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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 黃慧璧(Hui-Pi Huang) | |
| dc.contributor.author | Hung-Yin Chen | en |
| dc.contributor.author | 陳虹吟 | zh_TW |
| dc.date.accessioned | 2021-05-17T09:14:24Z | - |
| dc.date.available | 2015-08-28 | |
| dc.date.available | 2021-05-17T09:14:24Z | - |
| dc.date.copyright | 2012-08-28 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-15 | |
| dc.identifier.citation | chapter 1 reference:
1. Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (Pituitary Basophilism). Bull Johns Hopkins Hosp 1932;50:137-195. 2. Feldman EC, Nelson RW. Hyperadrenocorticism (Cushing's syndrome). In: Feldman EC, Nelson RW, eds. Canine and Feline Endocrinology and Reproduction. Philadelphia: WB Saunders; 2004:252-357. 3. Reusch CE, Feldman EC. Canine hyperadrenocorticism due to adrenocortical neoplasia. Pretreatment evaluation of 41 dogs. J Vet Intern Med 1991;5:3-10. 4. Feldman EC. Distinguishing dogs with functioning adrenocortical tumors from dogs with pituitary-dependent hyperadrenocorticism. J Am Vet Med Assoc 1983;183:195-200. 5. Feldman EC, Nelson RW. Neoplasms in the adenohypophysis of dogs. A clinical and pathologic study. Vet Pathol 1967;4:301-325. 6. Peterson ME, Krieger DT, Drucker WD, et al. Immunocytochemical study of the hypophysis in 25 dogs with pituitary-dependent hyperadrenocorticism. Acta Endocrinol 1982;101:15-24. 7. Pollard RE, Reilly CM, Uerling MR, et al. Neurologic, endocrinologic, and pathologic findings associated with large pituitary tumors in dogs: eight cases. J Am Vet Med Assoc 2010;24:160-165. 8. Nelson RW, Ihle SL, Feldman EC. Pituitary macroadenomas and macroadenocarcinomas in dogs treated with mitotane for pituitary-dependent hyperadrenocorticism: 13 cases (1981-1986). J Am Vet Med Assoc 1989;194:1612-1617. 9. Pollard RE, Reilly CM, Uerling MR, et al. Cross-Sectional Imaging Characteristics of Pituitary Adenomas, Invasive Adenomas and Adenocarcinomas in Dogs: 33 Cases (1988 –2006). J Vet Intern Med 2010;24:160-165. 10. Ettinger SJ, Feldman EC. Textbook of veterinary internal medicine : diseases of the dog and the cat. St. Louis, Mo.: Elsevier Saunders; 2010. 11. Hoerauf A, Reusch C. Ultrasonographic characteristics of both adrenal glands in 15 dogs with functional adrenocortical tumors. J Am Anim Hosp Assoc 1999;35:193-199. 12. Anderson CR, Birchard SJ, Powers BE, et al. Surgical treatment of adrenocortical tumors: 21 cases (1990-1996). J Am Anim Hosp Assoc 2001;37:93-97. 13. Ford SL, Feldman EC, Nelson RW. Hyperadrenocorticism caused by bilateral adrenocortical neoplasia in dogs: four cases (1983-1988). J Am Vet Med Assoc 1993;202:789-792. 14. Kyles AE, Feldman EC, De Cock HE, et al. Surgical management of adrenal gland tumors with and without associated tumor thrombi in dogs: 40 cases (1994-2001). J Am Vet Med Assoc 2003;223:654-662. 15. Labelle P, Kyles AE, Farver TB, et al. Indicators of malignancy of canine adrenocortical tumors: histopathology and proliferation index. Vet Pathol 2004;41:490-497. 16. Colao A, Pivonello R, Spiezia S, et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J Clin Endocrinol Metab 1999;84:2664-2672. 17. Mancini T, Kola B, Mantero F, et al. High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf) 2004;61:768-777. 18. Tsuiki M, Tanabe A, Takagi S, et al. Cardiovascular risks and their long-term clinical outcome in patients with subclinical Cushing's syndrome. Endocr J 2008;55:737-745. 19. Magiakou MA, Mastorakos G, Oldfield EH, et al. Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med 1994;331:629-636. 20. Magiakou MA, Mastorakos G, Zachman K, et al. Blood pressure in children and adolescents with Cushing's syndrome before and after surgical care. J Clin Endocrinol Metab 1997;82:1734-1738. 21. Novellas R, de Gopegui RR, Espada Y. Determination of renal vascular resistance in dogs with diabetes mellitus and hyperadrenocorticism. Vet Rec 2008;163:592-596. 22. Lien YH, Hsiang TY, Huang HP. Associations among systemic blood pressure, microalbuminuria and albuminuria in dogs affected with pituitary- and adrenal-dependent hyperadrenocorticism. Acta Vet Scand 2010;52:61. 23. Goy-Thollot I, Pechereau D, Keroack S, et al. Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs. J Small Anim Pract 2002;43:489-492. 24. Ulick S, Wang JZ, Blumenfeld JD, et al. Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 1992;74:963-967. 25. Saruta T, Suzuki H, Handa M, et al. Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab 1986;62:275-279. 26. Saruta T. Mechanism of glucocorticoid-induced hypertension. Hypertens Res 1996;19:1-8. 27. Kirilov G, Tomova A, Dakovska L, et al. Elevated plasma endothelin as an additional cardiovascular risk factor in patients with Cushing's syndrome. Eur J Endocrinol 2003;149:549-553. 28. Sakaue M, Hoffman BB. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest 1991;88:385-389. 29. Boscaro M, Barzon L, Fallo F, et al. Cushing's syndrome. Lancet 2001;357:783-791. 30. Baykan M, Erem C, Gedikli O, et al. Assessment of left ventricular diastolic function and Tei index by tissue Doppler imaging in patients with Cushing's Syndrome. Echocardiography 2008;25:182-190. 31. Toja PM, Branzi G, Ciambellotti F, et al. Clinical relevance of cardiac structure and function abnormalities in patients with Cushing's syndrome before and after cure. Clin Endocrinol (Oxf) 2012;76:332-338. 32. Sugihara N, Shimizu M, Kita Y, et al. Cardiac characteristics and postoperative courses in Cushing's syndrome. Am J Cardiol 1992;69:1475-1480. 33. Bayram NA, Ersoy R, Aydin C, et al. Assessment of left ventricular functions by tissue Doppler echocardiography in patients with Cushing's disease. J Endocrinol Invest 2009;32:248-252. 34. Pereira AM, Delgado V, Romijn JA, et al. Cardiac dysfunction is reversed upon successful treatment of Cushing's syndrome. Eur J Endocrinol 2010;162:331-340. 35. Muiesan ML, Lupia M, Salvetti M, et al. Left ventricular structural and functional characteristics in Cushing's syndrome. J Am Coll Cardiol 2003;41:2275-2279. 36. Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations. Bull Johns Hopkins Hasp 1932;50:137-195. 37. Scholz DA, Sprague RG, Kernohan JW. Cardiovascular and renal complications of Cushing's syndrome. N Engl J Med 1957;256:833-837. 38. Sudhir K, Jennings GL, Esler MD, et al. Hydrocortisone-induced hypertension in humans: pressor responsiveness and sympathetic function. Hypertension 1989;13:416-421. 39. Dzau VJ. Cardiac renin-angiotensin system. Molecular and functional aspects. Am J Med 1988;84:22-27. 40. Ritchie CM, Sheridan B, Fraser R, et al. Studies on the pathogenesis of hypertension in Cushing's disease and acromegaly. Q J Med 1990;76:855-867. 41. Connell JM, Whitworth JA, Davies DL, et al. Effects of ACTH and cortisol administration on blood pressure, electrolyte metabolism, atrial natriuretic peptide and renal function in normal man. J Hypertens 1987;5:425-433. 42. Davis JO, Howell DS. Comparative effect of ACTH, cortisone and DCA on renal function, electrolyte excretion and water exchange in normal dogs. Endocrinology 1953;52:245-255. 43. Wen C, Fraser T, Li M, et al. Hemodynamic profile of corticotropin-induced hypertension in the rat. J Hypertens 1998;16:187-194. 44. Hall JE, Morse CL, Smith MJ, Jr., et al. Control of arterial pressure and renal function during glucocorticoid excess in dogs. Hypertension 1980;2:139-148. 45. Manning RD, Jr. Renal hemodynamic, fluid volume, and arterial pressure changes during hyperproteinemia. Am J Physiol 1987;252:F403-411. 46. Haentjens P, De Meirleir L, Abs R, et al. Glomerular filtration rate in patients with Cushing's disease: a matched case-control study. Eur J Endocrinol 2005;153:819-829. 47. Smets PM, Lefebvre HP, Meij BP, et al. Long-Term Follow-Up of Renal Function in Dogs after Treatment for ACTH-Dependent Hyperadrenocorticism. J Vet Intern Med 2012;26:565-574. 48. Lees GE, Brown SA, Elliott J, et al. Assessment and management of proteinuria in dogs and cats: 2004 ACVIM Forum Consensus Statement (small animal). J Vet Intern Med 2005;19:377-385. 49. Koh JM, Kim JY, Chung YE, et al. Increased urinary albumin excretion in Cushing's syndrome: remission after correction of hypercortisolaemia. Clin Endocrinol (Oxf) 2000;52:349-353. 50. Hayashi Y, Morikawa A, Makino M. Heterogeneity of urinary albumin from diabetic patients. Clin Chim Acta 1990;190:93-103. 51. Hurley KJ, Vaden SL. Evaluation of urine protein content in dogs withpituitary-dependent hyperadrenocorticism. J Am Vet Med Assoc 1998;212:369-373. 52. Ortega TM, Feldman EC, Nelson RW, et al. Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism. Journal of the American Veterinary Medical Association 1996;209:1724-1729. 53. Hsieh Ck Fau - Hsieh YP, Hsieh Yp Fau - Wen YK, Wen Yk Fau - Chen ML, et al. Focal segmental glomerulosclerosis in association with Cushing's disease. 2007. 54. Tatsumi T, Morishima T, Watarai T, et al. Recurrent Cushing's disease associated with nephrotic syndrome. Intern Med 1995;34:10-14. 55. Center SA, Smith CA, Wilkinson E, et al. Clinicopathologic, renal immunofluorescent, and light microscopic features of glomerulonephritis in the dog: 41 cases (1975-1985). J Am Vet Med Assoc 1987;190:81-90. 56. Bohs LN, Trahey GE. A novel method for angle independent ultrasonic imaging of blood flow and tissue motion. IEEE Trans Biomed Eng 1991;38:280-286. 57. Perk G, Tunick PA, Kronzon I. Non-Doppler two-dimensional strain imaging by echocardiography--from technical considerations to clinical applications. J Am Soc Echocardiogr 2007;20:234-243. 58. Urheim S, Edvardsen T, Torp H, et al. Myocardial strain by Doppler echocardiography. Validation of a new method to quantify regional myocardial function. Circulation 2000;102:1158-1164. 59. Blessberger H, Binder T. Two dimensional speckle tracking echocardiography: clinical applications. Heart 2010;96:2032-2040. 60. Pavlopoulos H, Nihoyannopoulos P. Strain and strain rate deformation parameters: from tissue Doppler to 2D speckle tracking. Int J Cardiovasc Imaging 2008;24:479-491. 61. Unverferth DV, Baker PB, Pearce LI, et al. Regional myocyte hypertrophy and increased interstitial myocardial fibrosis in hypertrophic cardiomyopathy. Am J Cardiol 1987;59:932-936. 62. Varnava AM, Elliott PM, Sharma S, et al. Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart 2000;84:476-482. 63. Sengupta PP, Mehta V, Arora R, et al. Quantification of regional nonuniformity and paradoxical intramural mechanics in hypertrophic cardiomyopathy by high frame rate ultrasound myocardial strain mapping. J Am Soc Echocardiogr 2005;18:737-742. 64. Rajiv C, Vinereanu D, Fraser AG. Tissue Doppler imaging for the evaluation of patients with hypertrophic cardiomyopathy. Curr Opin Cardiol 2004;19:430-436. 65. Kato TS, Noda A, Izawa H, et al. Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography. Circulation 2004;110:3808-3814. 66. Serri K, Reant P, Lafitte M, et al. Global and regional myocardial function quantification by two-dimensional strain: application in hypertrophic cardiomyopathy. J Am Coll Cardiol 2006;47:1175-1181. 67. Popović ZB, Kwon DH, Mishra M, et al. Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging. J Am Soc Echocardiogr 2008;21:1299-1305. 68. Wess G, Sarkar R, Hartmann K. Assessment of left ventricular systolic function by strain imaging echocardiography in various stages of feline hypertrophic cardiomyopathy. J Vet Intern Med 2010;24:1375-1382. 69. Nelson TR, Pretorius DH. The Doppler signal: where does it come from and what does it mean? AJR Am J Roentgenol 1988;151:439-447. 70. Garcia-Criado A, Gilabert R, Salmeron JM, et al. Significance of and contributing factors for a high resistive index on Doppler sonography of the hepatic artery immediately after surgery: prognostic implications for liver transplant recipients. AJR Am J Roentgenol 2003;181:831-838. 71. Topal NB, Kaya E, Ercan I, et al. The role of Doppler sonography in predicting severity of acute pancreatitis. J Clin Ultrasound 2008;36:141-147. 72. Nyman HT, Kristensen AT, Skovgaard IM, et al. Characterization of normal and abnormal canine superficial lymph nodes using gray-scale B-mode, color flow mapping, power, and spectral Doppler ultrasonography: a multivariate study. Vet Radiol Ultrasound 2005;46:404-410. 73. Rivers BJ, Walter PA, Polzin DJ, et al. Duplex doppler estimation of intrarenal pourcelot resistive index in dogs and cats with renal disease. J Vet Intern Med 1997;11:250-260. 74. Tublin ME, Bude RO, Platt JF. Review. The resistive index in renal Doppler sonography: where do we stand? AJR Am J Roentgenol 2003;180:885-892. 75. Chang YJ, Chan IP, Cheng FP, et al. Relationship between age, plasma renin activity, and renal resistive index in dogs. Vet Radiol Ultrasound 2010;51:335-337. 76. Mostbeck GH, Gossinger HD, Mallek R, et al. Effect of heart rate on Doppler measurements of resistive index in renal arteries. Radiology 1990;175:511-513. 77. Tublin ME, Tessler FN, Murphy ME. Correlation between renal vascular resistance, pulse pressure, and the resistive index in isolated perfused rabbit kidneys. Radiology 1999;213:258-264. 78. Umgelter A, Reindl W, Franzen M, et al. Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites. Intensive Care Med 2009;35:152-156. 79. Bude RO, Rubin JM. Relationship between the resistive index and vascular compliance and resistance. Radiology 1999;211:411-417. 80. Novellas R, Ruiz de Gopegui R, Espada Y. Assessment of renal vascular resistance and blood pressure in dogs and cats with renal disease. Vet Rec 2010;166:618-623. 81. Raff U, Schmidt BM, Schwab J, et al. Renal resistive index in addition to low-grade albuminuria complements screening for target organ damage in therapy-resistant hypertension. J Hypertens 2010;28:608-614. 82. Ohta Y, Fujii K, Arima H, et al. Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. J Hypertens 2005;23:1905-1911. 83. Novellas R, de Gopegui RR, Espada Y. Increased renal vascular resistance in dogs with hepatic disease. Vet J 2008;178:257-262. 84. Chetboul V, Daste T, Gouni V, et al. Renal resistive index in 55 dogs with degenerative mitral valve disease. J Vet Intern Med 2012;26:101-108. Chapter 2 reference: 1. Hurley KJ, Vaden SL. Evaluation of urine protein content in dogs with pituitary-dependent hyperadrenocorticism. J Am Vet Med Assoc 1998;212:369-373. 2. Ortega TM, Feldman EC, Nelson RW, et al. Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism. J Am Vet Med Assoc 1996;209:1724-1729. 3. Magiakou MA, Smyrnaki P, Chrousos GP. Hypertension in Cushing's syndrome. Best Pract Res Clin Endocrinol Metab 2006;20:467-482. 4. Jacob F, Polzin DJ, Osborne CA, et al. Association between initial systolic blood pressure and risk of developing a uremic crisis or of dying in dogs with chronic renal failure. J Am Vet Med Assoc 2003;222:322-329. 5. Jacob F, Polzin DJ, Osborne CA, et al. Evaluation of the association between initial proteinuria and morbidity rate or death in dogs with naturally occurring chronic renal failure. J Am Vet Med Assoc 2005;226:393-400. 6. Haentjens P, De Meirleir L, Abs R, et al. Glomerular filtration rate in patients with Cushing's disease: a matched case-control study. Eur J Endocrinol 2005;153:819-829. 7. Faggiano A, Pivonello R, Spiezia S, et al. Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab 2003;88:2527-2533. 8. Walser M, Ward L. Progression of chronic renal failure is related to glucocorticoid production. Kidney Int 1988;34:859-866. 9. Smets PM, Lefebvre HP, Meij BP, et al. Long-Term Follow-Up of Renal Function in Dogs after Treatment for ACTH-Dependent Hyperadrenocorticism. J Vet Intern Med 2012;26:565-574. 10. Novellas R, de Gopegui RR, Espada Y. Determination of renal vascular resistance in dogs with diabetes mellitus and hyperadrenocorticism. Vet Rec 2008;163:592-596. 11. Sugiura T, Wada A. Resistive index predicts renal prognosis in chronic kidney disease. Nephrol Dial Transplant 2009;24:2780-2785. 12. Ohta Y, Fujii K, Arima H, et al. Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography. J Hypertens 2005;23:1905-1911. 13. Petersen LJ, Petersen JR, Talleruphuus U, et al. The pulsatility index and the resistive index in renal arteries. Associations with long-term progression in chronic renal failure. Nephrol Dial Transplant 1997;12:1376-1380. 14. Stevens PE, Gwyther SJ, Hanson ME, et al. Noninvasive monitoring of renal blood flow characteristics during acute renal failure in man. Intensive Care Med 1990;16:153-158. 15. Rivers BJ, Walter PA, Polzin DJ, et al. Duplex doppler estimation of intrarenal pourcelot resistive index in dogs and cats with renal disease. J Vet Intern Med 1997;11:250-260. 16. Novellas R, Ruiz de Gopegui R, Espada Y. Assessment of renal vascular resistance and blood pressure in dogs and cats with renal disease. Vet Rec 2010;166:618-623. 17. Garcia-Criado A, Gilabert R, Berzigotti A, et al. Doppler ultrasound findings in the hepatic artery shortly after liver transplantation. AJR Am J Roentgenol 2009;193:128-135. 18. Topal NB, Kaya E, Ercan I, et al. The role of Doppler sonography in predicting severity of acute pancreatitis. J Clin Ultrasound 2008;36:141-147. 19. Lien Y-H, Huang H-P. Use of ketoconazole to treat dogs with pituitary-dependent hyperadrenocorticism: 48 cases (1994-2007). J Am Vet Med Assoc 2008;233:1896-1901. 20. Barthez PY, Nyland TG, Feldman EC. Ultrasonographic evaluation of the adrenal glands in dogs. J Am Vet Med Assoc 1995;207:1180-1183. 21. Hoerauf A, Reusch C. Ultrasonographic characteristics of both adrenal glands in 15 dogs with functional adrenocortical tumors. J Am Anim Hosp Assoc 1999;35:193-199. 22. Brown S, Atkins C, Bagley R, et al. Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med 2007;21:542-558. 23. Nyland TG, Fisher PE, Doverspike M, et al. Diagnosis of urinary tract obstruction in dogs using duplex Doppler ultrasonography. Vet Radiol Ultrasound 1993;34:348-352. 24. Pollard R, Nyland TG, Bernsteen L, et al. Ultrasonographic evaluation of renal autografts in normal cats. Vet Radiol Ultrasound 1999;40:380-385. 25. Rifkin MD, Needleman L, Pasto ME, et al. Evaluation of renal transplant rejection by duplex Doppler examination: value of the resistive index. AJR Am J Roentgenol 1987;148:759-762. 26. Novellas R, de Gopegui RR, Espada Y. Increased renal vascular resistance in dogs with hepatic disease. Vet J 2008;178:257-262. 27. Chetboul V, Daste T, Gouni V, et al. Renal resistive index in 55 dogs with degenerative mitral valve disease. J Vet Intern Med 2012;26:101-108. 28. Chang YJ, Chan IP, Cheng FP, et al. Relationship between age, plasma renin activity, and renal resistive index in dogs. Vet Radiol Ultrasound 2010;51:335-337. 29. Bude RO, DiPietro MA, Platt JF, et al. Age dependency of the renal resistive index in healthy children. Radiology 1992;184:469-473. 30. Platt JF. Duplex Doppler evaluation of native kidney dysfunction: obstructive and nonobstructive disease. AJR Am J Roentgenol 1992;158:1035-1042. 31. Hillege HL, Janssen WM, Bak AA, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med 2001;249:519-526. 32. Whittemore JC, Gill VL, Jensen WA, et al. Evaluation of the association between microalbuminuria and the urine albumin-creatinine ratio and systemic disease in dogs. J Am Vet Med Assoc 2006;229:958-963. 33. Koh JM, Kim JY, Chung YE, et al. Increased urinary albumin excretion in Cushing's syndrome: remission after correction of hypercortisolaemia. Clin Endocrinol (Oxf) 2000;52:349-353. 34. Hayashi Y, Morikawa A, Makino M. Heterogeneity of urinary albumin from diabetic patients. Clin Chim Acta 1990;190:93-103. 35. Kubota E, Hayashi K, Matsuda H, et al. Role of intrarenal angiotensin II in glucocorticoid-induced renal vasodilation. Clin Exp Nephrol 2001;5:186-192. 36. Jensen WA, Grauer GF, Andrew J, et al. Prevalence of microalbuminuria in dogs. J Vet Intern Med 2001;15:300. 37. Pressler BM, Vaden SL, Jensen WA, et al. Prevalence of microalbuminuria in dogs evaluated at a referral veterinary hospital. J Vet Intern Med 2001;15. 38. Goy-Thollot I, Pechereau D, Keroack S, et al. Investigation of the role of aldosterone in hypertension associated with spontaneous pituitary-dependent hyperadrenocorticism in dogs. J Small Anim Pract 2002;43:489-492. 39. Ulick S, Wang JZ, Blumenfeld JD, et al. Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome. J Clin Endocrinol Metab 1992;74:963-967. 40. Saruta T, Suzuki H, Handa M, et al. Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab 1986;62:275-279. 41. Saruta T. Mechanism of glucocorticoid-induced hypertension. Hypertens Res 1996;19:1-8. 42. Kirilov G, Tomova A, Dakovska L, et al. Elevated plasma endothelin as an additional cardiovascular risk factor in patients with Cushing's syndrome. Eur J Endocrinol 2003;149:549-553. 43. Sakaue M, Hoffman BB. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest 1991;88:385-389. 44. Finco DR. Association of systemic hypertension with renal injury in dogs with induced renal failure. J Vet Intern Med 2004;18:289-294. Chapter 3 reference: 1. Maron BJ, Towbin JA, Thiene G, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006;113:1807-1816. 2. Liu SK, Roberts WC, Maron BJ. Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs. Am J Cardiol 1993;72:944-951. 3. Varnava AM, Elliott PM, Sharma S, et al. Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart 2000;84:476-482. 4. Unverferth DV, Baker PB, Pearce LI, et al. Regional myocyte hypertrophy and increased interstitial myocardial fibrosis in hypertrophic cardiomyopathy. Am J Cardiol 1987;59:932-936. 5. Ferasin L, Sturgess CP, Cannon MJ, et al. Feline idiopathic cardiomyopathy: a retrospective study of 106 cats (1994-2001). Journal of feline medicine and surgery 2003;5:151-159. 6. Lindholm J, Juul S, Jorgensen JO, et al. Incidence and late prognosis of cushing's syndrome: a population-based study. J Clin Endocrinol Metab 2001;86:117-123. 7. Colao A, Pivonello R, Spiezia S, et al. Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J Clin Endocrinol Metab 1999;84:2664-2672. 8. Whitworth JA, Mangos GJ, Kelly JJ. Cushing, cortisol, and cardiovascular disease. Hypertension 2000;36:912-916. 9. Toja PM, Branzi G, Ciambellotti F, et al. Clinical relevance of cardiac structure and function abnormalities in patients with Cushing's syndrome before and after cure. Clin Endocrinol (Oxf) 2012;76:332-338. 10. Ainscough JF, Drinkhill MJ, Sedo A, et al. Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res 2009;81:592-600. 11. Connell JM, MacKenzie SM, Freel EM, et al. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev 2008;29:133-154. 12. Burns AT, La Gerche A, D'Hooge J, et al. Left ventricular strain and strain rate: characterization of the effect of load in human subjects. Eur J Echocardiogr 2010;11:283-289. 13. Brilla CG, Weber KT. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 1992;120:893-901. 14. Yiu KH, Marsan NA, Delgado V, et al. Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. Eur J Endocrinol 2012;166:27-34. 15. Imbalzano E, Zito C, Carerj S, et al. Left ventricular function in hypertension: new insight by speckle tracking echocardiography. Echocardiography 2011;28:649-657. 16. Amundsen BH, Helle-Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol 2006;47:789-793. 17. Wess G, Sarkar R, Hartmann K. Assessment of left ventricular systolic function by strain imaging echocardiography in various stages of feline hypertrophic cardiomyopathy. J Vet Intern Med 2010;24:1375-1382. 18. Bohs LN, Trahey GE. A novel method for angle independent ultrasonic imaging of blood flow and tissue motion. IEEE Trans Biomed Eng 1991;38:280-286. 19. Pellerin D, Sharma R, Elliott P, et al. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6526 | - |
| dc.description.abstract | 腎上腺功能亢進為中老年犬隻常見的內分泌疾病，長期暴露於高濃度的醣皮質醇會導致許多併發症，包括高血壓，左心室壁肥厚，心肌纖維化，絲球體硬化及血管阻力提高。除了結構改變，腎上腺功能亢進同時也會影響心臟及腎臟的功能，造成心臟舒張不良，尿液濃縮能力下降及蛋白尿比例提升。此論文包含兩個部份：（1）以腹腔超音波評估腎上腺功能亢進犬隻腎臟間動脈及後大動脈血管阻力改變，與蛋白尿與微蛋白尿的發生率（2）以新式的二維斑點追蹤超音波技術評估腎上腺功能亢進犬隻心肌運動性的改變。整體而言，腎上腺功能亢進犬隻顯著出現高血壓、心肌增厚、腎臟血管阻力增加與增加蛋白尿的發生率。此外本研究中，尿蛋白與腎臟阻抗係數成正相關，顯示尿蛋白的增加與腎臟血管阻力增加有關。在心臟評估方面，儘管傳統超音波用來計算心臟收縮功能的數值在所有犬隻都是正常且沒有差異的，但心肌厚的犬隻在斑點追蹤超音波結果顯示較正常犬來的低，其中又以腎上腺型腎上腺功能亢進的犬隻最為顯著。顯示心肌厚會同時影響舒張其收縮功能，而新式的二維斑點追蹤超音波可做為一敏感性較高的診斷工具。 | zh_TW |
| dc.description.abstract | Hyperadrenocorticism (HAC) is a common endocrine disorder in middle-aged and older dogs. Long-term exposure to high levels of glucocorticoids causes several complications, such as hypertension, left ventricular hypertrophy, myocardial fibrosis, glomerulosclerosis and elevated renal resistance. Meanwhile, HAC also contributed both cardiac and renal dysfunction. Left ventricular myocardial function was investigated using two-dimensional speckle tracking echocardiography (2D-STE). Resistive index (RI) and pulsatility index (PI) of the renal artery and aorta, as well as the presence of microalbuminuria were also evaluated. In the present study, the prevalence of hypertension, hypertrophic cardiomyopathy (HCM), renal vascular resistance and albuminuria were significantly increased in dogs with HAC compared with age-matched non-HAC group. In dogs with HCM, dogs with adrenal-dependent hyperadrenocorticism had significantly decreased longitudinal systolic and diastolic function despite systolic performance of left ventricular were normal when evaluated using parameters derived from the conventional echocardiography. The presence of albuminuria was positive associated with increased renal RI, suggesting that albuminuria might be associated with increased vascular resistance within the kidneys. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-17T09:14:24Z (GMT). No. of bitstreams: 1 ntu-101-R98643011-1.pdf: 518638 bytes, checksum: 7df9f02ab02cdea2bc7e61e0f9bc802e (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 口試委員審定書------------------------------------------i
Acknowledgement--------------------------------------ii Abstract---------------------------------------------iii 中文摘要----------------------------------------------iv Table of Contents------------------------------------v List of Tables---------------------------------------vi List of Figures--------------------------------------vii Chapter 1 General Introduction----------------------1 References--------------------------------13 Chapter 2 Vascular Resistance and Albuminuria in Dogs Affected with Chronic Hyperadrenocorticism and Chronic Degenerative Mitral Valvular Disease-----------------19 References--------------------------------32 Chapter 3 Assessment of Hypertrophic Cardiomyopathy in Small Breed Dogs Affected with Hyperadrenocorticism Using 2D Speckle-Tracking Echocardiography--------------------39 References--------------------------------54 Chapter 4 Summarized Discussion---------------------68 References--------------------------------72 | |
| dc.language.iso | en | |
| dc.title | 以超音波評估腎上腺功能亢進犬隻心臟及腎臟功能 | zh_TW |
| dc.title | Evaluation of Cardiac and Renal Function in Dogs Affected with Hyperadrenocorticism by Ultrasonography | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 吳應寧(Ying-Ling Wu),林荀龍(Shiun-Long Lin) | |
| dc.subject.keyword | 腎上腺功能亢進,肥厚性心肌病,斑點追蹤超音波,阻抗係數,犬, | zh_TW |
| dc.subject.keyword | Hyperadrenocorticism,Hypertrophic cardiomyopathy,STE,Resistive index,Canine, | en |
| dc.relation.page | 73 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2012-08-16 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| Appears in Collections: | 臨床動物醫學研究所 | |
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| ntu-101-1.pdf | 506.48 kB | Adobe PDF | View/Open |
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