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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60881完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林文澧 | |
| dc.contributor.author | Hung-Nien Chen | en |
| dc.contributor.author | 陳泓年 | zh_TW |
| dc.date.accessioned | 2021-06-16T10:34:33Z | - |
| dc.date.available | 2015-08-17 | |
| dc.date.copyright | 2013-08-17 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-14 | |
| dc.identifier.citation | [1] Chinzei K., Kikinis R., Jolesz F.A. “MR Compatibility of Mechatronic Devices: Design Criteria,” Int Conf Med Image Comput Comput Assist Interv., vol. 2, p.p. 1020-1031, 1999.
[2] Osama Al-Bataineh, Jurgen Jenne, Peter Huber, “Clinical and future applications of high intensity focused ultrasound in cancer,” Cancer Treat Rev., vol. 38, Issue 5, p.p. 346-353, August 2012. [3] Zhou YF, “High intensity focused ultrasound in clinical tumor ablation,” World J Clin Oncol. vol.2(1), p.p. 8-27, Jan 2011. [4] Ge Medical Systems (ed): MR Safety and MR Compatibility: Test and Guidelines for Signa SPTM. Version 1.0, http://www.ge.com/medical/mr/iomri/safety.htm, October, 1997 [5] Elhawary, H., Tse, Z. T. H., Hamed, A., Rea, M., Davies, B. L. and Lamperth, M. U. (2008), “The case for MR-compatible robotics: a review of the state of the art,” Int. J. Med. Robotics Comput. Assist. Surg., vol. 4, p.p. 105–113, June 2008. [6] 何乘孝，”圓柱型相位陣列超音波換能器應用於乳癌熱手術之研究” 國立臺灣大學醫學工程學研究所 碩士論文，2006。 [7] 林伯憲，“環形相位陣列聚焦式超音波結合磁振造影系統應用於乳房腫瘤治療的研究” 國立臺灣大學醫學工程學研究所 碩士論文，2011。 [8] Gassert, R., Yamamoto, A., Chapuis, D., Dovat, L., Bleuler, H. and Burdet, E., “Actuation Methods for Applications in MR Environments,” Concepts Magn. Reson., vol. 29B, p.p. 191–209, 2006. [9] K. Chinzei, K. Miller, “MRI Guided Surgical Robot,” proc 2001 Australian Conference on Robotics and Automation, pp.50-5, Sydney, 2001. [10] T. Hemsel, M. Mracek, J. Twiefel, P. Vasiljev, “Piezoelectric linear motor concepts based on coupling of longitudinal vibrations,” Ultrasonics, Vol. 44, p.p. e591-e596,Supplement, 22 December 2006. [11] Chopra R, Curiel L, Staruch R, Morrison L, Hynynen K “An MRI-compatible system for focused ultrasound expeirments in small animal models,” Med Phys. , vol. 36, p.p. 1867–1874, 2009. [12] A. Vanne, K. Hynynen, “MRI feedback temperature control for focused ultrasound surgery,” Phys Med Biol., vol. 48, pp. 31–43, 2003. [13] Song, S S-E., N B. Cho, G. Fischer, N. Hata, C. M. Tempany, G. Fichtinger, and I. Iordachita, “Development of a Pneumatic Robot for MRI-guided Transperineal Prostate Biopsy and Brachytherapy: New Approaches,” IEEE Int Conf Robot Autom. vol. 2010, p.p. 2580-2585. July 2010. [14] Gassert, R.; Burdet, E.; Chinzei, K., 'Opportunities and Challenges in MR-Compatible Robotics,' Engineering in Medicine and Biology Magazine, IEEE , vol.27, no.3, pp.15-22, May-June 2008. [15] Fischer GS, Krieger A, Iordachita I, Csoma C, Whitcomb LL, Gabor F., “MRI compatibility of robot actuation techniques--a comparative study.” Med Image Comput Comput Assist Interv.,11(Pt 2):509-17, 2008 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60881 | - |
| dc.description.abstract | 本研究的目標為研發出一套應用於磁振造影導引聚焦式超音波乳房腫瘤治療之MR相容的定位系統。利用磁振造影(Magnetic Resonance Imaging, MRI)結合高強度聚焦式超音波(High Intensity Focused Ultrasound, HIFU)做超音波熱手術，可以在診斷的同時做精準的導引與治療；其治療方式具有非侵入式的優點，並可進一步結合溫度影像及搭配其他治療方式增進其診斷治療效果。
本研究將使用超音波壓電陶瓷馬達作為致動器，以三軸滑軌疊加的形式來傳動，並以斜面來帶動Z軸，一共具有X、Y、Z三個自由度，分別各有50mm的行程。搭載乳房用環型超音波探頭時，斜面機構與超音波探頭將放置於方形水槽，所有的機構將以MR相容的材料製成。由於MRI特殊的環境條件，在受限的材料及空間下設計製造MR相容之定位機台，對於機械工程師來說是一項挑戰。 以雷射三角測距儀，對搭載探頭之原型定位平台之定位功能進行精準度測試，其誤差在經過校正後均小於500μm，經過MRI取像測試後，初步判斷其具有足夠的MR相容性，不會對人員產生安全上的危害，亦不會對MRI取像造成干擾，且能確實地將環型超音波換能器定位。 本研究針對乳房MRI造影系統，開發出適用於乳房超音波熱手術之定位移動平台系統。此系統有足夠的定位精準度及MR相容性，應可有效承載環狀陣列式超音波探頭做乳房腫瘤熱手術。 | zh_TW |
| dc.description.abstract | The main purpose of this study is to develop an MR-compatible three-dimensional positioning system applied in MRI-guided focused ultrasound thermal therapy for breast tumors. The positioning system is used to move a ring-shaped phased array ultrasound transducer to deliver sufficient acoustic power to the desired region for breast tumor treatment. The combination of MRI system and FUS (Focused Ultrasound) can supply tumor examination, treatment planning, treatment monitoring, non-invasive treatment etc. for tumor therapy.
In this study, the positioning system consists of three ultrasonic motors used as the actuators and linear three-axial guides stacked up together for a three-dimensional motion control with a ramp mechanism for the transmission of mechanical movement in the Z-dimension. The travel ranges of X-, Y-, and Z-dimension are all 50 mm. When the system drives a ring-shaped ultrasound transducer, the transducer/transducer holder and the ramp mechanism are placed in a rectangular water tank, and all components are manufactured from MR compatible materials. Under the severe MRI conditions and treatment requirements, it is a challenge for a mechanical engineer to develop an MR-compatible positioning system to meet the needs. The developed prototype of positioning system under the driving of the ring-shaped ultrasound transducer has been examined using a laser distance device for its positioning characteristics. The results showed that the position error is less than 500 μm after system calibration. For the MRI-compatibility test, the results revealed that the positioning system owns great MR compatibility. The positioning system can drive the ultrasound transducer to the desired locations with great precision without causing significant interference to MRI. In this study, we focused on the development of an MRI-compatible positioning system which is used to drive a ring-shaped ultrasound transducer for breast tumor thermal therapy. The system has great movement precision and MR compatibility, and owns the potential to effectively drive the ultrasound transducer for MRI-guided focused ultrasound thermal therapy. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T10:34:33Z (GMT). No. of bitstreams: 1 ntu-102-R00548021-1.pdf: 5782425 bytes, checksum: f5fe1ad3d3aa65914e4bada6e65b62ca (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 誌謝 i
中文摘要 ii ABSTRACT iii 目錄 v 圖目錄 viii 表目錄 xi 第1章 緒論 1 1.1 高強度聚焦式超音波 1 1.2 磁振造影 3 1.3 定位平台回顧 4 1.4 研究動機與目的 6 第2章 MR相容性設計準則 7 2.1 MR相容性(MR compatibility) 7 2.2 MRI設備分類 8 2.3 設計原則 9 2.3.1 致動器(Actuator) 9 2.3.2 感測器(Sensor) 11 2.3.3 機構元件 11 2.4 MR相容性檢查 13 第3章 定位平台系統設計 14 3.1 系統需求與限制 15 3.2 超音波馬達 17 3.2.1 Nanomotion HR4-U 18 3.2.2 驅動器 20 3.3 機構設計 21 3.3.1 材料與浮力量測 21 3.3.2 零組件製作－滾珠滑軌與滾珠滾輪 21 3.3.3 傳動方式 24 3.3.4 結合方式 24 3.3.5 機構成品 25 3.4 PID控制器 設計 28 3.4.1 參數調校 28 3.4.2 PID控制結果 31 3.5 系統架構與佈線規劃 34 3.6 治療程序規劃 36 第4章 實驗與結果討論 37 4.1 MR相容性測試 37 4.2 系統精度測試 45 4.2.1 實驗設計 45 4.2.2 實驗結果 48 第5章 結論 51 第6章 未來展望 52 參考文獻 53 附錄 55 | |
| dc.language.iso | zh-TW | |
| dc.subject | 磁振造影 | zh_TW |
| dc.subject | 超音波壓電陶瓷馬達 | zh_TW |
| dc.subject | 乳房腫瘤 | zh_TW |
| dc.subject | 磁振造影導引聚焦式超音波 | zh_TW |
| dc.subject | MR相容 | zh_TW |
| dc.subject | 定位系統 | zh_TW |
| dc.subject | MRI guided focused ultrasound | en |
| dc.subject | positioning system | en |
| dc.subject | MR compatible | en |
| dc.subject | ultrasonic motor | en |
| dc.subject | breast tumor | en |
| dc.subject | MRI | en |
| dc.title | 應用於磁振造影導引聚焦式超音波
乳房腫瘤治療之三維定位系統 | zh_TW |
| dc.title | A Three-dimensional Positioning System Applied in MRI-guided Focused Ultrasound Thermal Therapy for Breast Tumors | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳永耀,陳景欣 | |
| dc.subject.keyword | 磁振造影,定位系統,MR相容,超音波壓電陶瓷馬達,乳房腫瘤,磁振造影導引聚焦式超音波, | zh_TW |
| dc.subject.keyword | MRI,positioning system,MR compatible,ultrasonic motor,breast tumor,MRI guided focused ultrasound, | en |
| dc.relation.page | 58 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-08-14 | |
| dc.contributor.author-college | 文學院 | zh_TW |
| dc.contributor.author-dept | 歷史學研究所 | zh_TW |
| 顯示於系所單位： | 歷史學系 | |
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