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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李士傑(Shyh-Jye Lee) | |
| dc.contributor.author | Yu-Chuan Hsiao | en |
| dc.contributor.author | 蕭諭娟 | zh_TW |
| dc.date.accessioned | 2021-06-16T13:21:46Z | - |
| dc.date.available | 2023-06-04 | |
| dc.date.copyright | 2013-07-30 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-07-25 | |
| dc.identifier.citation | References
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61984 | - |
| dc.description.abstract | Cold shock is an acute reduction in ambient temperature that may cause rapid falling in body temperature and a cascade of physiological and behavioral responses. It is a big challenge for the survival of fish during winter. Previous works have provided solid information for fish mortality and physiological responses associated with cold shock. However, little is known for the molecular mechanisms regulating cold-shock responses. MicroRNAs (miRNAs) are noncoding small RNAs which play essential regulatory roles in development, cell differentiation, and metabolism. Moreover, few studies studied the roles of miRNAs for physiological response to environmental stresses in fish. To explore the role of miRNAs during cold shock, we performed genome-wide zebrafish miRNAs pattern analysis. We found 29 up-regulated miRNAs and 26 down-regulated miRNAs in cold-treated zebrafish larvae and obtained their target genes by bioinformatics analysis. We also found 1,424 cold-dependent genes using transcriptomic analysis. These genes are significant involved in signaling pathway, ligand-receptor interaction, lipid metabolism and biosynthesis. These genes are functional relevant to cold shock stress. In conclusion, our results reveal a potential regulatory role of miRNAs in underline cellular responses induced by cold shock stress. Here, we have studied several of those miRNAs and their target gene, such as circadian genes, to explore their roles in cold shock regulation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T13:21:46Z (GMT). No. of bitstreams: 1 ntu-102-R00b41011-1.pdf: 7105796 bytes, checksum: 68daef51192764f7d5f07e8350bfdf09 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | Contents
中文摘要 ...................................................................................................I Abstract ...................................................................................................II Contents ..................................................................................................IV List of Tables ...........................................................................................VI List of Figures ..........................................................................................VI Introduction ................................................................................................1 Environmental stress .................................................................................1 Cold shock response .................................................................................1 Cold shock affect gene expression ..............................................................3 MiRNA and function ...................................................................................3 Objectives of this study .............................................................................5 Materials and Methods .............................................................................7 Fish maintenance and embryo collection ......................................................7 Total RNA isolation, construction of miRNA libraries, and sequencing ............7 Total RNA isolation, construction of cDNA libraries, and sequencing ..............8 MiRNA identification and annotation ...........................................................9 Total RNA isolation, RT-PCR, and qRT-PCR analyses ................................9 Statistical analysis ..................................................................................10 Results ..................................................................................................11 Cold-induced responses in zebrafish larvae ..............................................11 Cold-induced changes in microRNA profiles ................................................12 MiRNAs expression profile ......................................................................13 Function annotation for target genes of the cold-dependent miRNAs ............13 Transcriptomic analyses of cold-induced genes ........................................14 Function annotation of the cold-dependent genes of transcriptome ..............15 Regulation of circadian-related miRNAs and their target genes ......................16 Discussion ...............................................................................................18 References ...............................................................................................22 | |
| dc.language.iso | en | |
| dc.subject | 冷休克 | zh_TW |
| dc.subject | 微型核醣核酸 | zh_TW |
| dc.subject | microRNAs | en |
| dc.subject | cold shock | en |
| dc.title | 冷休克在斑馬魚所引發之微型核醣核酸和轉錄體圖譜變化 | zh_TW |
| dc.title | Cold shock-induced changes of microRNAs and transcriptome in zebrafish | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 孫孝芳(H. Sunny Sun),朱家瑩(Chia-Ying Chu),陳示國(Shih-Kuo Chen),陳琮明(Tsung Ming Chen) | |
| dc.subject.keyword | 冷休克,微型核醣核酸, | zh_TW |
| dc.subject.keyword | cold shock,microRNAs, | en |
| dc.relation.page | 45 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-07-25 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
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