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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 錢宗良(Chung-Liang Chien) | |
| dc.contributor.author | Pei-Shan Hou | en |
| dc.contributor.author | 侯珮珊 | zh_TW |
| dc.date.accessioned | 2021-06-16T16:03:00Z | - |
| dc.date.available | 2018-09-24 | |
| dc.date.copyright | 2013-09-24 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-07-03 | |
| dc.identifier.citation | Abellan, A., A. Menuet, C. Dehay, L. Medina and S. Retaux (2010). 'Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds.' Cereb Cortex 20(8): 1788-1798.
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Nucleic Acids Res 29(19): 4070-4078. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/62473 | - |
| dc.description.abstract | The LIM homeobox 2 transcription factor LHX2 is known to control crucial aspects of neural development in various species. However, its function in human neural development is still elusive. Here, we demonstrate that LHX2 plays a critical role in human neural differentiation using hESCs as a model for differentiation. In hESC-derived neural progenitors (hESC-NPs), expression of LHX2 was prior to PAX6 and SOX1, and LHX2 was co-expressed with early neural markers. Conditional ectopic expression of LHX2 promoted the formation of neural rosette-like structures and upregulated neural transcription factor expression. Conversely, disruption of LHX2 expression by constitutive expression of LHX2 shRNA in hESCs significantly impaired neural differentiation both in vitro and in vivo. Furthermore, we demonstrated that LHX2 regulates neural differentiation in two levels, first, it promotes the expression of neurogenic gene Pax6 and second, it promotes the expression of Cerberus 1 to inhibit non-neural differentiation. LHX2 was found to regulate PAX6 expression in hESC-NPs by binding to PAX6 enhancers, which were enriched with the chromatin markers of active enhancers H3K4me1 and H3K27ac). Importantly, LHX2 was also found to attenuate BMP and WNT signaling and inhibit non-neural differentiation by augmenting the expression of BMP and WNT antagonist, Cerberus 1(CER1). Collectively, our studies provide further insights into the molecular mechanisms governing human neural differentiation, which has implications in the large-scale generation of neural cells for basic research and clinical applications. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T16:03:00Z (GMT). No. of bitstreams: 1 ntu-102-F95446004-1.pdf: 7677416 bytes, checksum: 3eb7aca02ad5f078a06a7062775e0f33 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | Table of contents ------------------------------------------------------------- 1
Abbreviation------------------------------------------------------------------- 2 Summary in Chinese -------------------------------------------------------- 3 Summary in English --------------------------------------------------------- 5 Chapter I. General Introduction ---------------------------------------- 7 Chapter II. LHX2 regulates the neural differentiation via transcriptional modulation of PAX6 and CER1--------------------- 19 Introduction ----------------------------------------------------------------------------- 20 Materials and Methods ----------------------------------------------------------------- 23 Results ----------------------------------------------------------------------------------- 35 Discussion ------------------------------------------------------------------------------- 51 Figure legends, Figures and Tables--------------------------------------------------- 59 Chapter III. Conclusions and Future Perspectives------------------- 116 Conclusions----------------------------------------------------------------------------- 117 Perspectives------------------------------------------------------------------------------ 117 Figure legends and Figures------------------------------------------------------------ 123 Bibliography ----------------------------------------------------------------- 125 Appendix --------------------------------------------------------------------- 138 | |
| dc.language.iso | en | |
| dc.subject | 人類胚胎幹細胞 | zh_TW |
| dc.subject | 神經分化 | zh_TW |
| dc.subject | LHX2 | zh_TW |
| dc.subject | PAX6 | zh_TW |
| dc.subject | CER1 | zh_TW |
| dc.subject | PAX6 | en |
| dc.subject | human embryonic stem cells | en |
| dc.subject | neural differentiation | en |
| dc.subject | CER1 | en |
| dc.subject | LHX2 | en |
| dc.title | 探討LHX2轉錄因子在人類神經分化扮演的角色 | zh_TW |
| dc.title | The Role of LHX2 in Human Neural Differentiation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 郭紘志(Hung-Chih Kuo),陳佑宗(You-Tzung Chen),周申如(Shen-Ju Chou),陳玉怜(Yuh-Lien Chen) | |
| dc.subject.keyword | 人類胚胎幹細胞,神經分化,LHX2,PAX6,CER1, | zh_TW |
| dc.subject.keyword | human embryonic stem cells,neural differentiation,LHX2,PAX6,CER1, | en |
| dc.relation.page | 138 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-07-03 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
| 顯示於系所單位： | 解剖學暨細胞生物學科所 | |
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