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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林璧鳳(Bi-Fong Lin) | |
dc.contributor.author | Tzung-Yang Lai | en |
dc.contributor.author | 賴宗揚 | zh_TW |
dc.date.accessioned | 2021-06-16T17:14:48Z | - |
dc.date.available | 2017-08-27 | |
dc.date.copyright | 2012-08-27 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-19 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/63612 | - |
dc.description.abstract | Allergic asthma is the most common disease of type I hypersensitivity. Patients with allergic asthma have higher levels of IgE in serum which then act on Th2-prone immune responses. Lactobacilli are probiotic bacteria that can improve the intestinal environment and regulate the allergic reaction, but the efficacy vary with the different varieties. Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) isolated from human faeces can promote Th1-prone immune responses of Peyer’s patches and primary splenocytes in several studies. The purpose of this study was to evaluate whether oral administration of the sample containing NTU 101 dead bacteria may prossess an immunomodulation effect on airway inflammation and gut immune responses in murine model of asthma.
In this study, the 8-week-old BALB/c female mice were sensitized with ovalbumin (OVA) in Al(OH)3 adjuvant intraperitoneally. Mice were grouped by total IgE concentration in serum after one OVA-injection. Seven groups of mice were: control group (OVA/Ctrl), low (OVA/L), medium (OVA/M), high (OVA/H) dose NTU 101 product, inulin filler group (OVA / Inu), prednisolone group (OVA / Pred) as positive control, and non-sensitized mice (PBS / PBS) as blank control. During the tube-feeding period, mice were challenged with 5% OVA aerosol to induce allergic airway inflammation. 24 hours after aerosol OVA challenge, the AHR challenged by Mch were measured. Mice were sacrificed after tube-feeding for twenty-two weeks. The results showed that fed with NTU 101 product can’t attenuate AHR, indicate NTU 101 product can not ameliorate airway smooth muscle hyperresponsiveness. But in BALF, NTU 101 product reduced IL-4, TNF-α and IL-6 content. OVA/H group also decreased lung tissue weight, eotaxin content and eosinophil cell count. Fed with NTU 101 product could decrease not only the IL-13 production of OVA-stimulated splenocytes, but also the IFN-γ production of LPS-stimulated splenocytes. NTU 101 increased IFN-γ and IL-6 production in Peyer’s patches. OVA/H group and OVA/Inu group had significantly higher IL-10 production in MLN. In PP and MLN, OVA/L group significantly increased IL-2 level. Serum OVA-IgG2a spectacularly decreased in OVA/L group and OVA/M group. OVA/M group had significantly higher serum total IgG, total IgA and phagocytotic activity. Subsequently, EL4 cell line was treated with heat-killed NTU 101, inulin and NTU 101 product. The results showed the three group decreased IL-4 secretion in EL4 cell line. NTU 101 product may alleviate the Th2-prone immune responses in allergic asthma. In conclusion, OVA-sensitized mice fed with NTU 101 product could decrease the Th2-prone immune responses, but promote intestinal Th1-prone immune responses. NTU 101 product may reduce the systemic inflammatory response and respiratory tract inflammation. | en |
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dc.description.tableofcontents | 第一章、 序論 1
第一節 文獻回顧 1 一、 免疫系統 1 (一) 免疫系統簡介 1 (二) 輔助型T細胞 2 二、 過敏性氣喘 3 (一) 過敏性氣喘之簡介 3 (二) 過敏性氣喘之機制 4 (三) 影響過敏性氣喘的抗體 5 (四) 參與過敏性氣喘之細胞 6 (五) 治療藥物 7 三、 黏膜免疫系統 8 (一) 黏膜免疫系統簡介 8 (二) 腸道淋巴系統 8 四、 益生質與益生菌 10 (一) 益生質 10 (二) 益生菌簡介 10 (三) 益生菌與過敏性氣喘 11 (四) 益生菌的免疫調節物質 12 (五) 乳酸菌 13 第二節 研究動機 16 第二章、 LACTOBACILLUS PARACASEI SUBSP. PARACASEI NTU 101對氣喘模式小鼠腸道與過敏免疫反應的影響 17 第一節 前言 17 第二節 材料與方法 18 一、 樣品來源 18 二、 動物實驗設計 18 (一)動物飼養 18 (二) 分組及實驗流程 19 (三) 致敏方式 19 (四) 劑量換算 20 (五) 呼吸道阻力(Airway hyperresponsiveness, AHR)測定 21 三、 動物犧牲及組織樣品收集與分析 22 (一) 血液 22 I. 血清之取得與保存 22 II. 血清特異性抗體IgE、IgG1、IgG2a測定 22 III. 血清總IgE、IgG、IgA、IgM抗體含量測定 24 IV. 吞噬細胞活性測定 25 (二) 肺支氣管沖洗液(Bronchoalveolar lavage fluid, BALF) 26 I. 肺支氣管沖洗液之取得與保存 26 II. 細胞激素含量測定 26 III. 免疫細胞計數 26 (三) 脾臟 27 I. 脾臟細胞之取得與培養 27 II. 脾臟細胞分泌細胞激素的能力 28 III. 脾臟細胞增生測定 28 IV. 自然殺手細胞活性分析 29 (四) 腹腔 30 I. 腹腔細胞之取得與培養 30 II. 腹腔細胞分泌細胞激素的能力 31 (五) 腸道組織 31 I. 腸道皮耶氏體細胞之取得與培養 31 II. 腸繫膜淋巴結細胞之取得與培養 32 III. 小腸沖洗液之取得 32 IV. 細胞激素含量測定 32 (六) 細胞激素含量測定 32 四、 統計方法 34 第三節 結果 35 一、 生長情形與攝食狀況 35 二、 器官重量與相對重量 35 三、 血清抗體含量 35 I. OVA特異性IgE、IgG1、IgG2a抗體含量 35 II. 血清中總IgE、IgM、IgG與IgA抗體含量 35 四、 呼吸道阻力(AHR) 36 五、 肺支氣管沖洗液(BALF)中各項指標變化 36 I. 氣喘過敏免疫反應相關介質分泌 36 II. 肺支氣管沖洗液(BALF)中的免疫細胞數目 36 六、 脾臟細胞細胞 37 I. 脾臟細胞細胞激素分泌量 37 II. 脾臟細胞增生反應 37 七、 血液中吞噬細胞之吞噬能力 38 八、 脾臟中自然殺手細胞活性 38 九、 腹腔細胞分泌激素分泌量的影響 38 十、 腸道組織 38 I. 皮耶氏體之細胞激素分泌量 38 II. 腸繫膜淋巴結之細胞激素分泌量 39 III. 小腸沖洗液中secretory IgA含量 39 第四節 討論 57 一、 餵食NTU 101產品對過敏性氣喘小鼠血清抗體生成之影響 57 二、 餵食NTU 101產品對小鼠呼吸道發炎反應的影響 58 三、 餵食NTU 101產品對過敏性氣喘小鼠全身性免疫反應之影響 59 四、 餵食NTU 101產品對過敏性氣喘小鼠腹腔細胞之激素分泌量的影響 61 五、 餵食NTU 101產品對過敏性氣喘小鼠GALT之影響 61 六、 餵食菊糖與高劑量NTU 101產品對過敏性氣喘小鼠影響之比較 62 第三章、 LACTOBACILLUS PARACASEI SUBSP. PARACASEI NTU 101 對EL4細胞株的影響 64 第一節 前言 64 第二節 材料與方法 65 一、 Heat-killed Lactobacillus paracasei subsp. paracasei NTU 101、菊糖與NTU 101產品製備 65 二、 EL4 小鼠T細胞株 65 三、 細胞存活分析 66 四、 細胞激素含量測定 66 五、 統計方法 66 第三節 結果 67 一、 NTU 101死菌、菊糖與NTU 101產品對EL4小鼠T細胞株存活率的影響 67 二、 NTU 101死菌、菊糖與NTU 101產品對EL4小鼠T細胞株IL-2及IL-4的影響 67 第四節 討論 69 一、 各樣品的免疫調節作用 69 二、 NTU 101死菌與菊糖對EL4細胞株的交互作用 69 第四章、 綜合討論與總結 70 第一節 綜合討論 70 一、 OVA致敏小鼠模式 70 二、 細胞膜式與氣喘小鼠模式之比較 70 三、 NTU 101影響腸道免疫反應可能機制 71 四、 餵食Inulin對對過敏性氣喘小鼠免疫的影響 71 五、 NTU 101餵食致敏小鼠與先前文獻的比較 72 第二節 結論 75 第五章、 參考文獻 76 | |
dc.language.iso | zh-TW | |
dc.title | Lactobacillus paracasei subsp. paracasei NTU 101對氣喘模式小鼠腸道與過敏免疫反應的影響 | zh_TW |
dc.title | Effects of Lactobacillus paracasei subsp. paracasei NTU 101 on gut mucosal and allergic immune responses in a murine model of asthma | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江伯倫(Bor-Luen Chiang),潘子明(Tzu-Ming Pan),陳妙齡(Miaw-Ling Chen),吳文勉(Wen-Mein Wu) | |
dc.subject.keyword | 氣喘,乳酸菌,NTU 101,呼吸道阻力,IgE,腸道免疫系統, | zh_TW |
dc.subject.keyword | asthma,lactic acid bacteria,AHR,IgE,GALT, | en |
dc.relation.page | 83 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-08-20 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生化科技學系 | zh_TW |
顯示於系所單位: | 生化科技學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-101-1.pdf 目前未授權公開取用 | 1.84 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。