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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60235完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳光超 | |
| dc.contributor.author | Hong-Ru Lin | en |
| dc.contributor.author | 林宏儒 | zh_TW |
| dc.date.accessioned | 2021-06-16T10:14:02Z | - |
| dc.date.available | 2018-08-29 | |
| dc.date.copyright | 2013-08-29 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-19 | |
| dc.identifier.citation | Alwan, H.A., and J.E. van Leeuwen. 2007. UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation. The Journal of biological chemistry. 282:1658-1669.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60235 | - |
| dc.description.abstract | 細胞主要利用泛素-蛋白酶體系統 (Ubiquitin-proteasome system) 和細胞自噬 (Autophagy) 兩機制將不需要的物質降解並維持體內恆定，而泛素 (Ubiquitin) 在其中扮演重要角色，除了協助兩者標記欲降解的物質，也可改變酵素活性或分子在細胞中的位置。目前對於泛素化 (Ubiquitination) 的了解較為透徹，且部份的泛素連接酶 (E3 ubiquitin ligase) 如 Parkin 與 Traf6 已被報導與細胞自噬有關。但泛素化的逆反應：去泛素化 (Deubiquitination) 及與細胞自噬的關聯性目前仍有相當大的研究空間。人體基因組中含有超過 90 種去泛素酶 (Deubiquitinating enzyme)負責進行此逆反應。根據其保守的催化域 (conserved catalytic domain) 可分為六群：USP, UCH, MJD, OUT, JAMM 和 MCPIP。最近研究指出 USP36 失去正常功能時會在營養充足的情況下促進細胞自噬的進行。藉由胺基酸序列的分析比對，我們在果蠅中找出超過 28 種去泛素酶，並進一步研究去泛素酶在調控細胞自噬中扮演的角色。除了 USP36，我們額外發現四種去泛素酶可促進或抑制細胞自噬的進行。我們的發現指出去泛素酶確實參與了細胞自噬的調控。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-16T10:14:02Z (GMT). No. of bitstreams: 1 ntu-102-R00b46013-1.pdf: 4804216 bytes, checksum: c5bd764dd3997dade8e0e978c9e1567c (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 論文口試委員審定書 ....................................................................................................... i
中文摘要 ........................................................................................................................... i Abstract ............................................................................................................................ iii Table of contents .............................................................................................................. iv List of figures ................................................................................................................... v List of tables ................................................................................................................... vii Chapter 1 - Introduction ................................................................................................... 1 1.1 Overview of autophagy ................................................................................ 1 1.2 Selective autophagy ...................................................................................... 3 1.3 Interplay between autophagy and UPS ......................................................... 4 1.4 Autophagic regulation by ubiquitination ...................................................... 5 1.5 Deubiquitination by DUBs ........................................................................... 6 1.6 Autophagic regulation by deubiquitination .................................................. 8 1.7 DUBs – promising therapeutic targets ......................................................... 11 Chapter 2 – Materials and methods ................................................................................ 13 Chapter 3 – Results ......................................................................................................... 16 Chapter 4 – Discussion ................................................................................................... 25 Chapter 5 - References ................................................................................................... 31 Chapter 6 – Figures ........................................................................................................ 43 Chapter 7 - Tables ........................................................................................................... 61 | |
| dc.language.iso | en | |
| dc.title | 果蠅去泛素酶調控細胞自噬之功能分析 | zh_TW |
| dc.title | Functional Analysis of Drosophila DUBs in Autophagic Regulation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳瑞華,簡正鼎 | |
| dc.subject.keyword | 細胞自噬,泛素-蛋白酶,體系統,泛素化,去泛素酶,選擇性自噬作用, | zh_TW |
| dc.subject.keyword | Autophagy,UPS,Ubiquitination,Deubiquitinase,selective autophagy, | en |
| dc.relation.page | 63 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2013-08-19 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科學研究所 | zh_TW |
| 顯示於系所單位： | 生化科學研究所 | |
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