研發新型樹脂黏著劑以增強與牙本質之鍵結強度

Abstract

邁入二十一世紀，牙科材料的研發推陳出新，秉持著使用簡單、方便又有效的理念原則，日新月異的技術與方法不斷的被研究出來並應用至臨床牙科。根管治療完成後，材料的選擇更是多元，本研究團隊長期以來著重於根管治療後，根柱與黏著系統材料的研發，先前已創新發展出獨特的玻璃纖維根柱（glass fiber post）與樹脂黏著劑（resin cement），其黏著強度不遜於其它市售材料，唯樹脂黏著劑所搭配使用之黏合劑為市售商品OptiBond Solo Plus，故本實驗將以研發牙本質黏合劑（bonding agent）為主，搭配使用先前的自製材料，以期將牙本質（dentin）、玻璃纖維根柱與樹脂黏著劑形成一體（monoblock），相信未來在臨床時，各方面之鍵結強度與效果將會大幅提昇。 本實驗使用Bis-GMA（Bisphenol-glycidyl-methacrylate）與TEGDMA（triethylene glycol dimethacrylate）作為樹脂基質（resin matrix），並添加少量之IBOA+EHA（10 wt%）合成樹脂黏著劑，而與牙本質接觸面所搭配使用之樹脂黏合劑（bonding agent）乃是相同成分的樹脂基質加入固定含量的HEMA與乙醇，並添加比例不一（30%、35%、40%）的BMEP （Bis[2-(methacryloyloxy)-ethyl]phosphate）所合成。利用微拉伸測試法、推離鍵結測試法與破裂韌性強度測試法量化與牙本質間之鍵結，結果顯示，使用BMEP（35%）之黏合效果其強度值（34.53 MPa、28.01 MPa、309.8 J/M2）可與四種市售材料（NX3、Variolink II、Unicem與Panavia F）相比甚至有所超越之。實驗驗證方面利用傅立葉轉換紅外線光譜儀（FTIR）、X射線電子光譜儀（XPS）觀察破裂面塊材與純樹脂黏著劑塊材，發現兩者之光譜圖形相同，可判斷破裂面塊材上確實有樹脂黏著劑的殘留，由此進行細微的研究分析，並得知相關之官能基與鍵結的化學性質。

In the 21st century, the research and development for dental materials have innovated continuously. Based on the principle of simple, convenient and effective, technologies and methods progress to change with each passing day and applied to clinical dentistry. The choice of materials is more diversified after endodontic therapy. Our team have made efforts in developing post and adhesive system materials for a long time and we have developed distinctive glass fiber post and resin cement. Their bond strength was not inferior to other commercial adhesive materials. However, the high bond strength of resin cement to root canal dentin has to use the commercial product Optibond Solo Plus as bonding agent. Therefore, the major aim of this study was to create a new bonding agent with the use of previously-made materials. Hoping to create a monoblock including dentin, glass fiber post and resin cement. We believe that all aspects of the bond strength and the effect will be improved significantly for clinical application in the future. In this study, Bis-GMA (Bisphenol-glycidyl-methacrylate) and TEGDMA (triethylene glycol dimethacrylate) were used as the resin matrix. To compose the IE-cement, a small amount of IBOA+EHA (10 wt%) were added. The bonding agent which contact dentin was synthesized by using the same composition of resin matrix. A fixed content of HEMA and ethanol, and different ratio of BMEP (Bis[2-(methacryloyloxy)-ethyl]phosphate) were added. We measured the bond strength between dentin and resin cement by using microtensile bond strength test, push-out bond strength test and fracture toughness test. The highest bond strength among all groups was measured for BMEP (35%), which was better than the four commercial available materials (NX3, Variolink II, Unicem and Panavia F). Analyses of the fracture modes of fracture toughness and pure cement were performed using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The spectra analysis demonstrate that the similarity of fracture to the pure resin cement, indicating that the fracture surface were covered with resin cement. We can know the information of related functional group and the chemical properties of the bonding by using this detailed analysis.