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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 曾明宗 | |
dc.contributor.author | Yi-Hsuan Lin | en |
dc.contributor.author | 林宜萱 | zh_TW |
dc.date.accessioned | 2021-06-17T01:24:58Z | - |
dc.date.available | 2027-08-07 | |
dc.date.copyright | 2017-09-14 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-08-08 | |
dc.identifier.citation | Apkarian AV, Sosa Y, Krauss BR, Thomas PS, Fredrickson BE, Levy RE, Harden RN, Chialvo DR (2004) Chronic pain patients are impaired on an emotional decision-making task. Pain 108:129-136.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67248 | - |
dc.description.abstract | In daily life, different top-down cognitive modulations are intermingled to shape human experiences of pain, but the neural mechanisms underlying the complex interactions of these factors remain largely unknown. Among the various cognitive factors, habituation (i.e., decreased responses to repetitive painful stimuli) and attention (e.g. directing attention away from pain reduces pain sensation) are two important processes that can provide immediate pain relief, and the aberrance of these processes has been suggested to play important roles in chronic pain. In the present functional MRI study, we asked whether distraction affects the influence of habituation on pain processing and investigated the underlying cerebral mechanisms. Participants underwent repetitive painful or non-painful stimuli to the leg skin when their attention towards stimuli was distracted to different degrees in Stroop tasks. Behavioral results showed that distraction accelerated habituation of pain but not non-pain. At the neural level, we found that the neural signal in the subgenual anterior cingulate cortex reflected the effect of distraction on pain. Although activation in the anterior insula tracked the degree of pain habituation, distraction has no effect on the relationship between insular activity and pain habituation. In contrast, distraction significantly altered the correlation between the extent of pain habituation and the activity in the subgenual anterior cingulate cortex. These findings suggest that the neural mechanisms underlying pain modulation by distraction also contribute to the effect of distraction on pain habituation, which provides new insights into the understanding of chronic pain mechanisms in the future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T01:24:58Z (GMT). No. of bitstreams: 1 ntu-106-R04454015-1.pdf: 1861966 bytes, checksum: a10b737ca678c80e8d667f7431aafd75 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 摘要......I
ABSTRACT......II CONTENTS......III INTRODUCTION......1 METHODS......3 Participants......3 Stimuli......3 Behavioral and training sessions......4 Experimental paradigm......4 Statistical analysis......6 fMRI data acquisition......6 fMRI data analysis......7 RESULTS......10 Behavioral results......10 Pain-related brain activation......11 Brain activation related to pain habituation......12 Brain activation related to distraction modulation on pain......12 Brain region mediating distraction modulation on pain habituation......13 DISCUSSION......15 Enhanced pain habituation during distraction......15 Role of aIC in pain habituation......16 Involvement of sgACC in pain perception and pain habituation......16 Conclusion......18 REFERENCES......19 LIST OF FIGURES AND TABLES......21 Figures......22 Tables......29 | |
dc.language.iso | en | |
dc.title | 注意力對疼痛習慣化的調節機轉 | zh_TW |
dc.title | How Distraction Modulates Pain Habituation | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳恩賜,周泰立 | |
dc.subject.keyword | 疼痛,注意力,習慣化,功能性磁振造影,膝下前扣帶迴,前腦島, | zh_TW |
dc.subject.keyword | pain,distraction,habituation,fMRI,sgACC,aIC, | en |
dc.relation.page | 30 | |
dc.identifier.doi | 10.6342/NTU201702685 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-08-08 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 腦與心智科學研究所 | zh_TW |
顯示於系所單位: | 腦與心智科學研究所 |
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