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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 江福田(Fu-Tien Chiang) | |
dc.contributor.author | Yi-Li Huang | en |
dc.contributor.author | 黃誼禮 | zh_TW |
dc.date.accessioned | 2021-06-16T10:19:32Z | - |
dc.date.available | 2018-09-24 | |
dc.date.copyright | 2013-09-24 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-16 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60488 | - |
dc.description.abstract | 心房震顫是所有心律不整症狀中最為常見的一種,且有相當高的發病率及死亡率。在近幾十年中,許多研究指出腎素-血管張力素-醛固酮系統(rennin-angiotensin-aldosterone system;RAAS)對心房震顫扮演著非常重要的角色,在過去實驗室的研究中發現到經由胞外電位紀錄在HL-1新房心肌細胞中,Angiotensin II (AngII)可以透過鈉鈣交換蛋白 (sodium-calcium exchanger; NCX)及cAMP-response element binding protein (CREB)造成震顫現象。另一方面,aldsoterone也被證實會去誘發心律不整的產生。在本篇研究中,我們想要了解與AngII同屬於RAAS的aldosterone是否會去調控NCX mRNA表現,且也想去了解CREB是否也參與在其中的訊息傳遞。我們發現同樣在不同濃度或不同時間的醛固酮刺激下,NCX mRNA的表現量有隨之上升的情形。同樣也在NCX的基因預測出promoter中有CREB的binding site,利用染色質免疫共沉澱法,確認了CREB的確可以與所預測的結合位做結合。除此之外,同樣利用轉染dominant-negative CREB(pCMV-CREB133和pCMV-KCREB)到HL-1中發現到因醛固酮所造成的NCX mRNA表現量上升的情況因此減弱。最後的實驗發現醛固酮所造成的CREB磷酸化程度的上升並不會因為給予了PKC inhibitor或PKD inhibitor而有所減弱,但再給予蛋白質生成抑制劑(cycloheximide)、礦物質皮質固酮接受器阻斷劑(mineralocorticoid receptor blocker; MR blocker)或活性氧物質清除劑(ROS scavenger; N-acetyl cysteine)後醛固酮所誘導的CREB磷酸化增加則有下降的情形。綜合上述,醛固酮可以增加NCX mRNA的表現量,同時醛固酮可以透過ROS或MR的genomic effect進而增加CREB磷酸化的程度 | zh_TW |
dc.description.abstract | Atrial fibrillation (AF) is a common arrhythmia that causes significant morbidity and mortality. In recent decades, the rennin-angiotensin-aldosterone system (RAAS) has been proven to play an important role in AF. Previous results in our lab have demonstrated that angiotensin II can induce fibrillary-like electrical activity in HL-1 atrail myocytes through sodium-calcium exchanger (NCX) and cAMP response element-binding protein (CREB). Aldosterone has also been shown to trigger AF. In this study, we investigated whether aldosterone, a critical component in RAAS, can modulate the expression of NCX mRNA and whether CREB is involved in its signaling pathway. We found that aldosterone increased NCX expression through a concentration and time dependent manner. A CREB binding site was identified in the promoter of NCX gene, and binding of CREB to this cognate binding site was confirmed by chromatin-immunoprecipitation assay (ChIP). We further found that aldosterone increased CREB serine 133 phosphorylation, and aldosterone induced NCX expression was attenuated by dominant-negative CREB (pCMV-CREB133 and pCMV-KCREB). Finally, aldosterone induced CREB serine 133 phosphorylation was not inhibited by protein kinase C or protein kinase D inhibitor, but was attenuated by protein synthesis inhibitor cycloheximide, mineralocorticoid receptor blocker spironolactone, and reactive oxygen species scavenger N-acetyl cysteine. In conclusion, aldosterone increases NCX expression thorugh CREB, and aldosterone increases CREB phosphorylation through reactive oxygen species and the genomic effect of mineralocorticoid receptor. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T10:19:32Z (GMT). No. of bitstreams: 1 ntu-102-R00441018-1.pdf: 4065395 bytes, checksum: bd01bfdabe0318823a27a333a55c8659 (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 目錄
中文摘要 3 Abstract 4~5 第一章 導論 6 第一節 心房震顫 (Atrial Fibrillation; AF) 6~7 第二節 心房震顫形成機制總括 7 第三節 心房震顫臨床之分類 7 第四節 心房震顫與腎素-血管收縮素-醛固酮系統(renin-angiotensin -aldosterone system; RAAS)之關係 7 1. 腎素-血管收縮素-醛固酮系統 (renin-angiotensin-aldosterone system; RAAS) 7~8 2. 醛固酮 (Aldosterone) 8 3. 礦物質皮質固酮接受器 (Mineralocoritcoid receptor; MR) 8~9 4. 第二型血管收縮素 (Angiotensin II; Ang II)之訊息傳遞與心房震顫9 4-1 Protein kinase C (PKC)訊息傳遞 10 4-1-1 PKC與protein kinase D (PKD)之協同作用 10 4-2 cAMP Response Element Binding Protein (CREB)10~11 4-3 Sodium-Calcium Exchanger (NCX) 11~12 4-3-1 NCX對鈣離子排出之機制 12 4-3-2 心臟中NCX之作用 12 4-3-3 NCX與心房震顫之關係 12~13 4-4 Reactive Oxygen Species (ROS) 13 第五節 研究目的 14 第二章 材料與方法 15 第一節 HL-1心肌細胞培養 15~16 第二節 西方墨點法 (Western Blot) 17~20 第三節 PKC活性測定 20~21 第四節 染色質免疫共沉澱 (Chromatin immunoprecipitation; ChIP) 21~24 第五節 RNA抽取與逆轉錄聚合酶連鎖反應(Reverse Transcription Polymerase Chain Reaction; RT-PCR) 24~27 第六節 及時定量聚合酶連鎖反應(Real-Time PCR) 27~29 第七節 質體轉染(Transfection) 29~30 第八節 統計與分析 30 第三章 實驗結果 31 第一節 在HL-1心房心肌細胞中aldosterone對sodium-calcium exchanger mRNA表現之影響 31~32 第二節 在HL-1心肌細胞中aldosterone對CREB磷酸化之影響 33 第三節 Aldosterone透過CREB磷酸化調控Sodium-Calcium Exchanger之表現 33~35 第四節 以在HL-1心房心肌細胞表現Dominant-Negative CREB證實Aldosterone對NCX表現調控可透過CREB之磷酸化 36~37 第五節 在HL-1心肌細胞中aldosterone透過Kinase造成CREB磷酸化改 37~38 第六節 在HL-1心肌細胞中aldosterone對PKC活性之影響 38~39 第七節 Aldosterone透過MR、ROS對CREB磷酸化及CREB生合成之影響 39~40 第四章 討論 41~43 參考文獻 44~55 圖表 51~60 附錄 61~68 | |
dc.language.iso | zh-TW | |
dc.title | 醛固酮於心房心肌細胞中透過CREB增加納鈣交換體之表現:在心房震顫中醛固酮之角色含義 | zh_TW |
dc.title | Aldosterone Increases Sodium-calcium Exchanger Expression through CREB in Atrail Myocytes: Implications of The Role of Aldosterone in Atrial Fibrillation | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 蔡佳醍(Chia-Ti Tsai) | |
dc.contributor.oralexamcommittee | 徐國碁(Kou-Gi Shyu) | |
dc.subject.keyword | 心房震顫,腎素-血管張力素-醛固酮系統,鈉鈣交換蛋白,cAMP response element-binding protein (CREB),礦物質皮質固酮接受器,活性氧物質, | zh_TW |
dc.subject.keyword | Atrial fibrillation (AF),renin-angiotensin-aldosterone system (RAAS),sodium-calcium exchanger (NCX),cAMP response element-binding protein (CREB),mineralocorticoid receptor (MR),reactive oxygen species (ROS), | en |
dc.relation.page | 68 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-16 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 生理學研究所 | zh_TW |
顯示於系所單位: | 生理學科所 |
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