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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蔡錦華(Ching-Hwa Tsai) | |
| dc.contributor.author | Wei-Chu Liao | en |
| dc.contributor.author | 廖維筑 | zh_TW |
| dc.date.accessioned | 2021-06-16T13:10:41Z | - |
| dc.date.available | 2018-09-24 | |
| dc.date.copyright | 2013-09-24 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-07-31 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61719 | - |
| dc.description.abstract | EB病毒(Epstein-Barr virus, EBV)隸屬於人類疱疹病毒科(Herpesviridae)的γ疱疹病毒亞科。EB病毒係第一個被報導與人類癌症直接相關的病毒，目前已知與多種惡性腫瘤及淋巴細胞增生疾病相關。EB病毒可將人類初代B細胞轉形成為具有無限增殖能力的的淋巴母芽細胞株(Lymphoblastoid cell line, LCL)。為了探討EB病毒將細胞不朽化的過程中對基因的調控，我們利用cDNA微陣列分析欲釐清在EB病毒感染後的基因表現。根據cDNA微陣列分析的結果，我們發現許多干擾素誘導基因(Interferon-stimulated genes, ISGs)在淋巴母芽細胞株中的表現量較在人類初代B細胞中高。由於干擾素誘導穿膜蛋白質(Interferon-induced transmembrane protein, IFITM)家族被報導具有抑制RNA病毒進入細胞或抑制RNA病毒複製的能力，因此我們以它們作為研究之焦點。而IFITM1的表現量為之中最高者，故挑選其作為本論文的研究目標。自即時定量聚合酶連鎖反應(real-time quantitative polymerase chain reaction, RT-Q-PCR)及西方墨點法(Western blotting, WB)的結果顯示，EB病毒潛伏期膜蛋白質1 (Latent membrane protein 1, LMP1)會利用其C-terminal activation region 1 (CTAR1)及CTAR2活化NF-κB的抑制劑進行處理後，IFITM1的表現量並未完全受到抑制，因此推測可能有其他因子亦可調控IFITM1的表現。以表現LMP1的細胞之條件培養液(conditional medium)培養Akata EBV(-)細胞的確觀察到IFITM1被誘導產生的現象。同時，我們亦透過反轉錄聚合酶連鎖反應(reverse transcription polymerase chain reaction, RT-PCR)觀察IFN-β在表現LMP1的細胞中的表現量上升。因此，我們推測干擾素可能參與在LMP1調控IFITM1表現的路徑當中。由目前的實驗結果顯示LMP1可能係透過直接及間接的方式調控IFITM1的表現。在探討IFITM1生物功能的方面，我們以慢病毒感染方式將淋巴母芽細胞株中的IFITM1剔除，發現IFITM1可協助維持淋巴母細胞株中的EB病毒處於潛伏期。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-16T13:10:41Z (GMT). No. of bitstreams: 1 ntu-102-R00445119-1.pdf: 3326860 bytes, checksum: cb6b01fdc31d716540aebf80aaaf0f68 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 中文摘要 i
英文摘要 iii 第一章 序論 1 第二章 實驗材料與方法 13 第三章 實驗結果 41 第四章 討論 50 第五章 圖表 59 第六章 附錄 84 第七章 參考文獻 99 | |
| dc.language.iso | zh-TW | |
| dc.subject | IFITM1 | zh_TW |
| dc.subject | EB病毒 | zh_TW |
| dc.subject | LMP1 | zh_TW |
| dc.subject | 干擾素 | zh_TW |
| dc.subject | 干擾素誘導基因 | zh_TW |
| dc.subject | IFITM1 | en |
| dc.subject | ISGs | en |
| dc.subject | LMP1 | en |
| dc.subject | IFN | en |
| dc.subject | EBV | en |
| dc.title | 干擾素誘導穿膜蛋白質1在EB病毒感染之B細胞中所扮演的角色 | zh_TW |
| dc.title | Role of Interferon-induced transmembrane protein 1 (IFITM1) in EBV-infected B Cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李建國,林素珍 | |
| dc.subject.keyword | EB病毒,LMP1,干擾素,干擾素誘導基因,IFITM1, | zh_TW |
| dc.subject.keyword | EBV,LMP1,IFN,ISGs,IFITM1, | en |
| dc.relation.page | 109 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-07-31 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 微生物學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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