請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6735
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 賴文崧 | |
dc.contributor.author | Ya-Shan Chen | en |
dc.contributor.author | 陳雅珊 | zh_TW |
dc.date.accessioned | 2021-05-17T09:17:08Z | - |
dc.date.available | 2017-08-01 | |
dc.date.available | 2021-05-17T09:17:08Z | - |
dc.date.copyright | 2012-08-01 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-07-27 | |
dc.identifier.citation | Abdi, H. (2010). Signal detection theory (SDT). In P. L. Peterson, E. Baker, & B. McGaw (Eds.), International encyclopedia of education (3rd ed., Vol. 7, pp. 407-410). New York: Elsevier.
American Psychiatric Association (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: Author. Antonova, E., Sharma, T., Morris, R., & Kumari, V. (2004). The relationship between brain structure and neurocognition in schizophrenia: A selective review. Schizophrenia Research, 70, 117-145. Arguello, P. A., & Gogos, J. A. (2006). Modeling madness in mice: One piece at a time. Neuron, 52, 179-196. Austin, J. (2005). Schizophrenia: An Update and Review. Journal of Genetic Counseling, 14, 329-340. Bajestan, S. N., Sabouri, A. H., Nakamura, M., Takashima, H., Keikhaee, M. R., Behdani, F., ...Osame, M. (2006). Association of AKT1 haplotype with the risk of schizophrenia in Iranian population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B, 383-386. Bari, A., Dalley, J. W., & Robbins, T. W. (2008). The application of the 5-choice serial reaction time task for the assessment of visual attentive processes and impulse control in rats. Nature Protocols, 3, 759-767. Barnett, J. H., Robbins, T. W., Leeson, V. C., Sahakian, B. J., Joyce, E. M., & Blackwell, A. D. (2010). Assessing cognitive function in clinical trials of schizophrenia. Neuroscience and Biobehavioral Reviews, 34, 1161-1177. Baunez, C., & Robbins, T. W. (1999). Effects of dopamine depletion of the dorsal striatum and further interaction with subthalamic nucleus lesions in an attentive task in rats. Neuroscience, 92, 1343-1356. Beaulieu, J. M., Del'guidice, T., Sotnikova, T. D., Lemasson, M., & Gainetdinov, R. R. (2011). Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors. Frontiers in Molecular Neuroscience, 4(38). Beaulieu, J. M., Gainetdinov, R. R., & Caron, M. G. (2009). Akt/GSK3 Signaling in the Action of Psychotropic Drugs. Annual Review of Pharmacology and Toxicology, 49, 327-347. Beaulieu, J. M., Sotnikova, T. D., Yao, W. D., Kockeritz, L., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004). Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proceedings of the National Academy of Sciences of the United States of America, 101, 5099-5104. Beaulieu, J. M. (2011). A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. Journal of Psychiatry & Neuroscience, 37, 7-16. Beck, L. H., Bransome, E. D., Jr., Mirsky, A. F., Rosvold, H. E., & Sarason, I. (1956). A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343-350. Bellacosa, A., Franke, T. F., Gonzalez-Portal, M. E., Datta, K., Taguchi, T., Gardner, J., ...Tsichlis, P. N. (1993). Structure, expression and chromosomal mapping of c-akt: Relationship to v-akt and its implications. Oncogene, 8, 745–754. Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991). A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science, 254, 274-277. Benes, F. M., McSparren, J., Bird, E. D., SanGiovanni, J. P., & Vincent, S. L. (1991). Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Archives of General Psychiatry, 48, 996-1001. Braff, D. L., Geyer, M. A., & Swerdlow, N. R. (2001). Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology, 156, 234-258. Brown, A. S. (2011). The environment and susceptibility to schizophrenia. Progress in Neurobiology, 93, 23-58. Bizarro, L., Patel, S., Murtagh, C., & Stolerman, I. P. (2004). Differential effects of psychomotor stimulants on attentive performance in rats: Nicotine, amphetamine, caffeine and methylphenidate. Behavioural Pharmacology, 15, 195-206. Blasi, G., Napolitano, F., Ursini, G., Taurisano, P., Romano, R., Caforio, G., ...Bertolino, A. (2011). DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentive processing, and response to olanzapine treatment in schizophrenia. Proceedings of the National Academy of Sciences, 108, 1158-1163. Calkins, M. E., & Iacono, W. G. (2003). Schizophrenia (2nd ed., pp. 1402-1405). New York: Thomson-Gale. Calleja, V., Alcor, D., Laguerre, M., Park, J., Vojnovic, B., Hemmings, B. A., ...Larijani, B. (2007). Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biology, 5, e95. Carli, M., Robbins, T. W., Evenden, J. L., & Everitt, B. J. (1983). Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats: Implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural Brain Research, 9, 361-380. Chen, W. J., & Faraone, S. V. (2000). Sustained attention deficits as markers of genetic susceptibility to schizophrenia. American Journal of Medical Genetics, 97, 52-57. Chen, Y. C., Chen, Y. W., Hsu, Y. F., Chang, W. T., Hsiao, C. K., Min, M. Y., & Lai, W. S. (2012). Akt1 deficiency modulates reward learning and reward prediction error in mice. Genes, Brain and Behavior, 11, 157-169. Chen, Y. W., Chen, Y. S., & Lai, W. S. (2011, November). The deficiency of AKT1 results in the reduction of hippocampus-related cognitive performance and hippocampal neuromorphology in mice. Poster session presented at the meeting of the Society for Neuroscience, Washington, DC Chen, Y. W., & Lai, W. S. (2011). Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics. Neuroscience, 174, 178-189. Cho, H. (2001). Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. Journal of Biological Chemistry, 276, 38349-38352. Chudasama, Y., & Robbins, T. W. (2004). Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: Implications for schizophrenia. Psychopharmacology, 174, 86–98. Clinton, S. M., & Meador-Woodruff, J. H. (2004). Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder. Neuropsychopharmacology, 29, 1353-1362. Coffer, P. J., & Woodgett, J. R. (1991). Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. European Journal of Biochemistry, 201, 475-481. Cohen, R. M., Nordahl, T. E., Semple, W. E., Andreason, P., & Pickar, D. (1998). Abnormalities in the distributed network of sustained attention predict neuroleptic treatment response in schizophrenia. Neuropsychopharmacology, 19, 36-47. Cole, B. J., & Robbins, T. W. (1989). Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: Implications for theories of selective attention and arousal. Behavioural Brain Research, 33, 165-179. Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience, 3, 201-215. Cornblatt, B. A., & Keilp, J. G. (1994). Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophrenia Bulletins, 20, 31-46. Corti, C., Crepaldi, L., Mion, S., Roth, A. L., Xuereb, J. H., & Ferraguti, F. (2007). Altered dimerization of metabotropic glutamate receptor 3 in schizophrenia. Biological Psychiatry, 62, 747-755. Coyle, J. T. (2006). Glutamate and schizophrenia: Beyond the dopamine hypothesis. Cellular and Molecular Neurobiology, 26, 365-384. Dalley, J., Cardinal, R., & Robbins, T. (2004). Prefrontal executive and cognitive functions in rodents: Neural and neurochemical substrates. Neuroscience and Biobehavioral Reviews, 28, 771-784. Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991). Dopamine in schizophrenia: A review and reconceptualization. American Journal of Psychiatry, 148, 1474-1486. Davis, J. M., Chen, N., & Glick, I. D. (2003). A meta-analysis of the efficacy of second-generation antipsychotics. Archives of General Psychiatry, 60, 553-564. Debruin, N., Fransen, F., Duytschaever, H., Grantham, C., & Megens, A. (2006). Attentive performance of (C57BL/6J×129Sv)F2 mice in the five-choice serial reaction time task. Physiology & Behavior, 89, 692-703. Emamian, E. S., Hall, D., Birnbaum, M. J. Karayiorgou, M., & Gogos, J. A. (2004). Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia. Nature Genetics, 36, 131-137. Elvevag, B., & Goldberg, T. E. (2000). Cognitive impairment in schizophrenia is the core of the disorder. Critical Reviews in Neurobiology, 14, 1-21. Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology, 146, 348-361. Fell, M. J., McKinzie, D. L., Monn, J. A., & Svensson, K. A. (2012). Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia. Neuropharmacology, 62, 1473-1483. Field, J. R, Walker, A. G, & Conn, P. J. (2011). Targeting glutamate synapses in schizophrenia. Trends in Molecular Medicine, 17, 689-698. Franke, T. F. (2008). PI3K/Akt: getting it right matters. Oncogene, 27, 6473-6488. Freyberg, Z., Ferrando, S. J., & Javitch, J. A. (2010). Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. The American Journal of Psychiatry, 167, 388-396. Gainetdinov, R. R., Mohn, A. R., & Caron, M. G. (2001). Genetic animal models: Focus on schizophrenia. TRENDS in Neurosciences, 24, 527-533. Gazzaniga, M. S. (2009). The cognitive neurosciences (4th ed., p. 219). Cambridge, Massachusetts Institute of Technology: MIT Press. Gold, J. M. (2004). Cognitive deficits as treatment targets in schizophrenia. Schizophrenia Research, 72, 21-28. Gonzalez-Maeso, J., Ang, R. L., Yuen, T., Chan, P., Weisstaub, N. V., Lopez-Gimenez, J. F., ...Sealfon, S. C. (2008). Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature, 452, 93-97. Gottesman, I. I. (1991). Schizophrenia genesis: The origins of madness. New York: Freeman. Gradin, V. B., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., ...Steele, J. D. (2011). Expected value and prediction error abnormalities in depression and schizophrenia. Brain, 134, 1751-1764. Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000). Enhanced and impaired attentive performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex. The Journal of Neuroscience, 20, 1208-1215. Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? The American Journal of Psychiatry, 153, 321-330. Green, M. F. (2006). Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 67(Supplement 9), 3-8. Grottick, A. J., & Higgins, G. A. (2002). Assessing a vigilance decrement in aged rats: Effects of pre-feeding, task manipulation, and psychostimulants. Psychopharmacology, 164, 33-41. Gupta, D. S., McCullumsmith, R. E., Beneyto, M., Haroutunian, V., Davis, K. L., & Meador-Woodruff, J. H. (2005). Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia. Synapse, 57, 123-131. Gur, R. E., Calkins, M. E., Gur, R. C., Horan, W. P., Nuechterlein, K. H., Seidman, L. J., & Stone, W. S. (2007). The Consortium on the Genetics of Schizophrenia: Neurocognitive endophenotypes. Schizophrenia Bulletin, 33, 49-68. Houthoofd, S. A., Morrens, M., & Sabbe, B. G. (2008). Cognitive and psychomotor effects of risperidone in schizophrenia and schizoaffective disorder. Clinical Therapeutics, 30, 1565-1589. Howes, O. D., & Kapur, S. (2009). The dopamine hypothesis of schizophrenia: Version III-the final common pathway. Schizophrenia Bulletin, 35, 549-562. Hoyle, E., Genn, R. F., Fernandes, C., & Stolerman, I. P. (2006). Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology, 189, 211-223. Humby, T., Wilkinson, L. S., & Dawson, G. R. (2005). Assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. Current Protocols in Neuroscience, 8.5H.1-8.5H.15. Ikeda, M., Iwata, N., Suzuki, T., Kitajima, T., Yamanouchi, Y., Kinoshita, Y., ...Ozaki, N. (2004). Association of AKT1 with schizophrenia confirmed in a Japanese population. Biological Psychiatry, 56, 698-700. Iversen, S. D., & Iversen, L. L. (2007). Dopamine: 50 years in perspective. Trends in Neurosciences, 30, 188-193. James, W. (1890). The principles of psychology (vol. 1, pp. 403-404). New York: Henry Holt. Javitt, D. C., & Zukin, S. R. (1991). Recent advances in the phencyclidine model of schizophrenia. The American Journal of Psychiatry, 148, 1301-1308. Javitt, D.C. (2010). Glutamatergic theories of schizophrenia. Israel Journal of Psychiatry and Related Sciences, 47, 4-16. Jones, C. A., Watson, D. J., & Fone, K. C. (2011). Animal models of schizophrenia. British Journal of Pharmacology, 164, 1162-1194. Jones, P. F., Jakubowicz, T., Pitossi, F. J., Maurer, F., & Hemmings, B.A. (1991). Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proceedings of the National Academy of Sciences of the United States of America, 88, 4171-4175. Kapur, S. (2003). Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia. The American Journal of Psychiatry, 160, 13-23. Kapur, S., Mizrahi, R., & Li, M. (2005). From dopamine to salience to psychosis-linking biology, pharmacology and phenomenology of psychosis. Schizophrenia Research, 79, 59-68. Keeler, J. F., & Robbins, T. W. (2011). Translating cognition from animals to humans. Biochemical Pharmacology, 81, 1356-1366. Kieling, C., Roman, T., Doyle, A. E., Hutz, M. H., & Rohde, L. A. (2006). Association between DRD4 gene and performance of children with ADHD in a test of sustained attention. Biological Psychiatry, 60, 1163-1165. Kim, J. S., Kornhuber, H. H., Schmid-Burgk, W., & Holzmüller, B. (1980). Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neuroscience Letters, 20, 379-382. Koelega, H. S. (1993). Stimulant drugs and vigilance performance: A review. Psychopharmacology, 111, 1-16. Kollins, S. H., Anastopoulos, A. D., Lachiewicz, A. M., FitzGerald, D., Morrissey-Kane, E., Garrett, M. E., ...Ashley-Koch, A. E. (2008). SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 147B, 1580–1588. Kosslyn, S. M., & Rosenberg, R. S. (2011). Introducing psychology (4th ed., pp. 422-423). New Jersey: Pearson Education, Incorporation. Kulhara, P., & Chakrabarti, S. (2001). Culture and schizophrenia and other psychotic disorders. Psychiatric Clinics of North America, 24, 449-464. Kumar, C. C., & Madison, V. (2005). AKT crystal structure and AKT-specific inhibitors. Oncogene, 24, 7493-7501. Lai, W. S., Xu, B., Westphal, K. G. C., Paterlini, M., Olivier, B., Pavlidis, P., ...Gogos, J. A. (2006). Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proceedings of the National Academy of Sciences, 103, 16906-16911. Lawrence, C. A., Barry, R. J., Clarke, A. R., Johnstone, S. J., McCarthy, R., Selikowitz, M., & Broyd, S. J. (2005). Methylphenidate effects in attention deficit/hyperactivity disorder: Electrodermal and ERP measures during a continuous performance task. Psychopharmacology, 183, 81-91. Levin, E. D., Bushnell, P. J., & Rezvani, A. H. (2011). Attention-modulating effects of cognitive enhancers. Pharmacology Biochemistry and Behavior, 99, 146-154. Loo, S. K., Specter, E., Smolen, A., Hopfer, C., Teale, P. D., & Reite, M. L. (2003). Functional effects of the DAT1 polymorphism on EEG measures in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 986-993. MacDonald, A. W. 3rd, Carter, C. S., Kerns, J. G., Ursu, S., Barch, D. M., Holmes, A. J., ...Cohen, J. D. (2005). Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. The American Journal of Psychiatry, 162, 475-484. Maira, S. M., Galetic, I., Brazil, D. P., Kaech, S., Ingley, E., Thelen, M., & Hemmings, B. A. (2001). Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science, 294, 374-380. Manning, B. D., & Cantley, L. C. (2007). AKT/PKB signaling: Navigating downstream. Cell, 129, 1261-1274. Mathur, A., Law, M. H., Megson, I. L., Shaw, D. J., & Wei, J. (2010).Genetic association of the AKT1 gene with schizophrenia in a British population. Psychiatric genetics, 20, 118-122. Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167-202. Moghaddam, B., & Adams, B. W. (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science, 281, 1349-1352. Mueser, K. T., & McGurk, S. R. (2004). Schizophrenia. Lancet, 363, 2063-2072. Mulle, J. G. (2012). Schizophrenia genetics: Progress, at last. Current Opinion in Genetics & Development, 22, 1-7. Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., ...Fletcher, P. C. (2008). Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry, 13, 267-276. Nestler, E. J., Hyman, S. E., & Malenka, R. C. (2009). Molecular neuropharmacology: A foundation for clinical neuroscience (2nd ed., pp. 148-151). New York: McGraw-Hill Medical. Nestler, E. J., & Hyman, S. E. (2010). Animal models of neuropsychiatric disorders. Nature Neuroscience, 13, 1161-1169. Neve, K. A., Seamans, J. K., & Trantham-Davidson, H. (2004). Dopamine receptor signaling. Journal of Receptors and Signal Transduction Research, 24, 165-205. Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004). Identification of separable cognitive factors in schizophrenia. Schizophrenia Research, 72, 29-39. Nuechterlein, K. H., Green, M. F., Kern, R. S., Baade, L. E., Barch, D. M., Cohen, J. D., ...Marder, S. R. (2008). The MATRICS Consensus Cognitive Battery, part 1: Test selection, reliability, and validity. The American Journal of Psychiatry, 165, 203-213. O'Carroll, R. (2000). Cognitive impairment in schizophrenia. Advances in Psychiatric Treatment, 6, 161-168. Ohi, K., Hashimoto, R., Yasuda, Y., Fukumoto, M., Nemoto, K., Ohnishi, T., ...Takeda, M. (2011). The AKT1 gene is associated with attention and brain morphology in schizophrenia. World Journal of Biological Psychiatry. Early Online, 1-14. doi:10.3109/15622975.2011.591826. O'Toole, K., Abramowitz, A., Morris, R., & Dulcan, M. (1997). Effects of methylphenidate on attention and nonverbal learning in children with attention-deficit hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 531-538. Passetti, F., Chudasama, Y., & Robbins, T. W. (2002). The frontal cortex of the rat and visual attentive performance: Dissociable functions of distinct medial prefrontal subregions. Cerebral Cortex, 12, 1254-1268. Patel, S., Stolerman, I., Asherson, P., & Sluyter, F. (2006). Attentive performance of C57BL/6 and DBA/2 mice in the 5-choice serial reaction time task. Behavioural Brain Research, 170, 197-203. Pezze, M. -A., Dalley, J. W., & Robbins, T. W. (2006). Differential Roles of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Attentive Performance on the Five-Choice Serial Reaction Time Task. Neuropsychopharmacology, 32, 273-283. Pietiläinen, O. P., Paunio, T., Loukola, A., Tuulio-Henriksson, A., Kieseppä, T., Thompson, P., ...Peltonen, L. (2009). Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B, 683-692. Platt, S. R. (2007). The role of glutamate in central nervous system health and disease--a review. The Veterinary Journal, 173, 278-286. Posner, M. I., & Boies, S. J. (1971). Components of attention. Psychological Review, 78, 391-408. Posner, M. I., & Rothbart, M. K. (2007). Research on attention networks as a model for the integration of psychological science. Annual Review of Psychology, 58, 1-23. Powell, C., & Miyakawa, T. (2006). Schizophrenia-relevant behavioral testing in rodent models: A uniquely human disorder? Biological Psychiatry, 59, 1198-1207. Raz, A., & Buhle, J. (2006). Typologies of attentional networks. Nature Reviews Neuroscience, 7, 367-379. Relkovic, D., Doe, C. M., Humby, T., Johnstone, K. A., Resnick, J. L., Holland, A. J., ...Isles, A. R. (2010). Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome. European Journal of Neuroscience, 31, 156-164. Remington, G., Agid, O., & Foussias, G. (2011) Schizophrenia as a disorder of too little dopamine: Implications for symptoms and treatment. Expert Review of Neurotherapeutics, 11, 589-607. Robbins, T. (2002). The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology, 163, 362-380. Rorick-Kehn, L. M., Johnson, B. G., Knitowski, K. M., Salhoff, C. R., Witkin, J. M., Perry, K. W., ...Schoepp, D. D. (2007). In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders. Psychopharmacology, 193, 121-136. Saeedi, H., Remington, G., & Christensen, B. K. (2006). Impact of haloperidol, a dopamine D2 antagonist, on cognition and mood. Schizophrenia Research, 85, 222-231. Sanchez-Roige, S., Peña-Oliver, Y., & Stephens, D. N. (2012). Measuring impulsivity in mice: The five-choice serial reaction time task. Psychopharmacology, 219, 253-270. Schwab, S. G., Hoefgen, B., Hanses, C., Hassenbach, M. B., Albus, M., Lerer, B., ...Wildenauer, D.B. (2005). Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families. Biological Psychiatry, 58, 446-450. Seeman, P. (1987). Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse, 1, 133-152. Staal, S. P., Hartley, J. W., & Rowe, W. P. (1977). Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 74, 3065–3067. Stahl, S. M. (2007). Beyond the dopamine hypothesis to the NMDA glutamate receptor hypofunction hypothesis of schizophrenia. CNS Spectrums, 12, 265-268. Stubbs, L. (1996). How closely related are mice and humans? What percentage of genes are the same? Human Genome News, 8, 16. Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003). Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies. Archives of General Psychiatry, 60, 1187-1192. Sullivan, P. F. (2005). The genetics of schizophrenia. PLoS Medicine, 2, e212. Tan, H. Y., Chen, A. G., Chen, Q., Browne, L. B., Verchinski, B., Kolachana, B., ...Weinberger, D. R. (2011). Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications. Molecular Psychiatry, 1-11. Tan, H. Y., Nicodemus, K. K., Chen, Q., Li, Z., Brooke, J. K., Honea, R, ...Weinberger, D. R. (2008). Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. Journal of Clinical Investigation, 118, 2200-2208. Tandon, R. (2011). Antipsychotics in the Treatment of Schizophrenia. The Journal of Clinical Psychiatry, 72(supplement 1), 4-8. Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009). Schizophrenia, 'just the facts' 4. Clinical features and conceptualization. Schizophrenia Research, 110, 1-23. Tamminga, C. A., & Holcomb, H. H. (2005). Phenotype of schizophrenia: A review and formulation. Molecular Psychiatry, 10, 27-39. Thiselton, D. L., Vladimirov, V.I., Kuo, P. H., McClay, J., Wormley, B., Fanous, A., ...Riley, B. P. (2008). AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biological Psychiatry, 63, 449-457. Tost, H., & Meyer-Lindenberg, A. (2012). Puzzling over schizophrenia: Schizophrenia, social environment and the brain. Nature Medicine, 18, 211-213. Uylings, H. B., Groenewegen, H. J., & Kolb, B. (2003). Do rats have a prefrontal cortex? Behavioural Brain Research, 146, 3-17. van Os, J., Rutten, B. P., & Poulton, R. (2008). Gene-environment interactions in schizophrenia: Review of epidemiological findings and future directions. Schizophrenia Bulletin, 34, 1066-1082. Walker, S. E., Peña-Oliver, Y., & Stephens, D. N. (2011). Learning not to be impulsive: Disruption by experience of alcohol withdrawal. Psychopharmacology, 217, 433-442. Weinberger, D. R. (1988). Schizophrenia and the frontal lobe. Trends in Neurosciences, 11, 367-370. Wilkinson, R. T. (1963). Interaction of noise with knowledge of results and sleep deprivation. Journal of Experimental Psychology, 66, 332-337. Xu, M. Q., Xing, Q. H., Zheng, Y. L., Li, S., Gao, J. J., He, G., ...He, L. (2007). Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. The Journal of clinical psychiatry, 68, 1358-1367. Yang, J., Cron, P., Good, V. M., Thompson, V., Hemmings, B. A., & Barford, D. (2002). Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nature Structural Biology, 9, 940-944. Yang, Z. Z., Tschopp, O., Baudry, A., Dummler, B., Hynx, D., & Hemmings, B. A. (2004). Physiological functions of protein kinase B/Akt. Biochemical Society Transactions, 32, 350-354. Young, J. W., Powell, S. B., Risbrough, V., Marston, H. M., & Geyer, M. A. (2009). Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacology & Therapeutics, 122, 150-202. Carli, M., Robbins, T. W., Evenden, J. L., & Everitt, B. J. (1983). Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behavioural Brain Research, 9, 361-380. Chen, Y. C., Chen, Y. W., Hsu, Y. F., Chang, W. T., Hsiao, C. K., Min, M. Y., & Lai, W. S. (2012). Akt1 deficiency modulates reward learning and reward prediction error in mice. Genes, Brain and Behavior, 11, 157-169. Chen, Y. W., & Lai, W. S. (2011). Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics. Neuroscience, 174, 178-189. Dalley, J. W., Theobald, D. E., Eagle, D. M., Passetti, F., & Robbins, T. W. (2002). Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex. Neuropsychopharmacology, 26, 716-728. Emamian, E. S., Hall, D., Birnbaum, M. J. Karayiorgou, M., & Gogos, J. A. (2004). Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia. Nature Genetics, 36, 131-137. Humby, T., Laird, F. M., Davies, W., & Wilkinson, L. S (1999). Visuospatial attentive functioning in mice: interactions between cholinergic manipulations and genotype. European Journal of Neuroscience, 11, 2813-2823. Jones, D. N., & Higgins, G. A. (1995). Effect of scopolamine on visual attention in rats. Psychopharmacology, 120, 142-149. Lai, W. S., Xu, B., Westphal, K. G. C., Paterlini, M., Olivier, B., Pavlidis, P., ...Gogos, J. A. (2006). Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proceedings of the National Academy of Sciences, 103, 16906-16911. Robbins, T. (2002). The 5-choice serial reaction time task: Behavioural pharmacology and functional neurochemistry. Psychopharmacology, 163, 362-380. Rutledge, R. B., Lazzaro, S. C., Lau, B., Myers, C. E., Gluck, M. A., & Glimcher, P. W. (2009). Dopaminergic drugs modulate learning rates and perseveration in Parkinson’s patients in a dynamic foraging task. The Journal of Neuroscience, 29, 15104-15114. Sanchez-Roige, S., Peña-Oliver, Y., & Stephens, D. N. (2011). Measuring impulsivity in mice: The five-choice serial reaction time task. Psychopharmacology, 219, 253-270. Tan, H. Y., Nicodemus, K. K., Chen, Q., Li, Z., Brooke, J. K., Honea, R, ...Weinberger, D. R. (2008). Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. Journal of Clinical Investigation, 118, 2200-2208. Young, J. W., Powell, S. B., Risbrough, V., Marston, H. M., & Geyer, M. A. (2009). Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacology & Therapeutics, 122, 150-202. Zeeb, F. D., Robbins, T. W., & Winstanley, C. A. (2009). Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. Neuropsychopharmacology, 34, 2329-2343. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6735 | - |
dc.description.abstract | 精神分裂症是一種嚴重且多因子的精神疾患,並且具有高度的遺傳性。從人類遺傳學以及動物研究中,有愈來愈多的結果顯示AKT1基因可能參與了精神分裂症的致病歷程。在眾多精神分裂的臨床症狀上,精神分裂症患者具有明顯的認知功能異常,特別是注意力功能的缺損。連續操作測驗(continuous performance test)是常用於測量精神分裂症患者注意力功能的測驗,無論是精神分裂症患者或是與其有高血緣關係的親屬,普遍可觀察到他們在這測驗中具有較差的注意力表現。在動物研究中,五擇一序列反應時程作業(five-choice serial reaction time task)是個類似連續操作測驗的注意力作業,近年來廣泛用於評估大鼠或是小鼠的注意力表現。相較於針對人類所進行精神疾病遺傳連鎖研究的侷限性,基因突變小鼠的模式更能直接探究精神分裂症候選基因(如Akt1基因)的生物功能以及它在精神分裂症致病上之因果關係。本論文旨在探討AKT1是否參與精神分裂症的注意力功能,以Akt1基因缺損小鼠為模式,觀察牠們在五擇一序列反應時程作業中,是否表現與精神分裂症類似的注意力功能缺失。實驗採用的Akt1同型合子、異型合子與野生控制組之雄性小鼠,皆在改良式五擇一序列反應時程作業的儀器中進行注意力表現的評估。實驗程序可以概分成學習階段與測驗階段,小鼠接受一系列每日的訓練學習階段,直到連續三天在刺激燈亮2秒的情況下,達到大於80 %準確率、小於20 %遺漏率的基本學習標準,接著才能進入測驗階段。測驗階段包含四種需要更多注意力功能的測驗:降低刺激燈亮時間、改變等待刺激燈亮時間、增加刺激燈的亮度、以及加入聲音的干擾。實驗結果顯示,Akt1同型合子之小鼠在學習的第一階段持續地表現出較高的遺漏率。當給予足夠的訓練達到基本的學習標準後,Akt1基因缺損小鼠則與野生控制組小鼠皆具有相同的行為表現。在測驗階段的四個測試中,只有在增加刺激燈之亮度與聲音干擾的測驗中,Akt1基因缺損小鼠表現出不一致的衝動行為。本論文結果顯示Akt1基因缺損會影響小鼠注意力功能的表現,特別是學習的初期以及需要更多注意力投注的作業中。由此可以推測在病人身上AKT1的缺損會造成與精神分裂症相關之注意力功能的異常,進而影響其他認知功能的表現。 | zh_TW |
dc.description.abstract | Schizophrenia is a severe and multifactor psychiatric disorder with a strong genetic component, and accumulating evidence from human genetics and animal studies suggest that AKT1 gene might play a role in the pathogenesis of schizophrenia. Schizophrenia contains heterogeneous clinical symptoms marked by significant cognitive impairments especially attentive dysfunction. Attention deficits measured by the continuous performance test (CPT), the most popular clinical-based measure in schizophrenia research, is commonly observed among schizophrenia patients and those at genetic risk for the disease. The five-choice serial reaction time task (5-CSRTT) has been considered to analogue to the CPT and increasingly used to assess attentive functions in rats and mice. As a mutant mouse model is a simple and relatively straightforward approach for determining the causal relationships and biological functions of AKT1 in schizophrenia, this thesis aims to discover the involvement of AKT1 in attetional functions of schizophrenia through investigating whether Akt1deficiency in mice results in attentive impairments by using the 5-CSRTT. In this study, male Akt1 homozygous (HOM) and heterozygous (HET) mutant mice and their wild-type (WT) littermates were tested in a modified version of the 5-CSRTT. Mice were trained in a sequence of daily learning sessions until they reached the baseline criteria with ≥ 80% accuracy and ≤ 20% omissions in the condition with 2-sec stimulus durations for three consecutive days. After reaching these criteria, each subject went over a sequence of four test conditions, which required more attentive load, including manipulations of stimulus duration, inter-trial-interval, stimulus brightness, and white noise distractors. Behavioral analysis indicated that Akt1 HOM mice have abnormal attention in the initially learning stage of the 5-CSRTT. After reaching preset criteria, Akt1-mutant mice showed normal baseline performances to enter those following tests. Both tests of brightness and white noise distractor inconsistently induced impulsive behavior instead of attention-related responses in Akt1-mutant mice. Our findings suggest that AKT1 may participate in attentive functions of schizophrenia. | en |
dc.description.provenance | Made available in DSpace on 2021-05-17T09:17:08Z (GMT). No. of bitstreams: 1 ntu-101-R98227103-1.pdf: 1541783 bytes, checksum: 561094c6ad04142107f287a3c1e7c926 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | Chapter 1: General Introduction......1
1. Overview of schizophrenia......1 2. Cognitive symptoms of schizophrenia......2 3. The neurochemistry of schizophrenia......4 4. The etiology of schizophrenia......13 5. What is AKT1?......15 6. Using animal models to study schizophrenia......19 7. The objective of this study......25 Chapter 2: Materials and Methods......27 1. Animals......27 2. Experimental apparatus......28 3. Experimental procedures......29 4. Data analysis......36 Chapter 3: Results......39 Chapter 4: General Discussion......57 Reference......101 Appendix: A Modification of the 5-CSRTT to Reexamine the Behavioral Performance of Akt1 Heterozygous Mice in an Automatic Version of Dynamic Foraging Task......123 Introduction......123 Materials and methods......126 Results......133 Discussion......134 Reference......137 | |
dc.language.iso | en | |
dc.title | 評估精神分裂症動物模式之Akt1基因缺損小鼠在五擇一序列反應時程作業的注意力功能 | zh_TW |
dc.title | Evaluation of Attentive Functions in Akt1 Mouse Model of Schizophrenia: Using the Five-Choice Serial Reaction Time Task (5-CSRTT) | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李季湜,邱麗珠,梁庚辰,劉亞平 | |
dc.subject.keyword | 精神分裂症,Akt1,注意力,連續操作測驗,五擇一序列反應時程作業, | zh_TW |
dc.subject.keyword | schizophrenia,Akt1,attention,continuous performance test,five-choice serial reaction time task, | en |
dc.relation.page | 139 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2012-07-27 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 心理學研究所 | zh_TW |
顯示於系所單位: | 心理學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-101-1.pdf | 1.51 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。