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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王若松(Juo-Song Wang) | |
| dc.contributor.author | Yu-Ju Liao | en |
| dc.contributor.author | 廖于茹 | zh_TW |
| dc.date.accessioned | 2021-06-16T17:39:25Z | - |
| dc.date.available | 2013-09-17 | |
| dc.date.copyright | 2012-09-17 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-15 | |
| dc.identifier.citation | Akimenko, M. A., Johnson, S. L., Westerfield, M. and Ekker, M. (1995). Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development 121, 347-57.
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(2011). Effects of clodronate combined with hydroxyapatite on multi-directional differentiation of mesenchymal stromal cells. Arch Med Sci 6, 670-7. Lo, J. C., O'Ryan, F. S., Gordon, N. P., Yang, J., Hui, R. L., Martin, D., Hutchinson, M., Lathon, P. V., Sanchez, G., Silver, P. et al. (2009). Prevalence of 68 osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg 68, 243-53. Naidu, A., Dechow, P. C., Spears, R., Wright, J. M., Kessler, H. P. and Opperman, L. A. (2008). The effects of bisphosphonates on osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106, 5-13. Ott, S. M. (2005). Long-term safety of bisphosphonates. J Clin Endocrinol Metab 90, 1897-9. Pazianas, M. and Abrahamsen, B. (2011). Safety of bisphosphonates. Bone 49, 103-10. Pazianas, M., Miller, P., Blumentals, W. A., Bernal, M. and Kothawala, P. (2007). 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L. and Jacinto, A. (2011). Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development 138, 3897-905. Thisse, C. and Thisse, B. (2008). High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc 3, 59-69. Turek, J., Ebetino, F. H., Lundy, M. W., Sun, S., Kashemirov, B. A., McKenna, C. E., Gallant, M. A., Plotkin, L. I., Bellido, T., Duan, X. et al. (2012). Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits. Calcif Tissue Int 90, 202-10. Zhou, Q., Zhao, Z. N., Cheng, J. T., Zhang, B., Xu, J., Huang, F., Zhao, R. N. and Chen, Y. J. (2011). Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs. Biochem Biophys Res Commun 404, 127-32. 吳俊學. (2010). 利用斑馬魚活體實驗來探討雙磷酸鹽造成顎骨壞死之可能機制. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64298 | - |
| dc.description.abstract | Bisphosphonates are effective drugs widely used to treat osteoporosis, Paget's disease, osteogenesis imperfecta and skeletal complications caused by metastatic cancer. Although generally well tolerated, there is a rare but potentially severe side effect, bisphosphonate related osteonecrosis of the jaw (BRONJ), first described in 2003. The clinical manifestation of the disease is exposure of bone, which is frequently accompanied by pain, soft tissue swelling or ulceration, suppuration, and abscess formation. BRONJ significantly impairs the quality of life and complicates dental treatment, such as tooth extraction and dental implant restorations.
To date, the definitive mechanism of BRONJ still remains elusive. In this study, we use zebrafish as an in vivo animal model to dissect the etiology of BRONJ to unravel the underlying molecular mechanism using whole-mount in situ hybridization (ISH) on regenerative caudal fins after the amputation surgery. Our preliminary results suggest that bisphosphonates (alendronate) have no significant effects on gene expression related to mesenchymal cell proliferation and differentiation during the early stage of fin regeneration. However, further studies are needed to characterize the possible effects of bisphophobates during the entire process of fin regeneration. Eventually, we expect to unravel the detailed mechanism of BRONJ and shed light on potential treatment of this disease. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T17:39:25Z (GMT). No. of bitstreams: 1 ntu-101-R98422023-1.pdf: 9181718 bytes, checksum: 12faac43645250392fa7cf77ffdd63d1 (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 壹、前言......................................................................... ...1
貳、實驗材料................................................................... .16 參、實驗方法.....................................................................19 肆、結果...........................................................................23 伍、討論...........................................................................29 陸、結論...........................................................................40 柒、圖表...........................................................................41 參考文獻...........................................................................64 | |
| dc.language.iso | zh-TW | |
| dc.subject | 雙磷酸鹽 | zh_TW |
| dc.subject | 基因表現 | zh_TW |
| dc.subject | 間葉組織細胞增生及分化 | zh_TW |
| dc.subject | 斑馬魚尾鰭再生 | zh_TW |
| dc.subject | 雙磷酸鹽相關顎骨壞死 | zh_TW |
| dc.subject | mesenchymal cells | en |
| dc.subject | BRONJ | en |
| dc.subject | zebrafish fin regeneration | en |
| dc.subject | whole-mount in situ hybridization (ISH) | en |
| dc.subject | gene expression | en |
| dc.subject | Bisphosphonates | en |
| dc.title | 以原位雜合反應探討雙磷酸鹽對骨骼再生之影響 | zh_TW |
| dc.title | Evaluating Effects of Bisphosphonates on Bone Regeneration in Zebrafish by whole-mount in situ hybridization.------- A Preliminary Study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 張百恩(Bei-En Chang) | |
| dc.contributor.oralexamcommittee | 洪志遠 | |
| dc.subject.keyword | 雙磷酸鹽,雙磷酸鹽相關顎骨壞死,斑馬魚尾鰭再生,基因表現,間葉組織細胞增生及分化, | zh_TW |
| dc.subject.keyword | Bisphosphonates,BRONJ,zebrafish fin regeneration,whole-mount in situ hybridization (ISH),gene expression,mesenchymal cells, | en |
| dc.relation.page | 67 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-08-15 | |
| dc.contributor.author-college | 牙醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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