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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 黃璉華(Lian-Hua Huang) | |
| dc.contributor.author | Hai-Yun Ko | en |
| dc.contributor.author | 柯海韻 | zh_TW |
| dc.date.accessioned | 2021-06-16T16:45:02Z | - |
| dc.date.available | 2015-09-24 | |
| dc.date.copyright | 2013-09-24 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-21 | |
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Brain, 132(10), 2659. 台灣神經學學會. (2010). 台灣庫賈氏病及人類傳播性海綿樣腦症之通報監測實驗室診斷及教育訓練計畫報告. 臺北. 行政院衛生署疾病管制局. (2008). 庫賈氏病及其他人類傳播性海綿樣腦症感染控制與通報指引手冊. 臺北. 行政院衛生署疾病管制局. (2011). 庫賈氏病疾病介紹. 流行現況, from http://www.cdc.gov.tw/sp.asp?xdurl=disease/disease_content.asp&id=1689&mp=1&ctnode=1498#1 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/63488 | - |
| dc.description.abstract | 庫賈氏病為罕見的進行性神經退化性疾病，全世界發生率為每年每百萬人口0.5-1人，從出現臨床症狀至死亡約為4.5個月-14個月，目前無有效治療方法。我國自1996年開始持續監測，自2008年後通報病例數激增，年發率及相關流行病學有顯著改變，本研究目的為分析我國2001年~2010年台灣地區庫賈氏病流行分布狀況及相關危險因子，作為防治策略制定的依據，以使監測及防治機制更臻完善。應用回溯性病例對照研究法，以2001年~2010年通報疾病管制局經審查研判為可能、極可能及確定157例病例中118例為實驗組，審查為排除病例中108例為對照組，研究疾病發生之危險因子。結果發現我國年發生率為每百萬人口0.3~0.8人，有明顯上升趨勢，存活分析平均為537天，發病年齡每上升1歲，存活風險增加1.064倍，影響罹病之危險因子以至國外旅遊者、喝酒及家族罹患失智症顯著增加。所以衛生主管機關宜及早規劃因病例增加及存活時間增加所衍生之長期照護需求及落實相關感染控制措施。 | zh_TW |
| dc.description.abstract | Abstract
Creutzfeldt-Jakob disease is a rare neurodegenerative disease, the world incidence rate is 0.5 people per million population, about 4.5-14 months from the onset of clinical symptoms to death, currently no effective treatment. Taiwan began monitoring since 1996. Surge in the number of cases notified in 2008, the annual incidence rates and the epidemiology of Creutzfeldt-Jakob disease change significantly. The purpose of this study for analysis of 2001 to 2010 of Creutzfeldt-Jakob disease epidemic distribution and risk factors, as the basis for the control strategies developed to enable monitoring and control mechanisms to be perfected. Application of retrospective case control study, subjects were informed of the case of the Centers for Disease Control from 2001 to 2010, which judged to possible, probable and definite the case of 118 cases for the experimental group, judged to exclude the cases of 108 cases in the control group. The results showed that the annual rate were from 0.3 to 0.8 per million population, there is a clear upward trend. Survival analysis is an average of 537 days, age of onset for each increase of 1-year-old, survival increased risk of 1.064 times. The risk factors of morbidity as well as foreign tourists, drinking, and family dementia increased significantly. Therefore, health authorities should be early planning derived from long-term care, and strengthening infection control measures. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T16:45:02Z (GMT). No. of bitstreams: 1 ntu-101-R97426023-1.pdf: 1698048 bytes, checksum: a83e11a86c2d8d537e14e1bfb7853b77 (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 口試委員審定書………………………………………………………………i
致謝………………………………………………………………………………ii 中文摘要………………………………………………………………………...iii Abstract…………………………………………………………………………..vi 第一章 緒論 第一節 研究背景…………………………………………………………1 第二節 研究動機、重要性及目的………………………………………2 第二章 文獻查證 第一節 庫賈氏病與普利昂蛋白…………………………………………4 第二節 庫賈氏病臨床診斷與分類………………………………………7 第三節 庫賈氏病流行現況………………………………………………12 第四節 庫賈氏病相關危險因子…………………………………………15 第三章 研究設計與研究方法 第一節 研究架構…………………………………………………………17 第二節 研究問題…………………………………………………………18 第三節 研究假設…………………………………………………………18 第四節 名詞解釋…………………………………………………………18 第五節 研究方法、對象與工具…………………………………………19 第六節 資料收集方法……………………………………………………20 第七節 研究步驟與資料收集流程………………………………………20 第八節 資料處理與資料分析……………………………………………21 第四章 研究結果 第一節 研究對象基本資料描述…………………………………………22 第二節 疾病發生情形……………………………………………………26 第三節 研究對象存活情形………………………………………………28 第四節 疾病發生之危險因子……………………………………………29 第五章 討論與建議……………………………………………………………..32 參考文獻………………………………………………………………………..36 | |
| dc.language.iso | zh-TW | |
| dc.title | 台灣地區庫賈氏病流行分布及相關危險因子之探討 | zh_TW |
| dc.title | Epidemiology and Risk Factor for Creutzfeldt-Jakob Disease in Taiwan | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳順勝(Shun-Sheng Chen),江英隆(Yin-Long Jiang) | |
| dc.subject.keyword | 庫賈氏病,流行病學,危險因子, | zh_TW |
| dc.subject.keyword | Creutzfeldt-Jakob disease,Epidemiology,Risk Factor, | en |
| dc.relation.page | 62 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-08-21 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 護理學研究所 | zh_TW |
| 顯示於系所單位： | 護理學系所 | |
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