥品混合與生物分子檢測。在微奈米尺度下,流體為層流狀態,自然擴散為其主要的藥品輸送方式。然而,此種機制需要耗費很長的時間才能達到良好的傳輸效果,在混合與生化反應之使用上效果有限。本研究引入交流電動力,以期能提升混合效能並縮短反應所需之時間。
交流電動力主要的機制有:操縱微小粒子與擾動微流體流場。此外,不同的流體導電度、電壓、交流電訊號頻率、操作尺度等條件能產生不同作用方式的交流電動力,其大致可分為介電泳、電熱效應以及交流電滲三種。 本論文以有限元素分析軟體COMSOL Multiphysics針對電熱效應式石英晶體微天平 (ETE-QCM) 與交流電動式微混合器 (ACEK micromixer) 之實驗架構,進行數值模擬分析,以達到預測實驗走向之效果,並結合相關理論解釋實驗之現象。 | zh_TW |
dc.description.abstract | Microfluidic devices such as quartz crystal microbalances (QCM) and micromixers are often applied in Biochemistry and Biomedicine to mix different samples and biomolecular detection. At a micro- or nano-scale level, fluid flow is constantly in the state of laminar flow where pure diffusion is its primary mechanism of transporting specimens. However, the transportation through such mechanism consumes considerable time before reaching a point where transportation gets efficient. Thus it poses a restriction on the application of microfluidic devices to both medical mixing and bio-detecting. In this thesis, AC-electrokinetics is adopted to be integrated into microfluidic systems to enhance the mixing efficiency and reduce the detection time.
AC-electrokinetics (ACEK) is used to manipulate micro-scale particles and disturb the fluid field in microfluidic systems. On the basis of different conductivities, applied voltages, AC-signal frequencies, and scales etc. AC-electrokinetics can be classified into Dielectrophoresis (DEP), Electrothermal effect (ETE) and AC-electroosmosis (ACEO). In this paper, we conduct the numerical simulations of the experiments on an Electrothermal-QCM chip and an ACEK-micromixer by commercial software “COMSOL Multiphysics”. In the end, the simulated results are compared with the experimental ones done by other students in our research group. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T02:17:32Z (GMT). No. of bitstreams: 1 ntu-106-R03543072-1.pdf: 4381785 bytes, checksum: f26a4460bd69d0b5afd0cff9b841531f (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 致謝 I
摘要 II ABSTRACT III 目錄 IV 圖目錄 VIII 表目錄 XI 第1章 緒論 1 1.1 前言 1 1.2 文獻回顧 2 1.2.1 石英晶體微天秤 2 1.2.2 微混合器 2 1.2.3 電熱效應 3 1.2.4 交流電滲 3 1.3 研究動機 4 1.3.1 電熱效應式石英晶體微天平(ETE-QCM)之人體免疫蛋白檢測 4 1.3.2 交流電動力式微混合器(ACEK-Micromixer) 4 1.4 論文架構 5 第2章 理論介紹 6 2.1 石英晶體微天平簡介 6 2.1.1 生物感測器 6 2.1.2 石英晶體特性 7 2.1.3 理想負載於石英晶體 9 2.1.4 液態負載於石英晶體 10 2.2 生物分子親合與解離反應 11 2.2.1 生物化學結合與解離 11 2.2.2 親和力分析[30] 12 2.3 微混合器簡介 14 2.4 混合指標 15 2.5 濃度場 16 2.5.1 菲克第一定律 16 2.5.2 菲克第二定律及對流擴散 17 2.6 交流電動力 19 2.6.1 交流電動力分類 19 2.6.2 交流電動力應用於石英晶體微天平[14][34] 20 2.7 電熱效應 21 2.7.1 電場[16] 21 2.7.2 電流密度[16] 22 2.7.3 非齊性介面之高斯定律[16] 22 2.7.4 電荷守恆[16] 22 2.7.5 電熱力[16] 23 2.7.6 溫度場[16] 24 2.7.7 不可壓縮流場[20] 25 2.8 電熱效應下流場溫度變化及流速大小 26 2.8.1 溫度變化[16] 26 2.8.2 電熱力強度[16] 27 2.8.3 流速大小[20] 28 2.9 電滲效應[15] 29 2.9.1 電雙層 29 2.9.2 電滲流 30 2.10 交流電滲理論-電滲流速解析解[18] 32 2.10.1 理論之簡化與基本假設 32 2.10.2 電場與離子濃度場 33 2.10.3 不可壓縮流場 37 第3章 ETE-QCM之數值模擬設定 39 3.1 實驗架構與方法[14] 39 3.1.1 實驗架構[14] 39 3.1.2 實驗方法與流程 41 3.2 電熱效應式石英晶體微天平之有限元素模型 42 3.3 電熱效應之物理場邊界設定 45 3.3.1 電場之邊界條件設定 45 3.3.2 溫度場之邊界條件設定 46 3.3.3 不可壓縮流場之邊界條件設定 47 3.4 濃度場與表面反應之邊界、初始條件設定 48 3.4.1 濃度場之邊界、初始條件設定 48 3.4.2 表面反應之邊界、初始條件設定 50 第4章 結果與討論 51 4.1 自然擴散之表面鍵結頻率變化 51 4.2 電熱效應式石英晶體微天平之數值模擬結果 55 4.2.1 電熱效應之電場、溫度場、流場模擬結果 55 4.2.2 電熱效應之頻率反應模擬結果 58 第5章 交流電動力式微混合器之模擬 61 5.1 實驗架設及方法[15] 61 5.2 模擬模型之設計[15] 62 5.3 電熱效應之物理場邊界條件設定 64 5.3.1 電場之邊界條件 64 5.3.2 溫度場之邊界條件 64 5.3.3 不可壓縮流場之邊界條件 64 5.3.4 濃度場之邊界條件 64 5.4 交流電滲之物理場數值模擬設定 67 5.4.1 理想極化電雙層之電場[16][19] 67 5.4.2 非理想極化電雙層之電場[19][24] 68 5.4.3 流場[19] 68 5.4.4 電熱效應與交流電滲共存之數值模擬設定 69 第6章 結果與討論 70 6.1 單純電熱效應之數值模擬結果 70 6.2 電熱效應與交流電滲共存之數值模擬結果 72 6.2.1 理想極化電雙層之數值模擬結果 72 6.2.2 非理想極化電雙層之數值模擬結果 73 第7章 結論與未來展望 75 7.1 結論 75 7.2 未來展望 77 參考文獻 78 | |
dc.language.iso | zh-TW | |
dc.title | 交流電動力應用於石英晶體微天平及微混合器之數值模擬 | zh_TW |
dc.title | Numerical Simulation of Applying AC-Electrokinetics on Quartz Crystal Microbalances and Micromixers | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳光鐘,沈弘俊,陳世豪,黃冠榮 | |
dc.subject.keyword | 交流電動力,電熱效應,石英晶體微天平,微混合器,有限元素法, | zh_TW |
dc.subject.keyword | AC-electrokinetics,Quartz crystal microbalance,micromixer,finite element method, | en |
dc.relation.page | 81 | |
dc.identifier.doi | 10.6342/NTU201702153 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-28 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 應用力學研究所 | zh_TW |
顯示於系所單位: | 應用力學研究所 |
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