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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林仁混(Jen-Kun Lin) | |
| dc.contributor.author | Zheng-Hui Liu | en |
| dc.contributor.author | 劉政輝 | zh_TW |
| dc.date.accessioned | 2021-06-16T13:08:24Z | - |
| dc.date.available | 2013-09-24 | |
| dc.date.copyright | 2013-09-24 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-01 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/61648 | - |
| dc.description.abstract | 糖尿病為一種代謝症候群的疾病主要可分為第一型及第二型，其中第二型是由胰島素阻抗而造成的高血糖且較為常見約佔90~95%，因此葡萄糖的代謝與恆定對於治療糖尿病是很重要的。
普洱茶是一種在雲南生產全發酵茶，根據先前的研究指出普洱茶多醣在活體實驗中具有降血糖的功能，但是在細胞內的分子機制仍不清楚。本研究將茶多醣模擬成抗糖尿病藥物thiazolidinedione (TZD)的作用並研究其可能的作用機制，以3T3-L1脂肪細胞來探討茶多醣是否具有促進脂肪細胞分化及葡萄糖攝取作用。實驗中發現普洱茶多醣具有促進前驅脂肪細胞分化、三酸甘油酯累積及葡萄糖攝取之作用。普洱茶多醣可增加PPARγ和GLUT4的蛋白表現。分化的脂肪細胞具有較好的胰島素敏感度且分泌較多的adiponectin促使更多的葡萄糖進入細胞內。 另外由棕櫚酸誘導脂肪細胞產生胰島素阻抗的實驗中發現普洱茶多醣可增加葡萄糖攝取及脂肪堆積，並且磷酸化的Akt和AMPK也有增加的情形。綜合以上結果顯示，普洱茶多醣能夠藉由刺激PPARγ和GLUT4的蛋白表現來促進脂肪細胞分化及葡萄糖攝取，因此普洱茶多醣可能具有改善胰島素阻抗及降血糖的作用，並發揮抗糖尿病之作用。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-16T13:08:24Z (GMT). No. of bitstreams: 1 ntu-102-R00442014-1.pdf: 11019641 bytes, checksum: efbb629b1c706cdbe2aa88aa9663d61a (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 誌謝………………………………………………………………………i
中文摘要…………………………………………………………………ii Abstract………………………………………………………………….iii Table of contant………………………………………………………….v List of figures……………………………………………………………vi Abbreviations…………………………………………………………...vii Introduction………………………………………………………………1 Materials and Methods…………………………………………………...7 Results…………………………………………………………….…….14 Discussion……………………………………………………….……...20 References…………………………………………………….………...24 Figures………………………………………………………….……….33 | |
| dc.language.iso | en | |
| dc.title | 普洱茶多醣促進3T3-L1脂肪細胞分化及葡萄糖攝取之機制探討 | zh_TW |
| dc.title | Pu-erh tea polysaccharides stimulate adipogenesis and glucose uptake in 3T3-L1 adipocyte | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蕭水銀(Shoei-Yn Shiau),梁有志(Yu-Chih Liang),鍾景光(Jing-Gung Chung),李宣佑(Shuan-Yow Li) | |
| dc.subject.keyword | 普洱茶多醣,脂肪細胞,脂肪細胞分化,葡萄糖攝取,糖尿病,胰島素阻抗, | zh_TW |
| dc.subject.keyword | Pu-erh tea polysaccharides,adipocyte,adipogenesis,glucose uptake,diabetes,insulin resistance, | en |
| dc.relation.page | 49 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-08-01 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 生物化學暨分子生物學研究所 | zh_TW |
| 顯示於系所單位： | 生物化學暨分子生物學科研究所 | |
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