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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳焜裕 | |
| dc.contributor.author | En-Hsuan Lu | en |
| dc.contributor.author | 盧恩萱 | zh_TW |
| dc.date.accessioned | 2021-06-17T01:36:14Z | - |
| dc.date.available | 2020-08-23 | |
| dc.date.copyright | 2017-08-23 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-08-01 | |
| dc.identifier.citation | Aeenehvand, S., Z. Toudehrousta, M. Kamankesh, M. Mashayekh, H. R. Tavakoli, and A. Mohammadi. 2016. 'Evaluation and application of microwave-assisted extraction and dispersive liquid-liquid microextraction followed by high-performance liquid chromatography for the determination of polar heterocyclic aromatic amines in hamburger patties', Food Chemistry, 190: 429-35.
Alaejos, M. S., and A. M. Afonso. 2011. 'Factors that affect the content of heterocyclic aromatic amines in foods', Compr Rev Food Sci Food Saf, 10: 52-108. Alaejos, M. S., V. Gonzalez, and A. M. Afonso. 2008. 'Exposure to heterocyclic aromatic amines from the consumption of cooked red meat and its effect on human cancer risk: a review', Food Addit Contam, 25: 2-24. Amersi, F., M. Agustin, and C. Y. Ko. 2005. 'Colorectal cancer: epidemiology, risk factors, and health services', Clin Colon Rectal Surg, 18: 133–40. Armbrecht, H. J., V. M. Lakshmi, J. Wickstra, F. F. Hsu, and T. V. Zenser. 2007. 'Metabolism of a heterocyclic amine colon carcinogen in young and old rats', Drug Metab Dispos, 35: 633-9. Arnold, M., M. S. Sierra, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2016. 'Global patterns and trends in colorectal cancer incidence and mortality', Gut, 0: 1-9. Bendaly, J., K. J. Metry, M. A. Doll, G. Jiang, J. C. States, N. B. Smith, J. R. Neale, J. L. Holloman, W. M. Pierce, and D. W. Hein. 2009. 'Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts', Xenobiotica, 39: 399-406. Bouvard, Véronique, Dana Loomis, Kathryn Z. Guyton, Yann Grosse, Fatiha El Ghissassi, Lamia Benbrahim-Tallaa, Neela Guha, Heidi Mattock, and Kurt Straif. 2015. 'Carcinogenicity of consumption of red and processed meat', Lancet Oncol, 16: 1599-600. Brockton, N., J. Little, L. Sharp, and S. C. Cotton. 2000. 'N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review', Am J Epidemiol, 151: 846-61. Busquets, R., H. Frandsen, J. A. Jonsson, L. Puignou, M. T. Galceran, and K. Skog. 2013. 'Biomonitoring of dietary heterocyclic amines and metabolites in urine by liquid phase microextraction: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a possible biomarker of exposure to dietary PhIP', Chem Res Toxicol, 26: 233-40. Butler, L. M., R. Sinha, R. C. Millikan, C. F. Martin, B. Newman, M. D. Gammon, A. S. Ammerman, and R. S. Sandler. 2003. 'Heterocyclic amines, meat intake, and association with colon cancer in a population-based study', Am J Epidemiol, 157: 434-45. Cha, Hyun-Jeong, Nam-Hee Kim, Eun-Kyung Jeong, and Yun-Cheol Na. 2010. 'Analysis of heterocyclic amines in human urine using multiple solid-phase extraction by liquid chromatography/mass spectrometry', Bull Korean Chem Soc, 31: 2322-28. Chan, D. S., R. Lau, D. Aune, R. Vieira, D. C. Greenwood, E. Kampman, and T. Norat. 2011. 'Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies', PLoS One, 6: e20456. Chao, A., M. J. Thun, C. J. Connell, M. L. McCullough, E. J. Jacobs, W. D. Flanders, C. Rodriguez, R. Sinha, and E. E. Calle. 2005. 'Meat consumption and risk of colorectal cancer', JAMA, 293: 172-82. Chao, A., M. J. Thun, E. J. Jacobs, S. J. Henley, C. Rodriguez, and E. E. Calle. 2000. 'Cigarette smoking and colorectal cancer mortality in the cancer prevention study II', J Natl Cancer Inst, 92: 1888-96. Chen, C., X. Ma, M. A. Malfatti, K. W. Krausz, S. Kimura, J. S. Felton, J. R. Idle, and F. J. Gonzalez. 2007. 'A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach', Chem Res Toxicol, 20: 531-42. Cheung, C., X. Ma, K. W. Krausz, S. Kimura, L. Feigenbaum, T. P. Dalton, D. W. Nebert, J. R. Idle, and F. J. Gonzalez. 2005. 'Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2', Chem Res Toxicol, 18: 1471-8. De Andres, F., M. Zougagh, G. Castaneda, and A. Rios. 2010. 'Determination of heterocyclic amines in urine samples by capillary liquid chromatography with evaporated light-scattering detection', Anal Bioanal Chem, 397: 223-31. Fede, J. M., A. P. Thakur, N. J. Gooderham, and R. J. Turesky. 2009. 'Biomonitoring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its carcinogenic metabolites in urine', Chem Res Toxicol, 22: 1096-105. Fedirko, V., I. Tramacere, V. Bagnardi, M. Rota, L. Scotti, F. Islami, E. Negri, K. Straif, I. Romieu, C. La Vecchia, P. Boffetta, and M. Jenab. 2011. 'Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies', Ann Oncol, 22: 1958-72. Ferrucci, L. M., R. Sinha, W. Y. Huang, S. I. Berndt, H. A. Katki, R. E. Schoen, R. B. Hayes, and A. J. Cross. 2012. 'Meat consumption and the risk of incident distal colon and rectal adenoma', Br J Cancer, 106: 608-16. Frandsen, H., H. Frederiksen, and J. Alexander. 2002. '2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)', Food Chem Toxicol., 40: 1125-30. Fu, Y., G. Zhao, S. Wang, J. Yu, F. Xie, H. Wang, and J. Xie. 2014. 'Simultaneous determination of fifteen heterocyclic aromatic amines in the urine of smokers and nonsmokers using ultra-high performance liquid chromatography-tandem mass spectrometry', J Chromatogr A, 1333: 45-53. Fuchs, C. S., E. L. Giovannucci, G. A. Colditz, D. J. Hunter, F. E. Speizer, and W. C. Willett. 1994. 'A prospective study of family history and the risk of colorectal cancer', N Engl J Med, 331: 1669-74. Funk, W., V. Dammann, and G. Donnevert. 2007. 'Quality assurance in analytical chemistry: applications in environmental, food and materials analysis, biotechnology, and medical engineering': 38-46. Garte, S., L. Gaspari, A. K. Alexandrie, C. Ambrosone, H. Autrup, J. L. Autrup, H. Baranova, L. Bathum, S. Benhamou, P. Boffetta, C. Bouchardy, K. Breskvar, J. Brockmoller, I. Cascorbi, M. L. Clapper, C. Coutelle, A. Daly, M. Dell'Omo, V. Dolzan, C. M. Dresler, A. Fryer, A. Haugen, D. W. Hein, A. Hildesheim, A. Hirvonen, L. L. Hsieh, M. Ingelman-Sundberg, I. Kalina, D. Kang, M. Kihara, C. Kiyohara, P. Kremers, P. Lazarus, L. Le Marchand, M. C. Lechner, E. M. van Lieshout, S. London, J. J. Manni, C. M. Maugard, S. Morita, V. Nazar-Stewart, K. Noda, Y. Oda, F. F. Parl, R. Pastorelli, I. Persson, W. H. Peters, A. Rannug, T. Rebbeck, A. Risch, L. Roelandt, M. Romkes, D. Ryberg, J. Salagovic, B. Schoket, J. Seidegard, P. G. Shields, E. Sim, D. Sinnet, R. C. Strange, I. Stücker, H. Sugimura, J. To-Figueras, P. Vineis, M. C. Yu, and E. Taioli. 2001. 'Metabolic gene polymorphism frequencies in control populations', Cancer Epidemiol Biomarkers Prev, 10: 1239-48. Gibis, Monika. 2016. 'Heterocyclic aromatic amines in cooked meat products: causes, formation, occurrence, and risk assessment', Compr Rev Food Sci Food Saf, 15: 269-302. Gu, D., L. McNaughton, D. Lemaster, B. G. Lake, N. J. Gooderham, F. F. Kadlubar, and R. J. Turesky. 2010. 'A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine', Chem Res Toxicol, 23: 788-801. Gu, D., M. M. Raymundo, F. F. Kadlubar, and R. J. Turesky. 2011. 'Ultraperformance liquid chromatography-tandem mass spectrometry method for biomonitoring cooked meat carcinogens and their metabolites in human urine', Anal Chem, 83: 1093-101. Hasegawa, R., I. Yoshimura, K. Imaida, N. Ito, and T. Shirai. 1996. 'Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat', Jpn J Cancer Res, 87: 1125-33. Hein, D. W. 2002. 'Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis', Mutat Res, 506-507: 65-77. Hein, D. W. 2006. 'N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk', Oncogene, 25: 1649-58. Hemminki, K. 1993. 'DNA adducts, mutations and cancer', Carcinogenesis, 14: 2007-12. Holland, R. D., T. Gehring, J. Taylor, B. G. Lake, N. J. Gooderham, and R. J. Turesky. 2005. 'Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians', Chem Res Toxicol, 18: 579-90. Holland, R. D., J. Taylor, L. Schoenbachler, R. C. Jones, J. P. Freeman, D. W. Miller, B. G. Lake, N. J. Gooderham, and R. J. Turesky. 2004. 'Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry', Chem Res Toxicol, 17: 1121-36. Huang, C. C., W. P. Chien, R. H. Wong, Y. W. Cheng, M. C. Chen, M. C. Chou, and H. Lee. 2007. 'NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan', Dis Colon Rectum, 50: 981-9. Huang, C. S., H. D. Chern, C. Y. Shen, S. M. Hsu, and K. J. Chang. 1999. 'Association between N-acetyltransferase 2 (NAT2) genetic polymorphism and development of breast cancer in post-menopausal Chinese women in Taiwan, an area of great increase in breast cancer incidence', Int J Cancer, 82: 175-79. Jägerstad, M., K. Skog, P. Arvidsson, and A. Solyakov. 1998. 'Chemistry, formation and occurrence of genotoxic heterocyclic amines identified in model systems and cooked foods', Z Lebensm-Unters Forsch A, 207: 419–27. Kataoka, H., T. Inoue, N. Ikekita, and K. Saito. 2014. 'Development of exposure assessment method based on the analysis of urinary heterocyclic amines as biomarkers by on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry', Anal Bioanal Chem, 406: 2171-8. Keating, G. A., and K. T. Bogen. 2004. 'Estimates of heterocyclic amine intake in the US population', J Chromatogr B Analyt Technol Biomed Life Sci, 802: 127-33. Larsson, S. C., and A. Wolk. 2006. 'Meat consumption and risk of colorectal cancer: A meta-analysis of prospective studies', Int J Cancer, 119: 2657–64. Le Marchand, L., J. H. Hankin, L. M. Pierce, R. Sinha, P. V. Nerurkar, A. A. Franke, L. R. Wilkens, L. N. Kolonel, T. Donlon, A. Seifried, L. J. Custer, A. Lum-Jones, and W. Chang. 2002. 'Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii', Mutat Res, 506-507. Lee, J. M., Y. C. Lee, S. Y. Yang, W. L. Shi, C. J. Lee, S. P. Luh, C. J. Chen, C. Y. Hsieh, and M. T. Wu. 2000. 'Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus', Int J Cancer, 89: 458-64. Lezamiz, J., T. Barri, J. A. Jonsson, and K. Skog. 2008. 'A simplified hollow-fibre supported liquid membrane extraction method for quantification of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in urine and plasma samples', Anal Bioanal Chem, 390: 689-96. Lilla, C., E. Verla-Tebit, A. Risch, B. Jager, M. Hoffmeister, H. Brenner, and J. Chang-Claude. 2006. 'Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption', Cancer Epidemiol Biomarkers Prev, 15: 99-107. Liu, J., D. Ding, X. Wang, Y. Chen, R. Li, Y. Zhang, and R. Luo. 2012. 'N-acetyltransferase polymorphism and risk of colorectal adenoma and cancer: a pooled analysis of variations from 59 studies', PLoS One, 7: e42797. Luks, H. J., T. E. Spratt, M. T. Vavrek, S. F. Roland, and J. H. Weisburger. 1989. 'Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats', Cancer Res., 49: 4407-11. Malfatti, M. A., K. H. Dingley, S. Nowell-Kadlubar, E. A. Ubick, N. Mulakken, D. Nelson, N. P. Lang, J. S. Felton, and K. W. Turteltaub. 2006. 'The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon DNA adducts after a low-dose exposure in humans', Cancer Res, 66: 10541-7. Manabe, S., H. Suzuki, O. Wada, and A. Ueki. 1993. 'Detection of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in beer and wine', Carcinogenesis, 14: 899-901. Matsumoto, T., D. Yoshida, and H. Tomita. 1981. 'Determination of mutagens, amino-alpha-carbolines in grilled foods and cigarette smoke condensate', Cancer Lett, 12: 105-10. Matuszewski, B. K., M. L. Constanzer, and C. M. Chavez-Eng. 2003. 'Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS', Anal Chem, 75: 3019-30. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Veterinary Medicine. 2013. 'Guidance for industry, bioanalytical method validation'. Metry, K. J., J. R. Neale, J. Bendaly, N. B. Smith, W. M. Pierce, Jr., and D. W. Hein. 2009. 'Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline', Drug Metab Dispos, 37: 2123-6. Michels, K. B., W. C. Willett, C. S. Fuchs, and E. Giovannucci. 2005. 'Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer', J Natl Cancer Inst, 97: 282-92. Murray, S., B. G. Lake, S. Gray, A. J. Edwards, C. Springall, E. A. Bowey, G. Williamson, A. R. Boobis, and N. J. Gooderham. 2001. 'Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man', Carcinogenesis, 22: 1413-20. Nagao, M., K. Wakabayashi, T. Ushijima, M. Toyota, Y. Totsuka, and T. Sugimura. 1996. 'Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals', Environ Health Perspect, 104: 497-501. Norat, T., A. Lukanova, P. Ferrari, and E. Riboli. 2002. 'Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies', Int J Cancer, 98: 241-56. Nowell, S. A., J. S. Massengill, S. Williams, A. Radominska-Pandya, T. R. Tephly, Z. Cheng, C. P. Strassburg, R. H. Tukey, S. L. MacLeod, N. P. Lang, and F. F. Kadlubar. 1999. 'Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved', Carcinogenesis, 20: 1107-14. Nowell, S., B. Coles, R. Sinha, S. MacLeod, R. D. Luke, C. Stotts, F. F. Kadlubar, C. B. Ambrosone, and N. P. Lang. 2002. 'Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk', Mutat Res, 506-507: 175-85. Ognjanovic, S., J. Yamamoto, G. Maskarinec, and L. Le Marchand. 2006. 'NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries', Cancer Causes Control, 17: 1175-82. Ohgaki, H., S. Takayama, and T. Sugimura. 1991. 'Carcinogenicities of heterocyclic amines in cooked food', Mutat Res, 259: 399-410. National Toxicology Program. 2002. 'Report on Carcinogens Background Document for Selected Heterocyclic Amines PhIP, MeIQ, and MeIQx'. National Toxicology Program. 2016. 'Report on Carcinogens, Fourteenth Edition'. Richling, E., C. Decker, D. Häring, M. Herderich, and P. Schreier. 1997. 'Analysis of heterocyclic aromatic amines in wine by high-performance liquid chromatography-electrospray tandem mass spectrometry', J Chromatogr A, 791: 71-77. Rohrmann, S., S. Hermann, and J. Linseisen. 2009. 'Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study', Am J Clin Nutr, 89: 1418-24. Sabbagh, A., P. Darlu, B. Crouau-Roy, and E. S. Poloni. 2011. 'Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey', PLoS One, 6: e18507. Schmit, S. L., H. S. Rennert, G. Rennert, and S. B. Gruber. 2016. 'Coffee consumption and the risk of colorectal cancer', Cancer Epidemiol Biomarkers Prev, 25: 634-9. Schut, H. A., and E. G. Snyderwine. 1999. 'DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis', Carcinogenesis, 20: 353-68. Sekine, A., S. Saito, A. Iida, Y. Mitsunobu, S. Higuchi, S. Harigae, and Y. Nakamura. 2001. 'Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population', J Hum Genet, 46: 314-19. Sentellas, S., E. Moyano, L. Puignou, and M. T. Galceran. 2004. 'Optimization of a clean-up procedure for the determination of heterocyclic aromatic amines in urine by field-amplified sample injection–capillary electrophoresis–mass spectrometry', J Chromatogr A, 1032: 193-201. Shah, F. U., T. Barri, J. A. Jonsson, and K. Skog. 2008. 'Determination of heterocyclic aromatic amines in human urine by using hollow-fibre supported liquid membrane extraction and liquid chromatography-ultraviolet detection system', J Chromatogr B Analyt Technol Biomed Life Sci, 870: 203-8. Shin, A., M. J. Shrubsole, J. M. Rice, Q. Cai, M. A. Doll, J. Long, W. E. Smalley, Y. Shyr, R. Sinha, R. M. Ness, D. W. Hein, and W. Zheng. 2008. 'Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk', Cancer Epidemiol Biomarkers Prev, 17: 320-9. Shin, J. H., Y. C. Na, J. H. Chung, S. Gorinstein, and Y. G. Ahn. 2014. 'Quantitative analysis of heterocyclic amines in urine by liquid chromatography coupled with tandem mass spectrometry', Anal Biochem, 447: 169-76. Sinha, R. 2002. 'An epidemiologic approach to studying heterocyclic amines', Mutat Res, 506-507: 197-204. Sinha, R., M. Kulldorff, W. H. Chow, J. Denobile, and N. Rothman. 2001. 'Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas', Cancer Epidemiol Biomarkers Prev, 10: 559-62. Stillwell, W. G., R. Sinha, and S. R. Tannenbaum. 2002. 'Excretion of the N2 -glucuronide conjugate of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in urine and its relationship to CYP1A2 and NAT2 activity levels in humans', Carcinogenesis, 23: 831-38. Strickland, P. T., Z. Qian, M. D. Friesen, N. Rothman, and R. Sinha. 2002. 'Metabolites of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human urine after consumption of charbroiled or fried beef', Mutat Res, 506-507: 163-73. Sugimura, T., K. Wakabayashi, H. Nakagama, and M. Nagao. 2004. 'Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish', Cancer Sci, 95: 290-99. Sun, C. L., J. M. Yuan, W. P. Koh, and M. C. Yu. 2006. 'Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies', Carcinogenesis, 27: 1301-9. Sung, Joseph J. Y., James Y. W. Lau, K. L. Goh, and W. K. Leung. 2005. 'Increasing incidence of colorectal cancer in Asia: implications for screening', Lancet Oncol, 6: 871-76. Tang, D., J. J. Liu, A. Rundle, C. Neslund-Dudas, A. T. Savera, C. H. Bock, N. L. Nock, J. J. Yang, and B. A. Rybicki. 2007. 'Grilled meat consumption and PhIP-DNA adducts in prostate carcinogenesis', Cancer Epidemiol Biomarkers Prev, 16: 803-8. Turesky, R. J. 2002. 'Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis', Drug Metab Rev, 34: 625-50. Turesky, R. J., R. C. Garner, D. H. Welti, J. Richoz, S. H. Leveson, K. H. Dingley, K. W. Turteltaub, and L. B. Fay. 1998. 'Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans', Chem Res Toxicol, 11: 217-25. Turesky, R. J., N. P. Lang, M. A. Butler, C. H. Teitel, and F. F. Kadlubar. 1991. 'Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon', Carcinogenesis, 12: 1839-45. Turesky, R. J., and L. Le Marchand. 2011. 'Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines', Chem Res Toxicol, 24: 1169-214. Turesky, R. J., J. Taylor, L. Schnackenberg, J. P. Freeman, and R. D. Holland. 2005. 'Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS', J Agric Food Chem, 53: 3248-58. Turteltaub, K. W., K. H. Dingley, K. D. Curtis, M. A. Malfatti, R. J. Turesky, R. C. Garner, J. S. Felton, and N. P. Lang. 1999. 'Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses', Cancer Lett, 143: 149-55. Turteltaub, K. W., J. S. Vogel, C. E. Frantz, and N. Shen. 1992. 'Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in mice at a human dietary equivalent dose', Cancer Res, 52: 4682-87. Viberg, P., K. G. Wahlund, and K. Skog. 2006. 'On-line capillary based quantitative analysis of a heterocyclic amine in human urine', J Chromatogr A, 1133: 347-52. Wakabayashi, K., M. Nagao, H. Esumi, and T. Sugimura. 1992. 'Food-derived mutagens and carcinogens', Cancer Res, 52: 2092-98. Wong, K. Y., J. Su, M. G. Knize, W. P. Koh, and A. Seow. 2005. 'Dietary exposure to heterocyclic amines in a Chinese population', Nutr Cancer, 52: 147-55. Wu, I. C., C. H. Lee, C. H. Kuo, F. C. Kuo, D. C. Wu, Y. C. Ko, and F. J. Yu. 2009. 'Consumption of cigarettes but not betel quid or alcohol increases colorectal cancer risk', J Formos Med Assoc, 108: 155-63. Yeh, C. C., L. L. Hsieh, R. Tang, C. R. Chang-Chieh, and F. C. Sung. 2003. 'Risk factors for colorectal cancer in Taiwan: a hospital-based case-control study', J Formos Med Assoc, 102: 305-12. Zheng, W., and S. A. Lee. 2009. 'Well-done meat intake, heterocyclic amine exposure, and cancer risk', Nutr Cancer, 61: 437-46. Zhu, J., P. Chang, M. L. Bondy, A. A. Sahin, S. E. Singletary, S. Takahashi, T. Shirai, and D. Li. 2003. 'Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer', Cancer Epidemiol Biomarkers Prev, 12: 830-7. Zhu, J., A. Rashid, K. Cleary, J. L. Abbruzzese, H. Friess, S. Takahashi, T. Shirai, and D. Li. 2006. 'Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)-DNA adducts in human pancreatic tissues', Biomarkers, 11: 319–28. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67529 | - |
| dc.description.abstract | 大腸直腸癌發生率已連續八年高居臺灣十大癌症之首，發生率及死亡率逐年增加，文獻指出攝食高溫處理的紅肉與肉類加工產品所產生的異環胺為危險因子。N-乙醯基轉移酶參與異環胺在生物體內的代謝，進而影響DNA共價鍵結物生成。由於國人N-乙醯基轉移酶基因多型性與歐美人種不同，異環胺暴露對於國人產生的致癌風險無法一概而論，其真實致癌風險至今仍未有系統性研究。因此，本研究欲探討異環胺(IQ、MeIQ、MeIQx和PhIP)暴露、N-乙醯基轉移酶2(NAT2)之基因多型性與罹患大腸直腸癌的相關性。
本篇初探研究共收集臺大醫院及臺北榮民總醫院共65名大腸直腸癌病患與19名控制組病患，並利用高效液相層析串聯質譜儀建立異環胺於人體尿液中的分析方法，作為異環胺暴露的生物指標，亦收集血液以定序NAT2之基因多型性，並進行問卷調查受試者的飲食習慣與生活方式。 六個大腸癌尿液檢體偵測到小於定量極限的PhIP，檢出率為7.14%，快速/中代謝型與慢代謝型的NAT2在大腸癌病患中比例分別為72.13%與27.87%，在控制組病患中比例則分別為42.10%與57.90%，而臺灣族群主要攜帶快代謝型之NAT2*4基因，然而並未發現病患與控制組之間有顯著差異性。年齡為罹患大腸癌之干擾因子，高程度喜愛攝食火炒肉品者會比中/低程度喜愛火炒肉品者多2.04倍罹患大腸癌風險(95% 信賴區間: 0.65, 6.42)，然而未有統計上顯著差異性。 本研究建立同時偵測四種異環胺(IQ、MeIQ、MeIQx和PhIP)之高效液相層析串聯質譜儀分析方法，因樣本數限制無法鑑定NAT2基因多型性與大腸直腸癌之間的相關性，然而本研究發現臺灣人口傾向攜帶NAT2快速乙醯化基因型，與歐美人口基因分布不同。未來研究需要應用更先進之分析儀器以提高偵測靈敏度，並且需要藉由更長時間、收集更多病患來評估大腸癌致癌風險。 | zh_TW |
| dc.description.abstract | Colorectal cancer has dominated the top 10 cancer incidence list for eight years in Taiwan. Both incidence and death rates are on the rise. Previous studies indicated that exposure to heterocyclic amines (HCAs) formed from the consumption of high-temperature processed meat, including red and white meat, fish, and processed meat products could elevate the risks of colorectal cancer. N-acetyltransferase (NAT) acetylation is involved in the metabolism of HCAs, thus further affecting the formation of DNA adducts. Besides, Taiwanese NAT genetic polymorphisms are different from those of Europeans and Americans and may interact with HCAs exposure so as to lead to colorectal cancer development. Colorectal cancer risk has yet to be systematically investigated through measurement of NAT genetic polymorphisms and HCAs exposures. Thus, this study aims to clarify the relationship of HCAs (IQ, MeIQ, MeIQx, PhIP) exposure, NAT2 genetic polymorphisms and the development of colorectal cancer.
A total of 65 colorectal cancer patients and 19 controls in National Taiwan University Hospital and Taipei Veterans General Hospital were recruited in this pilot study. A high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed to measure urinary HCAs parent compounds which served as biomarkers for HCAs exposures. Human blood was genotyped to denote NAT2 genetic polymorphisms. Dietary habits and lifestyles variables were collected by using questionnaires. Low concentrations of PhIP (below LOQ) were detected in six urine samples, which resulted in 7.14% of detectable rates. The rapid/intermediate genotype and slow genotype of NAT2 in colorectal cancer patients were found to be 72.13% and 27.87% respectively, while in controls were 42.10% and 57.90% respectively. The fast NAT2*4 haplotype dominates in Taiwanese population. However, no statistical difference was found in NAT2 acetylator genotypes among cases and controls. Age was a confounding factor of risk of colorectal cancer. High preference of pan-fried showed increased 2.04-fold of odds ratio (95% CI: 0.65, 6.42) compared with low/medium preference, although no statistically significant association existed. This study demonstrated the HPLC-MS/MS method as to determine four HCA compounds (IQ, MeIQ, MeIQx, PhIP) in urine simultaneously. Limited numbers of study subjects were not able to identify the association between NAT2 genetic polymorphisms and colorectal cancer risk. However, this study still found that Taiwanese population tends to possess fast NAT2 acetylator genotype, which differs from the distributions of Europeans and Americans. Further research needs to improve the sensitivity of the method by using more advanced instrument. The results need to be confirmed with longer and larger recruitment of participants as to assess the risk of colorectal cancer. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T01:36:14Z (GMT). No. of bitstreams: 1 ntu-106-R04841007-1.pdf: 9530838 bytes, checksum: 19a14be3ab4e3a9759bd3559398d9793 (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 摘要 i
Abstract ii Table of Contents v List of Figures vii List of Tables ix Chapter 1: Introduction 1 1.1 Heterocyclic amines 1 1.2 Metabolism of HCAs 3 1.3 Mutagenicity and carcinogenicity of HCAs 7 1.4 Epidemiologic studies 9 Chapter 2: Objective 18 Chapter 3: Method 20 3.1 Chemicals 20 3.2 Study design 21 3.3 Urine sample pre-treatment 23 3.4 HPLC-MS/MS method development 24 3.5 HPLC-MS/MS method validation 25 3.6 NAT2 genotyping 28 3.7 Statistical analysis 31 Chapter 4: Results 33 4.1 Study population 33 4.2 HPLC-MS/MS parameter optimizations and method validation 33 4.3 Analysis of urinary IQ, MeIQ, MeIQx and PhIP in study subjects 35 4.4 NAT2 genetic polymorphisms of study subjects 35 4.5 Dietary data 36 Chapter 5: Discussion 38 Chapter 6: Conclusion and recommendations 43 References 44 Appendix I Clinical Research Approval of NTUH 90 Appendix II Clinical Research Approval of TPEVGH 92 Appendix III Informed Consent of NTUH 94 Appendix IV Informed Consent of TPEVGH 99 Appendix V Questionnaire 107 | |
| dc.language.iso | en | |
| dc.subject | N-乙醯基轉移? | zh_TW |
| dc.subject | 異環胺 | zh_TW |
| dc.subject | 大腸直腸癌 | zh_TW |
| dc.subject | 高效液相層析串聯質譜儀 | zh_TW |
| dc.subject | N-acetyltransferase | en |
| dc.subject | Colorectal cancer | en |
| dc.subject | Heterocyclic amine | en |
| dc.subject | HPLC-MS/MS | en |
| dc.title | 異環胺暴露與N-乙烯基轉移酶基因多型性之於臺灣大腸癌風險初探 | zh_TW |
| dc.title | A Pilot Study of Heterocyclic Amines Exposure and N-Acetyltransferase Genetic Polymorphisms related to Colorectal Cancer Risk in Taiwan | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 105-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 鄭尊仁,施惟量,邱瀚模,林靖愉 | |
| dc.subject.keyword | 異環胺,大腸直腸癌,N-乙醯基轉移?,高效液相層析串聯質譜儀, | zh_TW |
| dc.subject.keyword | Heterocyclic amine,Colorectal cancer,N-acetyltransferase,HPLC-MS/MS, | en |
| dc.relation.page | 120 | |
| dc.identifier.doi | 10.6342/NTU201702331 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2017-08-01 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
| 顯示於系所單位： | 職業醫學與工業衛生研究所 | |
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