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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鍾孝文 | |
dc.contributor.author | Chao-Chun Lin | en |
dc.contributor.author | 林昭君 | zh_TW |
dc.date.accessioned | 2021-05-16T16:19:38Z | - |
dc.date.available | 2018-08-23 | |
dc.date.available | 2021-05-16T16:19:38Z | - |
dc.date.copyright | 2013-08-23 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-08 | |
dc.identifier.citation | Chapter1
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The FASEB Journal. 2012;26(6):2239-52. 28. Locatelli F, Bersano A, Ballabio E, et al. Stem cell therapy in stroke. Cell Mol Life Sci. 2009;66(5):757-72. 29. Meltzer CC, Kondziolka D, Villemagne VL, et al. Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke. Neurosurgery. 2001;49(3):586-91; discussion 91-2. 30. Nelson PT, Kondziolka D, Wechsler L, et al. Clonal Human (hNT) Neuron Grafts for Stroke Therapy: Neuropathology in a Patient 27 Months after Implantation. The American Journal of Pathology. 2002;160(4):1201-6. Chapter2 1. Arbab AS, Liu W, Frank JA. Cellular magnetic resonance imaging: current status and future prospects. Expert Rev Med Devices. 2006;3(4):427-39. 2. Modo M, Cash D, Mellodew K, et al. Tracking tansplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. NeuroImage. 2002;17(2):803-11. 3. Guzman R, Uchida N, Bliss TM, et al. Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proceedings of the National Academy of Sciences. 2007;104(24):10211-6. 4. Kuhlpeter R, Dahnke H, Matuszewski L, et al. R2 and R2* mapping for sensing cell-bound superparamagnetic nanoparticles: in vitro and murine in vivo testing. Radiology. 2007;245(2):449-57. 5. Fleige G, F S, D L. In vitro characterization f two different ultrasmall iron oxide particles for magnetic resonance cell tracking. Invest Radiol. 2002;37(9):482-8. 6. Jendelová PH, Vít; Urdziková, Lucia; Glogarová, Kateřina; Rahmatová, Šárka; Fales, Ivan; Andersson, Benita; Procházka, Pavel; Zamečník, Josef; Eckschlager, Tomáš; Kobylka, Petr; Hájek, Milan; Syková, Eva. Magnetic Resonance Tracking of Human CD34 Progenitor Cells Separated by Means of Immunomagnetic Selection and Transplanted Into Injured Rat Brain. Cell Transplantation. 2005;14:173-82. 7. Jendelová P, Herynek V, Urdzíková L, et al. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. Journal of Neuroscience Research. 2004;76(2):232-43. 8. Richel DJ. Highly purified CD34+ cells isolated using magnetically activated cell selection provide rapid engraftment following high-dose chemotherapy in breast cancer patients. Bone marrow transplantation. 2000;25(3):243. 9. Liu W, Dahnke H, Rahmer J, Jordan EK, Frank JA. Ultrashort T2* relaxometry for quantitation of highly concentrated superparamagnetic iron oxide (SPIO) nanoparticle labeled cells. Magn Reson Med. 2009;61(4):761-6. 10. Langkammer C, Krebs N, Goessler W, et al. Quantitative MR imaging of Brain Iron: A Postmortem Validation Study. Radiology. 2010;257(2):455-62. 11. Rad AM, Arbab AS, Iskander ASM, Jiang Q, Soltanian-Zadeh H. Quantification of superparamagnetic iron oxide (SPIO)-labeled cells using MRI. Journal of Magnetic Resonance Imaging. 2007;26(2):366-74. 12. Modo M, Mellodew K, Cash D, et al. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage. 2004;21(1):311-7. 13. Kim D-E, Schellingerhout D, Ishii K, Shah K, Weissleder R. Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model. Stroke. 2004;35(4):952-7. 14. Magnitsky S, Watson DJ, Walton RM, et al. In vivo and ex vivo MRI detection of localizaed and disseminated neural sem cell grafts in the mouse brain. NeuroImage. 2005;26:744-54. 15. Zhang RL, Zhang L, Zhang ZG, et al. Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum. Neuroscience. 2003;116:373-82. 16. Goolsby J, Marty MC, Heletz D, et al. Hematopoietic progenitors express neural genes. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(25):14926-31. 17. Handgretinger R, Lang P, Ihm K, et al. Isolation and transplantation of highly purified autologous peripheral CD34(+) progenitor cells: purging efficacy, hematopoietic reconstitution and long-term outcome in children with high-risk neuroblastoma. Bone marrow transplantation. 2002;29(9):731-6. 18. Kim JK, Kucharczyk W, Henkelman RM. Cavernous hemangiomas: dipolar susceptibility artifacts at MR imaging. Radiology. 1993;187(3):735-41. 19. Akihiko Taguchi TS, Hidekazu Tanaka, Takayoshi Kanda, Hiroyuki Nishimura, Hiroo Yoshikawa, Yoshitane Tsukamoto, Hiroyuki Iso, Yoshihiro Fujimori, David M. Stern, Hiroaki Naritomi and Tomohiro Matsuyama. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model. The Journal of Clinical Investigation;114(3):330-8. 20. Shen LH, Li Y, Chen J, et al. Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience. 2006;137(2):393-9. 21. Shyu W-C, Lin S-Z, Chiang M-F, Su C-Y, Li H. Intracerebral Peripheral Blood Stem Cell (CD34+) Implantation Induces Neuroplasticity by Enhancing beta1 Integrin-Mediated Angiogenesis in Chronic Stroke Rats. J Neurosci. 2006;26(13):3444-53. 22. Walczak P, Kedziorek DA, Gilad AA, Barnett BP, Bulte JWM. Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: The case of the Shiverer dysmyelinated mouse brain. Magnetic Resonance in Medicine. 2007;58(2):261-9. 23. Hoehn M, Küstermann E, Blunk J, et al. Monitoring of implanted stem cell migration in vivo: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proceedings of the National Academy of Sciences. 2002;99(25):16267-72. 24. Gomori JM, Grossman RI. Mechanisms responsible for the MR appearance and evolution of intracranial hemorrhage. Radiographics. 1988;8(3):427-40. 25. Terrovitis J. Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation. 2008;117(12):1555. 26. Zhu J, Zhou L, XingWu F. Tracking Neural Stem Cells in Patients with Brain Trauma. New England Journal of Medicine. 2006;355(22):2376-8. 27. Dahnke H, T S. Limits of Detection of SPIO at 3.0 T Using T2* Relaxometry. Magnetic Resonance in Medicine. 2005;53:1202-6. Chapter3 1. Modo M, Stroemer RP, Tang E, Patel S, Hodges H. Effects of Implantation Site of Stem Cell Grafts on Behavioral Recovery From Stroke Damage. Stroke. 2002;33(9):2270-8. 2. Chen J, Li Y, Wang L, et al. Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats. Stroke. 2001;32(4):1005-11. 3. Li Y, Chen J, Wang L, Lu M, Chopp M. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology. 2001;56(12):1666-72. 4. Chen J, Zhang ZG, Li Y, et al. Intravenous Administration of Human Bone Marrow Stromal Cells Induces Angiogenesis in the Ischemic Boundary Zone After Stroke in Rats. Circ Res. 2003;92(6):692-9. 5. Englund U, Bjrklund A, Wictorin K, Lindvall O, Kokaia M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(26):17089-94. 6. Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone Marrow-Derived Endothelial Progenitor Cells Participate in Cerebral Neovascularization After Focal Cerebral Ischemia in the Adult Mouse. Circ Res. 2002;90(3):284-8. 7. Shen LH, Li Y, Chen J, et al. Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience. 2006;137(2):393-9. 8. Shyu W-C, Lin S-Z, Chiang M-F, Su C-Y, Li H. Intracerebral Peripheral Blood Stem Cell (CD34+) Implantation Induces Neuroplasticity by Enhancing beta1 Integrin-Mediated Angiogenesis in Chronic Stroke Rats. J Neurosci. 2006;26(13):3444-53. 9. Taguchi A, Soma T, Tanaka H, et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model. The Journal of Clinical Investigation. 2004;114(3):330-8. 10. Calamante F, Gadian DG, Connelly A. Delay and dispersion effects in dynamic susceptibility contrast MRI: Simulations using singular value decomposition. Magnetic Resonance in Medicine. 2000;44(3):466-73. 11. Jiang Q, Zhang ZG, Ding GL, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. NeuroImage. 2005;28(3):698-707. 12. Majka M, Janowska-Wieczorek A, Ratajczak J, et al. Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood. 2001;97(10):3075-85. 13. Staykov D, Wagner I, Volbers B, et al. Natural Course of Perihemorrhagic Edema After Intracerebral Hemorrhage. Stroke. 2011;42(9):2625-9. 14. Dousset V, Delalande C, Ballarino L, et al. In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance. Magnetic Resonance in Medicine. 1999;41(2):329-33. 15. Byrne JL, Carter GI, Ellis I, Haynes AP, Russell NH. Autologous GVHD following PBSCT, with evidence for a graft-versus-myeloma effect. Bone Marrow Transplantation. 1997;20(6):517-20. 16. Jones R, Hess A, Mann R, et al. INDUCTION OF GRAFT-VERSUS-HOST DISEASE AFTER AUTOLOGOUS BONE MARROW TRANSPLANTATION. The Lancet. 1989;333(8641):754-7. 17. Richel DJ, Johnsen HE, Canon J, et al. Highly purified CD34+ cells isolated using magnetically activated cell selection provide rapid engraftment following high-dose chemotherapy in breast cancer patients. Bone marrow transplantation. 2000;25(3):243-9. 18. Mamula P, Piccoli DA, Peck SN, Markowitz JE, Baldassano RN. Total Dose Intravenous Infusion of Iron Dextran for Iron-Deficiency Anemia in Children With Inflammatory Bowel Disease. Journal of Pediatric Gastroenterology and Nutrition. 2002;34(3):286-90. 19. Kricka LJ. Human Anti-Animal Antibody Interferences in Immunological Assays. Clinical Chemistry. 1999;45(7):942-56. 20. Klee GG. Human Anti-Mouse Antibodies. Archives of Pathology & Laboratory Medicine. 2000;124(6):921-3. 21. Juweid ME. Radioimmunotherapy of B-Cell Non-Hodgkin’s Lymphoma: From Clinical Trials to Clinical Practice. Journal of Nuclear Medicine. 2002;43(11):1507-29. 22. Smith HK, Gavins FNE. The potential of stem cell therapy for stroke: is PISCES the sign? The FASEB Journal. 2012;26(6):2239-52. 23. Rempp KA, Brix G, Wenz F, Becker CR, Gückel F, Lorenz WJ. Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology. 1994;193(3):637-41. 24. Rad AM, Arbab AS, Iskander ASM, Jiang Q, Soltanian-Zadeh H. Quantification of superparamagnetic iron oxide (SPIO)-labeled cells using MRI. Journal of Magnetic Resonance Imaging. 2007;26(2):366-74. 25. Gomori JM, Grossman RI. Mechanisms responsible for the MR appearance and evolution of intracranial hemorrhage. Radiographics. 1988;8(3):427-40. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6029 | - |
dc.description.abstract | 中風為2010年台灣第三大死因,但目前尚無任何讓慢性中風病人神經再生的治療方法。有越來越多的動物研究顯示,幹細胞將是中風未來一個嶄新的治療。在本院臨床二期試驗中,我們將大腦周邊血液的造血幹細胞(CD34+)植入慢性中風患者腦內,並運用MRI非侵入性的特點,以R2*弛緩率觀察被超順磁性氧化鐵顯影劑標幟之植入幹細胞。
由動物研究推測,CD34+細胞能誘導缺血區的血管新生,此發現推測在神經再生中扮演重要角色。因此,我們希望以T2*灌流序列量測慢性中風病人在接種幹細胞前後的腦血流改變,證明腦血流速及腦血流量增加與幹細胞移植的相關性。 | zh_TW |
dc.description.abstract | Stroke is the 3rd leading cause of death in Taiwan on 2010. In the chronic stage, no treatment currently exists to restore lost neurological function after stroke. A growing number of studies highlight the potential of stem cell transplantation in animal model as a novel therapeutic approach for stroke. One phase II clinical trial in our institution studied the therapeutic effects with intracerebral peripheral blood hematopoietic stem cell (CD34+) implantation for chronic stroke patients. This regular MRI follow-ups are aimed to noninvasively monitor the fate, behavior of the implanted stem cells labeled with superparamganetic iron oxide by R2* relaxivity. Besides, since animal studies hypothesize that CD34+ cells may play a positive role in neuroregeneration by inducing neovascularization in the ischemic zone, we want to test the hypothesis of increased cerebral blood flow and volume associated with stem cell implantation, also by MR T2* perfusion sequence. | en |
dc.description.provenance | Made available in DSpace on 2021-05-16T16:19:38Z (GMT). No. of bitstreams: 1 ntu-102-D97945004-1.pdf: 5870499 bytes, checksum: 49308cc68fbff534c6b332fdb285f659 (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 口試委員審定書 ii
論文致謝 iii 中文摘要 vi Abstract vii Table of Contents viii List of Figures x List of Tables xii Chapter1 Stem cell therapy for chronic stroke 1 1.1 Stroke in Taiwan 1 1.2 Current stroke treatment 1 1.3 Plasticity of cortical projections after stroke 2 1.4 Stem cell-mediated brain repair for stroke in animal studies 4 1.5 Potential mechanisms of transplanted cell-mediated recovery 5 1.6 Current clinical trials involving stem cells as stroke therapy 7 References 11 Chapter2 Applicability and Limitations of tracking intracerebral implanted CD 34+ stem cells with R2* relaxivity in chronic stroke patients 16 2.1 Backgrounds and purposes 16 2.11 How to track the implanted stem cell on MRI: SPIO and gadolinium 16 2.12 MRI Sequences for quantification of superparamagnetic iron oxide 18 2.13 Image findings in animal 19 2.14 The aim of this study 20 2.2 Materials and methods 21 2.3 Results 27 2.31 Longitudinal relative quantitative measurement with R2* relaxivity 28 2.32 Is the persisted residual hypointensity in the injected area SPIO? 32 2.33 Is there any migration? 35 2.4 Discussion 42 2.5 Conclusion 48 2.6 Publication 49 References 50 Chapter3 Longitudinal perfusion change after intracerebral CD 34+ stem cells implantation in chronic stroke patients 56 3.1 Backgrounds and purposes 56 3.2 Materials and methods 58 3.3 Results 63 3.4 Discussion 72 3.5 Conclusion 80 3.6 Publication 81 References 82 | |
dc.language.iso | en | |
dc.title | 慢性中風病人接種幹細胞後以磁振造影追蹤及測量灌流變化的應用和限制 | zh_TW |
dc.title | Applicability and limitations of MR tracking and Perfusion change after intracerebral stem cell Implantation in chronic stroke patients | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 吳文超,劉益瑞,阮春榮,黃騰毅,郭萬祐 | |
dc.subject.keyword | CD34+細胞,慢性中風,灌流磁振造影,R2*弛緩率,幹細胞, | zh_TW |
dc.subject.keyword | CD34+ cell,Chronic stroke,MR perfusion,R2* relaxivity,stem cell, | en |
dc.relation.page | 86 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2013-08-08 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
顯示於系所單位: | 生醫電子與資訊學研究所 |
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