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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳青周 | |
dc.contributor.author | Yi-Ting Lin | en |
dc.contributor.author | 林怡亭 | zh_TW |
dc.date.accessioned | 2021-06-16T23:25:30Z | - |
dc.date.available | 2022-12-31 | |
dc.date.copyright | 2012-09-18 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-07-31 | |
dc.identifier.citation | Abrahamsson, A. E., I. Geron, et al. (2009). 'Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.' Proc Natl Acad Sci U S A 106(10): 3925-3929.
Agarwal, B., S. Bhendwal, et al. (1999). 'Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.' Clin Cancer Res 5(8): 2223-2229. Akbar Waljee, P. D. R. H. (2006). 'Statins Reduce Inflammation, DVT, Osteoporosis, and Colon Cancer: Could They Be of Benefit in IBD?' PRACTICAL GASTROENTEROLOGY 19: 34-45. Al-Hajj, M., M. S. Wicha, et al. (2003). 'Prospective identification of tumorigenic breast cancer cells.' Proc Natl Acad Sci U S A 100(7): 3983-3988. Anton Aparicio, L. M., R. Garcia Campelo, et al. (2007). 'Prostate cancer and Hedgehog signalling pathway.' Clin Transl Oncol 9(7): 420-428. Axelsson, L. G., E. Landstrom, et al. (1998). 'Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine.' Aliment Pharmacol Ther 12(9): 925-934. Axelsson, L. G., E. Landstrom, et al. (1996). 'Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice.' Inflamm Res 45(4): 181-191. Bailey, R. W. and E. J. Bourne (1961). 'Intracellular glycosidases of dextran-producing bacteria.' Nature 191: 277-278. Bao, S., Q. Wu, et al. (2006). 'Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.' Cancer Res 66(16): 7843-7848. Barker, N., R. A. Ridgway, et al. (2009). 'Crypt stem cells as the cells-of-origin of intestinal cancer.' Nature 457(7229): 608-611. Barker, N., J. H. van Es, et al. (2007). 'Identification of stem cells in small intestine and colon by marker gene Lgr5.' Nature 449(7165): 1003-1007. Beier, D., P. Hau, et al. (2007). 'CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.' Cancer Res 67(9): 4010-4015. Bernstein, C. N., J. F. Blanchard, et al. (1999). 'Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study.' Am J Epidemiol 149(10): 916-924. Bolden, J. E., M. J. Peart, et al. (2006). 'Anticancer activities of histone deacetylase inhibitors.' Nat Rev Drug Discov 5(9): 769-784. Bonnet, D. and J. E. Dick (1997). 'Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.' Nat Med 3(7): 730-737. Breider, M. A., M. Eppinger, et al. (1997). 'Intercellular adhesion molecule-1 expression in dextran sodium sulfate-induced colitis in rats.' Vet Pathol 34(6): 598-604. Capper, D., T. Gaiser, et al. (2009). 'Stem-cell-like glioma cells are resistant to TRAIL/Apo2L and exhibit down-regulation of caspase-8 by promoter methylation.' Acta Neuropathol 117(4): 445-456. Charafe-Jauffret, E., F. Monville, et al. (2008). 'Cancer stem cells in breast: current opinion and future challenges.' Pathobiology 75(2): 75-84. Cho, J. H. (2008). 'The genetics and immunopathogenesis of inflammatory bowel disease.' Nature Rev. Immunol. 8: 458-466. Cho, J. H. (2008). 'The genetics and immunopathogenesis of inflammatory bowel disease.' Nat Rev Immunol 8(6): 458-466. Colliver, D. W., N. P. Crawford, et al. (2006). 'Molecular profiling of ulcerative colitis-associated neoplastic progression.' Exp Mol Pathol 80(1): 1-10. Crea, F., E. Giovannetti, et al. (2009). 'Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.' Mol Cancer Ther 8(7): 1964-1973. Dalerba, P., S. J. Dylla, et al. (2007). 'Phenotypic characterization of human colorectal cancer stem cells.' Proc Natl Acad Sci U S A 104(24): 10158-10163. de Ruijter, A. J., A. H. van Gennip, et al. (2003). 'Histone deacetylases (HDACs): characterization of the classical HDAC family.' Biochem J 370(Pt 3): 737-749. Deng, G., Y. Lu, et al. (1996). 'Loss of heterozygosity in normal tissue adjacent to breast carcinomas.' Science 274(5295): 2057-2059. Duester, G. (2000). 'Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.' Eur J Biochem 267(14): 4315-4324. Edwards, A. J. and S. L. Pender (2011). 'Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases.' Biochem Soc Trans 39(4): 1092-1095. Egger, B., M. Bajaj-Elliott, et al. (2000). 'Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency.' Digestion 62(4): 240-248. Fang, K., C. C. Chiu, et al. (2007). 'Cisplatin-induced senescence and growth inhibition in human non-small cell lung cancer cells with ectopic transfer of p16INK4a.' Oncol Res 16(10): 479-488. Fearon, E. R. and B. Vogelstein (1990). 'A genetic model for colorectal tumorigenesis.' Cell 61(5): 759-767. Fujimoto, K., R. D. Beauchamp, et al. (2002). 'Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression.' Gastroenterology 123(6): 1941-1948. Gao, L., M. A. Cueto, et al. (2002). 'Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.' J Biol Chem 277(28): 25748-25755. Gaudio, E., G. Taddei, et al. (1999). 'Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects.' Dig Dis Sci 44(7): 1458-1475. Gauthaman, K., C. Y. Fong, et al. (2009). 'Statins, stem cells, and cancer.' J Cell Biochem 106(6): 975-983. Ginestier, C., M. H. Hur, et al. (2007). 'ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.' Cell Stem Cell 1(5): 555-567. Glauben, R., A. Batra, et al. (2006). 'Histone hyperacetylation is associated with amelioration of experimental colitis in mice.' J Immunol 176(8): 5015-5022. Glauben, R., A. Batra, et al. (2008). 'Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.' Gut 57(5): 613-622. Hans, W., J. Scholmerich, et al. (2000). 'The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice.' Eur J Gastroenterol Hepatol 12(3): 267-273. Hill, R. and H. Wu (2009). 'PTEN, stem cells, and cancer stem cells.' J Biol Chem 284(18): 11755-11759. Hoey, T., W. C. Yen, et al. (2009). 'DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.' Cell Stem Cell 5(2): 168-177. Huang, E. H., M. J. Hynes, et al. (2009). 'Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.' Cancer Res 69(8): 3382-3389. Huang, E. H. and M. S. Wicha (2008). 'Colon cancer stem cells: implications for prevention and therapy.' Trends Mol Med 14(11): 503-509. Hynes, M. J., K. M. Huang, et al. (2009). 'Review paper: Implications of the 'cancer stem cell' hypothesis on murine models of colon cancer and colitis-associated cancer.' Vet Pathol 46(5): 819-835. Itzkowitz, S. H. and X. Yio (2004). 'Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation.' Am J Physiol Gastrointest Liver Physiol 287(1): G7-17. Iwanaga, T., O. Hoshi, et al. (1994). 'Morphological analysis of acute ulcerative colitis experimentally induced by dextran sulfate sodium in the guinea pig: some possible mechanisms of cecal ulceration.' J Gastroenterol 29(4): 430-438. Jakobisiak, M. and J. Golab (2003). 'Potential antitumor effects of statins (Review).' Int J Oncol 23(4): 1055-1069. Jamieson, C. H., L. E. Ailles, et al. (2004). 'Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.' N Engl J Med 351(7): 657-667. Jeon, Y. K., S. H. Kim, et al. (2010). 'Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers.' World J Gastroenterol 16(25): 3153-3160. Jin, L., K. J. Hope, et al. (2006). 'Targeting of CD44 eradicates human acute myeloid leukemic stem cells.' Nat Med 12(10): 1167-1174. Jordan, C. T., M. L. Guzman, et al. (2006). 'Cancer Stem Cells.' New England Journal of Medicine 355(12): 1253-1261. Kanagarajan, N., J. H. Nam, et al. (2008). 'Disease modifying effect of statins in dextran sulfate sodium model of mouse colitis.' Inflamm Res 57(1): 34-38. Karbanova, J., E. Missol-Kolka, et al. (2008). 'The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia.' J Histochem Cytochem 56(11): 977-993. Kitano, A., N. Oshitani, et al. (1996). 'CD44 variants in ulcerative colitis and Crohn's disease.' Lancet 348(9022): 266-267. Kodach, L. L., R. J. Jacobs, et al. (2011). 'Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.' Gut 60(11): 1544-1553. Kondo, T., T. Setoguchi, et al. (2004). 'Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.' Proc Natl Acad Sci U S A 101(3): 781-786. Korkaya, H., A. Paulson, et al. (2009). 'Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.' PLoS Biol 7(6): e1000121. Kullmann, F., H. Messmann, et al. (2001). 'Clinical and histopathological features of dextran sulfate sodium induced acute and chronic colitis associated with dysplasia in rats.' Int J Colorectal Dis 16(4): 238-246. Kureishi, Y., Z. Luo, et al. (2000). 'The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.' Nat Med 6(9): 1004-1010. Lee, H. B., H. Noh, et al. (2007). 'Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy.' Kidney Int Suppl(106): S61-66. Lee, J., I. Lee, et al. (2006). 'Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells.' Biochem Biophys Res Commun 339(3): 748-754. Leedham, S. J. and N. A. Wright (2008). 'Expansion of a mutated clone: from stem cell to tumour.' J Clin Pathol 61(2): 164-171. Li, C., D. G. Heidt, et al. (2007). 'Identification of pancreatic cancer stem cells.' Cancer Res 67(3): 1030-1037. Lin, H. and T. Schagat (1997). 'Neuroblasts: a model for the asymmetric division of stem cells.' Trends Genet 13(1): 33-39. Loftus, E. V., Jr. (2004). 'Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.' Gastroenterology 126(6): 1504-1517. Loftus, E. V., Jr., M. D. Silverstein, et al. (1998). 'Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival.' Gastroenterology 114(6): 1161-1168. Loftus, E. V., Jr., M. D. Silverstein, et al. (2000). 'Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival.' Gut 46(3): 336-343. Mahler, M., I. J. Bristol, et al. (1998). 'Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.' Am J Physiol 274(3 Pt 1): G544-551. Mani, S. A., W. Guo, et al. (2008). 'The epithelial-mesenchymal transition generates cells with properties of stem cells.' Cell 133(4): 704-715. Melgar, S., A. Karlsson, et al. (2005). 'Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation.' Am J Physiol Gastrointest Liver Physiol 288(6): G1328-1338. Murohara, T., H. Ikeda, et al. (2000). 'Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization.' J Clin Invest 105(11): 1527-1536. Murthy, S., H. S. Cooper, et al. (1999). 'Combination therapy of pentoxifylline and TNFalpha monoclonal antibody in dextran sulphate-induced mouse colitis.' Aliment Pharmacol Ther 13(2): 251-260. Murthy, S. N., H. S. Cooper, et al. (1993). 'Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin.' Dig Dis Sci 38(9): 1722-1734. Naito, Y., K. Katada, et al. (2006). 'Rosuvastatin, a new HMG-CoA reductase inhibitor, reduces the colonic inflammatory response in dextran sulfate sodium-induced colitis in mice.' Int J Mol Med 17(6): 997-1004. Nightingale, K. P., L. P. O'Neill, et al. (2006). 'Histone modifications: signalling receptors and potential elements of a heritable epigenetic code.' Curr Opin Genet Dev 16(2): 125-136. O'Brien, C. A., A. Kreso, et al. (2010). 'Cancer stem cells and self-renewal.' Clin Cancer Res 16(12): 3113-3120. O'Brien, C. A., A. Pollett, et al. (2007). 'A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.' Nature 445(7123): 106-110. Okayasu, I., S. Hatakeyama, et al. (1990). 'A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice.' Gastroenterology 98(3): 694-702. Peng, X. D., X. H. Wu, et al. (2010). 'Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.' J Pharmacol Exp Ther 332(1): 46-56. Ponti, D., A. Costa, et al. (2005). 'Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.' Cancer Res 65(13): 5506-5511. Prince, M. E., R. Sivanandan, et al. (2007). 'Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma.' Proc Natl Acad Sci U S A 104(3): 973-978. Purton, L. E., I. D. Bernstein, et al. (2000). 'All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells.' Blood 95(2): 470-477. Rao, S., D. C. Porter, et al. (1999). 'Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase.' Proc Natl Acad Sci U S A 96(14): 7797-7802. Ricci-Vitiani, L., A. Pagliuca, et al. (2008). 'Colon cancer stem cells.' Gut 57(4): 538-548. Robertson, F. M., W. A. Woodward, et al. (2010). 'Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids.' Cancer 116(11 Suppl): 2760-2767. Roth, S. Y., J. M. Denu, et al. (2001). 'Histone acetyltransferases.' Annu Rev Biochem 70: 81-120. Santilli, G., M. Binda, et al. (2011). 'Breast Cancer-Initiating Cells: Insights into Novel Treatment Strategies.' Cancers 3(1): 1405-1425. Sasaki, M., S. Bharwani, et al. (2003). 'The 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor pravastatin reduces disease activity and inflammation in dextran-sulfate induced colitis.' J Pharmacol Exp Ther 305(1): 78-85. Seo, D. C., J. M. Sung, et al. (2007). 'Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells.' Mol Cancer 6: 75. Shmelkov, S. V., J. M. Butler, et al. (2008). 'CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.' J Clin Invest 118(6): 2111-2120. Solomon, L., S. Mansor, et al. (2010). 'The dextran sulphate sodium (DSS) model of colitis: an overview.' Comparative Clinical Pathology 19(3): 235-239. Stevceva, L., P. Pavli, et al. (2001). 'The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it.' BMC Clin Pathol 1(1): 3. Taieb, N., M. Maresca, et al. (2009). 'The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif.' Cancer Lett 278(2): 164-173. Talley, N. J., M. T. Abreu, et al. (2011). 'An evidence-based systematic review on medical therapies for inflammatory bowel disease.' Am J Gastroenterol 106 Suppl 1: S2-25; quiz S26. Tao, R., E. F. de Zoeten, et al. (2007). 'Deacetylase inhibition promotes the generation and function of regulatory T cells.' Nat Med 13(11): 1299-1307. Thiagalingam, S., K. H. Cheng, et al. (2003). 'Histone deacetylases: unique players in shaping the epigenetic histone code.' Ann N Y Acad Sci 983: 84-100. Tilkin-Mariame, A. F., C. Cormary, et al. (2005). 'Geranylgeranyl transferase inhibition stimulates anti-melanoma immune response through MHC Class I and costimulatory molecule expression.' FASEB J 19(11): 1513-1515. Todaro, M., M. G. Francipane, et al. (2010). 'Colon cancer stem cells: promise of targeted therapy.' Gastroenterology 138(6): 2151-2162. Veillard, N. R. and F. Mach (2002). 'Statins: the new aspirin?' Cell Mol Life Sci 59(11): 1771-1786. Vermeulen, L., E. M. F. De Sousa, et al. (2010). 'Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.' Nat Cell Biol 12(5): 468-476. Weis, M., C. Heeschen, et al. (2002). 'Statins have biphasic effects on angiogenesis.' Circulation 105(6): 739-745. Williams, R. T. and C. J. Sherr (2008). 'The INK4-ARF (CDKN2A/B) locus in hematopoiesis and BCR-ABL-induced leukemias.' Cold Spring Harb Symp Quant Biol 73: 461-467. Yamada, M., T. Ohkusa, et al. (1992). 'Occurrence of dysplasia and adenocarcinoma after experimental chronic ulcerative colitis in hamsters induced by dextran sulphate sodium.' Gut 33(11): 1521-1527. Youssef, S., O. Stuve, et al. (2002). 'The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.' Nature 420(6911): 78-84. Zhao, C., A. Chen, et al. (2009). 'Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.' Nature 458(7239): 776-779. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65109 | - |
dc.description.abstract | 發炎性腸道疾病 (IBD) 為一慢性疾病,尚未有治癒之藥物,僅能使症狀獲得控制與緩解,腸道長期處於發炎狀態易導致併發症並增加罹癌風險,長期發炎導致之癌症可能是源於癌幹細胞。JMF-1為statin-SAHA conjugated藥物,在DSS誘發結腸炎之動物模式具有預防與治療之作用,可減緩DSS造成之體重減輕及臨床症狀表徵如腹瀉及糞便潛血,亦可恢復變短結腸之長度,以及抑制Th1型細胞激素之釋放。JMF-1可保護腸道內皮不受破壞,維持crypts完整或重建發炎之黏膜結構,且發炎細胞之浸潤較輕微。此外,我們發現HCT116人類大腸直腸癌細胞具癌幹細胞族群,會形成tumorspheres、有較多ALDH+族群及具高度致瘤之能力,JMF-1可抑制colonospheres形成及癌幹細胞之生長,也可抑制colonosphere-induced xenograft之腫瘤生長並縮小體積,因此JMF-1可預防並治療結腸炎,也能降低癌幹細胞族群,是具潛力之抗發炎和抗癌藥物。 | zh_TW |
dc.description.abstract | Inflammatory bowel disease (IBD) is a lifelong manifestation. Currently, there is no medication to cure it, and just to keep symptoms under control. IBD patients are at increased risk for the development of colorectal cancer, one of the reasons is that cancer stem cells (CSCs) are out of control. The aim of the present study was to elucidate the beneficial effect of JMF-1, a statin-SAHA conjugated compound, on colonic mucosal damage and on the inflammatory response in dextran sulfate sodium (DSS)-induced colitis model. In acute inflammation murine model, JMF-1 showed both preventive and therapeutic effect. It attenuated DSS-induced weight loss, diarrhea, hematochezia and shortening of colon length, and also inhibited Th1 type cytokine release. JMF-1-treated mice completely maintained crypts architecture or only showed mild crypts disruption and a scanty infiltration of inflammatory cells. We also found that human colorectal cancer HCT116 cells had a small population of CSCs, characterized by tumorspheres formation and high ALDH activity and tumorigenicity. JMF-1 not only blocked self-renewal of colonospheres but also decreased CSCs population. Furthermore, JMF-1 repressed colonosphere-induced xenograft expansion. Taken together, JMF-1 might be a potential agent for acute colitis, and also a promising agent for targeting CSCs to prevent colorectal cancer development. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T23:25:30Z (GMT). No. of bitstreams: 1 ntu-101-R99443004-1.pdf: 5480686 bytes, checksum: 5c30ff73271728d9087fbf8b778fccf3 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 縮寫表 (Abbreviations) 2
中文摘要 (Abstract in Chinese) 4 英文摘要 (Abstract in English) 6 第一章、緒論 (Introduction) 8 第一節、發炎性腸道疾病 9 第二節、癌幹細胞 21 第三節、組織蛋白去乙醯酶 41 第四節、Statins 48 研究動機 55 第二章、實驗材料與方法 (Materials and Methods) 56 第三章、結果 (Results) 65 第四章、討論 (Discussion) 91 第五章、結論 (Conclusions) 94 參考資料 (Reference) 96 | |
dc.language.iso | zh-TW | |
dc.title | 新穎HDAC抑制劑在結腸炎及大腸直腸癌幹細胞之研究 | zh_TW |
dc.title | Effects of a novel HDAC inhibitor on colitis and colorectal cancer stem cells | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳明賢,黃偉謙 | |
dc.subject.keyword | HDAC 抑制劑,結腸炎,癌幹細胞, | zh_TW |
dc.subject.keyword | HDAC inhibitor,colitis,cancer stem cells, | en |
dc.relation.page | 103 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-08-01 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥理學研究所 | zh_TW |
顯示於系所單位: | 藥理學科所 |
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