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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 劉?睿 | |
dc.contributor.author | Chien-Hua Liao | en |
dc.contributor.author | 廖建華 | zh_TW |
dc.date.accessioned | 2021-06-16T10:32:34Z | - |
dc.date.available | 2018-08-17 | |
dc.date.copyright | 2013-08-17 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-14 | |
dc.identifier.citation | 參考文獻
林家民。2007。精芻料比例調整與飼糧微生物添加對台灣長鬃山羊採食及糞便型態之影響。碩士論文。國立台灣大學動物科學技術學系。 黃書瑢。2010。利用膠原吸附蛋白在乳酸菌細胞表面展現聚葡萄糖酶。碩士論文。國立台灣大學動物科學技術學系。 何佳慧。2012。添加Bacillus licheniformis CK1及其幾丁聚糖發酵液對白肉雞生長性狀之影響。碩士論文。國立台灣大學動物科學技術學系。 Aires, K. A., A. M. Cianociarullo, S. M. Carneiro, L. L. Villa, E. Boccardo, and G. Perez-Martinez. 2006. Production of human papilomavirus type 16 L1 virus like particles by recombinant Lactobacillus casei cells. Appl. Environ. Microbiol. 72:745-752. Annamalai, T. and R. K. Selvaraj. 2012. Effects of in ovo interleukin-4-plasmid injection on anticoccidia immune response in a coccidia infection model of chickens. Poult. Sci. 91:1326-1334 Apata, D. F. 2008. Growth performance, nutrient digestibility and immune response of broiler chicks fed diets supplemented with a culture of Lactobacillus bulgaricus. J. Sci. Food Agric. 88:1253-1258. Awad, W. A., K. Ghareeb, S. Abdel-Raheem, and J. Bohm. 2009. Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens. Poult. Sci. 88:49-55 Bahey-El-Din, M., P. G. Casey, B. T. Griffin, and C. G. M. Gahan. 2008. Lactococcus lactis-expressing listeriolysin O provides protection and specific CD8 T cells against Listeria monocytogenes in the murine infection model. Vaccine 26:5304-5314. Beninati, C., M. R. Oqqioni, M. Boccanera, M. R. Spinosa, T. Maggi, S. Conti, W. Magliani, F. De Bernardis, G. Teti, A. Cassone, G. Pozzi, and L. Polonelli. 2000. Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria. Nature Biotechnol. 18:1060-1064. Berlec, A., M. Ravnikar, and B. Strukelj. 2012. Lactic acid bacteria as oral delivery systems for biomolecules. Pharmazie 67:891-898. Bermudez-Brito, M., J. Plaza-Diaz, S. Munoz-Quezada, C. Gomez-Llorente, and A. Gil. 2012. Probiotic Mechanisms of Action. Ann. Nutr. Metab. 61:160-174. Bermudez-Humaran, L. G., P. Langella, N. G. Cortes-Perez, A. Gruss, R. S. Tamez-Guerra, S. C. Oliveira, O. Saucedo-Cardenas, R. M. de Oca-Luna, and Y. LeLoir. 2003. Intranasal immunization with recombinant Lactococcus lactis secreting murine interleukin-12 enhances antigen-specific Th1 cytokine production. Infect. Immun. 71:1887-1896. Braat, H., P. Rottiers, D. W. Hommes, N. Huyghebaert, E. Remaut, J. P. Remon, S. J. van Deventer, S. Neirynck, M. P. Peppelenbosch, and L. Steidler. 2006. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn’s disease. Clin. Gastroenterol. Hepatol. 4:754-759. Buccato, S., D. Maione, C. D. Rinaudo, G. Volpini, A. R. Taddei, R. Rosini, J. L. Telford, G. Grandi, and I. Margarit. 2006. Use of Lactococcus lactis expressing pili from group B Streptococcusas a broad-coverage vaccine against streptococcal disease. J. Infect. Dis. 194:331-340. Campos, I. B., M. Darrieux, D. M. Ferreira, E. N. Miyaji, D. A. Silva, A. P. Areas, K. A. Aires, L. C. Leite, P. L. Ho, and M. L. Oilveira. 2008. Nasal immunization of mice with Lactobacillus casei expressing the pneumococcal surface protein A: Induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge. Microbes Infect. 10:481-488. Cao, H. P., H. N. Wang, A. Y. Zhang, M. D. Ding, S. T. Liu, H. Cheng, Y. S. Zhou, and X. Li. 2012. Expression of avian infectious bronchitis virus multi-epitope based peptide EpiC in Lactococcus lactis for oral immunization of chickens. Biosci. Biotechnol. Biochem. 76:1871-1876. Caspary, W. F. 1992. Physiology and pathophysiology of intestinal absorption. Am. J. Clin. Nutr. 55:299-308. Chatel, J. M., S. Nouaille, K. Adel-Patient, Y. Le Loit, H. Boe, A. Gruss, J. M. Wai, and P. Langella. 2003. Characterization of a Lactococcus lactis strain that secretes a major epitope of bovine beta-lactoglobulin and evaluation of its immunogenicity in mice. Appl. Environ. Microbiol. 69:6620-6627. Charng, Y. C., C. C. Lin, and C. H. Hsu. 2006. Inhibition of allergen-induced airway inflammation and hyperreactivity by recombinant lactic acid bacteria. Vaccine. 24:5931-5936. Cheung, Q. C., Z. Yuan, P. W. Dyce, D. Wu, K. DeLange, and J. Li. 2009. Generation of epidermal growth factor-expressing Lactococcus lactis and its enhancement on intestinal development and growth of early-weaned mice. Am. J. Clin. Nutr. 89:871-879. Chichlowski, M., J. Croom, B. W. McBride, L. Daniel, G. Davis, and M. D. Koci. 2007. Direct-fed microbial PrimaLac and salinomycin modulate whole-body and intestinal oxygen consumption and intestinal mucosal cytokine production in the broiler chick. Poult. Sci. 86:1100-1106. Dale, J. B. 2008. Current status of group A streptococcal vaccine development. In A. Finn and A. J. Pollard (Eds.), Hot topics in infection and immunity in children. Springer, New York, USA. Daniel, C., A. Repa, C. Wild, A. Pollak, B. Pot, H. Breiteneder, U. Wiedermann, and A. Mercenier. 2006. Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1. Allergy 61:812-819. de Jong, M. D., and T. T. Hien. 2006. Avian influenza A (H5N1). J. Clin. Virol. 35:2-13. de Vrese, M. and J. Schrezenmeir. 2008. Probiotics, prebiotics, and synbiotics. Adv. Biochem. Eng. Biotechnol. 111:1-66. Dieye, Y., A. Hoekman, F. Clier, V. Juillard, H. Boot, and J. Piard. 2003. Ability of Lactococcus lactis to export viral capsid antigens: a crucial step for development of live vaccines. Appl. Environ. Microbiol. 69:7281-7288. FAO/WHO. 2001. Report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Co’rdoba, Argentina. Farnell, M. B., A. M. Donoghue, F. S. De Los Santos, P. J. Blore, B. M. Hargis, G. Tellez, and D. J. Donoghue. 2006. Upregulation of oxidative burst and degranulation in chicken heterophils stimulated with probiotic bacteria. Poult. Sci. 85:1900-1906. Formal, S. B., L. S. Baron, D. J. Kopecko, O. Washington, C. Powell, and C. A. Life. 1981. Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain. Infect. Immun. 34:746-750. Frossard, C. P., L. Steidler, and P. A. Eigenmann. 2007. Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization. J. Allergy Clin. Immunol. 119:952-959. Fuller, R. 1989. Probiotics in man and animals. J. Appl. Bacteriol. 66:365-378. Fuller, R. 2001. The chicken gut microflora and probiotic supplements. J. Poult. Sci. 38:189-196. Gomez-Llorente, C., S. Munoz, and A. Gil. 2010. Role of Toll-like receptors in the development of immunotolerance mediated by probiotics. Proc. Nutr. Soc. 69:381-389. Gross, W. B. and H. S. Siegel, 1983. Evaluation of the heterophil/lymphocyte ratio as a measure of stress in chickens. Avian Dis. 27:972-979. Hamady, Z. Z., N. Scott, M. D. Farrar, J. P. Lodge, K. T. Holland, T. Whitehead, and S. R. Carding. 2010. Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus. Gut 59:461-469. Haghighi, H. R., J. H. Gong, C. L. Gyles, M. A. Hayes, B. Sanei, P. Parvizi, H. Gisavi, J. R. Chambers, and S. Sharif. 2005. Modulation of antibody-mediated immune response by probiotics in chickens. Clin. Diagn. Lab. Immunol. 12:1387-1392. Hazebrouck, S., R. Oozeer, K. Adel-Patient, P. Langella, S. Rabot, J. M. Wal, and G. Corthier. 2006. Constitutive delivery of bovine beta-lactoglobulin to the digestive tracts of gnotobiotic mice by engineered Lactobacillus casei. Appl. Environ. Microbiol. 72:7460-7467. Hou, X. L., L. Y. Yu, J. Liu, and G. H. Wang. 2007. Surface-displayed porcine epidemic diarrhea viral (PEDV) antigens on lactic acid bacteria. Vaccine 26:24-31. Huibregtse, I. L., V. Snoeck, A. de Creus, H. Braat, E. C. De Jong, S. J. Van Deventer, and P. Rottiers. 2007. Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin. Gastroenterology 133:517-528. Islam, M. W., M. M. Rahman, S. M. L. Kabir, S. M. Kamruzzaman, and M. N. Islam. 2004. Effects of probiotics supplementation on growth performance and certain haemato-biochemical parameters in broiler chickens. Bangl. J. Vet. Med. 2:39-43. Jacobs, R. P., R. M. Blaese, and J. J. Oppenheim. 1972. Inhibition of antigen-stimulated in vitro proliferation of thymic dependent chicken spleen cells by specific antibody. J. Immunol. 109:324-33. Jin, L. Z., H. W. Ho, N. Abdullah, and S. Jalaludin. 2000. Digestive and bacteria enzyme activities in broilers fed diets supplemented with Lactobacillus cultures. Poult. Sci. 79:886-891. Jeon, S. H. and R. Arnon. 2002. Immunization with influenza virus hemagglutinin globular region containing the receptor-binding pocket. Viral Immunol. 15:165-176. Kabir, S. M. L., M. M. Rahman, M. B. Rahman, and S. U. Ahmed. 2004. The dynamics of probiotics on growth performance and immune response in broilers. Int. J. Poult. Sci. 3:361-364. Kabir, S. M. L. 2009. The role of probiotics in the poultry industry. Int. J. Mol. Sci. 10:3531-3546. Kajikawa, A., E. Satoh, R. J. Leer, S. Yamamoto, and S. Igimi. 2007. Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar Enteritidis. Vaccine 25:3599-3605. Kamruzzaman, S. M., S. M. L. Kabir, M. M. Rahman, M. W. Islam, and M. A. Reza. 2005. Effect of probiotics and antibiotic supplementation on body weight and haemato-biochemical parameters in broilers. Bangl. J. Vet. Med. 3:100-104. Kandler, O. 1983. Carbohydrate metabolism in lactic acid bacteria. Antonie Van Leeuwenhoek 49:209-224. Kang, S. M., J. M. Song, and R. W. Compans. 2011. Novel vaccines against influenza viruses. Virus Res. 162:31-38. Khajali, F., S. Karimi, and D. Qujeq. 2008. Probiotics in drinking water alleviate stress of induced molting in feed-deprived laying hens. Asian-Aust. J. Anim. Sci. 21:1196-1200. Khurana, S., S. Verma, N. Verma, C. J. Crevar, D. M. Carter, J. Manischewitz, T. M. Ross, L. R. King, and H. Golding. 2010. Properly folded bacterially expressed H1N1 hemagglutinin globular head and ectodomain vaccines protect ferrets against H1N1 pandemic influenza virus. PLoS One 5:1-11. Khurana, S., S. Verma, N. Verma, C. J. Crevar, D. M. Carter, J. Manischewitz, L. R. King, T. M. Ross, and H. Golding. 2011. Bacterial HA1 vaccine against pandemic H5N1 influenza virus: evidence of oligomerization, hemagglutination, and cross-protective immunity in ferrets. J. Virol. 85:1246-1256. Kim, J. S., S. L. Ingale, and Y. W. Kim. 2012. Effect of supplementation of multi-microbe probiotic product on growth performance, apparent digestibility, cecal microbiota and small intestinal morphology of broilers. J. Anim. Physiol. Anim. Nutr. 96:618-626. Koenen, M. E., J. Kramer, R. Van Der Hulst, L. Heres, S. H. M. Jeurissen, and W. J. A. Boersma. 2004. Immunomodulation by probiotic lactobacilli in layer- and meat-type chickens. Br. Poult. Sci. 45:355-366. Kondo, J. K. and L. L. McKay. 1982. Transformation of Streptococcus lactis protoplast by plasmid DNA. Appl. Environ. Microbiol. 43:1213-1215. Kondo, Y., Y. Okimoto, and A. Abe. 2003. Response to mitogens of chicken splenocytes determined by three methods of measurement. Anim. Sci. J. 74:31-36. Kralik, G., Z. Milakovic, and S. Ivankovic. 2004. Effect of probiotic supplementation on the performance and intestinal microflora of broilers. Acta. Agric. Kapo. 8:23-31. Kruger, C., Y. Hu, Q. Pan, H. Marcotte, A. Hultberg, D. Delwar, P. J. van Dalen, P. H. Pouwels, R. J. Leer, C. G. Kellt, C. van Dollenweerd, J. K. Ma, and L. Hammarstom. 2002. In situ delivery of passive immunity by lactobacilli producing single-chain antibodies. Nat. Biotechnol. 20:702-706. Kruisselbrink, A., M. J. Heijne Den Bak-Glashouwer, C. E. Havenith, J. E. Thole, and R. Janssen. 2001. Recombinant Lactobacillus plantarum inhibits house dust mite-specific T-cell responses. Clin. Exp. Immunol. 126:2-8. Lebeer, S., J. Vanderleyden, and S. C. De Keersmaecker. 2010. Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat. Rev. Microbiol. 8:171-184. Lee, J. S., H. Poo, D. P. Han, S. P. Hong, K. Kim, M. W. Cho, E. Kim, M. H. Sung, and C. J. Kim. 2006. Mucosal immunization with surface displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice. J. Virol. 80:4079-4087. Lei, H., Y. H. Xu, J. A. Chen, X. H. Wei, and D. M. K. Lam. Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules. 2010. Virology 407:319-324. Li, L. L., Z. P. Hou, T. J. Li, G. Y. Wu, R. L. Huang, Z. R. Tang, C. B. Yang, J. Gong, H. Yu, and X. F. Kong. 2008. Effects of dietary probiotic supplementation on ileal digestibility of nutrients and growth performance in 1- to 42-day-old broilers. J. Sci. Food Agric. 88:35-42. Li, S. P., X. J. Zhao, and J. Y. Wang. 2009. Synergy of Astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks. Poult. Sci. 88:519-525. Lilly, D. M. and R. H. Stillwell. 1965. Probiotics: growth promoting factors produced by microorganisms. Science 147:747-748. Luchansky, J. B., P. M. Muriana, and T. R. Klaenhammer. 1988. Application of electroporation for transfer of plasmid DNA to Lactobacillus, Lactococcus, Leuconostoc, Listeria, Pediococcus, Bacillus, Staphylococcus, Enterococcus and Propionibacterium. Mol. Microbiol. 2:637-646. Male, D., J. Brostoff, D. B. Roth, and I. Roitt. 2006. Immunology. 7th ed. Elsevier, Canada. Mannam, P., K. F. Jones, and B. L. Geller. 2004. Mucosal vaccine made from live recombinant Lactococcus lactis protects mice against pharyngeal infection with Streptococcus pyogenes. Infect. Immun. 72:3444-3450. Miyamoto, T., W. Min, and H. S. Lillehoj. 2002. Lymphocyte proliferation response during eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay. Avian Dis. 46:10-16. Moeini, H., R. A. Rahim, A. R. Omar, N. Shafee, and K. Yusoff. 2011. Lactobacillus acidophilus as a live vehicle for oral immunization against chicken anemia virus. Appl. Microbiol. Biotechnol. 90:77-88. Mountzouris, K. C., P. Tsirtsikos, E. Kalamara, S. Nitsch, G. Schatzmayr, and K. Fegeros. 2007. Evaluation of the efficacy of a probiotic containing Lactobacillus, Bifidobacterium, Enterococcus, and Pediococcus strains in promoting broiler performance and modulating cecal microflora composition and metabolic activities. Poult. Sci. 86:309-317. Orla-Jensen, S. 1919. The lactic acid bacteria. Fred Host and Son. Copenhagen. Parker, R. B. 1974. Probiotics, the other half of the antibiotics story. Anim. Nutr. Health 29:4-8. Patterson, J. A. and K. M. Burkholder. 2003. Application of prebiotics and probiotics in poultry production. Poult. Sci. 82:627-631. Paul G., V. Khare, and C. Gasche. 2012. Inflamed gut mucosa: downstream of interleukin-10. Eur. J. Clin. Invest. 42:95-109. Pelicano, E. R. L., P. A. de Souza, H. B. A. de Souza, A. Oba, E. A. Norkus, L. M. Kodawara, and T. M. A. de Lima. 2003. Effect of different probiotics on broiler carcass and meat quality. Br. J. Poult. Sci. 5:207-214. Plotkin, S., W. Orenstein, and P. Offit. 2012. Vaccines. 6th ed. Elsevier, Canada. Rigaux, P., C. Daniel, M. Hisbergues, E. Muraille, P. Hols, B. Pot, J. Pestel, and A. Jacquet. 2009. Immunomodulatory properties of Lactobacillus plantarum and its use as a recombinant vaccine against mite allergy. Allergy 64:406-414. Repa, A., C. Grangette, C. Daniel, R. Hochreiter, K. Hoffmann-Sommreqruber, J. Thalhamer, D. Kraft, H. Breiteneder, A. Mercenier, and U. Wiedermann. 2003. Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. Vaccine 22:87-95. Rogl, H., K. Kosemund, W. Kuhlbrandt, and I. Collinson. 1998. Refolding of Escherichia coli produced membrane protein inclusion bodies immobilised by nickel chelating chromatography. FEBS Letters 432:21-26. Ryan, W. and S. J. Paruleka. 1991. Recombinant protein synthesis and plasmid instability in continuous cultures of Escherichia coli JM103 harboring a high copy number plasmid. Biotechnol. Bioeng. 37:415-429. Schwarzer, M., A. Repa, C. Daniel, I. Schabussova, T. Hrncir, B. Pot, R. Stepankova, T. Hudcovic, A. Pollak, H. Tlaskalova-Hogenova, U. Wiedermann, and H. Kozakova. 2011. Neonatal colonization of mice with Lactobacillus plantarum producing the aeroallergen Bet v 1 biases towards Th1 and T-regulatory responses upon systemic sensitization. Allergy 66:368-375. Sen, S., S. L. Ingale, and Y. W. Kim. 2012. Effect of supplementation of Bacillus subtilis LS 1-2 to broiler diets on growth performance, nutrient retention, caecal microbiology and small intestinal morphology. Res. Vet. Sci. 93:264-268. Shim, Y. H., S. L. Ingale, and J. S. Kim. 2012. A multi-microbe probiotic formulation processed at low and high drying temperatures: effects on growth performance, nutrient retention and caecal microbiology of broilers. Br. Poult. Sci. 53:482-490. Shoji, Y., H. Bi, K. Musiychuk, A. Rhee, A. Horsey, G. Roya, B. Green, M. Shamloul, C. E. Farrance, B. Taggart, N. Mytle, N. Ugulava, S. Rabindran, V. Mett, J. A. Chichester, and V. Yusibov. 2009. Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza. Vaccine 27:1087-1092. Steidler, L., K. Robinson, L. Chamberlain, K. M. Schofield, E. Remaut, R. W. Le Page, and J. M. Wells. 1998. Mucosal delivery of murine interleukin-2 (IL-2) and IL-6 by recombinant strains of Lactococcus lactis coexpressing antigen and cytokine. Infect. Immun. 66:3183-3189. Steidler, L., W. Hans, L. Schotte, S. Neirynck, F. Obermeier, W. Falk, W. Fiers, and E. Remaut. 2000. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289:1352-1355. Stropkovska, A., J. Janulikova, and E. Vareckova. 2010. Trends in development of the influenza vaccine with broader cross-protection. Acta Virol. 54:7-19. Teo, A. Y. and H. M. Tan. 2007. Evaluation of the performance and intestinal gut microflora of broilers fed on corn-soy diets supplemented with Bacillus subtilis PB6. J. Appl. Poult. Res. 16:296-303. van den Berg, T., B. Lambrecht, S. Marche, M. Steensels, S. Van Borm, and M. Bublot. 2008. Influenza vaccines and vaccination strategies in birds. Comp. Immunol. Microbio. Infect. Dis. 31:121-165. Vicente, J. L., L. Avina, A. Torres-Rodriguez, B. Hargis, and G. Tellez. 2007. Effect of a Lactobacillus spp-based probiotic culture product on broiler chicks performance under commercial conditions. Int. J. Poult. Sci. 6:154-156. Webster, R. G., W. J. Bean, O. T. Gorman, T. M. Chambers, and Y. Kawaoka. 1992. Evolution and ecology of influenza A viruses. Microbiol. Rev. 56:152-179. Wells, J. M. and A. Mercenier. 2008. Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria. Nat. Rev. Microbiol. 6:349-362. Wang, Z. S., Q. H. Yu, J. K. Gao, and Q. Yang. 2012. Mucosal and systemic immune responses induced by recombinant Lactobacillus spp. expressing the hemagglutinin of the avian influenza virus H5N1. Clin. Vaccine Immunol. 19:174-179. Wen, L. J., X. L. Hou, G. H. Wang, L. Y. Yu, X. M. Wei, J. K. Liu, W. Liu, and C. H. Wei. 2012. Immunization with recombinant Lactobacillus casei strains producing K99, K88 fimbrial protein protects mice against enterotoxigenic Escherichia coli. Vaccine 30:3339-3349. WHO. 2009. Influenza. WHO media centre on line, available at http://www.who.int/influenza/en. WHO. 2013. Cumulative number of confirmed human cases for avian influenza A (H5N1) reported to WHO, 2003-2013. WHO, available at: http://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/index.html. Wu, C. M., and T. C. Chung. 2007. Mice protected by oral immunization with Lactobacillus reuteri secreting fusion proteins of Escherichia coli enterotoxin subunit protein. FEMS Immun. Med. Microbio. 50:354-365. Xin, K. Q., Y. Hoshino, Y. Toda, S. Igimi, Y. Kojima, and N. Jounai. 2003. Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env. Blood 102:223-228. Xu, Y. G., L. Cui, C. Tian, G. Zhang, G. Huo, Li. Tang, and Y. Li. 2011. Immunogenicity of recombinant classic swine fever virus CD8(+) T lymphocyte epitope and porcine parvovirus VP2 antigen coexpressed by Lactobacillus casei in swine via oral vaccination. Clin. Vaccine Immunol. 18:1979-1986. Yang, C. M., G. T. Cao, P. R. Ferket, T. T. Liu, L. Zhou, L. Zhang, Y. P. Xiao, and A. G. Chen. 2012. Effects of probiotic, Clostridium butyricum, on growth performance, immune function, and cecal microflora in broiler chickens. Poult. Sci. 91:2121-2129. Yason, C. V., B. A. Summers, and K. A. Schat. 1987. Pathogenesis of rotavirus infection in various age groups of chickens and turkeys: pathology. Am. J. Vet. Res. 6:927-938. Yoon, S. W., C. H. Lee, J. Y. Kim, M. H. Sung, and H. Poo. 2008. Lactobacillus casei secreting alpha-MSH induces the therapeutic effect on DSS-induced acute colitis in Balb/c mice. J. Microbiol. Biotechnol. 18:1975-1983. Yu, B., J. R. Liu, M. Y. Chiou, Y. R. Hsu, and P. W. S. Chiou. 2007. The effects of probiotic Lactobacillus reuteri Pg4 strain on intestinal characteristics and performance in broiler. Asian-Aust. J. Anim. Sci. 20:1243-1251. Yu, B., J. R. Liu, F. S. Hsiao, and P. W. S. Chiou. 2008. Evaluation of Lactobacillus reuteri Pg4 strain expressing heterologous β-glucanase as a probiotic in poultry diets based on barley. Anim. Feed Sci. Technol. 141:82-91. Yu, Z., Z. Zeng, Z. Huang, J. Lian, J. Yang, Q. Deng, and W. Zeng. 2010. Increased mRNA expression of interferon-induced Mx1 and immunomodulation following oral administration of IFN-alpha2b-transformed Bifidobacterium longum to mice. Arch. Microbiol. 92:633-638. Yu, Z., Z. Zeng, Z. Huang, J. Lian, J. Yang, Q. Deng, and W. Zeng. 2011. Oral administration of interferon-alpha2b-transformed Bifidobacterium longum protects BALB/c mice against coxsackievirus B3-induced myocarditis. Virol. J. 8:1-6. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60840 | - |
dc.description.abstract | 高病原性家禽流行性感冒H5N1亞型對全球人類及家禽而言是重大的威脅,而家禽接種疫苗是預防禽流感並防止病毒傳播之重要措施。在新興疫苗研究中,應用乳酸菌做為疫苗載體具有較高安全性及方便性之優勢,因此本試驗應用重組技術將益生菌株Lactobacillus reuteri Pg4建構成可表達禽流感病毒表面抗原-血球凝集素(hemagglutinin;HA)之重組乳酸菌L. reuteri pNZ-HA,並評估其是否仍具益生菌特性及應用於雞隻之疫苗功效。
結果顯示,從DNA、RNA及蛋白質層次之分析,均證實重組菌株具表達外源HA之能力。在動物試驗部分,1日齡白肉雞逢機分置於Control組(基礎飼糧)、Pg4組(飼糧含原始菌株)及pNZ-HA組(飼糧含重組菌株)等處理組,Pg4組及pNZ-HA組雞隻於21及35日齡時分別給予5日含有原始菌株及重組菌株之飼糧,試驗期為49天。結果顯示,雞隻之生長性狀及單核球、淋巴球及異嗜球比例在三個處理組之間並無顯著差異。然而,pNZ-HA組雞隻之血清免疫球蛋白濃度則顯著高於Control組(P <0.05)。迴腸絨毛長度、腺窩深度、大腸桿菌數及大腸桿菌群數量在三個處理組雞隻之間並無顯著差異,然而,Pg4組雞隻之絨毛長度與腺窩深度比值及乳酸菌數皆顯著高於Control組(P <0.05),而pNZ-HA組雞隻之數值僅略高於Control組。抗體分析結果顯示,pNZ-HA組雞隻具有顯著較高之血清專一性抗體力價(P <0.05),然而,黏膜專一性抗體含量則無顯著差異。而脾臟細胞之抗原專一性增生反應分析之結果顯示,雞隻並未誘發專一性之細胞免疫反應。 綜上所述,本試驗成功將外源HA表達於L. reueri pNZ-HA,雖然菌株在此餵飼策略並無明顯之益生菌特性,但仍成功誘發雞隻產生顯著較高之抗體力價。L. reueri pNZ-HA能以添加於飼糧的方式達到免疫雞隻之效果,說明此菌株可應用於大群動物的便利性,而藉由發酵生產即可產製抗原也降低疫苗生產的成本,顯示L. reueri pNZ-HA具有開發成禽用流行性感冒口服疫苗之潛力。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-16T10:32:34Z (GMT). No. of bitstreams: 1 ntu-102-R00626025-1.pdf: 1837851 bytes, checksum: f0dd1f0963b7d1e2d7962a3ce11c0daa (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 中文摘要 1
英文摘要 2 序言 4 第一章、文獻探討 5 一、益生菌之介紹與特性 5 (一)益生菌之介紹 5 (二)益生菌於動物之影響 7 二、基因改造乳酸菌之發展 9 (一)基因改造乳酸菌在生物醫學之研究 9 (二)乳酸菌做為疫苗載體之研究 11 三、甲型流行性感冒與血球凝集素抗原蛋白 15 (一)動物之免疫系統 15 (二)疫苗之種類 25 (三)甲型流行性感冒與家禽流行性感冒 28 (四)血球凝集素抗原蛋白於疫苗之應用 32 第二章、材料與方法 33 一、乳酸菌系統表達血球凝集素 33 (一)大腸桿菌-乳酸桿菌穿梭載體建構 33 (二)乳酸菌勝任細胞製備 34 (三)電穿孔反應條件 35 (四)菌落聚合酶鏈鎖反應 35 (五)反轉錄聚合酶鏈鎖反應 36 (六)西方轉漬 38 二、重組乳酸菌餵飼雞隻之效果評估 42 (一)雞隻試驗 42 (二)生長性能分析 46 (三)血液學分析 46 (四)免疫球蛋白含量分析 46 (五)迴腸組織切片分析 46 (六)腸道菌相分析 47 (七)專一性抗體力價及含量分析 49 (八)脾臟細胞T淋巴球之抗原專一性增生反應分析 51 (九)統計分析 53 第三章、結果與討論 54 一、L. reuteri pNZ-HA表達血球凝集素 54 (一)穿梭質體構築與選殖 54 (二)L. reuteri pNZ-HA之mRNA表現 56 (三)L. reuteri pNZ-HA之蛋白質表現 58 (四)L. reuteri Pg4及其轉形株之生長情形 60 二、L. reuteri pNZ-HA之益生菌特性 62 (一)L. reuteri pNZ-HA對白肉雞生長性狀之影響 62 (二)L. reuteri pNZ-HA對白肉雞單核球、淋巴球及異嗜球比例之影響 65 (三)L. reuteri pNZ-HA對白肉雞脾臟相對重量之影響 68 (四)L. reuteri pNZ-HA對白肉雞免疫球蛋白濃度之影響 70 (五)L. reuteri pNZ-HA對白肉雞迴腸菌相之影響 72 (六)L. reuteri pNZ-HA對白肉雞迴腸黏膜組織型態之影響 74 三、L. reuteri pNZ-HA之疫苗功效 76 (一)L. reuteri pNZ-HA對白肉雞體液免疫反應之影響 76 (二)L. reuteri pNZ-HA對白肉雞細胞免疫反應之影響 78 第四章、結論 80 參考文獻 81 作者小傳 94 | |
dc.language.iso | zh-TW | |
dc.title | 應用乳酸桿菌表達家禽流行性感冒病毒之血球凝集素並評估其益生菌特性及對雞隻之疫苗功效 | zh_TW |
dc.title | Expression of Hemagglutinin of Avian Influenza Virus by Lactobacillus and Evaluation of Its Probiotic Characteristics and Vaccine Efficacy on Chicken | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳明汝,余碧,劉啟德,鄭光成 | |
dc.subject.keyword | 家禽流行性感冒,血球凝集素,Lactobacillus,益生菌,口服疫苗, | zh_TW |
dc.subject.keyword | avian influenza,hemagglutinin,Lactobacillus,probiotics,oral vaccine, | en |
dc.relation.page | 94 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-14 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
顯示於系所單位: | 動物科學技術學系 |
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