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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 呂東武(Tung-Wu Lu) | |
dc.contributor.author | Yu-Shen Kuo | en |
dc.contributor.author | 郭祐伸 | zh_TW |
dc.date.accessioned | 2021-05-17T09:15:22Z | - |
dc.date.available | 2017-08-28 | |
dc.date.available | 2021-05-17T09:15:22Z | - |
dc.date.copyright | 2012-08-28 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-10 | |
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Fung, H.-C., et al., Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan. Neuroscience Letters, 2006. 394(1): p. 33-36. 8. Hoehn, M.M. and M.D. Yahr, Parkinsonism: onset, progression and mortality. Neurology, 1967. 17(5): p. 427-42. 9. Chen, H.C., et al., Stepping over obstacles: gait patterns of healthy young and old adults. J Gerontol, 1991. 46(6): p. M196-203. 10. Austin, G.P., G.E. Garrett, and R.W. Bohannon, Kinematic analysis of obstacle clearance during locomotion. Gait Posture, 1999. 10(2): p. 109-20. 11. Sparrow, W.A., et al., Characteristics of gait in stepping over obstacles. Hum. mov. sci. , 1996. 15(4): p. 605-622. 12. Chen, H.L., T.W. Lu, and H.C. Lin, Three-dimensional kinematic analysis of stepping over obstacles in young subjects. Biomed Eng Appl Basis Comm, 2004. 16: p. 157-64. 13. Lu, T.W., H.L. Chen, and S.C. Chen, Comparisons of the lower limb kinematics between young and older adults when crossing obstacles of different heights. Gait Posture, 2006. 23(4): p. 471-9. 14. Lu, T.-W., H.-C. Yen, and H.-L. Chen, COMPARISONS OF THE INTERJOINT COORDINATION BETWEEN LEADING AND TRAILING LIMBS WHEN CROSSING OBSTACLES OF DIFFERENT HEIGHTS. J Biomech, 2007. 40, Supplement 2(0): p. S163. 15. Yen, H.C., et al., Age effects on the inter-joint coordination during obstacle-crossing. J Biomech, 2009. 42(15): p. 2501-6. 16. Huang, S.-C., et al., Age and height effects on the center of mass and center of pressure inclination angles during obstacle-crossing. Medical Engineering & Physics, 2008. 30(8): p. 968-975. 17. Chou, L.S. and L.F. Draganich, Stepping over an obstacle increases the motions and moments of the joints of the trailing limb in young adults. J Biomech, 1997. 30(4): p. 331-7. 18. Chou, L.S. and L.F. Draganich, Increasing obstacle height and decreasing toe-obstacle distance affect the joint moments of the stance limb differently when stepping over an obstacle. Gait Posture, 1998. 8(3): p. 186-204. 19. Chen, H.L. and T.W. Lu, Comparisons of the joint moments between leading and trailing limb in young adults when stepping over obstacles. Gait Posture, 2006. 23(1): p. 69-77. 20. Anderson, F.C. and M.G. Pandy, A Dynamic Optimization Solution for Vertical Jumping in Three Dimensions. Comput Methods Biomech Biomed Engin, 1999. 2(3): p. 201-231. 21. Pandy, M.G., B.A. Garner, and F.C. Anderson, Optimal control of non-ballistic muscular movements: a constraint-based performance criterion for rising from a chair. J Biomech Eng, 1995. 117(1): p. 15-26. 22. Chou, L.S., S.M. Song, and L.F. Draganich, Predicting the kinematics and kinetics of gait based on the optimum trajectory of the swing limb. J Biomech, 1995. 28(4): p. 377-85. 23. Nubar, Y. and R. 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Mansour, Simulation of the double limb support phase of human gait. J Biomech Eng, 1988. 110(3): p. 223-9. 30. Onyshko, S. and D.A. Winter, A mathematical model for the dynamics of human locomotion. J Biomech, 1980. 13(4): p. 361-368. 31. Amirouche, F.M.L. and S.K. Ider, Simulation and analysis of a biodynamic human model subjected to low accelerations—A correlation study. Journal of Sound and Vibration, 1988. 123(2): p. 281-292. 32. Hatze, H., A three-dimensional multivariate model of passive human joint torques and articular boundaries. Clinical Biomechanics, 1997. 12(2): p. 128-135. 33. McFadyen, B.J. and H. Carnahan, The superimposed adjustments for obstacle clearance and level-to-stair transition during normal human gait. J Biomech, 1994. 27(6): p. 809. 34. Lu, T.-W., Geometric and mechanical modelling of the human locomotor system. 1997. 35. Dempster, W.T., Space requirement of the seated operator. 1955: Aerospace Medical Research Laboratories, Ohio. 36. Chen, Z.-Y., Movement analysis in patients with Parkinson's disease during walking and obstacle crossing.2012: National Taiwan Univercity, Taiwan. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6620 | - |
dc.description.abstract | 動作的改變帕金森氏症最主要的臨床特徵,過去的研究也指出帕金森氏症患者在執行日常動作例如走路、跨越障礙物較為困難。跨越失敗將導致跌倒與受傷[1-3]。
帕金森氏症患者跨越障礙物的動作分析研究,著重其運動系統參數的表現,如關節角度、關節力矩、關節間協調性、身體質量中心與壓力中心傾斜角的差異性[36],隨障礙物高度的不同,有些參數改變,有些參數不變,運動參數確實可對關節表現討論,但無法討論整體動作控制策略。Lu(2012)提出的多目標最佳控制方法,定義跨越障礙物之目標函數可由最小能量消耗與最大足部間隙妥協組合而成,並可描述跨越障礙物之控制策略[4]。 本研究目的為使用多目標最佳控制方法,探討帕金森氏症跨越不同高度障礙物之動作控制策略,並探討後腳跨越障礙物與前腳跨越障礙物之策略差異。受試者分為三組:15位正常中老年人(Normal),15位帕金森氏症第一期患者(PD-I),15位帕金森氏症第二至三期患者(PD-II&III),每位受試者被要求跨越三種不同高度之障礙物。本研究結果指出,跨越障礙物之控制策略並無高度間差異,有明顯的組間差異,其中PD-I表現與Normal接近,與PD-II&III服藥前有顯著差異,PD-II&III服藥前(Off)有較保守的跨越障礙物策略;PD-I健側(Non-Dominant)與患側(Dominant)跨越障礙物之控制策略無顯著差異;PD-II&III用藥後(On)控制策略較接近PD-I & PD-II&III;前後腳控制策略只有Normal有顯著差異,Normal後腳跨越的控制策略趨於保守,PD-I & PD-II&III前後腳控制策略並無顯著差異,表示視覺回饋在帕金森氏症患者的控制策略沒有影響。本研究結果提供帕金森氏症患者與前後腳跨越障礙物一個簡單、明確並足以描述跨越障礙物神經控制系統的指標,未來可用於帕金森氏症分級與用藥效果評估之參考。 | zh_TW |
dc.description.abstract | Movement change is the essential symptom of Parkinson’s disease (PD). Obstacle crossing and walking with a simple cognitive task increase the task demands for the patients with PD. Failure to cross the obstacle will result in falls and injuries[1-3].
Kinematic and kinetic data, such as joint angle, joint moment, inter-joint coordination and COM-COP inclination angle, is used in motion analysis of patients with PD during obstacle crossing[36]. Although these data are useful for evaluating the functional performance of patients with PD, there still exist difficulties in the synthesis of the information to uncover the overall control strategies. Lu(2012) suggested that obstacle-crossing was formulated as an optimal control problem with two conflicting objectives: minimization of mechanical energy expenditure and maximization of foot-obstacle clearance[4]. The purposes of the present study were to identify the control strategy of patients with PD obstacle-crossing of different heights with a multi-objective optimal control (MOOC) technique. 15 mid-old subjects, 15 1st stage of patients(PD-I), 15 2nd-3rd stage of patients(PD-II&III) were asked to walked and crossed obstacles of three different heights while their kinematic and ground reaction force data were measured simultaneously. Differences of control strategies of obstacle crossing were not found in height effects, but found in group effects. The strategies of PD-I are similar to Normal group, but different with PD-II&III. PD-II&III before treatment (Off) is shown an conservative control strategies; There were no significant differences of control strategies between non-dominant limb and dominant limb during obstacle crossing; Strategies of PD-II&III after treatment (On) is similar to PD-I & PD-II&III; Differences of control strategies in leading and trailing limbs were only found in Normal group, control strategies of Normal trailing limb is more conservative, this mean the visual feedback is not effect in patients with PD. The present study is useful for studying obstacle-crossing form a system level perspective in patient with PD. The results will help in classification of PD and estimation of medical treatment. | en |
dc.description.provenance | Made available in DSpace on 2021-05-17T09:15:22Z (GMT). No. of bitstreams: 1 ntu-101-R99548026-1.pdf: 2266111 bytes, checksum: 3862ff69ca0d3fd113d6a4c9d324eb37 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 口試委員審定書 I
誌謝 II 中文摘要 III Abstract IV 第一章 緒論 1 1.1 研究背景 1 1.1.1 帕金森氏症 1 1.1.2 跨越障礙物 3 1.1.3 跨越障礙物之運動系統控制策略 5 1.1.4 運動系統之連桿模型 6 1.2 研究目的 7 第二章 材料與方法 9 2.1 受試者 9 2.2 實驗器材與流程 10 2.2.1 實驗器材 10 2.2.2 實驗流程 11 2.3 實驗資料處理 12 2.3.1 下肢局部座標系統定義 12 2.3.2 廣義/局部座標系統轉換 18 2.3.3 力板資訊 19 2.4 二維人體模型建立 20 2.4.1 七連桿運動學 21 2.4.2 七連桿模型動力學 23 2.5 跨越障礙物之最佳化控制 31 2.5.1 最佳化控制方法 31 2.5.2 單目標最佳化控制數學模型 33 2.5.3 多目標最佳化控制模式數學模型 34 2.5.4 單目標與多目標最佳化收斂軌跡示範圖 35 2.6 統計分析 40 第三章 結果 41 3.1 前腳跨越 41 3.1.1 組間差異 42 3.1.2 高度間差異 43 3.2 後腳跨越障礙物 44 3.2.1 組間差異 45 3.2.2 高度間差異 46 3.3 帕金森氏症第一期患者健側與患側跨越障礙物控制策略比較 47 3.4 帕金森氏症第二至三期患者用藥前後跨越障礙物控制策略比較 48 3.5 前後腳跨越障礙物之控制策略比較 49 第四章 討論 51 4.1 正常受試者權重值分布 51 4.2 高度間差異 51 4.3 組間差異 52 4.4 帕金森氏症第一期患者健側與患側跨越障礙物控制策略比較 52 4.5 帕金森氏症第二至三期患者用藥前後跨越障礙物控制策略比較 52 4.6 前腳與後腳跨越障礙物之控制策略比較 53 4.7 研究限制與未來展望 53 第五章 結論 54 參考文獻 55 | |
dc.language.iso | zh-TW | |
dc.title | 帕金森氏症患者行走跨越障礙物之多目標最佳控制策略 | zh_TW |
dc.title | Multi-Objective Optimal Control Strategies of the Locomotor System During Obstacle-Crossing in Patients with Parkinson's Disease | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 楊秉祥(Bing-Shiang Yang),許維君(Wei-Chun Hsu),謝宏榮(Hong-Jung Hsieh) | |
dc.subject.keyword | 動作分析,帕金森氏症,運動控制策略,跨越障礙物, | zh_TW |
dc.subject.keyword | Parkinson’s disease,motion analysis,motor control strategy,obstacle-crossing, | en |
dc.relation.page | 57 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2012-08-10 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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