請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68004完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳克強 | |
| dc.contributor.author | Fu-Yu Hung | en |
| dc.contributor.author | 洪福佑 | zh_TW |
| dc.date.accessioned | 2021-06-17T02:11:08Z | - |
| dc.date.available | 2020-08-21 | |
| dc.date.copyright | 2018-08-21 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2018-01-18 | |
| dc.identifier.citation | 5. References
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68004 | - |
| dc.description.abstract | 摘要
在真核生物系統中，組蛋白修飾藉由改變染色體結構而扮演一個調控基因表達的重要角色。其中組蛋白的乙醯化（acetylation）和組蛋白H3K4的甲基化（H3K4 methylation）是啟動基因表達的重要修飾之一，而組蛋白去乙醯化酶（HDACs）以及H3K4去甲基化酶（H3K4 demethylases）皆是抑制基因表達的重要酵素。在酵母及動物系統中已經發現 HDACs 和 Lysine-Specific Demethylase 1（LSD1）在同一個蛋白複合體參與調控基因表達。我們也發現了在阿拉伯芥中的 LSD1-LIKE 1（LDL1） 以及 LDL2 會直接與 HDA6 蛋白交互作用，表示他們可能也會共同調控基因表達。進一步我們利用 ChIP-seq 發現了1895個基因為LDL1 和 HDA6 的共同靶基因。透過 Gene Ontology（GO）分析，我們發現這些LDL1 和 HDA6 的共同靶基因大多參與植物開花以及生長發育的負向調控。在hda6/ldl1/ldl2植物中也發現了延遲開花以及生長遲緩的表現型。 我們在 GO 分析中也發現 LDL1 和 HDA6 的共同靶基因包括許多生物時鐘基因。生物時鐘在植物生長發育階段都扮演重要調控角色。目前已發現許多轉錄因子參與調控生物時鐘，形成一個複雜的回饋調節網路。生物時鐘之中心節律有幾個主要轉錄因子，包括在清晨大量表達的 CCA1 (CIRCADIAN CLOCK ASSOCIATED 1) 、 LHY (LATE ELONGATED HYPOCOTYL) 以及在傍晚大量表達的TOC1 (TIMING OF CAB EXPRESSION 1)，它們彼此互相抑制並在每日形成一個循環。前人研究中指出組蛋白修飾在生物時鐘中心節律的調控扮演重要角色，但其調控機制仍未被清楚瞭解。我們發現 LDL1、LDL2 以及 HDA6 可以和生物時鐘中心節律的轉錄因子 CCA1、 LHY 交互作用，並透過組蛋白修飾來調控 TOC1。這個的結果對於組蛋白修飾如何參與調控生物時鐘之中心節律，提供了一個新的可能的調控機制。 | zh_TW |
| dc.description.abstract | Abstract
Histone modification and DNA methylation are important epigenetic marks in eukaryotic cells. The functional consequences of histone modifications can directly cause structural changes to chromatin to activate or repress gene expression. Histone acetylation and H3K4 methylation are important gene activation markers. Histone deacetylases (HDACs) and H3K4 demethylases can act as important transcription corepresser. In yeast and animal systems, HDACs and H3K4 Lysine-Specific Demethylase 1 (LSD1) can interact with each other and they were identified as the core components of several multi-protein complexes. In this research, we found that LSD1-LIKE 1 (LDL1) and LDL2 can interact with the histone deacetylase HDA6 in Arabidopsis. Furthermore, 1895 co-targeted genes of HDA6 and LDL1 were identified by using ChIP-sequencing assays. These co-targeted genes were significantly associated with negative regulation of many different biological processes including growth, flowering and circadian rhythm in the Gene Ontology (GO) analysis. hda6/ldl1/ldl2 triple mutant plants displayed delayed growth rate and strong late flowering phenotypes. Together, these results indicated that the HDA6-LDL1/2 complex generally act as an positive regulator of plant growth and development. In Arabidopsis, the circadian clock central oscillator genes are important cellular components for generating and maintaining circadian rhythms. Recent studies indicate that histone modifications play an important role in the regulation of the central oscillators. However, the regulatory relationship between histone modifications and the circadian clock genes remains largely unclear. In this study, we found that HDA6, LDL1 and LDL2 can interact with morning genes CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) to repress the expression of evening gene TIMING OF CAB EXPRESSION 1 (TOC1) by histone demetylation and deacetylaion. These results provide new insight into the molecular mechanism of how the circadian clock central oscillator genes are regulated through histone modifications. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T02:11:08Z (GMT). No. of bitstreams: 1 ntu-106-D01b42004-1.pdf: 31544295 bytes, checksum: 9727f56c2cf9c9d26a45a26a23b6fc05 (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 誌謝 ii
摘要 iii Abstract iv 1. Introduction 1 1.1 Histone Demethylases 1 1.2 Histone Deacetylases and HDAC Complexes 3 1.3 Circadian Clock and Histone Modifications 5 1.4 The Specific Aims of This Study 7 2. Materials and Methods 9 2.1 Plant materials and growth conditions 9 2.2 Plasmid construction and plant transformation 9 2.3 Bimolecular fluorescence (BiFC) complementation assays 10 2.4 Yeast two-hybrid (Y2H) assays 10 2.5 Co- Immunoprecipitation (Co-IP) assays 10 2.6 Quantitative reverse transcriptase PCR analysis 11 2.7 Protoplast transient assays 11 2.8 Chromatin immunoprecipitation (ChIP) assays 12 2.9 ChIP-seq and data analyses 12 3. Results 15 3.1 Genome-wide occupancy profiles of HDA6 and LDL1 15 3.1.1 LDL1 and LDL2 directly interact with HDA6 15 3.1.2 Identification of genome-wide binding sites of HDA6 and LDL1 15 3.1.3 HDA6-LDL1 co-targeted genes are involved in negative regulation of multiple biological processes 17 3.2 The HDA6/LDL1/2 complex regulates circadian clock central oscillators 18 3.2.1 LDL1 and LDL2 directly interact with CCA1 and LHY. 18 3.2.2 LDL1, LDL2 and HDA6 acts synergistically to repress the TOC1 expression by histone deacetylation and H3K4 demethylation 19 3.2.3 The LDL1-HDA6 complex interacts with CCA1 and targets directly to the TOC1 promoter 20 3.2.4 LDL1 and CCA1 co-target genes involved in the circadian rhythm 22 3.2.5 LDL1/LDL2 and HDA6 also regulate CCA1/LHY expression 24 3.3 HDA6/LDL1/2 complex positive regulate flowering and growth in Arabidopsis 25 3.3.1 Arabidopsis HDA6 and LDL1/2 act synergistically to regulate flowering time in multiple regulation pathways 25 3.3.2 HDA6 and LDL1/2 act synergistically to regulate Arabidopsis growth 26 3.3.3 Genes involved in flowering regulation and growth are synergistically regulated by HDA6 and LDL1/2 27 3.4 Functional Correlation Between HDA6 and the H3K9 demethylae JMJ25/IBM1 28 3.4.1 HDA6 direct interacts with JMJ25/IBM1 in HD and JMJ-C Domain 28 3.4.2 The jmj25/ibm1 mutant phenotype can be partially rescued by hda6 29 3.4.3 HDA6 Targets on JMJ25/IBM1 gene-body and affect its transcription variation 30 4. Discussion 31 4.1 LDL1/2 and HDA6 form a histone modification complex 31 4.2 The HDA6-LDL1/2 complex is important in regulation of circadian clock central oscillators 32 4.3 The HDA6-LDL1/2 complex is a positive regulator of growth and development 34 4.4 HDA6 acts as a negative regulator of the JMJ25/IBM1 function 36 5. References 39 Figures 55 Tables 97 Appendix 105 | |
| dc.language.iso | en | |
| dc.subject | LDL1 | zh_TW |
| dc.subject | ChIP-seq | zh_TW |
| dc.subject | HDA6 | zh_TW |
| dc.subject | 開花調控 | zh_TW |
| dc.subject | TOC1 | zh_TW |
| dc.subject | CCA1/LHY | zh_TW |
| dc.subject | 阿拉伯芥 | zh_TW |
| dc.subject | 生物時鐘 | zh_TW |
| dc.subject | Flowering | en |
| dc.subject | LDL1 | en |
| dc.subject | ChIP-Seq | en |
| dc.subject | circadian clock | en |
| dc.subject | CCA1/LHY | en |
| dc.subject | TOC1 | en |
| dc.subject | HDA6 | en |
| dc.subject | Arabidopsis | en |
| dc.title | 阿拉伯芥LDL1/2與HDA6參與生物時鐘中心節律調節 | zh_TW |
| dc.title | Arabidopsis LDL1/2 and HDA6 regulate the circadian clock central oscillators | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 吳素幸,涂世隆,蔡皇龍,張英?,陳伯仰 | |
| dc.subject.keyword | HDA6,LDL1,ChIP-seq,生物時鐘,CCA1/LHY,TOC1,開花調控,阿拉伯芥, | zh_TW |
| dc.subject.keyword | HDA6,LDL1,ChIP-Seq,circadian clock,CCA1/LHY,TOC1,Flowering,Arabidopsis, | en |
| dc.relation.page | 277 | |
| dc.identifier.doi | 10.6342/NTU201800099 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-01-19 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 植物科學研究所 | zh_TW |
| 顯示於系所單位： | 植物科學研究所 | |
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