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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林?輝 | |
dc.contributor.author | Keng-Yuan Li | en |
dc.contributor.author | 李耕源 | zh_TW |
dc.date.accessioned | 2021-06-17T01:09:52Z | - |
dc.date.available | 2025-01-21 | |
dc.date.copyright | 2020-01-21 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-01-17 | |
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Journal of Dentistry, 1999. 27(5): p. 383-389. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/66866 | - |
dc.description.abstract | 齲齒是人類中最常見的口腔疾病。利用填補材料治療齲齒是目前臨床上最常使用的方法。填補材料發展至今已經多年,歷經多種不同材料的演進,然而目前市面上所販售之複合樹酯產品幾乎沒有氟離子的釋放與再填充能力,無法維持口腔中相當濃度氟離子而達到預防二次齲齒的效果。因此本研究的目的是開發一種具有優異的氟離子釋放和再填充能力的複合樹酯。我們利用氟化鈉插層之氟化蒙脫石以及矽皖化處理後的二氧化鋯作為bis-GMA基材中的兩種無機填料。X光繞射、熱重分析及紅外線光譜儀用於分析無機填料的改質。複合樹脂的機械性能分析中顯示徑向拉伸強度,彎曲強度以及耐磨性性質的平均值均明顯高於商業對照組。細胞增殖以及細胞染色實驗用於驗證該材料有良好的生物相容性。此外,口腔環境的模擬證實了該複合樹脂具有良好的氟離子釋放和再填充能力。因此,在這項研究中開發的複合樹脂可以減少二次齲齒的發生,並為將來的臨床治療提供新的選擇。 | zh_TW |
dc.description.abstract | Dental caries are the most frequent oral disease in humans. Filling cavities with a dental restorative material is the most common clinical treatment. With the evolution of many different restorative materials through the years, the composite resin products currently on the market have almost no fluoride ion release and rechargeability, and cannot maintain a considerable concentration of fluoride ions in the oral cavity to prevent secondary dental caries. The purpose of this study was to develop a composite resin with excellent fluoride ion release and recharge ability. We developed a fluorinated montmorillonite intercalated with sodium fluoride and zirconium dioxide after hydrophobized treatment as two inorganic fillers in the bis-GMA matrix. X-ray diffraction, thermogravimetric analysis, and infrared spectrometry were used to analyze the modification of inorganic fillers. Mechanical property tests for diametral tensile strength, flexural strength, and wear resistance showed the average values of the developed composite resin were significantly higher than those of a commercial control group. WST-1 and Live/Dead staining were used to verify that the material had good biocompatibility. In addition, simulation of the oral environment confirmed that the composite resin showed good fluoride ion release and rechargeability. Thus, the composite resin developed in this study may reduce secondary caries and provide a new choice for future clinical treatments. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T01:09:52Z (GMT). No. of bitstreams: 1 ntu-109-D03548006-1.pdf: 2867830 bytes, checksum: 330c7bf51da3961cd2df2ee8322ee5a3 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 委員審定書 I
致謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES viii LIST OF TABLES xi LIST OF EQUATIONS xii LIST OF ABBREVIATION xiii Chapter 1 INTRODUCTION 1 1.1 Epidemiology of Dental Caries 1 1.2 Restorative History 6 1.3 Requirement 9 1.4 Purpose of Study 11 Chapter 2 THEORETICAL BASIS 12 2.1 Fluoride 12 2.1.1 Remineralization of initial lesions 12 2.1.2 Role of fluoride in demineralization and remineralization of enamel 12 2.1.3 Interference with microorganisms 12 2.1.4 Conversion of HAp to FAp 13 2.2 Composite Resin 15 2.2.1 Conventional composite resins 15 2.2.2 Homogeneous and heterogeneous microfilled composite resins 16 2.2.3 Hybrid composite resins 17 2.3 Montmorillonite (MMT) 17 2.3.1 Montmorillonite 17 2.3.2 Hydrophobization of Montmorillonite 19 2.3.3 Fluoride- montmorillonite 20 2.4 Zirconia 23 2.4.1 3YSZ 24 2.4.2 Silane treatment 25 2.5 Bis-GMA 26 Chapter 3 MATERIALS AND METHODS 30 3.1 Experimental Instrument 30 3.2 Experimental Chemicals 31 3.3 Experimental Processes 32 3.4 MMT Modification 33 3.4.1 Preparation of fluoride-montmorillonite (FMMT) 33 3.4.2 Preparation of N-methylformamide-intercalated fluoride-montmorillonite (FMMT/NMF) 34 3.4.3 Preparation of acrylamide-intercalated fluoride-montmorillonite (FMMT/AAm) 35 3.4.4 Preparation of NaF-containing acrylamide-intercalated fluoride-montmorillonite (FMMT/AAm-NaF) 35 3.5 3YSZ Silane Treatment 36 3.6 Fluoride-releasing Composite Resin Synthesis 36 3.7 Material Characteristics 37 3.7.1 XRD 37 3.7.2 FTIR 38 3.7.3 TGA 38 3.7.4 EDS 39 3.7.5 Particle size 40 3.8 Mechanical Analysis 40 3.8.1 Curing depth 40 3.8.2 Micro hardness 41 3.8.3 Diametral tensile strength 42 3.8.4 Flexural strength 43 3.8.5 Wear resistance 44 3.9 Biocompatibility 45 3.9.1 WST-1 45 3.9.2 Live/Dead Staining 46 3.10 Oral Environment Simulatability 47 3.10.1 Fluoride release measurement 47 3.10.2 Fluoride recharge measurement 48 3.11 Statistical Analyses 48 Chapter 4 RESULTS 49 4.1 Material Analysis and Characterization 49 4.1.1 XRD 49 4.1.2 FTIR 52 4.1.3 TGA 54 4.1.4 EDS 55 4.1.5 Particle size 56 4.2 Mechanical Analysis 58 4.2.1 Curing depth 59 4.2.2 Micro hardness 60 4.2.3 Diametral tensile strength 61 4.2.4 Flexural strength 62 4.2.5 Wear resistance 63 4.3 Biocompatibility 64 4.3.1 WST-1 64 4.3.2 Live/Dead staining 65 4.4 Oral Environment Simulation 66 4.4.1 Fluoride release measurement 66 4.4.2 Fluoride recharge measurement 67 Chapter 5 DISCUSSION 69 Chapter 6 CONCLUSION 72 REFERENCES 73 | |
dc.language.iso | en | |
dc.title | 利用氟化鈉插層之氟化蒙脫石及二氧化鋯製成具備雙重氟離子釋放與再填充能力之牙科複合樹酯 | zh_TW |
dc.title | The Study of NaF Intercalated FMMT and ZrO2 as the Inorganic Filler to Prepare Dual F-releasing and Rechargeable Dental Composition Resin | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-1 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 林俊彬 | |
dc.contributor.oralexamcommittee | 郭士民,黃義侑,方旭偉 | |
dc.subject.keyword | 齲齒,填補材料,複合樹酯,蒙脫石,二氧化鋯,機械強度,氟離子, | zh_TW |
dc.subject.keyword | Dental caries,restore material,composite resin,bis-GMA,montmorillonite,zirconia,mechanical strength,fluoride, | en |
dc.relation.page | 77 | |
dc.identifier.doi | 10.6342/NTU202000081 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-01-17 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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