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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林中天(Chung-Tien Lin) | |
dc.contributor.author | Ya-Fei Chang | en |
dc.contributor.author | 張雅斐 | zh_TW |
dc.date.accessioned | 2021-06-16T17:26:30Z | - |
dc.date.available | 2014-08-19 | |
dc.date.copyright | 2012-08-19 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-16 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/64013 | - |
dc.description.abstract | 水晶體後囊混濁 (posterior capsular opacification, PCO),是現代白內障摘除手術後最常見的長期併發症,在人類,植入人工水晶體已成為預防後囊混濁的策略之一。人工水晶體抑制後囊混濁的效果,會受到其生物相容性與幾何構造的影響。目前,針對犬隻所使用之人工水晶體與後囊混濁間的相關性,尚無系統性的研究。本研究的目的,是希望能夠利用兔模式來模擬犬隻白內障手術後,水晶體後囊混濁的程度,藉以評估犬隻專用人工水晶體CLV-12 (Cara TM Life, Inc.) 抑制水晶體後囊混濁的效果。
實驗中,六隻紐西蘭大白兔、共十二顆眼球被隨機分成三組:無水晶體組、IOL-C與IOL-H組。無水晶體組在接受超音波乳化術後,不再植入人工水晶體,使囊袋保持無水晶體狀態;IOL-C組植入犬隻人工水晶體 CLV-12、而IOL-H組則植入人類之人工水晶體Akreos® Adapt (Bausch& Lomb) 作為比較對照。在八週的臨床觀察期後,合併肉眼檢查、組織學與免疫化學染色等方式,進行後囊混濁的評估與分析。 結果顯示,水晶體後囊混濁的臨床得分會隨時間增加,到第八週時,各組間的混濁程度並無顯著差異。肉眼觀察下,偽水晶體組 (IOL-C與IOL-H) 週邊混濁的程度較無水晶體組少;而中央區的部分,各組皆保持清澈。病理切片下顯示,人工水晶體具有減少囊袋空間、阻擋細胞增生與移行的屏障能力,而無水晶體囊袋則依靠前後囊的沾黏,來阻止細胞往視軸中央移行。另外,臨床與肉眼觀察結果僅有中度相關性。 總結來說,本研究證實犬隻專用人工水晶體具有抑制兔模式週邊後囊混濁的效果,而無水晶體組中央囊袋的混濁度低,其程度與偽水晶體組類似。 | zh_TW |
dc.description.abstract | Posterior capsular opacification (PCO) is the most common long-term complication of modern cataract surgery both in human and dogs. Intraocular lenses (IOLs) have been introduced specifically to prevent PCO in humans. Biocompatibility and geometry are two major factors determined the inhibitory effect of IOLs. Different combinations of IOL designs and materials may result in different PCO grades. The relationship between PCO and canine IOLs is still unclear. The purpose of this study was to evaluate the inhibitory effect of currently available canine IOL- CLV12 (Cara TM Life, Inc.) in a rabbit model.
Six New Zealand white rabbits were divided into 3 groups, the aphakic, IOL-C and IOL-H. In aphkic group, capsular bags were kept in aphakic after receiving phacoemulsificaiton. In IOL-C and IOL-H groups, canine IOL CLV-12 and human IOL Akreos® Adapt (Bausch& Lomb) were implanted respectively. Clinical evaluation, gross examination, and histological analysis of PCO were performed in 8-week follow up period. The results showed that clinical PCO scores increased gradually with time, but there was no statistical difference between groups. Under gross examination, pseudophakic groups (IOL-C and IOL-H) had less peripheral PCO formation than aphakic group, which indicate the inhibitory of IOLs. As for central (optic) areas of capsular bags, all groups remained clear. Histopathological evaluation confirmed the barrier effect of IOLs, and also noted that adhesion between anterior and posterior capsule were effective in preventing lens epithelium cells (LECs) migration, which results in low axial PCO grade of aphakic eyes. Clinical and gross PCO scores were moderately correlated. In conclusion, this study confirms the peripheral PCO inhibitory effects of CLV-12. Central area of aphakic eyes can remain as clear as pseudophakic ones, which achieved by capsular adhesion. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T17:26:30Z (GMT). No. of bitstreams: 1 ntu-101-R98643001-1.pdf: 11479146 bytes, checksum: 232a9ff2dc74f93085129ad3ccd0d157 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 口試委員審定書…………………………………………………………………………………………………... I
致謝………………………………………………………………………………………………………………………. II 中文摘要..................................................................................................................... III 英文摘要………………………………………………………………………………………………………………. IV 目錄………………………………………………………………………………………………………………………. V 第一章 緒論............................................................................................................. 1 第一節 白內障與白內障摘除手術………………………………………….…………………. 1 第二節 水晶體後囊混濁……………………………………………………………………..…….. 1 第三節 人工水晶體的發展與應用………………………………………………………….... 2 第四節 研究目的………………………………………………………………………….……….. 3 第二章 文獻探討 …………………………………………………………………………………………….. 4 第一節 白內障疾病介紹與治療……………………………………………………………….. 4 第二節 水晶體後囊混濁之病生理機制與處置………………………………………… 6 2-1 病生理機制…………………………………………………………………………………... 6 2-2 後囊混濁對視力的影響……………………………………………….……………… 7 2-3 處置方式與預防策略………………………………………………………………….. 8 第三節 人工水晶體抑制後囊混濁之原理……………………….………………………. 11 3-1 彎折效應與屏障效應……………………………..………………………….……….. 11 3-2 人工水晶體與囊袋間的關係………………………………………………………. 12 第四節 後囊混濁之動物模式……………………………………………………..……………. 13 第五節 後囊混濁之評估方法…………………………………………………………………… 14 5-1 臨床評估…………………………………………………………………………………….… 14 5-2 肉眼評估…………………………………………………………………………………….… 15 5-3 組織病理學評估…………………………………………………………………………… 17 第六節 人工水晶體於獸醫眼科學之應用……………………………………………….. 17 6-1 犬隻的水晶體後囊混濁與處置…………………………………………………… 17 6-2 人工水晶體於犬隻的應用……………………………………………………………. 18 6-3 犬隻後囊混濁與人工水晶體間的關係………………………………………… 18 第三章 實驗材料與方法....................................................................................... 20 第一節 實驗架構與分組…………………………………………………………………………... 20 第二節 實驗材料………………………………………………………………………………………. 20 2-1 實驗動物………………………………………………………………………………………. 20 2-2 人工水晶體…………………………………………………………………………………… 21 第三節 實驗方法………………………………………………………………………………………. 21 3-1 水晶體後囊混濁之兔模式…………………………………………………………… 21 3-2 後囊混濁之臨床紀錄觀察……………………………………………………………. 22 3-3 後囊混濁之肉眼紀錄觀察……………………………………………………………. 23 3-4 組織病理學分析…………………………………………………………………………… 23 3-5 統計分析………………………………………………………………………………………. 24 第四章 實驗結果................................................................................................... 25 第一節 臨床觀察…………………………………………………………………………………...... 25 第二節 肉眼觀察……………………………………………………………………………………… 25 2-1 整體囊袋…………………………………………………………………………………….. 26 2-2 週邊囊袋……………………………………………………………………………………… 26 2-3 中央囊袋…………………………………………………………………………………….. 26 第三節 組織病理學觀察………………………………………………………………………..... 26 第四節 臨床與肉眼觀察結果之相關性分析…………………………………………… 27 第五章 討論 ......................................................................................................... 28 第一節 水晶體後囊混濁之兔模式………………………………………………………….. 28 1-1 實驗動物的選擇…………………………………………………………………………. 28 1-2 臨床觀察之考量…………………………………………………………………………. 28 1-3 肉眼觀察之分析方法……………………………………………………………….... 29 1-4 組織病理切片之製作………………………………………………………………. . 29 第二節 肉眼觀察下各組後囊混濁之差異…………………………………………………. 29 2-1 無水晶體與偽水晶體後囊混濁之差異……………………………………. .. 29 2-2 CLV-12與Akreos® Adapt間後囊混濁之差異……………………………….. 31 第三節 臨床觀察與肉眼病變之相關性…………………………………………………… 32 第四節 動物模式、臨床檢查技術及人工水晶體在獸醫的應用與發展… 32 第五節 本研究之限制與未來工作………………………………………………………….. 34 第六章 結論……………………………………………………………………………………………….. 35 圖目錄……………………………………………………...……………………………………………………….. 36 表目錄……………………………………………………………………………………………………………….. 58 參考文獻................................................................................................................. 62 | |
dc.language.iso | zh-TW | |
dc.title | 不同型人工水晶體抑制兔模式水晶體後囊混濁之效果評估 | zh_TW |
dc.title | The inhibitory effect on posterior capsular opacification by different intraocular lenses in a rabbit model | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 葉力森,劉振軒,林荀龍 | |
dc.subject.keyword | 水晶體後囊混濁,後發性白內障,人工水晶體,兔模式,犬隻, | zh_TW |
dc.subject.keyword | posterior capsular opacification,after cataract,intraocular lenses,rabbit model,dog, | en |
dc.relation.page | 68 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-08-16 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
顯示於系所單位: | 臨床動物醫學研究所 |
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